149例HIV阳性孕产妇所生婴幼儿的随访情况分析

目的分析江门地区感染人类免疫缺陷病毒(HIV)孕产妇所生婴儿的母婴阻断措施和跟踪随访情况。方法对2006-2014年江门地区HIV阳性产妇分娩的婴幼儿按规范服药、人工喂养、儿童体检、血生化、HIV抗体检验等为指标,全程跟踪随访,观察到婴儿满18个月,母婴同时随访。结果 149例HIV阳性孕产妇所生婴幼儿低出生体重儿18例,发生率为12.08%,人工喂养率达97.5%,孕产妇抗病毒药物服药率为91.28%,婴幼儿的抗病毒药物服用率为97.79%,18月龄婴幼儿随访率为94.12%,婴幼儿的抗体阳性检出率为1.23%(1/81)。结论江门地区预防艾滋病、梅毒和乙肝母婴传播工作开展效果显著,一对一的服务模式,产科和儿保科之间的无缝对接,有效提高服务对象的依从性,减少母婴传播,增加HIV阳性孕产妇生育健康儿童的机会,促进优生优育状况。     

7例HIV阳性孕产妇母婴传播阻断体会

目的 观察7例HIV阳性孕产妇母婴传播阻断效果.方法 对我院收治HIV阳性孕产妇进行母婴传播阻断,干预措施,抗病毒药物治疗+产科干预+个人喂养.结果 7例HIV阳性孕产妇所生婴儿分别于12个月及18个月时进行HIV抗体检测均为阴性.结论 HIV阳性孕产妇行母婴传播阻断干预措施效果明显.     

龙岗区60例艾滋病感染孕产妇所生儿童随访分析

目的研究龙岗区60例艾滋病(AIDS)感染孕产妇所生儿童随访结果。方法回顾性分析从2014年1月～2018年12月于龙岗区各级医院产检330 757例和分娩的孕产妇206 699例作为研究对象,分析孕产妇HIV抗体阳性检出率、抗病毒药物应用情况。此外,分析HIV阳性孕产妇和所生婴幼儿抗病毒药物应用情况对母婴传播的影响,HIV阳性孕产妇所生婴幼儿12月龄生长发育情况。结果龙岗区2014年～2018年行HIV抗体检测孕产妇共537 456例,检出HIV抗体阳性77例,HIV检出率为0.11‰,其中HIV检出率最高年份为2016年的0.13‰,最低年份为2015年的0.10‰。60例HIV阳性产妇中抗病毒药物治疗100%,其中孕前已服用抗病毒治疗32例,占53.33%,孕期服用抗病毒药物治疗22例,占36.67%,产时服用抗病毒药物治疗6例,占10%。60例HIV阳性孕产妇所生婴幼儿HIV阳性检出率为1.67%(1/60)。龙岗区60例HIV阳性孕产妇所生婴幼儿12月龄时的年龄别体重、年龄别身长、身长别体重评价为上级人数占比分别为5.00%、3.33%、5.00%,中级人数占比分别为91.67%、93.33%、88.33%,下级人数占比分别为3.33%、3.33%、6.67%。结论龙岗区HIV阳性孕产妇所生儿童生长发育尚可,并且最大程度的减低了HIV母婴传播率。     

艾滋病母婴阻断抗病毒治疗依从性及相关因素分析

目的探索艾滋病母婴传播阻断抗病毒治疗依从性的主要影响因素,为提高艾滋病母婴传播阻断抗病毒治疗依从性的方法提供依据。积极推广综合防治模式,动员和支持社会组织参与防治工作。方法收集2005~2013年,某县检出艾滋病抗体阳性的孕产妇105例,其中终止妊娠36例,分娩69例,对分娩的艾滋病抗体阳性的69例孕产妇及所生婴儿对艾滋病母婴传播阻断抗病毒治疗的依从性进行调查。结果69例阳性分娩的孕产妇中,抗病毒治疗依从性良好者占97.10%,所生婴儿服药率95.59%。结论艾滋病抗体阳性感染孕产妇母婴阻断抗病毒治疗依从性好坏受多种因素的影响。     

