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M. I. Ryakhovskaya G. S. Grinenko L. M. Alekseeva G. N. Engalycheva V. B. Nikitin M. É. Kaminka R. G. Glushkov 《Pharmaceutical Chemistry Journal》1991,25(4):235-238
Translated from Khimiko-farmatsevitcheskii Zhurnal, Vol. 25, No. 4, pp. 16–18, April, 1991. 相似文献
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谷氨酸硫酸镧固体配合物的合成,性质及抗癌活性 总被引:5,自引:0,他引:5
合成了新的谷氨酸硫酸镧固体配合物,并确定了该配合物的组成为La2(Glu)4(SO4)3·8H2O.并对其荧光光谱、摩尔电导及抗癌活性进行了研究.结果表明,该配合物对K562(红白血病)、H22(小鼠肝癌)和SW480(人结肠癌)有显著的抑制作用 相似文献
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The NMDA receptor is an ionotropic receptor complex widely distributed in the central nervous system and its activation, particularly in hypoxic conditions such as stroke, traumatic head injury and hypoglycemia, results in a massive influx of calcium ions into the post-synaptic neurones, leading to cell death through the activation of several neurotoxic cascades. The NMDA receptor is a unique ionotropic receptor complex because its activation requires the simultaneous binding of glutamate and glycine and selective antagonists at the glycine binding site are endowed with a better side-effect profile than competitive NMDA antagonists. Then, considerable efforts have been devoted to find potent and selective ligands, resulting in the identification of several classes of glycine antagonists. The research at Glaxo Wellcome has been aimed at the identification of novel in vivo active glycine antagonists, and led to the synthesis and pharmacological characterization of a number of novel, potent and systemically active compounds belonging to different chemical classes. 相似文献
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M. E. Kon’shin B. Ya. Syropyatov M. I. Vakhrin P. G. Neifel’d V. P. Feshin S. N. Shurov T. F. Odegova 《Pharmaceutical Chemistry Journal》2010,44(9):476-479
A series of substituted amides of 3-carboxypicolinic acid have been synthesized via the interaction of quinolinic acid anhydride
with alkyl(aryl)amines. Their structures were studied by 1H and 13C NMR spectroscopy. The direction of the reaction was explained by quantum-chemistry methods. Three compounds demonstrated
hemostatic activity. Two substances exhibited anticoagulant properties. Most substances also exhibited weak bacteriostatic
activity. 相似文献
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A. G. Panosyan M. N. Lebedeva A. N. Oryekhov V. V. Tertov Kh. A. Khashimov S. É. Akopov É. S. Gabrielyan 《Pharmaceutical Chemistry Journal》1989,23(9):749-753
Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 23, No. 9, pp. 1084–1088, September 1989. 相似文献
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