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1.
胰腺局灶性病变的超声造影表现及与微血管密度的相关性 总被引:4,自引:3,他引:4
目的 探讨胰腺局灶性病变(FLPs)的增强超声(CEUS)造影模式及定量参数特征,分析定量参数与病灶微血管密度的相关性.方法 对26例疑有胰腺占位的患者进行CEUS检查.分析不同病理类型FLPs的造影表现,并定量分析病灶的始增时间、达峰时间及峰值强度,计算始增-峰值时间进行分析.对病灶组织切片进行免疫组化标记CD34,计数病灶组织的MVD,分析病灶MVD与TIC定量参数间的相关性.结果 在CEUS中,胰腺腺癌多呈低增强,胰腺内分泌肿瘤呈高增强,胰腺实性假乳头状瘤表现为周边环状等增强及内部不均匀增强.用低增强模式诊断胰腺腺癌的敏感性为85.71%,特异性为100%,阳性预测值100%,阴性预测值80.00%,准确性为90.91%.恶性组病灶与正常胰腺实质的平均始增-峰值时间比较差异有统计学意义(P<0.01).病灶的峰值强度与MVD呈显著正相关(r=0.75,P<0.01).结论 不同病理类型FLPs的CEUS增强表现不同,CEUS能评价病灶的血管生成情况,在病灶的分期及预后评估上有很好的应用前景. 相似文献
2.
《Ultrasound in medicine & biology》2015,41(12):3109-3119
The aim of this study was to assess the relative efficacy of contrast-enhanced ultrasound (CEUS) and baseline ultrasound (B-US) in diagnosing renal pelvic lesions. B-US findings on 58 suspected renal pelvis lesions were examined. The B-US and CEUS results were classified into five grades. Receiver operating characteristic curve analysis was used to compare the diagnostic efficacy of the two imaging modalities. CEUS characteristics of renal pelvis malignancies at different tumor stages and pathologic grades were examined. In the final diagnosis, 29 patients had malignant lesions (27 transitional cell carcinomas, 1 squamous cell carcinoma and 1 renal cell carcinoma) and 29 had benign lesions. On B-US, echogenicity and renal pelvis separation pattern in patients with malignant renal lesions overlapped those of patients with benign lesions. CEUS significantly increased the diagnostic grade of malignant lesions and decreased the grade of benign lesions (p = 0.000). The area under the receiver operating characteristic curve of CEUS was larger than that of B-US (p = 0.030). Enhancement shape and intensity in the wash-in phase markedly differed in lesions of higher tumor stage and higher pathologic grade, compared with lesions of lower stage and grade. In this study, compared with B-US, CEUS had significantly higher diagnostic efficacy in patients with renal pelvis lesions. 相似文献
3.
The purposes of this study were (1) to evaluate the color Doppler sonographic findings in patients with transitional cell carcinoma of the bladder and renal pelvis, (2) to determine if color Doppler sonography could predict tumor grade and stage, and (3) to determine whether tumor vascularity is related to size. A total of 15 patients with 16 bladder transitional cell carcinomas and one patient with renal pelvic transitional cell carcinoma were evaluated prospectively with transabdominal color Doppler ultrasonography. The presence or absence of visible vascularity and the resistive index were correlated with tumor size, cytologic grade, and tumor stage. Statistical analysis was performed with Fisher's exact test. Seven (41%) of 17 tumors had visible vascularity: five (45%) of 11 high-grade transitional cell carcinomas were vascular, whereas two (33%) of six low-grade transitional cell carcinomas were vascular (P = 1.00). Three of five (60%) of the invasive lesions were vascular, but the vascularity was not predictive of tumor stage (P = 0.593). The vascular high-grade tumors tended to have more numerous and larger visible vessels than the vascular low-grade lesions. No tumor smaller then 23 mm was vascular, but the size of the tumor was not predictive of the vascularity (P = 0.1172). The resistive index was measurable in six tumors, but it was not predictive of grade or stage. Color Doppler ultrasonography is not helpful clinically in the evaluation of transitional cell carcinoma as tumor grade, stage, and size are not related to vascularity.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
4.
