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目的评价褐藻胶微球(AMG)作为栓塞材料在部分性脾栓塞术(PSE)治疗肝硬化脾功能亢进(脾功能亢进)中的疗效及并发症。方法2003—2005年42例肝硬化脾功能亢进行PSE患者,栓塞材料为250~450μmAMG。超选择性脾下极动脉部分性脾栓塞。结果共进行脾栓塞42次,栓塞范围40%~70%。栓塞后有35例出现发热,持续3~15d,38例出现腹痛,其中27例需用强效止痛药。少量胸腔积液6例,保守治疗后消失。未出现脾脓肿等严重并发症。术后24h白细胞和血小板计数开始升高(P<0.05),术后3个月白细胞维持在正常值为38例,血小板维持在正常值为39例。结论AMG可作为PSE术的栓塞材料治疗脾功能亢进,减轻术后反应。 相似文献
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肝硬化门脉高压继发脾功能亢进的介入治疗 总被引:2,自引:0,他引:2
目的 探讨肝硬化门脉高压引起脾功能亢进的介入栓塞治疗效果。方法 采用Seldinger法穿刺股动脉 ,选择或超选择插管进入脾动脉和 /或其分支血管 ,行部分性栓塞共 2 6例 ,术前血小板、白细胞计数均明显低于正常水平。结果 脾动脉栓塞后 3~ 5d血小板、白细胞显著增加 ,1~ 2周升至或超过正常范围。术后 2月血小板、白细胞计数明显高于术前 ,具有极显著性意义 (Ρ <0 .0 1)。 2 6例患者术后均有脾区疼痛 ,2 4例有发热 ,随访时间 1~ 44月 ,平均 15 .7个月 ,除 2例死于肝癌外其他病例均存活 ,2例血小板计数低于正常 ,但高于术前水平。结论 脾动脉部分栓塞属微创手术 ,既能保留脾脏的免疫功能 ,又能有效地缓解脾功能亢进和门脉高压 ,对肝硬化脾功能亢进的患者是一条安全、有效的治疗途径 相似文献
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部分性脾栓塞术治疗肝硬化脾功能亢进的远期疗效观察 总被引:28,自引:0,他引:28
目的 目的评价部分性脾栓塞术 (Partialsplenicembolization ,PSE)治疗肝硬化脾功能亢进的远期疗效。方法 对 1998年 5月以前采用PSE治疗的 6 2例肝硬化脾功能亢进患者进行长期随访 ,随访指标主要为外周血白细胞、血小板和红细胞计数。选取术后 1~ 5年资料完整的 38例进行分析 ,其中栓塞程度≥ 6 0 %者 2 3例 ,5 0 %~ 5 9%者 9例 ,<5 0 %者 6例。结果 白细胞和血小板计数分别于术后第 3天和 2周达到峰值 ,然后二者逐渐下降 ,但对不同的栓塞程度其下降趋势差异具有显著性意义 (P =0 .0 0 1)。栓塞程度≥ 6 0 %者 ,术后白细胞和血小板计数均较术前显著升高并一直维持到术后第 5年 (P <0 .0 0 1) ,且第 5年时白细胞计数仍为正常 ,第 4年时血小板计数仍达正常。栓塞程度5 0 %~ 5 9%者 ,术后白细胞和血小板计数也较术前明显升高并可达到术后第 5年和第 4年 (P <0 .0 5 )水平 ,但它们分别在术后第 2年和第 1年就降至正常范围以下。而对于栓塞程度 <5 0 %者 ,术后 1个月白细胞和血小板计数都降至正常范围以下。红细胞计数在术后一直无明显变化 (P >0 .0 5 )。随着栓塞程度的增加 ,术后反应加重 ,并发症也随之增加。结论 栓塞程度控制在 6 0 %~ 70 %可有效治疗肝硬化脾功能亢进 ,分次栓塞可减轻术后反应 相似文献
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目的:探讨部分性脾栓塞术的临床应用价值。方法:采用Seldinger用明胶海绵颗粒或/和明胶海绵条行部分性脾栓塞术62例,其中原发性肝癌伴脾功能亢进32例,肝炎后肝硬化伴门脉高压、脾功能亢进25例,原发性血小板减少性紫癜5例。栓塞范围40.0%~80.0%。栓塞前后测定血细胞数量及肝功。结果:检塞术后3d、2w、4w复查血细胞,白细胞及血小板较术前明显升高;术后3d、4w复查肝功,肝功能呈一过性损害。栓塞范围40.0%~70.0%54例,出现少量腹水8例,左侧少量胸腔积液9例,胸腹水6例,胸水伴左下肺炎1例;栓塞量70.0%以上8例,出现左侧胸水、腹水及腹膜炎2例,左侧胸水、左下肺炎1例,左侧胸水、大量腹水伴左膈下脓肿1例,多器官衰竭死亡1例。结论:各种原因引起的脾功能亢进所致的外周血细胞减少,用部分性脾栓塞术治疗安全,疗效好,创伤小,并发症少。 相似文献
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原发性肝癌伴脾亢的介入治疗(附31例报告) 总被引:11,自引:2,他引:9
目的 探讨肝动脉化疗栓塞联合部分性脾动脉栓塞 (PSE)治疗原发性肝癌合并脾功能亢进的意义及方法。方法 原发性肝癌合并脾亢 3 1例 ,采用经皮穿刺肝动脉化疗栓塞术 (TACE)和PSE治疗 ,治疗前后测定血细胞数量 ,CT观察肝脏肿瘤及脾脏大小改变。结果 PSE术后 2 4h、1周、4周血白细胞和血小板均较栓塞前明显升高 (Ρ <0 .0 1)。 2 8例脾栓塞面积在 40 %~70 % ,2例 80 % ,1例 <40 %。术后 1月CT复查肝脏肿瘤缩小 2 2例 ,占 70 .97% (2 2 / 3 1)。脾脏有所缩小 ,内可见均一低密度梗死区。结论 肝动脉化疗栓塞及部分性脾动脉栓塞是治疗肝癌合并肝硬化脾功能亢进安全、有效的方法 相似文献
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脾动脉栓塞与脾切除的对比分析 总被引:9,自引:0,他引:9
目的探讨脾动脉栓塞和脾切除治疗脾功能亢进的疗效及并发症,为临床治疗脾功能亢进方式提供选择依据。方法回顾分析我院近年部分性脾动脉栓塞46例和脾切除33例,比较两种方法治疗后血象改善及并发症发生情况。结果两种方法均能有效改善肝硬化继发脾肿大脾功能亢进患者血小板和白细胞计数(P<0.001),但两组患者中脾切除组术后血小板计数改善明显优于脾动脉栓塞组,而白细胞计数的改善两组无明显差异。脾动脉栓塞组术后并发症发生率明显高于脾切除组(P<0.001)。结论对于腹水较多、门脉高压明显、脾脏巨大的患者不宜行脾动脉栓塞治疗,行脾切除术较好;对于肝脏功能较差、凝血功能严重障碍、高龄和伴肝癌的脾功能亢进患者宜行脾动脉栓塞治疗。 相似文献
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自1995年以来,采用部分性脾栓塞(PSE),治疗肝硬化及采用肝动脉化疗栓塞术(THAE)和(PSE)治疗合并肝硬化、门脉高压和牌功亢进的肝癌,取得了良好效果。就其方法、疗效及价值报告如下:1材料和方法1.1一般资料患者10例。7例为临床诊断原发性肝癌在接受介入治疗,3例为肝硬化合并门脉高压,脾功能亢进。男吕例,女2例,年龄35~68岁。10例均有脾大、门脉高压。脾功亢进9例。外周血白细胞计数(1.8~4.6)×10’几血小板(46~72)×10’/L,食道静脉曲张百例,有呕血史2例,腹水4例。1.2方法对肝癌,于肝血管造影后,将导管… 相似文献