重庆地区艾滋病病毒感染孕产妇接受预防艾滋病母婴传播干预现状及对策分析

目的通过对艾滋病病毒(HIV)感染孕产妇及所生婴儿采取预防艾滋病母婴传播措施的现状分析,探讨重庆地区预防艾滋病母婴传播干预措施实施的相关影响因素及对策。方法采用统一问卷及个案表,对68例HIV感染孕产妇进行有关检测时间、感染原因、妊娠结局、影响各种预防传播措施的实施情况的回顾性调查。结果在调查的68例HIV感染孕产妇中,22例在孕期终止了妊娠,占32.4%。28.3%的分娩产妇和68.6%的新生儿服用了抗逆转录病毒药物,100%婴儿采用了人工喂养方式。结论现行的预防艾滋病母婴传播措施是可行的。孕产妇初次产检的时间影响了孕产妇的服药比例,应该提高孕早期检测率。     

应用PCR病毒定量评价免疫预防对阻断母婴垂直传播乙型肝炎价值的研究

目的：探讨HBsAg阳性孕妇孕前、产前降低血清HBV—DNA含量水平,对阻断HBV母婴传播的意义。方法：应用荧光定量聚合酶链反应（PCR）技术。结果：检测血清乙型肝炎病毒表面抗原（HBsAg）阳性的234例孕妇及配对新生儿血清HBV—DNA含量,婴儿HBV传播率为31．2％。乳汁排毒率32．9％。根据孕妇HBV—DNA测定值高低分组,其中,孕前治疗组62例;孕前未接受治疗孕中免疫阻断组97例;对照组75例。三组比较母婴传播率,均有显著性差异（P〈0．01）。且传播率依次为11．3％、29．9％及49．3％。三组间的乳汁排毒率均有显著性差异（P〈0．001）,排毒率依次为9．7％、29．9％及56．0％。分娩前HBV—DNA值〈10^4copies／ml的67例孕妇,其产婴儿未检测出HBV感染。结论：孕妇于孕前抗病毒治疗（有效降低HBV携带量）及孕期通过HBIG免疫,可有效预防HBV宫内感染。     

不同免疫策略的母婴传播阻断进展

肝炎病毒是一种严重危害人类健康的世界性传染病，我国是乙肝高发区，人群感染率高达60％，乙肝表面抗原（HBsAg）携带者亦高达10％-15％。慢性HBV携带者超过1．2亿，我国的慢性乙型肝炎病毒（HBV）感染者约有30％-50％是通过母婴传播形成的。接种乙型肝炎（乙肝）疫苗是预防慢性HBV感染有效手段，但现行的免疫措施用于阻断HBV母婴传播时，仍有免疫失败发生。上世纪80年代中期才有学者运用免疫病理学和分子生物学技术，在HBsAg阳性孕妇的流产死胎肝细胞内检测到HBV-DNA和HbsAg，从而证实了宫内感染的存在。宫内感染为母婴传播方式的一种，其他还可通过分娩、哺乳、喂养等方式。上述方式所引起的HBV感染约占我国婴幼儿HBV感染的1／3。故了解其传播特点，采取有效的预防措施，阻断母婴问的乙肝病毒传播是一个极其重要的问题。现将不同免疫策略的母婴传播阻断进展情况综述如下。     

台山市HIV／AIDS配偶间感染状况分析

目的了解台山市HIV感染者／病人配偶间HIV感染状况,为制定有效干预措施提供科学依据。方法从艾滋病综合防治信息管理系统筛选出2012年存活可随访到的现住址为台山市、有配偶且配偶为阴性或阳性的HIV／AIDS病例资料,建立数据库进行分析。结果共有164对HIV双阳或单阳配偶,HIV双阳率为61．59％（101／164）,HIV单阳率38．41％（63／164）。男方HIV感染阳性率为58．11％,高于女方的41．89％,差异有统计学意义（X2=13．95,P〈0．01）,30～39岁年龄段的人数最多占49．06％（130／265）。传播途径为注射毒品感染占80．49％（132／164）。配偶中以男方先检出的占64．63％（106／164）,其中52．83％为羁押场所检出,而以女方为先检出的配偶中47．73％为孕产期检查检出。双阳配偶中。44．55％的夫妻检测阳性时间间隔在3个月以内。单阳家庭接受抗病毒治疗的比例比双阳家庭高,差异有统计学意义（X2=38．88,P〈0．01）。结论台山市配偶间HIV传播率较高,开展监测早期发现感染者。加强30～39岁年龄段人群干预工作力度,是阻断家庭内性传播的重点工作。     