肾盂癌超声造影的初步研究 总被引:6,自引:1,他引:6
目的分析11例肾盂癌的超声造影灌注过程,初步探讨超声造影对肾盂癌的诊断价值。方法应用对比脉冲序列(CPS)成像技术和声诺维造影剂SonoVue对11例肾盂癌患者行超声造影,记录并分析造影灌注过程。结果注射造影剂后11例肿块均可见强化,肿块开始显影时间为8~20S,显影增强达高峰时间为14~25s,增强开始减退时间为18~30S。肿块显影高峰强度:高于肾实质2例,等同于肾实质4例,稍低于肾实质5例。肿块的血流灌注方式:“快进慢退”2例,“同进慢退”5例,“慢进慢退”4例;7例为整体均~性增强和均一性减退,3例为向心性增强,1例为离心性减退。结论CPS技术结合造影剂SonoVue能描绘肾盂肿块的血流灌注情况,使肾盂肿块显示更清晰,有助于肾盂癌的诊断。 相似文献
5.
甲状腺单发结节超声造影与微血管密度的相关性 总被引:1,自引:0,他引:1
目的 探讨甲状腺单发结节CEUS的特点及其与微血管密度(MVD)间的相关性。方法 对45例甲状腺单发甲状腺结节患者术前行CEUS,分析结节的造影特点;术后以CD34单克隆抗体染色肿瘤组织,于光镜下计数肿瘤的微血管数。结果 结节性甲状腺肿23例,腺瘤8例,甲状腺癌14例,CEUS峰值强度分别为(26.82±4.48)dB,(31.50±4.22)dB,(22.36±6.13)dB,MVD分别为(58.55±7.32)条/高倍视野、(68.67±10.62)条/高倍视野、(35.00±6.16)条/高倍视野,峰值强度与MVD呈正相关(r=0.692,P=0.001)。结论 CEUS对甲状腺结节有一定诊断价值,其峰值强度可反映结节的MVD,可于术前反映结节的血管生成情况。 相似文献
6.
M. D'Onofrio G.A. Zamboni R. Malagò W. Mantovani F. Principe A. Gallotti N. Faccioli M. Falconi P. Capelli R. Pozzi Mucelli 《Ultrasound in medicine & biology》2009
The aim of our study was to determine whether the enhancement pattern of pancreatic adenocarcinoma at contrast-enhanced ultrasonography (CEUS) is related to patient prognosis after resection. CEUS of 42 resected adenocarcinomas were retrospectively reviewed. Tumors were divided into two groups: group A = poorly vascularized (presence of avascular areas) or group B = well vascularized (absence of avascular areas). All lesions were resected and underwent pathological examination assessing tumor differentiation as: undifferentiated (poorly differentiated) or differentiated (moderately and well differentiated). Mean vascular density (MVD) was also evaluated. CEUS enhancement and pathology were correlated (Spearman's test). Survival was analyzed with the Kaplan-Meier method. Multivariate analysis was performed with the Cox regression model. There were 30 differentiated and 12 undifferentiated adenocarcinomas at pathology. At CEUS, 10 lesions were poorly vascularized, whereas 32 lesions were well vascularized. Positive correlation was observed between CEUS groups and tumoral differentiation (rs = 0.51; p = 0.001) and between CEUS and MVD (rs = 0.74; p < 0.0001). Median survival in patients with group A vascularization at CEUS was significantly lower than in group B (p = 0.015). Cox proportional hazard model revealed the presence of poorly vascularized tumor at CEUS (p = 0.0001) as a predictor of higher mortality. In conclusion, CEUS enables accurate depiction of the vascularization of adenocarcinoma, with positive correlation to histology grade and MVD. (E-mail: mirko.donofrio@univr.it) 相似文献
7.