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目的:探讨部分脾动脉栓塞在肝硬化脾功能亢进治疗中的疗效及临床意义。方法选择47例肝硬化脾功能亢进患者,采用Seldinger技术用PVA微粒行脾动脉部分栓塞术,并观察术前、术后血象变化。结果47例患者术后1个月、3个月复查,随访3年:外周血白细胞、血小板较术前明显升高;红细胞较前大致相仿。结论部分脾动脉栓塞术治疗脾功能亢进疗效好,并发症少,值得临床运用。 相似文献
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Knee injury and Osteoarthritis Outcome Score (KOOS) - validation of a Swedish version 总被引:5,自引:0,他引:5
E. M. Roos H. P. Roos C. Ekdahl L. S. Lohmander 《Scandinavian journal of medicine & science in sports》1998,8(6):439-448
The Knee injury and Osteoarthritis Outcome Score (KOOS) is a self-administered instrument measuring outcome after knee injury at impairment, disability, and handicap level in five subscales. Reliability, validity, and responsiveness of a Swedish version was assessed in 142 patients who underwent arthroscopy because of injury to the menisci, anterior cruciate ligament, or cartilage of the knee. The clinimetric properties were found to be good and comparable to the American version of the KOOS. Comparison to the Short Form-36 and the Lysholm knee scoring scale revealed expected correlations and construct validity. Item by item, symptoms and functional limitations were compared between diagnostic groups. High responsiveness was found three months after arthroscopic partial meniscectomy for all subscales but Activities of Daily Living. 相似文献
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Acute limping may be the result of multiple pathologies in children. The differential diagnosis varies based on the age of the child. Irrespective of age, the initial imaging work-up includes AP and frog leg radiographs of the pelvis and ultrasound; MRI may sometimes be helpful. In children less than 3 years, infections and trauma are most frequent. MRI is the imaging modality of choice when osteomyelitis is clinically suspected. Between the ages of 3 and 10 years, transient synovitis of the hip and Legg-Calvé-Perthes disease are main considerations but infection, inflammation and focal bony lesions are also considered. In children over 10 years, slipped capital femoral epiphysis also is considered. 相似文献
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Introduction Ankle sprains are the most common musculoskeletal injury that occurs inathletes particularly in sports that require jumping landing on one foot such assoccer and basketball 《中国运动医学杂志》2008,27(3):378-381
Introduction Ankle sprains are the most common musculo-skeletal injury that occurs in athletes,particularly in sports that require jumping and landing on one foot such as soccer,and basketball(1-4).These injuries often result in significant time loss from participation,long-term disability,and have a major impact on health care costs and resources(5-8). 相似文献
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Martin J.Gibala 《中国运动医学杂志》2008,27(3)
KEY POINTS ·High-intensity interval training(HIT)is characterized by repeated sessions of relatively brief,intermittent exercise.often performed with an“a11 out”effort or at an intensity close to that which elicits peak oxygen uptake(i.e.,≥90%of VO2 peak). 相似文献
