注意缺陷多动障碍儿童的错误相关负电位的检测

目的探讨注意缺陷多动障碍(ADHD)患儿的错误相关负电位(ERN)的变化特点。方法应用事件相关脑电位仪,对30例ADHD患儿和30名健康儿童做ERN检测并比较。结果与健康儿童相比,ADHD患儿的正确反应率明显降低、正确反应和错误反应的反应时明显延长;ERN潜伏期(Cz、Fz、C3和C4)明显延迟、波幅(Cz、C3、Fz和Pz)降低。结论 ADHD患儿的ERN潜伏期和波幅异常,可能反映了患者内在错误监控机制存在缺陷。     

注意缺陷多动障碍患儿事件相关电位N400研究

目的:探讨注意缺陷多动障碍(ADHD)患儿汉语句子结尾词匹配和非匹配语言时相关电位(ERP)N400的变化。方法:应用ERP仪,采用汉语正常句子结尾词匹配与非匹配的范式,对35例ADHD患儿(ADHD组)和41名正常儿童(正常对照组)进行视觉诱发电位N400检测。结果:在Cz脑区匹配及非匹配条件下,ADHD组N400潜伏期[(384±45)ms,(436±35)ms]比正常对照组[(348±32)ms,(399±29)ms]显著延迟(P均0.01);波幅ADHD组[(4.2±4.5)μV,(7.5±5.1)μV]显著低于正常对照组[(7.6±5.0)μV,(12.4±6.5)μV](P均0.01)。结论:ADHD患儿N400异常,N400检测可能成为判断注意缺陷多动障碍的客观指标。     

注意缺陷多动障碍患儿的P300检测

目的 探讨注意缺陷多动障碍(ADHD)患儿事件相关电位P 300指标及其治疗前后的特点.方法 应用美国Nicolet Spirit脑诱发电位仪,记录36例ADHD患儿和32名正常儿童(NC组)的P 300,对其中33例ADHD患儿于治疗6个月后再次检测P 300.结果 (1)ADHD组P 300-N2和P3靶潜伏期长于NC组,P 300-P3靶波幅低于NC组(P<0.01).(2)利太林治疗后,ADHD组随多动症状改善,脑诱发电位中P 300-N2靶潜伏期缩短[治疗前后分别为(273±20)ms和(260±17)ms,P<0.01],P3靶波幅升高[分别为(2.9±1.9)μV和(4.6±2.0)μV,P<0.01].结论 ADHD患儿P 300有变化,治疗后随着多动症状的改善,与认知功能有关的P 300指标也有相应改善.     

精神分裂症患者事件相关电位P300的对照研究

目的:探讨精神分裂症患者听觉诱发电位P300的特征及病程对P300的影响。方法:对68例精神分裂症患者(研究组)和30名正常对照(正常对照组)进行事件相关电位P300的检测,并分析比较不同病程对P300的影响。结果:研究组Fz、Cz、FC1的P300潜伏期较对照组明显延迟(t分别=2.67,3.48,3.36;P均<0.01);Fz、Cz、FC1、FC2的波幅较对照组显著降低(t分别=5.97,2.54,4.57,3.80;P均<0.01)。对研究组中病程<6个月组和病程>5年组的患者比较发现,病程>5年组的患者Fz、Cz潜伏期延迟(t=9.23,7.63;P均<0.01),波幅降低(t=11.97,6.66;P均<0.01)。结论:精神分裂症患者认知功能受损,病程越长,受损越重。     

康复期男性海洛因依赖者诱发电位P300研究

目的:探讨康复期男性海洛因依赖者(MPHD)听觉诱发电位P300(AEP-P300)与视觉诱发电位P300(VEP-P300)的特点. 方法:以Neuroscan脑诱发电位仪检测38例康复期MPHD(MPHD组)和14名健康对照者(对照组)前额区(Fz)、中央区(Cz)及顶区(Pz)AEP-P300与VEP-P300. 结果:MPHD Cz点AEP-P300波幅平均秩次为23.1μV,显著低于对照组的35.8μV(P<0.05).与对照组比较,在以动物图片为靶刺激(AT)时,MPHD组Fz点波幅显著升高,Cz、Pz点潜伏期显著缩短(u=2.37、2.56、3.10,P<0.05或P<0.01);在以药物图片为靶刺激(DT)时,两组VEP-P300各指标均差异无显著性(P>0.05).与以AT为靶刺激比较,在以DT为靶刺激时,MPHD组上述各点的Fz、cz、Pz点的VEP-P300潜伏期均显著缩短,Pz点波幅显著升高(t=3.39,P<0.01). 结论:康复期MPHD者仍然存在明显的神经电生理功能的紊乱,对药物相关刺激呈现一定的偏好.     

