脂肪细胞型脂肪酸结合蛋白与动脉粥样硬化的研究进展

脂肪细胞型脂肪酸结合蛋白是脂肪酸结合蛋白家族成员之一,与体重、糖脂代谢紊乱、高血压关系密切,有助于代谢综合征的诊断及预测。近年来逐渐成为动脉粥样硬化的标记物,并为动脉粥样硬化的治疗提供了新的靶点。     

脂肪细胞型脂肪酸结合蛋白研究进展

脂肪细胞型脂肪酸结合蛋白(A-FABP)是脂肪酸结合蛋白家族成员之一,与体重、糖脂代谢及胰岛素敏感性有密切关系,有助于代谢综合征的诊断及危险性预测,可能是代谢综合征一个独立的危险因子.此外,A-FABP还与多囊卵巢综合征以及动脉粥样硬化的发生和进展有关,为代谢性疾病的药物预防和治疗提供了新的潜在靶点.     

脂肪细胞型脂肪酸结合蛋白与支气管哮喘

脂肪细胞型脂肪酸结合蛋白(A-FABP)亦称脂肪细胞脂类结合蛋白、脂肪酸结合蛋白4、ap2、422蛋白或P15蛋白,是脂肪酸结合蛋白家族中最重要的一员,与支气管哮喘多种炎性细胞关系密切,研究认为A-FABP可能在支气管哮喘中发挥重要作用.     

脂肪细胞型脂肪酸结合蛋白与胆固醇代谢

脂肪细胞型脂肪酸结合蛋白(FABP4)主要在脂肪组织和巨噬细胞中表达,与脂质分子一起,主要生理作用为参与细胞内部的脂肪酸转运和靶向定位。近来许多研究表明 FABP4与胆固醇代谢关系密切,FABP4可通过影响胆固醇代谢相关的关键基因转录来调节胆固醇的代谢、储存和转运。随着 FABP4抑制剂研究的深入,以 FABP4为靶点的药物有望成为预防和治疗肥胖、2型糖尿病、高胆固醇血症以及动脉粥样硬化等疾病的新策略。     

脂肪细胞型脂肪酸结合蛋白在心血管疾病中的作用

<正>肥胖是代谢综合征和心血管疾病(CVD)发生发展的主要危险因素,并且内脏型的肥胖和非脂肪组织中的包括心脏在内的异位脂肪积累都与心脏结构异常和心脏代谢风险增加有关^[1]。相关研究表明肥胖、超重和CVD的发生呈正相关,肥胖和超重者患心力衰竭(HF)的风险更大^[2]。数据表明,肥胖与HF的风险直接相关,与代谢状态无关^[3]。脂肪组织作为一种内分泌器官,产生和分泌多种生物活性因子,即脂肪因子,参与脂肪组织与包括心脏在内的周围器官之间的交流。     

脂肪细胞型脂肪酸结合蛋白与代谢综合征相关

代谢综合征(MS)组(n=121)的血清脂肪细胞型脂肪酸结合蛋白(A-FABP)水平较对照组(n=120)显著升高[(14.7±4.8 vs 6.8±3.0)μg/L,P<0.001].腹型肥胖MS患者的血清A-FABP水平较非腹型肥胖MS患者显著升高[(15.7±4.2 vs 12.6±5.1)μg/L,P<0.001].血清A-FABP水平与体重指数、腰围、腰臀比、空腹胰岛素、稳态模型评估的胰岛素抵抗指数、空腹血糖、甘油三酯、总胆同醇及平均动脉压等指标均呈正相关(r分别为0.603、0.534、0.411、0.424、0.401、0.370、0.460、0.208和0.522,均P<0.05),而与HDL-C旱显著负相关(r=-0.448,P<0.001).     