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Objective To investigate endovascular treatment of traumatic direct carotid-cavernous fistulas (CCF) and their complications such as pseudoaneurysms. Methods: Over a five-year period, 22 patients with traumatic direct CCFs were treated endovascularly in our institution. Thirteen patients were treated once with the result of CCF occluded, 8 twice and 1 three times. Treatment modalities included balloon occlusion of the CCF, sacrifice of the ipsilateral internal carotid artery with detachable balloon, coll embolization of the cavernous sinus and secondary pseudoaneurysms, and covered-stem management of the pseudoaneurysms. Results All the direct CCFs were successfully managed endovascularly. Four patients developed a pseudoaneurysm after the occlusion of the CCF with an incidence of pseudoaneurysm formation of 18.2% (4/22). A total number of 8 patients experienced permanent occlusion of the ICA with a rate of ICA occlusion reaching 36.4% (8/22). Followed up through telephone consultation from 6 months to 5 years, all did well with no recurrence of CCF symptoms and signs. Conclusion Traumatic direct CCFs can be successfully managed with endovascular means. The pseudoaneurysms secondary to the occlusion of the CCFs can be occluded with stent-assisted coiling and implantation of covered stents. 相似文献
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Tucker VC Hopwood AJ Sprecher CJ McLaren RS Rabbach DR Ensenberger MG Thompson JM Storts DR 《Forensic science international. Genetics》2011,5(5):436-448
In response to the ENFSI and EDNAP groups’ call for new STR multiplexes for Europe, Promega® developed a suite of four new DNA profiling kits. This paper describes the developmental validation study performed on the PowerPlex® ESI 16 (European Standard Investigator 16) and the PowerPlex® ESI 17 Systems. The PowerPlex® ESI 16 System combines the 11 loci compatible with the UK National DNA Database®, contained within the AmpFlSTR® SGM Plus® PCR Amplification Kit, with five additional loci: D2S441, D10S1248, D22S1045, D1S1656 and D12S391. The multiplex was designed to reduce the amplicon size of the loci found in the AmpFlSTR® SGM Plus® kit. This design facilitates increased robustness and amplification success for the loci used in the national DNA databases created in many countries, when analyzing degraded DNA samples. The PowerPlex® ESI 17 System amplifies the same loci as the PowerPlex® ESI 16 System, but with the addition of a primer pair for the SE33 locus. Tests were designed to address the developmental validation guidelines issued by the Scientific Working Group on DNA Analysis Methods (SWGDAM), and those of the DNA Advisory Board (DAB). Samples processed include DNA mixtures, PCR reactions spiked with inhibitors, a sensitivity series, and 306 United Kingdom donor samples to determine concordance with data generated with the AmpFlSTR® SGM Plus® kit. Allele frequencies from 242 white Caucasian samples collected in the United Kingdom are also presented. The PowerPlex® ESI 16 and ESI 17 Systems are robust and sensitive tools, suitable for the analysis of forensic DNA samples. Full profiles were routinely observed with 62.5 pg of a fully heterozygous single source DNA template. This high level of sensitivity was found to impact on mixture analyses, where 54–86% of unique minor contributor alleles were routinely observed in a 1:19 mixture ratio. Improved sensitivity combined with the robustness afforded by smaller amplicons has substantially improved the quantity of data obtained from degraded samples, and the improved chemistry confers exceptional tolerance to high levels of laboratory prepared inhibitors. 相似文献