草酸艾司西酞普兰对抑郁症患者事件相关电位P300的影响

目的:探讨草酸艾司西酞普兰对抑郁症患者的事件相关电位P300影响。方法:随机将年龄在18～65岁之间符合中国精神障碍分类与诊断标准第3版抑郁症诊断标准患者30例作为研究组,选择30例性别年龄健康者作为对照组。研究组予草酸艾司西酞普兰治疗。两组分别予听觉P300检测,比较P300潜伏期及波幅的差异。结果:研究组Fz、Pz点潜伏期分别为(319±23)ms、(315±20)ms均比对照组分别为(300±22)ms、(299±21)ms延长,研究组Fz、Cz、Pz点分别为(2.5±1.8)μV、(2.6±2.4)μV、(2.5±3.3)μV波幅均比对照组分别为(3.8±2.0)μV、(3.7±1.9)μV、(4.1±3.0)μV降低(P<0.05或P<0.01)。治疗8周后,研究组Fz、Pz点潜伏期分别为(301±19)ms、(305±19)ms]明显缩短,Fz、Cz、Pz点分别为(3.5±1.8)μV、(3.7±2.1)μV、(3.6±3.5)μV波幅明显升高(P<0.05)。结论:抑郁症患者存在P300异常,草酸艾司西酞普兰具有改善这种异常现象的作用。     

注意力缺陷多动障碍儿童事件相关电位检测及与智力的相关性

目的研究注意力缺陷多动障碍儿童(attention deficit hyperactivity disorder,ADHD)事件相关电位(event related potential,ERP)的特征,研究ERP与多动指数及智力的相关性,探讨ADHD儿童的认知功能.方法选取2019年6月至2020年12月在厦门市仙岳医院门诊就诊的61例ADHD儿童作为研究组,选取符合纳入及排除标准的61名健康儿童作为对照组,行ERP及韦氏智力检查,对两组儿童照顾者行Conners父母问卷(PSQ)检查.结果在靶刺激下,研究组前额区、中央区、顶叶区的P3潜伏期明显长于对照组,差异均有统计学意义[(388.41±47.24)ms比(372.89±34.75)ms、(395.31±55.18)ms比(371.33±38.80)ms、(404.23±55.21)ms比(381.54±38.93)ms,t=2.07、2.78、2.62,均P<0.05];在靶刺激下,两组在前额区、中央区、顶叶区的P3波幅比较,差异均有统计学意义[9.61(7.60,15.63)μV比13.52(10.04,16.90)μV、11.20(5.81,17.43)μV比13.49(9.22,16.54)μV、12.33(7.05,18.85)μV比14.74(9.31,20.09)μV,Z=-2.77、-2.10、-2.06,均P<0.05].两组智力测验中的言语理解指数、知觉推理指数、工作记忆指数、加工速度指数及总智商得分比较,研究组均低于对照组,差异有统计学意义[98.0(89.0,103.5)比99.0(95.5,107.0)、94.0(86.0,103.0)比100.0(89.0,109.0)、85.0(75.0,97.0)比91.0(87.0,97.0)、83.0(77.0,95.0)比92.0(80.5,99.0)、83.0(77.0,95.0)比92.0(80.5,99.0),Z=-2.10、-2.54、-3.70、-3.33、-2.86,均P<0.05];研究组的多动指数评分高于对照组[1.80(1.60,2.10)比0.80(0.65,1.15),Z=-9.54,P<0.05].相关分析结果显示,研究组的P3潜伏期与工作记忆指数(WMI)和加工速度指数(PSI)呈负相关(r=-0.29、-0.26,P<0.05),N2P3峰值与PSI呈正相关(r=0.30,P<0.05).结论ADHD儿童存在一定程度的认知功能障碍,ERP能测量ADHD患儿的认知功能状况,ERP和韦氏智力联合使用有助于客观、全面地评价ADHD.     