脂肪细胞型脂肪酸结合蛋白与代谢综合征

脂肪细胞型脂肪酸结合蛋白(A-FABP)是近年来新发现的脂肪因子.动物实验表明其可以促进代谢综合征各组分如胰岛素抵抗、血脂紊乱、2型糖尿病和动脉粥样硬化的发生、发展.人群研究也发现,其过度表达而导致血浆中含量增加是反映代谢综合征的一个可靠生物标志物.随着研究的深入,A-FABP对于治疗代谢综合征的作用也日益受到人们的关注.以下主要就近年来有关A-FABP的分布、结构、特性及其与代谢综合征组分的关系作一综述.     

血清脂肪细胞型脂肪酸结合蛋白与冠心病及其危险因素的相关性

目的 研究血清脂肪细胞型脂肪酸结合蛋白水平与冠心痛及其危险因素之间的相关性.探讨其对冠心病及血管病变程度的预测价值.方法 经冠状动脉造影选取340名患者,用病变血管支数和Gensini积分表示冠状动脉病变程度,酶联免疫吸附法测定血清脂肪细胞型脂肪酸结合蛋白水平.结果 血清脂肪细胞型脂肪酸结合蛋白水平在三支病变组[18.6(13.8～24.0)μg/L]高于非冠心病组[16.4(13.5～20.4)μg/L,P<0.05]及单支病变组[17.5(13.5～20.3)μg/L,P<0.05];女性[20.0(16.9～23.9)μg/L]明显高于男性[15.4(12.5～20.3)μg/L,P=0.000];总体冠心痛组血清脂肪细胞型脂肪酸结合蛋白水平[18.3(13.2～22.8)μg/L]较非冠心病组[16.4(13.5～20.4)μg/L]升高,但差异无统计学意义(P=0.088).女性冠心病组血清脂肪细胞型脂肪酸结合蛋白[22.8(18.6～25.7)μg/L]明显高于非冠心病组[18.1(15.6～21.8)μg/L,P<0.01].血清脂肪细胞型脂肪酸结合蛋白与Gensini积分呈正相关(男性r=0.105,P<0.05;女性r=0.405,P<0.01),多元回归分析发现血清脂肪细胞型脂肪酸结合蛋白与女性Gensini积分有独立相关性(P=0.018).血清脂肪细胞型脂肪酸结合蛋白与甘油三酯(r=0.187,P<0.01)、空腹血糖(r=0.115,P<0.01)、高敏C反应蛋白(r=0.135,P<0.05)等心血管危险因素呈明显正相关,与高密度脂蛋白胆固醇(r=-0.168,P<0.01)及载脂蛋白A1(r=-0.126,P<0.05)呈明显负相关.结论 血清脂肪细胞型脂肪酸结合蛋白可能成为预测人类冠心病及血管病变程度的有用指标,它是女性冠心病的独立危险因素,可能对糖代谢及脂代谢有一定影响.     

脂肪细胞型脂肪酸结合蛋白与代谢综合征相关

Serum adipocyte fatty acid-binding protein (A-FABP) was raised in metabolic syndrome (MS)patients (n= 121) as compared with age-matched healthy subjects [n = 120, (14.7±4.8 vs 6.8 ±3. 0) μg/L,P<0.001]. It reached higher level in MS subjects with visceral obesity [(15.7±4.2 vs 12.6±5.1) μg/L, P<0.001]. Serum A-FABP concentration was positively correlated with body mass index, waist circumference, waist-tohip ratio, fasting insulin, homeostasis assessment for insulin resistance (HOMA-IR), fasting glucose, triglycerides,total cholesterol,and mean arterial blood pressure, whereas negatively correlated with HDL-C (r =-0. 448, P< 0.001).     

脂肪细胞型脂肪酸结合蛋白与代谢综合征相关

Serum adipocyte fatty acid-binding protein (A-FABP) was raised in metabolic syndrome (MS)patients (n= 121) as compared with age-matched healthy subjects [n = 120, (14.7±4.8 vs 6.8 ±3. 0) μg/L,P<0.001]. It reached higher level in MS subjects with visceral obesity [(15.7±4.2 vs 12.6±5.1) μg/L, P<0.001]. Serum A-FABP concentration was positively correlated with body mass index, waist circumference, waist-tohip ratio, fasting insulin, homeostasis assessment for insulin resistance (HOMA-IR), fasting glucose, triglycerides,total cholesterol,and mean arterial blood pressure, whereas negatively correlated with HDL-C (r =-0. 448, P< 0.001).     