Hui Liu Shuqiang Chen Chao Huang Qing Zheng Yuhong Ye Zhen Ye Guorong Lyu 《Ultrasound in medicine & biology》2021,47(8):2430-2441
We studied a rabbit model of rheumatoid arthritis (RA) to examine the time course of changes in synovial neovascularization based on quantitative power Doppler ultrasound and contrast-enhanced ultrasound (CEUS). Twenty-five male New Zealand rabbits were in the ovalbumin-induced arthritis (OIA) group, and 5 were in the control group. Both rear knee joints of all rabbits were examined using conventional US and CEUS over 16 weeks. The knee synoviums of OIA rabbits were sampled by US-guided biopsy, and expression of CD31 and vascular endothelial growth factor (VEGF) was determined by immunohistochemistry. The correlation of joint damage based on multimodal US with microvessel density (CD31 positivity) and VEGF expression at different times was analyzed. OIA rabbits had increased synovial expression of CD31 and VEGF from weeks 6 to 12 (p < 0.01). During the early stage of CEUS enhancement, “dot enhancement” was more common at weeks 6 and 8, and “stripe enhancement” was more common at weeks 12 and 16 (p < 0.05). There were significant positive correlations of synovial CD31 and VEGF expression with power Doppler image grade, CEUS grade and peak intensity (p < 0.05 for all). Thus, OIA rabbits mimicked early-stage RA at 6 to 8 weeks, middle-stage RA at 8 to 12 weeks and late-stage RA at 12 to 16 weeks. Power Doppler image grade, CEUS grade and peak intensity, especially when combined with CD31 expression data, accurately characterized the extent of synovial vascularization in a rabbit model of RA. Increased vascularity based on CEUS may have value for the early diagnosis of RA. 相似文献
8.
超声造影诊断肾盂癌 总被引:3,自引:1,他引:3
目的 探讨超声造影(CEUS)诊断肾盂癌的潜在价值.方法 对22例经手术病理证实为肾盂癌患者的常规超声及CEUS声像图进行回顾性分析.常规超声观察肾占位大小、回声、边界、有无彩色血流信号.CEUS观察肿块的增强时相和增强方式,包括肿块的增强、消退时间和灌注表现.结果 本组22个肿块直径范围1.5~8.5 cm.常规超声显示扁平样肿块7个,不规则团块样肿块15个;伴同侧肾脏积水11例.5个肿块内发现较丰富彩色血流信号,9个仅周边少量彩色血流信号,8个未显示彩色血流信号.CEUS显示皮质期22个肿块均增强;同步增强8个,缓慢增强14个;达峰值呈低回声18个,高回声3个,等回声1个;实质期快速消退20个,同步消退1个,缓慢消退1个.常规超声和CEUS的诊断准确率分别为63.64%(14/22)和81.82%(18/22).结论 CEUS可改善肾盂癌的血供显示,提高诊断率. 相似文献
9.
目的 探讨术中超声造影及定量分析在脑胶质瘤分级诊断中的应用价值.方法 对31例脑胶质瘤患者术中进行灰阶超声造影及Sonoliver软件定量分析.分别获取正常脑组织和肿瘤内部感兴趣区的峰值强度、达峰时间、上升时间及平均渡越时间,并对高、低级别胶质瘤和正常脑组织的造影参数进行比较分析.结果 术后病理证实15例为高级别胶质瘤,16例为低级别胶质瘤,超声造影显示峰值强度高于周围正常脑组织,达峰时间较周围正常脑组织短(P<0.05),平均渡越时间较周围正常脑组织长(P<0.05).高、低级别胶质瘤之间比较,峰值强度和达峰时间差异有统计学意义(P<0.05),而上升时间和平均渡越时间差异无统计学意义(P>0.05).结论 超声造影定量分析获得的造影参数可为脑胶质瘤的分级诊断提供有价值的信息. 相似文献
10.