精神分裂症患者认知异常的事件相关电位研究

目的探讨精神分裂症患者失匹配负波（mismatch negativity,MMN）的特征及药物对MMN的影响。方法对31例精神分裂症患者（研究组）和30名健康被试（对照组）行MMN的检测,并比较首发未用药组与已用药组MMN潜伏期、波幅的差异。结果（1）研究组和对照组Fz,Cz,Pz点均可见较明显MMN波形,精神分裂症组波形欠规则。（2）研究组Fz、Cz、Pz点的MMN潜伏期较对照组差异无统计学意义（t=0．74,0．09,0．63;P〉0．05）;三点波幅降低,较对照组比较差异具有统计学意义（t=5．04,5．83,4．47;P〈0．05）。（3）首发未用药病患组12例和已接受药物治疗的病患组19例,在Fz、Cz、Pz点MMN潜伏期、波幅,差异均未见统计学差异（t=0．59,1．17,1．73,1．88,1．12,0．90;P〉0．05）。结论精神分裂症患者认知功能受损,且MMN是一个稳定的素质性指标,不受药物影响。     

注意缺陷多动障碍不同亚型男性患儿家庭亲密度及适应性与养育方式调查

目的 了解不同亚型注意缺陷多动障碍(ADHD)患儿的家庭亲密度及适应性与养育方式特点.方法 对湖南省9495名儿童及其家长采用二阶段流行病学调查方法进行问卷调查,对其中部分符合美国精神障碍诊断与统计手册第4版ADHD诊断标准的患儿采用家庭亲密度及适应性量表(注意缺陷型40例,多动冲动型52例,混合型39例;对照组58例)和父母教养方式评价量表(注意缺陷型48例,多动冲动型42例,混合型56例;对照组6例)进行调查.结果 (1)ADHD 3个亚型的现实亲密度、亲密满意度、适应满意度评分与对照组的差异均无统计学意义(F检验,P均＞0.05);理想亲密度、现实适应性和理想适应性各分项与对照组的差异均有统计学意义[事后(Post Hoc)检验,P均＜0.05],尤以多动冲动型更为明显.(2)ADHD 3个亚型父亲情感温暖评分与对照组的差异均有统计学意义(Post Hoc检验,P均＜0.05);注意缺陷型父亲惩罚评分与对照组的差异有统计学意义(Post Hoc检验,P=0.011);ADHD 3个亚型母亲惩罚评分与对照组的差异均有统计学意义(Post Hoc检验,P均＜0.05);注意缺陷型和混合型母亲情感温暖评分与对照组的差异有统计学意义(Post Hoc检验,P均＜0.05).结论 ADHD男性患儿不同亚型在家庭亲密度及适应性和养育方式特点不尽一致,应针对性地进行家庭干预.     

注意缺陷多动障碍患儿哌甲酯治疗前后的脑诱发电位研究

目的 探讨注意缺陷多动障碍(ADHD)患儿4种脑诱发电位指标及其治疗前后的特点.方法 应用美国Nicolet Spirit脑诱发电位仪,记录37例ADHD患儿(ADHD组)和30名正常儿童(正常对照组)的事件相关电位P300、失配性负波(MMN)、关联性负变(CNV)和脑干听觉反应(ABR),对其中31例ADHD患儿于哌甲酯(10～15 mg口服)治疗4个月后再次检测.结果 (1)与正常对照组比较,ADHD组P300-N2靶潜伏期长,P300-P3靶波幅低;ABR-波Ⅲ绝对潜伏期短,绝对波幅波V低;MMN潜伏期长,波幅高;CNV-M2波幅低,反应时间(RT)长;差异均有统计学意义(P＜0.05～0.01).(2)哌甲酯治疗4个月后,ADHD组随多动症状改善,P300-N2靶潜伏期缩短[治疗前后分别为(278±18)ms和(261±16)ms,P＜0.01],P3靶波幅升高[分别为(2.8±1.8)μV和(4.2±1.9)μV,P＜0.05];MMN潜伏期缩短[分别为(208±24)ms和(193±24)ms,P＜0.05];CNV-M1波幅升高[分别为(10.3±5.0)μV和(14.3±4.1)μV,P＜0.01];RT缩短[分别为(478±158)ms和(349±144)ms,P＜0.01],但ABR治疗前后的差异无统计学意义(P＞0.05).结论 ADHD患儿的P300,MMN,CNV和ABR 4种脑电诱发电位较正常对照组均有改变;治疗后随多动症状的改善,与认知功能有关的P300,MMN和CNV 3项指标亦有相应的改善.     