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LI Yong-dong HAN Xin-wei WU Gang LI Ming-hua 《介入放射学杂志》2007,16(4):253-257
Objective To evaluate the preliminaily clinical efficacy and retrievability of a retrievable hinged covered metallic stent in the treatment of the bronchial stump fistula (BSF). Methods Between April 2003 and March 2005, 8 patients with bronchial stump fistula after pneumonectomy or lobectomy were treated with two types (A and B) of retrievable hinged covered metallic stents. Type A stent was placed in 6 patients and type B in 2 under fluoroscopic guidance. The stent was removed with a retrieval set when BSF was healed or complications occurred. Results Stent placement in the bronchial tree was technically successful in all patients, without procedure-related complications. Immediate closure of the BSF was achieved in all patients after the procedure. Stents were removed from all patients but one. Removal of the stents was difficult in two patients due to tissue hyperplasia. Patients were followed up for 6 - 21 months. Placement of the stents remained stable in all patients except one due to severe cough. Permanent closure of BSF was achieved in 7 (87.5%) of 8 patients. Conclusion Use of a retrievable hinged covered expandable metallic stent is a simple, safe, and effective procedure for closure of the BSF. Retrieval of the stent seems to be feasible. (J Intervent Radiol, 2007, 16: 253-257) 相似文献
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Prevalence and severity of hip and groin pain in sub‐elite male football: a cross‐sectional cohort study of 695 players
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K. Thorborg M. S. Rathleff P. Petersen S. Branci P. Hölmich 《Scandinavian journal of medicine & science in sports》2017,27(1):107-114
The purpose of this study was twofold: (a) to investigate the prevalence of hip and groin pain in sub‐elite male adult football in Denmark and (b) to explore the association between prevalence and duration of hip and groin pain in the previous season with the Copenhagen Hip and Groin Outcome Score (HAGOS) in the beginning of the new season. In total 695 respondents from 40 teams (Division 1–4) were included. Players completed in the beginning of the new season (July–Sept 2011) a self‐reported paper questionnaire on hip and/or groin pain during the previous season and HAGOS. In total 49% (95% CI: 45–52%) reported hip and/or groin pain during the previous season. Of these, 31% (95% CI: 26–36%) reported pain for >6 weeks. Players with the longest duration of pain during the previous season had the lowest HAGOS scores, when assessed at the beginning of the new season, P < 0.001. This study documents that half of sub‐elite male adult football players report pain in the hip and/or groin during a football season. The football players with the longest duration of pain in previous season displayed the lowest HAGOS scores in the beginning of the new season. 相似文献