2010-2015年成都市孕产妇艾滋病哨点监测结果分析

目的 了解成都市孕产期妇女人类免疫缺陷病毒(HIV)、丙型肝炎病毒(HCV)和梅毒的感染现状、艾滋病防治知识知晓情况及其影响因素,为当地防控策略制定和干预效果评估提供科学依据.方法 严格按照《全国艾滋病哨点监测实施方案操作手册》标准,于2010-2015年对符合监测条件的孕产妇开展行为学问卷调查和血清学检测.结果 2010-2015年间共监测孕产妇2400名,未发现HIV抗体阳性者,梅毒阳性检出率及HCV阳性检出率均为0.13％;艾滋病防治知识知晓率70.52％,呈逐年上升趋势(X2=75.68,P＜0.001),且文化水平越高、年龄越小、怀孕生育次数越少,其防治知识知晓率越高.结论 成都市孕产妇人群HIV、梅毒、HCV感染率均处于低于全国较低水平,但该人群艾滋病防治知识知晓率仍有待提升,今后应开展针对性的孕期健康教育及行为干预,预防艾滋病母婴传播的发生.     

HBV感染孕妇体内病毒前C区G1896A变异与母婴垂直传播的关系

目的 分析孕妇体内乙型肝炎病毒(HBV)前C区G1896A变异对母婴垂直传播的影响.方法 收集40例本院妇产科HBeAg(-)/HBsAg( )的孕妇血标本,同时收集这些孕妇分娩时新生儿脐带血40例.荧光定量PCR(FQ-PCR)检测HBV孕妇血清和新生儿脐带血中HBV-DNA栽量,PCR-ELISA法检测孕妇血清中HBV-DNA前C区G1896A变异.分析HBV前C区G1896A变异及孕妇血清HBV-DNA载量对母婴垂直传播率的影响.结果 40例孕妇血清共检测到25例HBV前C区G1896A变异(62.5%);变异组母婴垂直传播发生率为44.0%(11/25),未变异组母婴垂直传播发生率为40.0%(6/15),二组比较无统计学差异(x2=0.0614,P＞0.05).孕妇血中HBV-DNA高载量组(≥1×105 copies/ml)母婴垂直传播发生率为62.5%(10/16),低栽量组(＜1 × 105 copies/ml)母婴垂直传播发生率为29.2%(7/24),二组相比有显著性差异(x2=4.3649,P＜0.05).结论 HBV前C区G1896A变异未增加母婴HBV垂直传播率,孕妇血清中HBV-DNA栽量升高是母婴HBV垂直传播危险因素.     

Wasting during pregnancy increases the risk of mother-to-child HIV-1 transmission

OBJECTIVES: To examine whether wasting during pregnancy, as measured by weight loss and low weight gain, is associated with increased mother-to-child transmission (MTCT) of HIV-1. METHODS: This was a cohort study in Dar es Salaam, Tanzania, among 957 HIV-1-infected pregnant women. Weight was measured at the first prenatal visit and every month thereafter until delivery. Weight loss was defined as a weekly rate of weight gain 0 and /=167 g/wk, weight loss during pregnancy was related to higher risk of intrauterine MTCT (adjusted relative risk [RR] = 2.32, 95% CI = 1.23-4.36, P = 0.009), HIV positive at birth or fetal death (RR = 2.13, 95% CI = 1.40-3.24, P = 0.0004), and HIV positive at birth or early neonatal death (RR = 1.96, 95% CI = 1.26-3.07, P = 0.003). The rate of weight gain during the 3rd trimester was inversely related to the risk of intrapartum/early breast-feeding transmission (adjusted P value, test for trend = 0.05). CONCLUSIONS: Weight loss during pregnancy increases the risk of early MTCT. Identifying causes of wasting during pregnancy may provide clues for new strategies to prevent MTCT.     

内皮型一氧化氮合酶基因G894T多态性与青海省汉族妊娠高血压综合征的相关性

目的探讨内皮型一氧化氮合酶(eNOS)G894T基因多态性与青海省汉族妊娠高血压综合征(PIH)的相关性。方法采用限制性片段长度多态性聚合酶链反应(PCR-RFLP)方法对138名妊娠高血压综合征患者和135名正常孕妇e NOS基因G894T多态性进行分型,并测序验证。结果妊娠高血压综合征组基因型频率野生型(GG)、杂合子型(GT)和突变纯合子型(TT)分别为17.4%、82.6%、0;对照组分别为0、95.6%、4.4%,两组基因型频率分布有差异(P0.05)。妊娠高血压综合征组e NOS等位基因频率G、T分别为58.7%、41.3%;对照组分别为47.8%、52.2%,两组比较差异有统计学意义(P0.05),妊娠高血压综合征组G基因频率高于对照组。结论e NOS基因G894T多态性可能与青海省汉族妊娠高血压综合征有关,G等位基因可能为妊娠高血压综合征的易感基因(OR=1.229,95%CI:1.048~1.441),T等位基因可能为妊娠高血压综合征的保护基因。携带GG基因型的孕妇可作为青海省妊娠高血压综合征的易感人群。     

