Ménétrier病1例

病历简介男，45岁。因纳差、上腹痛3年就诊。既往无肝病史。体检：极度消瘦，贫血貌，心肺（－），腹平软，剑下明显压痛，未及包块，肝、牌不大。Hb77yL，血浆总蛋白469／L，白蛋白31g／L，血清ALT、AST及肾功、电解质均正常。上消化道钡透胃体皱襞巨大，蠕动减少且缓慢。胃镜示胃粘膜皱襞巨大，充气后不消失，其表面满布泡祥物，活检质地轨，易出血，胃窦及十二指肠粘膜充血水肿明显。病理报告（胃体）粘膜明显增厚，腺窝明显延长屈曲，腺管扩张，可见多数分泌粘液的细胞，提示为Mjn乏trier病。2讨论M6n6trier病又称肥厚增生性胃炎、…     

内镜微波治愈Ménétrier病1例

1临床资料患者女性，34岁，住院号95—426O，因间歇性上腹不适，隐痛9年伴面部及双下肢浮肿6年入院，9年前始于分娩后不久渐感上腹部不适，时有隐痛，纳差，恶。动频频，全身乏力，经数周休息后症状自行缓解，但缓解数周后上述症状又复出现，如此反复发作持续至今。6年前无明显诱因出现面部及双下肢浮肿，晨起及经前期加重，迄今未见改善，曾直有低蛋白血症，但肝、肾功能正常，近2年先后于外院3次胃镜检查均发现胃内有多发性息肉样隆起，但病理示炎性改变，为进一步排除胃肿瘤而住院。既往体健，否认心、肝、肾疾病，其母亲死于肠癌。查体…     

Ménétrier病的诊治现状及研究进展

Ménétrier病又称胃黏膜巨大肥厚症,该病为良性增生性胃病的一种,是一种由于胃黏膜过度增生导致胃黏膜皱襞肥厚巨大的疾病。1888年由法国病理学家Pierre Ménétrier首先报道,是以巨大肥厚的胃黏膜皱襞及低蛋白血症为特征的一组综合征[1],多伴有上腹部不适、恶心、呕吐等临床表现。1957年,131I标记的白蛋白应用于此类患者,进而发现大量白蛋白自胃液丢     

An unusual association of Ménétrier’s disease and colon cancer

Ménétrier’s disease (MD) is characterized by enlargement of gastric mucosal folds that most often involve the fundus. The cause of MD is unknown. Gastric cancer is the mostly reported association of Ménétrier’s disease. We present the first case of a patient having colonic adenocarcinoma and also Ménétrier’s disease.     

Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach

Ménétrier disease and gastrointestinal stromal tumors (GISTs) are hyperproliferative disorders of the stomach caused by dysregulated receptor tyrosine kinases (RTKs). In Ménétrier disease, overexpression of TGF-alpha, a ligand for the RTK EGFR, results in selective expansion of surface mucous cells in the body and fundus of the stomach. In GISTs, somatic mutations of the genes encoding the RTK KIT (or PDGFRA in a minority of cases) result in constitutive kinase activity and neoplastic transformation of gut pacemaker cells (interstitial cells of Cajal). On the basis of the involvement of these RTKs in the pathogenesis of these disorders, Ménétrier disease patients have been effectively treated with a blocking monoclonal antibody specific for EGFR and GIST patients with KIT and PDGFRA tyrosine kinase inhibitors.     

Ménétrier’s disease diagnosed by enteroclysis CT: a case report and review of the literature

This study reports a case of Ménétrier’s disease (MD) in an adult who presented with egigastric pain and peripheric edema. We focused in particular on the imaging and diagnostic aspects of the presenting case as well as clinical, histologic, and therapeutic aspects. Computed tomography (CT) enteroclysis is a new imaging technique which combines enteroclysis and spiral multislice CT. To the best of our knowledge this is the first report on a MD in an adult patient diagnosed by CT Enteroclysis.     

Mécanismes épigénétiques impliqués dans la douleur chronique

Epigenetics define inheritable and reversible gene expression modifications that do not involve change the DNA sequence. This review proposes a state of art of current knowledge on different epigenetic mechanisms involved in the transition from acute to chronic pain. Considering epigenetic modifications reversibility, identification of disrupted epigenetic regulations in chronic pain might contribute to the development of new therapeutic strategies for the restoration of altered neuronal functions.     

1例血红蛋白M病换血疗法的护理

先天性高铁血红蛋白病,分为两种,一为红细胞中高铁血红蛋白还原系统缺陷造成高铁血红蛋白症;二为异常血红蛋白造成者为血红蛋白M病,此为珠蛋白异常所致,又称为珠蛋白异常高铁血红蛋白症。临床二者可由对亚甲兰的暂时效应进行鉴别。二者均在临床中极少见。我科于1988年用换血疗法抢救成功1例珠蛋白异常高铁血红蛋白症。特将护理经验报告如下。病例:患儿女2天,于1988年3月31日入院,住院号:88—297。主诉:呼吸困难、青紫2天。现病史:患儿系第二胎,足月,顺产。出生后结扎脐带,在15—30分钟内全身青紫,呼吸困难。在当地医院抢救给予吸氧及辅酶类药物等治疗无缓解,而转入我院。其母身体健康,未接触过X线及化学有毒物质。孕期未患病无服药史。围产期内胎     

Médecins généralistes et chirurgie bariatrique : une enquête qualitative

This qualitative study focused on the opinions of general practitioners in France regarding bariatric surgery. The physicians declared that they had insufficient knowledge about this surgery. They favored prevention and education rather than the use of bariatric surgery as a tool to treat obesity. These results are discordant with the current recommendations on bariatric surgery and provide new leads for improving the care of bariatric surgery candidates and the long-term post-operative follow-up.     

IgG抗—M引引起新生儿溶血病1例

新生儿溶血病是一种由于母亲体内存在着与其胎儿红细胞不配合的ＩｇＧ血型抗体而引起的同种被动免疫性疾病 ,其中以ＡＢＯ系统血型不合最为常见 ,约为 85 3% ,其次为Ｒｈ系统 ,约为 14 6 % ,而ＭＮ系统血型不合引起的新生儿溶血病却极为少见 ,仅为 0 1% [1] 。笔者发现 1例由ＩｇＧ抗 Ｍ引起的严重新生儿溶血病 ,现报告如下。1　病例简介患儿 ,男 ,系第 2胎 ,第 1产 ,足月顺产。出生后第二天出现黄疸 ,皮肤黄染进行性加重 ,病情进展快 ,贫血明显 ,Ｈｂ为 10 1ｇ/Ｌ ,总胆红素为 344 μｍｏｌ/Ｌ ,直接胆红素为 2 4 5μｍｏｌ/Ｌ。根据…