目的描述并分析通过外科手术治疗后上尿路上皮癌患者的临床病理特征及其合并膀胱癌的情况。方法回顾性分析本院2001年1月至2007年12月收治的26例上尿路上皮癌患者,统计分析参数包括:患者年龄、性别、临床表现、诊断方法、原发肿瘤部位(肾孟或肾盏)、肿瘤分级和分期、是否伴发膀胱癌、有无泌尿道外器官转移等。结果男性患者占57%,无痛性肉眼血尿是最常见的临床症状,大多是非浸润性(54%)和低级别(62%)肿瘤,其中1例在上尿路上皮癌发生前1个月伴有膀胱癌,2例在确诊时伴有膀胱癌,4例在手术后8~36个月发生膀胱癌(平均术后16个月),1例肾孟癌发生双肺转移。结论上尿路上皮癌容易合并膀胱癌,所有患者在外科根治手术后需要一个严格的临床随访期,浸润性高级别的肿瘤可以发生远处转移。 相似文献
11.
Pingyu Zhang Yihan Chen JinFeng Liu Yali Yang Qing Lv Jing Wang Li Zhang Mingxing Xie 《Ultrasound in medicine & biology》2018,44(4):840-852
Combretastatin A4 phosphate (CA4P) is a vascular disrupting agent that rapidly shuts down blood supply to tumors. Early monitoring of tumor perfusion plays a crucial role in determining the optimal strategy to managing treatment and guiding future therapy. The aim of this study was to investigate the potential value of dynamic contrast-enhanced ultrasound (CEUS) in quantitative evaluation of tumor perfusion at an early stage in CA4P therapy. Central and peripheral perfusion of tumors was detected by CEUS pre-treatment (0?h) and 2, 12 and 48?h after CA4P injection. Two perfusion parameters, maximum intensity (IMAX) and time to peak (TTP), were calculated from the time–intensity curve. After CEUS, the efficacy of CA4P was immediately confirmed by immunofluorescence assay and hematoxylin and eosin, Hoechst 33342 and fluorescein isothiocyanate–lectin staining. In CEUS of the center region of tumors, IMAX gradually decreased from 0 to 12?h and regrew at 48?h (p?<?0.01). TTP increased only at 2?h. In the peripheral regions, IMAX did not change obviously from 0 to 12?h (p?>?0.05) and just increased at 48?h (p?<?0.01). The TTP of peripheral regions had the same tendency to vary tendency as that of center regions. In addition, microvascular density (MVD), vascular perfusion and necrotic area of the tumor were quantitatively analyzed. A close correlation between IMAX and MVD was observed in the center areas of tumors (r?=?0.72, p?<?0.01), whereas the correlation between IMAX and MVD in peripheral areas was weak (r?=?0.37, p?<?0.01). However, IMAX was positively correlated with tumor perfusion in both center and peripheral areas of tumors (r?=?0.82, p?<?0.01, and r?=?0.63, p?<?0.01, respectively). Consequently, IMAX was a reliable indicator of tumor perfusion evaluation by CEUS. The use of CEUS to quantify tumor perfusion could a promising method for the early detection of tumor responses in anti-vascular treatment. 相似文献
12.
