A Huge Intrapericardial Teratoma in an Infant

A case of huge intrapericardial teratoma diagnosed in a 9-month-old infant is presented. Echocardiography and thoracic computed tomography showed a voluminous multicystic intrapericardial mass with pericardial effusion. The tumor was resected surgically. Histopathological examination confirmed the diagnosis of immature teratoma.     

小儿胃畸胎瘤的诊治体会

目的 探讨小儿胃畸胎瘤的诊断、治疗与预后。方法 对我院1986年～2002年间9例小儿胃畸胎瘤进行回顾性分析。结果 8例胃良性畸胎瘤术后无复发，获治愈，1例恶性畸胎瘤术后化疗1个疗程后失访。结论 小儿胃畸胎瘤大多为良性畸胎瘤，经手术切除后，多无复发且预后良好。     

The Origin of Extragonadal Teratoma: Case Report of an Immature Teratoma Occurring in a Prenatal Brain

We describe a massive congenital intracranial teratoma (MCIT), which had a normal chromosome banding pattern 46,XY karyotype and a normal diploid DNA histogram, and which produced a variety of carcinoembryonic antigens. The volume density of primitive neural components (primitive neural tubes, small undifferentiated neuroepithelial cells, immature glial fibers and pigment cell components without neurofibrillar differentiation) was estimated to be 45%. We discuss the histogenesis, pathobiology and cell cycle kinetics.     

Immature gastric teratoma

Gastric teratoma, a very rare tumor of infancy is essentially benign. Immature (embryonic) elements have been described in only three of the sixty-six cases described previously. This report concerns with one“immature” gastric teratoma seen in infancy.     

Gastric teratoma

Gastric teratoma accounts for less than 1% of all teratomas occurring in children, usually males 1. These tumors may be benign or malignant and complete excision of the tumor in either case carries a good prognosis. This rare case is an addition to the few cases of gastric teratomas in females reported in world literature and presenting as an exophytic & endophytic growth.     

Gastric teratoma with thoracic extension in a 2-year-old boy

A case of gastric teratoma with intrathoracic extension in a 2-year-old boy is reported with a brief review of the literature. Offprint requests to: R. Shanthaveerappa     

Hodgkin's Disease Following Successful Treatment of Gastric Teratoma in a Neonatal Female

Teratomas of gastric origin are rare. We are aware of 90 such tumors having previously been reported, all of which have been benign and only three of which have arisen in females. We report a gastric teratoma that presented as an exophytic gastric tumor in an 8-week-old female, the fourth such recorded tumor in a female neonate. Complete surgical excision was followed by clinical and biochemical surveillance without adjuvant treatment. At 1 year the patient was well without evidence of residual or recurrent disease. The child developed Hodgkin's disease 3 years later, and we believe this to be the first recorded association of these two tumors.     

Teratoma of urogenital triangle

A teratoma found in an unusual site, the urogenital triangle of an 8-month-old male infant, is reported. Offprint requests to: W. H. Chua     

Neonatal Intracerebral Teratoma

A neonate, who presented with a large head but no neurological abnormalities, was diagnosed by ultrasound and CT scan as having a brain tumor. The pathological diagnosis was teratoma with matured tissues. The literature is briefly reviewed and the clinical manifestations and histological classification are documented.     

Rhabdomyosarcoma and Benign Teratoma

A case of mediastinal embryonal rhabdomyosarcoma occurring with a benign teratoma is reported. In all histologic sections of tumor, the two elements were distinctly separate. This is felt to represent two independently developing tumors that ultimately fused to form a “collision tumor” rather than a sarcoma arising in a benign teratoma.     

新生儿骶尾部畸胎瘤的诊治

目的总结新生儿骶尾部畸胎瘤的临床特点,探讨术前后检测血清AFP对判断畸胎瘤的良恶性是否有意义。方法自1988年12月～2004年1月共诊治新生儿骶尾部畸胎瘤25例,对临床表现、辅助检查、手术及病理等进行详细分析。结果本组25例中,年龄0～10d者16例,11～20d者5例,21～30d者4例。其中6例尿潴留,1例大便潴留伴发低位肠梗阻。囊性8例,实性4例,混合性13例,多数呈哑铃型。11例X线平片见骶尾部有边界较清楚肿物,偶见条状或斑块状钙化。9例术前MRI检查,可见低信号或混杂信号,个别者有钙化影。9例三维彩超见骶尾部及盆腔内囊实混合性肿物。术前用电化学发光法检测血清甲胎蛋白(AFP)15例,其中AFP≥400Iu/ml13例,2例<400Iu/ml。出院复查AFP<400Iu/ml10例,AFP≥400Iu/ml5例。出院后1～4个月复查AFP正常。全部病例出院。病理:成熟型畸胎瘤18例,未成熟型畸胎瘤6例,恶性小圆细胞性肿瘤1例。结论新生儿骶尾部畸胎瘤绝大多数为良性,混合型居多,早期以尿便障碍就诊。经骶尾部切口可完整切除肿瘤,无副损伤,预后良好。术前后检测血清甲胎蛋白(AFP),有一定参考意义,可作为畸胎瘤随访的客观指标。     

Neonatal sacrococcygeal teratoma communicating with the rectum

A unique case of benign sacrococcygeal teratoma communicating with the rectal lumen at birth is reported. A large air-fluid level in the teratoma was seen on the plain X-ray film.     