康复期男性海洛因依赖者注意力与听觉P300的研究

目的探讨处于康复期的海洛因依赖者注意力与听觉P300的特点以及二者的关系。方法以数字划销测验（NCT）评估38例康复期的男性海洛因依赖者（MPHD）和14例健康对照的注意力，同时以脑诱发电位仪检测康复期MPHD及健康对照前额区（Fz）、中央区（Cz）及项区（Pz）听觉P300。结果康复期MPHDNCTI阶段、Ⅱ阶段、Ⅲ阶段、V阶段净分及总净分均显著低于对照组（P〈0．05或P〈0．01）；Cz点AEP—P300波幅显著低于健康对照组（P〈0．05）。MPHDFz、Cz点AEP-P300波幅与净分V呈正相关（P〈0．01），在Pz点AEP—P300波幅与净分Ⅲ呈正相关（P〈0．05）；在Cz点AEP—P300潜伏期与净分工及净分Ⅲ呈正相关（P〈0．05）。结论康复期MPHD存在明显的注意力损害与皮质功能的紊乱，AEP—P300可在一定程度上反映海洛因依赖者注意力损害的程度。     

P300 differences exist between Tourette's syndrome with and without attention deficiency and hyperactivity disorder in children.

OBJECTIVE: To study the characteristics of P300 in Tourette's syndrome (TS) with and without attention deficiency and hyperactivity disorder (ADHD). METHOD: Auditory evoked P300 were recorded in 19 TS only (TS-ADHD) children, 15 TS with ADHD (TS + ADHD) children and 20 unaffected control subjects, and their waveforms, amplitudes, latencies and topographies were compared at Fz, Cz, C3, C4 and Pz. RESULTS: The TS + ADHD group showed shorter latencies than control subjects at all electrode sites (P<0.05 or 0.01), and the TS-ADHD group at CZ and PZ (P<0.05); however, there was no significant difference between control subjects and the TS-ADHD group. The TS-ADHD group showed smaller amplitudes than the control group at all electrode sites (P<0.05), and the TS + ADHD group at Cz (P<0.05); however, there were no significant differences between control subjects and the TS + ADHD group. There was no significant difference in the prevalence of abnormal waveforms between the control, TS, TS-ADHD and TS + ADHD groups, but there were significant differences in the variability of localization of P300 between the control and the TS group (P=0.003), control and TS + ADHD groups (P=0.000), and the TS-ADHD and TS + ADHD groups (P=0.039). P300 in the TS + ADHD group tended to spread out to the left and that of the TS-ADHD group tended to spread out to the right. CONCLUSIONS: P300 differences exist between TS-ADHD and TS + ADHD in children. These suggested that establishment different development defects or delay of communications between different structures rather than a delay in maturation of the structures themselves may be involved in TS + ADHD and TS-ADHD children and ADHD symptoms in TS patients are likely a trait rather than adventitious or acquired within the TS syndrome.     

综合心理行为干预对军事演习应激状态官兵心理健康和事件相关电位P300的影响

目的 探讨综合心理行为干预对军事演习应激状态下官兵心理健康和事件相关电位P300的影响.方法 以某部参加军事演习的127名官兵为研究对象,以班为单位按随机数字表法分为研究组(63例)和对照组(64例),研究组演习前进行6周的心理行为与太极拳训练等综合干预.干预前1 d(干预前)、军事演习后第2天(干预后)分别对2组进行症状自评量表(Symptom Checklist-90,SCL-90)评估和事件相关电位P300检测.结果 (1)心理健康指标比较:与干预前比较,研究组干预后躯体化、人际关系敏感、焦虑因子分均降低,对照组躯体化、人际关系敏感、恐怖因子分及SCL-90总分均升高(P均＜0.05);与对照组比较,干预前2组SCL-90总分及各项因子分差异均无统计学意义(P均＞0.05),干预后研究组躯体化、人际关系敏感、焦虑、恐怖因子分均低于对照组(P均＜0.05).(2)事件相关电位P300指标比较:与干预前比较,研究组干预后Cz与FPz点P300靶刺激P3波幅升高(q=3.45、3.46,P均＜0.05),FPz点非靶刺激P2潜伏期(167.8±23.5)ms,短于干预前[(188.3±25.2)ms;q=3.54,P＜0.05];对照组干预后FPz点靶刺激P3潜伏期长于干预前(q=3.64,P＜0.05);与对照组比较,干预前2组Cz、FPz点潜伏期及波幅的差异均无统计学意义(F检验,P均＞0.05);干预后研究组Cz与FPz点靶刺激P3和非靶刺激P2潜伏期均短于对照组(P均＜0.05),Cz与FPz点靶刺激P3和FPz点非靶刺激P2波幅均高于对照组(q=3.34、3.35、3.68,P均＜0.05).结论 综合心理行为干预能够改善军事演习应激条件下官兵的心理健康水平和部分电生理指标.