Soo Yeon Choi Deuk Jae Sung Kyung Sook Yang Kyeong Ah Kim Suk Keu Yeom Ki Choon Sim Na Yeon Han Beom Jin Park Min Ju Kim Sung Bum Cho Jeong Hyeon Lee 《Abdominal imaging》2016,41(6):1160-1169
Purpose
To evaluate the correlation between CT findings and histologic grade of small clear cell renal cell carcinoma (ccRCC).Methods
CT scans of 101 patients with small ccRCC were reviewed independently by two radiologists for tumor size, shape, margin, encapsulation, enhancement pattern, and visual relative enhancement. Enhancement patterns were defined according to the percentage of uniform enhancement [pattern 1, homogeneous (≥90%); pattern 2, relatively homogeneous (≥75 and <90%); and pattern 3, heterogeneous (<75%)]. Quantitative parameters representing attenuation and degree of enhancement were calculated. Histologic grade was classified as low (Fuhrman grade I or II) and high (Fuhrman grade III or IV). CT imaging variables were analyzed using univariate and multivariate analyses.Results
A total of 63 low-grade and 38 high-grade small ccRCCs were assessed. Low-grade tumors differed from high-grade tumors with respect to enhancement pattern 1 or 2 (p < 0.001 and p < 0.001), smaller size (p = 0.002 and p = 0.001), and lower attenuation on unenhanced scan (p < 0.001 and p = 0.008). In multivariate analysis, enhancement pattern 1 or 2 and low attenuation (≤30 HU) were identified as independent predictors of low-grade ccRCC. Accuracy derived from logistic regression analysis was 79.2% for reader 1 and 70.3% for reader 2.Conclusions
CT imaging features including tumor attenuation and enhancement pattern can be useful to predict the biologic behavior of small ccRCC for adequate treatment strategy.13.
肾肿瘤的超声造影研究 总被引:19,自引:0,他引:19
目的探讨各种不同肾肿瘤的超声造影表现。方法124例肾肿瘤(平均直径3.4cm),应用超声造影观察肿块回声增强时间和造影剂消退时间(皮质相与延迟相),观察肿块的假包膜(与二维声像图对比),所有患者均行手术和病理证实。结果透明细胞癌和乳头状癌98例,移行细胞癌5例,肾盂鳞癌6例,血管平滑肌脂肪瘤7例,肾盂上皮细胞癌1例,肾母细胞瘤5例,嗜酸细胞瘤2例(潜在恶性)。透明细胞癌98中超声造影有58例出现假包膜(58/98,73.3%),而二维声像图显示假包膜31例(31/98,17%);造影剂呈快进快退76例,快进慢退11例,慢进慢退7例,肿块局部回声增强4例。而血管平滑肌脂肪瘤回声增强程度明显低于肾细胞癌。结论超声造影有助于鉴别肾肿瘤,有助于显示出肾细胞癌的假包膜。 相似文献
14.
目的 应用实时灰阶超声造影技术评价乳腺肿瘤新生血管,探讨不同微血管密度(MVD)乳腺肿瘤的超声造影表现。方法 收集在我院接受乳腺肿瘤切除术的患者57例,良性肿瘤30例,恶性肿瘤27例。采用实时灰阶超声造影技术观察肿瘤增强模式及造影参数:峰值强度(PI)和达峰时间(TTP)。对肿瘤进行免疫组化染色,计算MVD。按照MVD均值将患者分为高MVD和低MVD组,比较两组超声造影参数的差异。结果 57例乳腺肿瘤患者MVD均值为(44.51±10.11)个/高倍视野(×200)。高MVD组肿瘤区PI值高于低MVD组(P<0.05);高MVD组和低MVD组肿瘤造影剂分布差异有统计学意义(P<0.05),其余参数差异均无统计学意义(P均>0.05)。结论 超声造影后PI值较高、呈不均匀增强的肿瘤,其恶性可能较大,MVD亦较高。 相似文献
15.
目的 探讨膀胱内翻性乳头状瘤(IPB)与膀胱尿路上皮癌的(BUC)CEUS时间-强度曲线(TIC)参数与微血管密度(MVD)的相关性。方法 回顾性分析经病理证实的IPB患者30例和BUC患者50例的临床和CEUS表现,采用QLab分析软件获得IPB和BUC的TIC参数,包括上升时间(RT)、平均渡越时间(MTT)、峰值强度(PI)、半洗漱时间(TPH)、上升斜率(WIS)、达峰时间(TP)、半降支斜率(DS),并进行统计学分析。对手术标本进行抗CD34因子免疫组化染色测量MVD,分析CEUS的TIC参数与MVD的相关性。结果 IPB和BUC的CEUS定量参数中,PI、TPH、TP、DS比较差异均有统计学意义(P<0.05)。BUC的MVD明显高于IPB(P<0.05)。各TIC参数中,TPH和DS与MVD均存在相关性(rs=0.74、-0.81,P均<0.05)。结论 CEUS在IPB与BUC的鉴别诊断中具有一定的临床价值;TIC参数可定量评估肿瘤内微血管生成情况。 相似文献
16.