脂肪细胞型脂肪酸结合蛋白与代谢综合征相关

Serum adipocyte fatty acid-binding protein (A-FABP) was raised in metabolic syndrome (MS)patients (n= 121) as compared with age-matched healthy subjects [n = 120, (14.7±4.8 vs 6.8 ±3. 0) μg/L,P<0.001]. It reached higher level in MS subjects with visceral obesity [(15.7±4.2 vs 12.6±5.1) μg/L, P<0.001]. Serum A-FABP concentration was positively correlated with body mass index, waist circumference, waist-tohip ratio, fasting insulin, homeostasis assessment for insulin resistance (HOMA-IR), fasting glucose, triglycerides,total cholesterol,and mean arterial blood pressure, whereas negatively correlated with HDL-C (r =-0. 448, P< 0.001).     

脂肪细胞型脂肪酸结合蛋白与代谢综合征相关

Serum adipocyte fatty acid-binding protein (A-FABP) was raised in metabolic syndrome (MS)patients (n= 121) as compared with age-matched healthy subjects [n = 120, (14.7±4.8 vs 6.8 ±3. 0) μg/L,P<0.001]. It reached higher level in MS subjects with visceral obesity [(15.7±4.2 vs 12.6±5.1) μg/L, P<0.001]. Serum A-FABP concentration was positively correlated with body mass index, waist circumference, waist-tohip ratio, fasting insulin, homeostasis assessment for insulin resistance (HOMA-IR), fasting glucose, triglycerides,total cholesterol,and mean arterial blood pressure, whereas negatively correlated with HDL-C (r =-0. 448, P< 0.001).     

脂肪细胞型脂肪酸结合蛋白与代谢综合征相关

Serum adipocyte fatty acid-binding protein (A-FABP) was raised in metabolic syndrome (MS)patients (n= 121) as compared with age-matched healthy subjects [n = 120, (14.7±4.8 vs 6.8 ±3. 0) μg/L,P<0.001]. It reached higher level in MS subjects with visceral obesity [(15.7±4.2 vs 12.6±5.1) μg/L, P<0.001]. Serum A-FABP concentration was positively correlated with body mass index, waist circumference, waist-tohip ratio, fasting insulin, homeostasis assessment for insulin resistance (HOMA-IR), fasting glucose, triglycerides,total cholesterol,and mean arterial blood pressure, whereas negatively correlated with HDL-C (r =-0. 448, P< 0.001).     

脂肪细胞型脂肪酸结合蛋白与代谢综合征相关

Serum adipocyte fatty acid-binding protein (A-FABP) was raised in metabolic syndrome (MS)patients (n= 121) as compared with age-matched healthy subjects [n = 120, (14.7±4.8 vs 6.8 ±3. 0) μg/L,P<0.001]. It reached higher level in MS subjects with visceral obesity [(15.7±4.2 vs 12.6±5.1) μg/L, P<0.001]. Serum A-FABP concentration was positively correlated with body mass index, waist circumference, waist-tohip ratio, fasting insulin, homeostasis assessment for insulin resistance (HOMA-IR), fasting glucose, triglycerides,total cholesterol,and mean arterial blood pressure, whereas negatively correlated with HDL-C (r =-0. 448, P< 0.001).     