Abstract：

Objective To explore the effects of the comprehensive psychological behavior intervention on the mental health and event-related potentials ( ERPs ) of the servicemen under military exercise. Methods One hundred and twenty-seven servicemen who participated in the military exercise were randomly divided into two groups, named the study group ( n = 63 ) and the control group ( n = 64 ). The servicemen in the study group were given the comprehensive psychological behavior intervention for 6 weeks.They were assessed with the Symptom Checklist-90 ( SCL-90 ) and event-related potential P300( P300 ) preintervention and post-intervention. Results ( 1 )The factors of somatization, interpersonal sensitivity, and anxiety of SCL-90 were significantly decreased after intervention in study group ( P ＜ 0. 05 ). In the control group, the factors of somatization, interpersonal sensitivity, phobic anxiety and total score post-intervention were significantly increased after military exercise ( P ＜0. 05 ). Before intervention, the difference on SCL-90score between the study group and the control group was not significant ( P ＞ 0. 05 ). After intervention, the factors of somatization, interpersonal sensitivity, anxiety, phobic anxiety and total score in the study group were significantly lower than that of the control group ( P ＜0. 05 ). ( 2 )After intervention, the study group showed higher amplitude on target P3 of P300 at Cz and FPz than the baseline ( q = 3.45, 3.46, P ＜ 0. 05 ),and shortened latency on non-target P2 at FPz[( 167.8 ± 23.5 )ms vs. ( 188. 3 ± 25. 2 )ms,q =3.54,P ＜0. 05] . The control group showed higher latency on target P3 at FPz than baseline ( q = 3.64, P ＜ 0. 05 ).Before intervention, there was no significant difference with P300 between two groups ( P ＞0. 05 ). Compared with the controls after intervention, the study group manifested shorter latency on target P3 and non-target P2at Cz and FPz ( P ＜0. 05 ). And higher amplitude on target P3 at Cz and FPz and on non-target P2 at FPz were appeared ( q = 3.34, 3. 35, 3.68, P ＜ 0. 05 ). Conclusion The comprehensive psychological behavior intervention could effectively improve the mental health and partly electrophysiological index of the serviceman in military stress.     

不同症状的精神分裂症患者事件相关电位研究

目的研究以不同症状为主的精神分裂症患者的事件相关电位。方法对16例阴性症状为主、19例阳性症状为主、21例混合型未服药的精神分裂症患者和15例正常对照组，进行ERPsN200、P300测查。结果三组精神分裂症患者中P300波幅与正常对照组相比均明显下降，差畀具有显著性（P〈0．05），只有阴性组P300的潜伏期与正常对照组相比明显延长（P〈0．05）；三组精神分裂症患者中T3点P300波幅与T4相比下降更明显（P〈0．05）；相关分析发现，阴性量表分与Fz的P300潜伏期显著正相关（r=0．33，P〈0．05）。结论不同症状为主的精神分裂症可能有不同的神经生物学基础。     

有暴力行为青少年事件相关电位N400的对照研究

目的：探讨有暴力行为青少年和正常青少年语言认知功能神经电生理的特点。方法：对我市未成年犯管教所服教的有暴力犯罪行为记录的51例男性青少年（暴力组）和40名既往无暴力犯罪行为记录的普通中学生（正常对照组）分别进行脑诱发电位N400的测定。结果：与对照组比较,暴力组N400Fz、Cz、Pz潜伏期明显延长（F=6.59、6.51、7.16,P均=0.00）,波幅显著降低（F=4.49、4.14、2.15,P〈0.05或P〈0.01）。结论：有暴力行为的男性青少年语言认知功能N400异常,提示可能存在语言认知功能的受损。     