F.M. Drudi N. Di Leo F. Malpassini F. Antonini E. Corongiu F. Iori 《Journal of Ultrasound》2012,15(4):247-251
IntroductionBladder cancer ranks 4th overall in the number of newly diagnosed cancers and 10th in causes of cancer deaths. More than 90% of all cases of bladder cancer are transitional cell carcinoma (TCC). The goal of this study is to confirm the usefulness of low mechanical index contrast-enhanced ultrasonography (CEUS), also in association with time–intensity curves, in the differentiation between high- and low-grade bladder malignant lesions.Materials and methodsFrom February 2006 to February 2012 we recruited 144 patients. All patients underwent grayscale ultrasonography (US), color-Doppler ultrasonography (CDUS) and contrast-enhanced ultrasonography (CEUS). Subsequently all patients underwent cystoscopy and TURB.ResultsHistological diagnoses were: 88 high-grade carcinomas (61.1%), and 56 low-grade carcinomas (38.9%). Sensitivity and specificity of CDUS were 87.5% (126/144) and 60%, respectively. Sensitivity and specificity of CEUS were 90.9% and 85.7%, respectively. Sensitivity and specificity of TIC were 91.6% (132/144) and 85.7%, respectively.Discussion and conclusionsCEUS is a reliable noninvasive method for differentiating low- and high-grade bladder carcinomas since it provides typical enhancement patterns as well as specific contrast-sonographic perfusion curves. 相似文献
17.
Yildirim U Erdem H Kayikci A Sahin AF Uzunlar AK Albayrak A 《The Journal of international medical research》2010,38(5):1689-1699
This study was designed to investigate the protein levels of cyclooxyogenase-2 (COX-2) and survivin in superficial urothelial carcinoma (UC) and their correlation with microvessel density (MVD). High-grade UC was positive for both COX-2 and survivin protein, and the proportion of tumours positive for both proteins increased with increasing tumour grade. The presence of COX-2 protein was significantly correlated with the presence of survivin protein. Both COX-2 and survivin positivity were significantly correlated with MVD in all patients regardless of tumour grade, but there was no correlation between MVD and COX-2 and survivin positivity by individual tumour grade. Although there was no significant difference in the proportion of COX-2-positive tumours when patients were stratified by tumour stage, a significantly higher proportion of patients with pT1 stage tumours were survivin-positive compared with patients with pTa stage tumours. COX-2 and survivin positivity were significantly correlated in all patients regardless of tumour grade or stage. COX-2 and survivin were significantly correlated in patients with pTa, but there was no correlation in pT1 tumours. These findings demonstrate that together, COX-2, survivin and MVD may play an important role in UC. 相似文献
18.