脂肪细胞型脂肪酸结合蛋白与代谢综合征相关

Serum adipocyte fatty acid-binding protein (A-FABP) was raised in metabolic syndrome (MS)patients (n= 121) as compared with age-matched healthy subjects [n = 120, (14.7±4.8 vs 6.8 ±3. 0) μg/L,P<0.001]. It reached higher level in MS subjects with visceral obesity [(15.7±4.2 vs 12.6±5.1) μg/L, P<0.001]. Serum A-FABP concentration was positively correlated with body mass index, waist circumference, waist-tohip ratio, fasting insulin, homeostasis assessment for insulin resistance (HOMA-IR), fasting glucose, triglycerides,total cholesterol,and mean arterial blood pressure, whereas negatively correlated with HDL-C (r =-0. 448, P< 0.001).     

脂肪细胞型脂肪酸结合蛋白与代谢综合征相关

Serum adipocyte fatty acid-binding protein (A-FABP) was raised in metabolic syndrome (MS)patients (n= 121) as compared with age-matched healthy subjects [n = 120, (14.7±4.8 vs 6.8 ±3. 0) μg/L,P<0.001]. It reached higher level in MS subjects with visceral obesity [(15.7±4.2 vs 12.6±5.1) μg/L, P<0.001]. Serum A-FABP concentration was positively correlated with body mass index, waist circumference, waist-tohip ratio, fasting insulin, homeostasis assessment for insulin resistance (HOMA-IR), fasting glucose, triglycerides,total cholesterol,and mean arterial blood pressure, whereas negatively correlated with HDL-C (r =-0. 448, P< 0.001).     

脂肪细胞型脂肪酸结合蛋白与代谢综合征相关

Serum adipocyte fatty acid-binding protein (A-FABP) was raised in metabolic syndrome (MS)patients (n= 121) as compared with age-matched healthy subjects [n = 120, (14.7±4.8 vs 6.8 ±3. 0) μg/L,P<0.001]. It reached higher level in MS subjects with visceral obesity [(15.7±4.2 vs 12.6±5.1) μg/L, P<0.001]. Serum A-FABP concentration was positively correlated with body mass index, waist circumference, waist-tohip ratio, fasting insulin, homeostasis assessment for insulin resistance (HOMA-IR), fasting glucose, triglycerides,total cholesterol,and mean arterial blood pressure, whereas negatively correlated with HDL-C (r =-0. 448, P< 0.001).     

脂肪细胞型脂肪酸结合蛋白与代谢综合征相关

Serum adipocyte fatty acid-binding protein (A-FABP) was raised in metabolic syndrome (MS)patients (n= 121) as compared with age-matched healthy subjects [n = 120, (14.7±4.8 vs 6.8 ±3. 0) μg/L,P<0.001]. It reached higher level in MS subjects with visceral obesity [(15.7±4.2 vs 12.6±5.1) μg/L, P<0.001]. Serum A-FABP concentration was positively correlated with body mass index, waist circumference, waist-tohip ratio, fasting insulin, homeostasis assessment for insulin resistance (HOMA-IR), fasting glucose, triglycerides,total cholesterol,and mean arterial blood pressure, whereas negatively correlated with HDL-C (r =-0. 448, P< 0.001).     

脂肪细胞型脂肪酸结合蛋白与肥胖及代谢综合征

脂肪细胞型脂肪酸结合蛋白(A-FABP)主要在脂肪组织中大量表达,其主要生理作用为参与细胞内部的脂肪酸转运和靶向定位.近期的研究发现,A-FABP是全身胰岛素敏感性以及糖脂代谢的重要调节冈素,与肥胖及代谢综合征的发生发展有紧密联系.     

脂肪细胞型脂肪酸结合蛋白与2型糖尿病的关系

脂肪细胞型脂肪酸结合蛋白(FABP)4是脂肪酸结合蛋白家族中的一员,主要在脂肪细胞和巨噬细胞中表达,其表达受胰岛素、过氧化物酶体增殖物活化受体(PPAR)-γ激动剂的调控,可调节机体炎性反应,在体内脂肪酸转运和能量代谢中起重要作用.研究发现,FABP4能增加2型糖尿病的风险,预测血糖水平.同时,FABP4与2型糖尿病危险因素及糖尿病并发症的发生、发展也密切相关.