Associations of chemokine receptor polymorphisms With HIV-1 mother-to-child transmission in sub-Saharan Africa: possible modulation of genetic effects by antiretrovirals

BACKGROUND: HIV-1 mother-to-child transmission (MTCT) remains an important route of infection in sub-Saharan Africa. METHODS: Genetic variants in CCR5 promoter, CCR2, CX3CR1, and Stromal cell-derived factor-1 (SDF-1) genes were determined in 980 infants from sub-Saharan Africa using real-time polymerase chain reaction to determine association with MTCT. RESULTS: In antiretroviral-naive mother-infant pairs (n = 637), CCR5 promoter polymorphisms at positions 59029: A allele vs. G/G [odds ratio (OR): 1.61, 95% confidence interval (CI): 1.04 to 2.48; P = 0.032] and 59356: T allele vs. C/C (OR: 0.63, 95% CI: 0.41 to 0.96; P = 0.033) and CCR2-180: G allele vs. A/A (OR: 3.32, 95% CI: 1.13 to 9.73; P = 0.029) were associated with risk of MTCT. Treatment of HIV-1-infected mothers and infants with single-dose nevirapine or perinatal zidovudine altered but did not eliminate the association of genetic variants with MTCT. CONCLUSIONS: CCR5 promoter, CCR2, and CX3CR1 polymorphisms were associated with risk of MTCT likely through their role as an HIV-1 coreceptor or by modulating the early immune response. Host genetics may continue to alter MTCT when short-course interventions that only partially suppress virus are used. These findings will need to be confirmed in validation cohorts with a large number of infected infants.     

2011-2013年安徽省手足口病病原构成和HEV71基因特征分析

目的 了解安徽地区2011-2013年引起手足口病(hand-foot-mouth disease,HFMD)发病的病原构成情况和人肠道病毒71型(human enterovirus 71,HEV71)分离株的基因特征.方法 利用“中国疾病预防控制信息系统”,对2011-2013年报告的安徽省HFMD病例病原学特征进行统计分析.对从HFMD病例咽拭子标本中分离的26株HEV71进行VP1基因全长扩增和序列测定,使用生物软件DNASTAR 7.1比对分析同源性和应用Mega 4.1构建系统发生树.结果 安徽省2011-2013年HFMD病原构成主要为HEV71,柯萨奇病毒A组16型(coxsackie virus A16,CVA16)和其他肠道病毒,阳性检出率分别为28.74％、10.77％和15.18％.HEV71 VP1区基因序列同源性比对分析和系统发生树构建表明,26株HEV71属于C4a基因亚型,与2008年安徽阜阳流行株(EU703812)相比亲缘关系较近,VP1区核苷酸和氨基酸同源性分别为92.9％～98.8％和90.3％～99.7％.结论 安徽省2011-2013年HFMD的主要病原体为HEV71,其次为其他肠道病毒和CVA16.26株HEV71的基因型属C4a亚型,与中国大陆同期主要流行毒株基因型相一致.     

Transmission rates in consecutive pregnancies exposed to single-dose nevirapine in Soweto, South Africa and Abidjan, Côte d'Ivoire