Hideyuki Tamai Yoshie Takiguchi Masashi Oka Naoki Shingaki Shotaro Enomoto Tatsuya Shiraki Machi Furuta Izumi Inoue Mikitaka Iguchi Kimihiko Yanaoka Kenji Arii Yasuhito Shimizu Hiroya Nakata Toshiaki Shinka Tokio Sanke Masao Ichinose 《Journal of ultrasound in medicine》2005,24(12):1635-1640
OBJECTIVE: The purpose of this study was to evaluate the usefulness of contrast-enhanced ultrasonography (CEUS) in the diagnosis of solid renal tumors. METHODS: Twenty-nine patients with solid tumors detected on gray scale ultrasonography underwent resection for suspected renal malignancy. Findings of arterial phase contrast computed tomography (CT) and CEUS were compared for each diagnosis. RESULTS: Histopathologic examination of resected lesions showed malignancy in 26 patients (clear cell carcinoma, n = 18; papillary renal cell carcinoma, n = 6; collecting duct carcinoma, n = 1; and infiltrative urothelial carcinoma, n = 1) and benign tumors in 3 patients (oncocytoma, n = 2; and angiomyolipoma, n = 1). Contrast CT failed to show tumor blood flow in 5 of 29 patients, whereas CEUS showed this in all patients. Positive predictive values of CEUS and contrast CT in the diagnosis of renal malignancy were 100% and 82.8%, respectively. Among clear cell carcinomas, hypervascularity was observed on contrast CT in 16 of 18 patients and on CEUS in 17 of 18 patients. On the basis of hypervascularity, diagnostic sensitivity values for clear cell carcinoma were 94.4% for CEUS and 88.9% for contrast CT, whereas specificity values were 45.5% for CEUS and 72.7% for contrast CT. Among papillary cell carcinomas, contrast CT showed avascular lesions in 4 of 6 patients. However, CEUS showed blood flow in these lesions, leading to diagnosis of hypovascular renal tumors. CONCLUSIONS: Contrast-enhanced ultrasonography was more sensitive for detecting slight tumor blood flow than contrast CT and was useful in preoperatively diagnosing malignant hypovascular renal tumors but was less so for hypervascular renal tumors. 相似文献
19.
目的探讨CEUS鉴别乳腺良、恶性肿瘤的价值,观察CEUS时间-强度曲线各参数与微血管密度(MVD)的相关性。方法对88例乳腺肿瘤患者(恶性52例,良性36例)行实时CEUS,分析肿瘤特点,记录时间-强度曲线各参数值,计算MVD。结果良、恶性肿瘤在CEUS增强强度、增强形态、增强边界及有无穿支血管方面差异均有统计学意义(P均<0.05)。恶性肿瘤峰值减半差值时间(ΔHT)、峰值强度(PI)、MVD均高于良性肿瘤,差异有统计学意义(P均<0.05)。PI与MVD呈显著正相关(r=0.85,P<0.05)。结论 CEUS有助于判断乳腺肿瘤的良、恶性,且肿瘤增强强度与MVD有关。 相似文献
20.
目的 探讨术中超声造影在评价不同病理级别脑胶质瘤血管生成变化中的应用价值.方法 对33例脑胶质瘤患者行超声造影检查,实时观察肿瘤血流灌注情况及增强特点,绘制时间-强度曲线获取定量指标.术后对切除的病灶行常规病理检查和免疫组织化学检测,记录肿瘤的微血管密度,定量分析不同级别脑胶质瘤血流灌注指标与术后病理微血管密度的相关性.结果 低级别和高级别脑胶质瘤的造影达峰时间和微血管密度值比较差异均有统计学意义(P=0.0001);不同分化程度的脑胶质瘤超声造影达峰时间与微血管密度之间呈负相关关系(r=-0.79,P=0.0001).结论 术中超声造影可以实时动态地观察微血管的灌注情况,超声造影可提示肿瘤内微血管密度,有助于术者准确判定脑胶质瘤病理分级,指导肿瘤的手术切除.Abstract: Objective To investigate the value of intraoperative contrast-enhanced ultrasound(CEUS) in evaluating pathological grades of cerebral gliomas. Methods Intraoperative CEUS was performed in 33 patients of cerebral gliomas of different pathological grades. Real-time blood perfusion and enhance characteristics of these tumors were observed,quantitative parameters from the automatically derived time-intensity curve (TIC) were obtained, and compared with the tumor microvessel density (MVD) by immunostaining with anti-CD34. Results The time to peak was significantly shorter and the MVD was significantly higher in the high grade cerebral gliomas compared with the low grade ones ( P <0. 05). The time to peak was negatively correlated with the MVD by immunostaining (r = -0.79, P < 0. 05). Conclusions Intraoperative CEUS could be used to observe microvascular perfusion in real-time, and could indirectly reflect the information of MVD in cerebral gliomas, which is of help to grade cerebral gliomas and guide surgical resections. 相似文献