Intracardiac Teratoma in a Child Simulating an Atrioventricular Nodal Tumor

Intracardiac teratoma is an extremely rare pediatric neoplasm. We studied the case of a 6-year-old girl with a right intraventricular cardiac mass. The tumor consisted of clusters of monotonous round epithelial cells scattered in a dense fibrotic stroma and was thought to represent an atrioventricular nodal tumor. Three years later the tumor recurred, with multiple mature elements derived from all three germ layers, and was diagnosed as mature cystic teratoma. Still present, however, were multiple areas that were histologically similar to the earlier lesion. Immunostaining revealed strong positivity for insulin, glucagon, somatostatin, and chromogranin consistent with overgrown pancreatic islets of Langerhans within a mature teratoma.     

小儿恶性骶尾部畸胎瘤的治疗

总结２３例小儿恶性骶尾部畸胎瘤的治疗结果。１２例采用单纯手术治疗，１１例死亡，平均生存期为７．８个月，１例已无瘤生存１６年。１１例采用手术＋联合化疗治疗，９例已无瘤生存１５个月～７年，平均３７个月，１例术前化疗过程中并发肺炎死亡，１例术后１９个月出现肺和腹股沟淋巴结转移死亡。     

Teratoma Associated with Endodermal Sinus Tumor

A 3-1/2-year-old girl was diagnosed as having a mediastinal endodermal sinus tumor with pulmonary, bony, and hilar lymph node metastases. Following 7 months of treatment with chemotherapy, thoracic CT (computerized tomogram) scan showed the presence of a residual mass. Upon further surgical exploration the residual mass, which was found to be intrapericardial and arising from the ascending aorta, was resected. This second lesion was shown to be a benign cystic teratoma.

The combination of an intrapericardial teratoma and a mediastinal endodermal sinus tumor in a female child is probably unique. The possible etiology for the combination of these two pathologies is discussed.     

Metastasizing Cervical Teratoma of the Fetus

We present one case with a metastasizing cervical teratoma in a newborn infant who died of respiratory failure due to extensive cervical tumor masses and multiple pulmonary tumor metastases. This case provides evidence that very rarely malignant behavior may occur in congenital cervical teratomas, the prenatal diagnosis of which may be important for any further therapeutic management.     

小儿复发性骶尾部畸胎瘤临床研究

目的 探讨骶尾部畸胎瘤(SCT)复发原因及降低SCT复发率的合理治疗方案。方法 回顾性分析12例复发性骶尾部畸胎瘤(RSCT)疗效。结果 12例RSCT，其中良性7例，恶性5例，施行骶尾路手术切除9例，腹骶尾联合切除3例。5例行化疗。随访1～20年，存活9例，恶性SCT复发转移于术后10月内死亡3例。结论 良性SCT复发主要原因是肿瘤和尾骨残留。恶性复发为瘤组织局部侵蚀，以及淋巴、血道转移。化疗可降低复发和死亡率。     

Congenital Nasopharyngeal Teratoma in a Neonate

Background

Congenital germ cell tumors are uncommon. The most common site of teratoma is in the sacrococcygeal region. Teratoma arising from the head and neck comprises less than 10% of reported cases and of these, nasopharyngeal lesions are rare. Teratomas are generally benign, and have a well recognized clinical and histopathological entity. We present a case of nasopharyngeal teratoma (NPT) associated with a wide cleft palate.

Case Presentation

A 20 day old female neonate with a teratoma of the nasopharyngeal area, and wide cleft palate was referred to our center. The protruded mass which measured 6×4×3cm, was of soft consistency, blocked the airway, and prevented oral feeding. Preoperative evaluation and imaging was performed and mass was excised 2 days after admission. Pathology revealed a well-differentiated mature solid teratoma (hairy polyp). The patient had no complication in the post-operative period. Cleft palate was surgically repaired when 2 years old. She is now a six year old girl with normal development.

Conclusion

Congenital nasopharyngeal teratomas are usually benign. Surgery is the treatment of choice, and should be undertaken on an urgent basis, especially in a patient who presents with signs and symptoms of airway obstruction.     

Teratoma in a thyroglossal duct cyst: A rare occurrence

Although teratoma is a relatively commonly encountered pediatric tumor, cervical teratomas are rare, with only 217 cases recorded to date. These are thought to arise from the thyroid gland, with only anecdotal reports of teratomas arising in thyroglossal duct cysts. Correspondence to: G. E. Besner M. D.     

Cardiac Teratoma of the Interventricular Septum with Congenital Aortic Stenosis in a Newborn

A 10-day-old infant presented with tachypnea, harsh murmur, and cardiomegaly. Echocardiography revealed a multicystic mass invading the entire interventricular septum and protruding into the left ventricular cavity without left ventricular tract outflow tract obstruction and aortic stenosis. The mass was subsequently resected and biopsy revealed it to be a cardiac teratoma. We present an unusually rare case of an intramyocardial teratoma with associated congenital aortic stenosis. Electronic supplementary material  The online version of this article (doi:) contains supplementary material, which is available to authorized users.