Prevention of Surgical Site Infections in Bone and Joint Procedures

There is strong evidence that preoperative nasal S. aureus screening/decolonization will significantly reduce surgical site infections (SSIs) after joint prostheses implantation. There is some evidence that antibiotic-containing bone cement may lower SSI rates. Timely administration of perioperative systemic antibiotic prophylaxis is recommended for patients with implants who are undergoing dental treatment, urogenital surgery, upper endoscopy, sigmoidoscopy, or colonoscopy. Advanced skin disinfection by chlorhexidine-gluconate-impregnated cloths may be protective. There is evidence that clippers are favored for hair removal, rather than razors, but no significant advantage, as compared with other modes of hair removal, has been found. Antibiotic-coated intramedullary nails and antibiotic-impregnated bone grafts may be useful for the treatment of chronic bone infections. No recommendation can be made for wound dressing types. Laminar air flow systems do not seem to prevent SSI but may even cause harm, instead. There is a strong association between the annual number of surgical procedures and low SSI rates.     

Gender Differences in Risk of Bloodstream and Surgical Site Infections

BACKGROUND

Identifying patients most at risk for hospital- and community-associated infections is one essential strategy for preventing infections.

OBJECTIVE

To investigate whether rates of community- and healthcare-associated bloodstream and surgical site infections varied by patient gender in a large cohort after controlling for a wide variety of possible confounders.

DESIGN

Retrospective cohort study.

PARTICIPANTS

All patients discharged from January 1, 2006 through December 31, 2008 (133,756 adult discharges and 66,592 pediatric discharges) from a 650-bed tertiary care hospital, a 220-bed community hospital, and a 280-bed pediatric acute care hospital within a large, academic medical center in New York, NY.

MAIN MEASURES

Data were collected retrospectively from various electronic sources shared by the hospitals and linked using patients’ unique medical record numbers. Infections were identified using previously validated computerized algorithms.

KEY RESULTS

Odds of community-associated bloodstream infections, healthcare-associated bloodstream infections, and surgical site infections were significantly lower for women than for men after controlling for present-on-admission patient characteristics and events during the hospital stay [odds ratios (95 % confidence intervals) were 0.85 (0.77–0.93), 0.82 (0.74–0.91), and 0.78 (0.68–0.91), respectively]. Gender differences were greatest for older adolescents (12–17 years) and adults 18–49 years and least for young children (<12 years) and older adults (≥70 years).

CONCLUSIONS

In this cohort, men were at higher risk for bloodstream and surgical site infections, possibly due to differences in propensity for skin colonization or other anatomical differences.     

Incidence of Surgical Site Infections in General Surgery in Italy

Abstract Background: Epidemiological study to determine surgical site infection (SSI) rates in surgical patients in Italy using the National Nosocomial Infections Surveillance system (NNIS), to monitor current surgical antimicrobial prophylaxis, and to identify possible modifiable risk factors for SSI. Materials and Methods: Thirty-two general surgeries participated in the study. Main criteria for site inclusion were: > 20 operations per week and amoxycillin/clavulanate among prophylactic options. Each patient operated from April 1st to May 30th 2002 was surveyed until 30 days after the operation. SSI cumulative incidence rates and 95% confidence intervals (95%CI) were calculated. Results: During the study period, 3,066 surgical procedures were performed in 2,972 patients. A total of 158 SSI were diagnosed in 154 patients: 96 (62.3%) were at superficial incision, 23 (14.9%) were at deep incision and 35 (22.7%) were at organ-space site. Incidence of SSI every 100 operations was 5.2% (95% CI 4.4–6.0). Of the 2,437 operated patients with clean or elective clean/contaminated or contaminated surgical procedure, 2,105 (86.4%) received antimicrobial prophylaxis, mainly amoxicillin/clavulanate (28.3%) and ceftizoxime (11.4%). Pre-operative hospital stay ≥ 48 h, diabetes, obesity, and HIV/AIDS infection were statistically significantly associated with increased risk of SSI. Conclusions: The SSI rates found are comparable with European studies and can be a benchmark for national incidence data and for inter- and intra-hospital SSI rate comparisons. The preliminary results of this study were presented at the 14th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) – May 1–4, 2004. Clin Microbiol Infect 2004; 10 (suppl 3): abstr P1521.