BACKGROUND: Large numbers of women receive single-dose nevirapine (sdNVP) to prevent mother-to-child transmission (MTCT) of HIV; over time, an increasing proportion will return to prevention of MTCT programs for a second pregnancy. Because sdNVP selects resistance in a high percentage of women, we compared the effectiveness of sdNVP in preventing peripartum MTCT in successive pregnancies. METHODS: Prospective cohorts were recruited from MTCT programs in South Africa and C?te d'Ivoire. HIV-1-infected women and their infants exposed to sdNVP in 2 consecutive pregnancies-used alone or with zidovudine (ZDV) or ZDV plus lamivudine-were included. RESULTS: The median age of women at their initial exposure to sdNVP in Soweto (n = 120) and Abidjan (n = 41) was 26 (interquartile range [IQR]: 22-29) years and 28 (IQR: 24-31) years, respectively, and their median delivery interval was 21 (IQR: 15-29) months and 26 (IQR: 20-32) months, respectively. Transmission rates in Soweto and in Abidjan were 11.1% and 13.2% for the first pregnancy and 11.1% and 5.4% for the second pregnancy (P = 1.000 and P = 0.449 for Soweto and Abidjan, respectively, in unpaired analysis). CONCLUSION: This analysis suggests that the effectiveness of sdNVP when used in successive pregnancies is probably not impaired, possibly because viral resistance selected by prior exposure to sdNVP may wane with time.     

2014-2015年河北省5岁以下婴幼儿病毒性腹泻病原学监测及流行特征分析

目的 了解河北省5岁以下婴幼儿病毒性腹泻病原构成及流行特点,为病毒性腹泻的防治提供参考依据.方法 收集河北省哨点医院2014年1月-2015年12月0-59月龄腹泻患儿粪便标本686份,同时填写个案调查表,采用ELISA方法检测轮状病毒(HRV),采用PCR或RT-PCR法检测杯状病毒(HuCV)、星状病毒(HAstV)和肠道腺病毒(HAdV),并对轮状和杯状阳性标本进行分型鉴定.结果 686份标本病毒性病原总检出率64.14％ (440/686),2014年62.71％(222/354),稍低于2015年的65.66％ (218/332) (x2=0.649,P=0.421),其中单纯轮状、杯状、星状和肠道腺病毒检出率分别为35.13％(241/686)、11.37％(78/686)、1.75％(12/686)和4.96％(34/686),合并感染率10.93％(75/686)(合并2种69份,合并3种6份).轮状病毒阳性检出率以13-24月龄最高(x2=22.289,P＜0.001),随月龄增长呈现先升高后降低趋势,且季节性分布明显,秋冬季(11月-次年2月)高发,以G9P[8]型为主(87.95％,270/307).杯状病毒全年呈多峰分布,3-6月份检出率较高,2015年(24.70％,82/332)高于2014年(13.56％,48/354)(x2=13.841,P＜0.001).结论 河北省5岁以下儿童病毒性腹泻病原复杂,混合感染比例较大,轮状病毒为主要致病病原体,该病毒主要侵犯2岁以下儿童,秋冬季高发,其中G9P[8]型成为本地区主要流行株.     

Association of HIV and malaria with mother-to-child transmission, birth outcomes, and child mortality

OBJECTIVE: To assess the impact of HIV and malaria coinfection on mother-to-child HIV transmission (MTCT) and adverse birth outcomes. METHODS: One hundred nine HIV-positive mother-infant pairs with a malaria diagnosis were identified in a community cohort and followed up postpartum. Maternal malaria was diagnosed by a rapid immunochromatographic test (ICT) on sera and histopathologic examination of placenta. Infant HIV was diagnosed within 6 weeks of birth using polymerase chain reaction (PCR) to capture in-utero and intrapartum HIV transmission. Log binomial models were used to assess the relative risk of MTCT, low birth weight, and preterm birth associated with malaria. RESULTS: Approximately 17.4% of infants were HIV positive at or around birth, and the prevalence of serologic and placental malaria were 31% and 32%, respectively. HIV-positive mothers with serological ICT malaria were significantly more likely to have low-birth-weight infants, and low-birth-weight infants had significantly higher risk of MTCT compared with infants of normal birth weight. Although placental and serologic ICT malaria were significantly associated with MTCT, after adjusting for maternal HIV viral load, the risk of MTCT was significantly increased only for mothers coinfected with placental malaria (relative risk [RR] = 7.9, P = 0.025). CONCLUSIONS: Placental malaria increases the risk of MTCT after adjustment for viral load. Programs should focus on enhanced malaria prevention during pregnancy to decrease the risk of adverse birth outcomes and MTCT.     

Maternal HIV-1 antibody and vertical transmission in subtype C virus infection

The role of maternal humoral immune response and viral load was analyzed in relation to the incidence of mother-to-child transmission (MTCT) of infants born to HIV-1 subtype C infected mothers. High levels of viral RNA in the serum correlated with MTCT as did high titers of subtype C consensus V3 peptide binding antibodies (BA) and neutralizing antibody (NA) to subtype B HIV-1MN. Logistic regression analysis showed that maternal viral load and V3 peptide subtype C BA were independent predictors for MTCT, odds ratio (OR) = 2.22 and OR = 2.52, respectively. No correlation between NA to homologous HIV-1 subtype C virus and MTCT was found. BA to V3 peptides may provide a rapid inexpensive method that can be used to determine the risk of HIV-1 MTCT.     