Changes in p300 following two yoga-based relaxation techniques

Cyclic meditation (CM) is a technique that combines "stimulating" and "calming" practices, based on a statement in ancient yoga texts suggesting that such a combination may be especially helpful to reach a state of mental equilibrium. The changes in the peak latency and peak amplitude of P300 auditory event-related potentials were studied before and after the practice of cyclic meditation compared to an equal duration of supine rest in 42 volunteers (group mean age +/- SD, 27 +/- 6.3 years), from Fz, Cz, and Pz electrode sites referenced to linked earlobes. The sessions were one day apart and the order was alternated. There was reduction in the peak latencies of P300 after cyclic meditation at Fz, Cz, and Pz compared to the "pre" values. A similar trend of reduction in P300 peak latencies at Fz, Cz, and Pz was also observed after supine rest, compared to the respective "pre" values, although the magnitude of change in each case was less after supine rest compared to after cyclic meditation. The P300 peak amplitudes after CM were higher at Fz, Cz, and Pz sites compared to the "pre" values. In contrast, no significant changes were observed in the P300 peak amplitudes at Fz, Cz, and Pz after supine rest compared to the respective "pre" state. The present results support the idea that "cyclic" meditation enhances cognitive processes underlying the generation of the P300.     

Frontal P300 Decrement and Executive Dysfunction in Adolescents with Conduct Problems

This study investigated the cognitive and cerebral function of adolescents with conduct problems by neuropsychological battery (STIM) and event-related potential (ERP). Eighteen adolescents with conduct disorder, and 18 age-matched normal subjects were included. Such cognitive functions as attention, memory, executive function and problem solving were evaluated using subtests of STIM. ERP was measured using an auditory oddball paradigm. The conduct group showed a significantly lower hit rate on the Wisconsin Card Sorting Test (WCST) than the control group. In addition, the conduct group showed reduced P300 amplitude at Fz and Cz, and prolonged P300 latency at Fz, and there was a significant correlation between P300 amplitude and Stroop test performance. These results indicate that adolescents with conduct problems have impairments of executive function and inhibition, and that these impairments are associated with frontal dysfunction.     

精神病风险综合征事件相关电位P300研究

目的探讨精神病风险综合征(clinical high risk of psychosis,CHR)者听觉事件相关电位P300波幅、潜伏期以及认知功能的特征。方法采用Oddball范式,对36例CHR者(研究组)和35名正常对照(对照组)进行事件相关电位P300测定,利用MATRICS成套认知测试评估两组被试认知功能,中文版精神病风险综合征定式访谈中精神疾病高危症状量表(scale of psychosis-risk symptoms,SOPS)评估CHR者临床症状。结果研究组信息处理速度、注意/警觉性、工作记忆、词语学习、视觉学习、推理和问题解决以及社会认知等7个领域认知功能得分均差于对照组(P0.01)。研究组Fz、Cz、Pz导联P300波幅比对照组降低(P0.05),Pz导联P300潜伏期延长(P0.05)。研究组Cz点P300潜伏期与SOPS阳性症状得分呈正相关(r=0.544,P=0.001),P300波幅与信息处理速度(言语流畅性)得分呈正相关(r=0.339,P=0.043)。结论 CHR者认知功能、事件相关电位P300存在异常。P300与CHR精神病症状、认知缺陷存在一定的相关性,提示其在精神病风险监控中的作用值得重视。     

精神分裂症患者事件相关电位研究

目的 :研究以阴性、阳性症状为主的精神分裂症患者的事件相关电位 (ERPs)。　方法 :将 2 2例阴性、 2 7例阳性未服药的精神分裂症患者和 17例正常对照组 ,进行 N1 0 0 、 P2 0 0 、 N2 0 0 、 P30 0 测查。　结果 :阴性组在 Fz,Cz,Pz,T7,T85个点的 P30 0 波幅显著低于和潜伏期明显长于正常对照组 ;阳性组在 Cz,Pz点的 P30 0 波幅低于正常对照组 (P<0 .0 5 )。 P30 0 的波幅与潜伏期在两组患者之间差异有显著性 (P<0 .0 5 ) ;阴性患者 N1 0 0 、N2 0 0 的波幅低于正常对照组 ;相关分析发现 ,阴性分量表分与 Fz的 P30 0波幅显著负相关 (r=— 0 .31,P<0 .0 5 ) ,与 T7、 T8点的潜伏期呈显著正相关 (r=0 .33,r=0 .35 ,P<0 .0 5 )。　结论 :以阳性、阴性症状为主的精神分裂症可能有不同的神经生物学基础。