机器人辅助与常规徒手开放椎弓根螺钉内固定的精确性与安全性的Meta分析

目的 使用Meta分析的方法分析比较机器人辅助和常规徒手开放椎弓根螺钉内固定的精确性和安全性.方法 计算机检索Pubmed、Embase、Cochrane library、中国生物医学文献(CBM)、万方、中国知网数据库(CNKI)中2016年12月1日前的文献.根据制定的纳入与排除标准,筛选合格文献并进行数据提取和质量评价.利用RevMan5.3软件进行Meta分析.对二分类数据采用相对危险度(RR)及95％置信区间(CI)表示效应差异.对连续型数据采用均数差(MD)或标准化均数差(SMD)表示效应差异.当P＜0.05,95％CI不含数值1时说明差异有统计学意义.结果 共纳入266例患者,包括机器人辅助138例、常规徒手开放128例;共置人螺钉1 200枚,包括机器人辅助608枚、常规徒手开放592枚.结果显示,根据Gertzbein-Robbins分级标准(A、B、C),机器人辅助和常规徒手开放方法之间的椎弓根螺钉置钉准确率差异无统计学意义,其中A(RR=1.07,95％CI:0.82,1.39,I2=46％,P=0.62)、B(RR=1.56,95％CI:0.86,2.82,I2=0％,P=0.14)、C(RR=0.91,95％CI:0.32,2.55,I2=0％,P=0.85).两组并发症发生率差异无统计学意义(RR=0.33,95％CI:0.05,2.17,I2=0％,P=0.25).两组螺钉修复率差异无统计学意义(RR=0.53,95％CI:0.10,2.90,I2=0％,P=0.47).两组手术时间差异有统计学意义(MD=20.90,95％CI:5.54,36.26,I2=15％,P=0.008).两组辐射曝光时间差异有统计学意义(SMD=-1.19,95％CI:-1.63,-0.75,I2=0％,P＜0.000 01).两组螺钉与关节面的距离差异有统计学意义(SMD=-1.15,95％CI:0.79,1.51,I2=16％,P＜0.000 01).结论 与常规徒手开放方法相比,目前的证据尚不能证实机器人辅助系统在椎弓根螺钉内固定的手术精确率与并发症发生率方面存在明显优势.脊柱手术机器人辅助系统作为新技术应用于脊柱外科手术具有深入开发的潜能.     

Perinatal predictors of sleep disturbances in young infants

The study aimed to identify risk factors of sleep disturbances in 2-month-old infants. It comprised 198?infants (86?boys, 112?girls) who were singletons born in St. Petersburg, Russia, in?2007. The mothers were asked to complete questionnaires addressing major infant, maternal, and demographic characteristics. Preexisting medical records were scrutinized. The mothers were requested to describe infant sleep troubles. The baby was defined as having sleep disturbances, if he or she had five or more episodes per week characterized by settling difficulties at bedtime (could not fall asleep within 20?minutes after being put to bed) or frequent night awakenings (woke up more than twice during the night). Of 198?infants, 96?(48.5%) reportedly had sleep disturbances. In the univariate analysis, the factors associated with increased risk of sleep disturbances were (odds ratio, OR; (95%?CI)) first birth order 3.55 (1.90?C6.69), previous abortions 2.08 (1.14?C3.83), maternal vaginal bleedings during pregnancy 2.58 (1.07?C6.29), maternal allergies 2.44 (1.17?C5.14), and maternal smoking during pregnancy 2.45 (1.27?C4.77). Stepwise backward logistic regression analysis identified combinations of the factors that best predicted the risk of infant sleep disturbances: first birth order, previous abortions, and maternal smoking during pregnancy. After inclusion into the multiple logistic regression equation, these factors provided moderate prediction (pseudo R²=0.15). The receiver operating characteristic (ROC) curve was constructed, and the area under the ROC curve was equal to 0.6636 (95%?CI=0.5905?C0.7406), p_(area=0.5)?<0.05. Findings from the maternal history may help to predict sleep disturbances in young infants.