浸润深度与结直肠癌患者临床特征及预后的关系

目的 探讨肿瘤浸润深度与结直肠癌患者临床特征及预后的关系.方法 收集122例结直肠癌患者的临床资料,根据肿瘤浸润深度进行分期,其中,T1～2期患者和T3～4期患者各61例.分析浸润深度与结直肠癌患者临床特征的关系.结直肠癌患者死亡的影响因素采用Logistic回归模型进行分析.结果 肿瘤直径≤5 cm、无器官转移、无淋...     

PD-L1在结直肠癌肿瘤细胞、肿瘤浸润免疫细胞中的表达与临床病理特征及预后的相关性

目的:探讨结直肠癌（colorectal cancer,CRC）原发灶肿瘤细胞（tumor cells,TC）、肿瘤浸润免疫细胞（tumor-infiltrating immune cells,TIIC）中程序性死亡-配体1（programmed death-ligand 1,PD-L1）的表达与临床病理特征及预后的相关性。方法:采用免疫组化法检测 2018-2021年我院72例行结直肠癌根治性切除术且病理证实的癌组织TC、TIIC中PD-L1的表达,分析其与临床病理特征及总生存期（overall survival,OS）的关系。结果:72例结直肠癌TC PD-L1阳性率为6.9%,与肿瘤分化程度相关。TIIC PD-L1阳性率为48.6%,与术前血CEA、CA199水平有关。Kaplan-Meier 及 Log-rank 结果显示,患者OS与分化程度、淋巴结转移、肝转移、TIIC PD-L1表达有关（P＜0.05）,TIIC PD-L1阳性患者比阴性患者OS长。Cox单因素和多因素回归分析显示:分化程度、淋巴结转移、肝转移、TIIC PD-L1 表达是影响CRC患者 OS 的独立预后因素。结论:PD-L1 在CRC TC及TIIC中均表达,TIIC PD-L1阳性患者比阴性患者OS长。TIIC PD-L1的表达更能反应肿瘤免疫微环境,为免疫治疗疗效预测、CRC预后预测提供参考。     

脉管或神经浸润在早期胃癌患者预后评估中的应用

目的 探讨脉管或神经浸润(LVI/PNI)在早期胃癌患者预后评估中的应用价值.方法 回顾性分析接受根治性手术的523例早期胃癌患者的临床资料,并随访术后5年无病生存期(DFS)情况.采用χ2检验分析LVI/PNI与临床病理特征的相关性;分别采用Kaplan-Meier法和Cox比例风险模型进行单因素和多因素预后分析;根...     

156例结直肠癌骨转移临床病理特征及预后分析

目的：探讨结直肠癌骨转移患者的相关临床病理学特点,分析结直肠癌骨转移患者预后的相关因素。方法：选取2010年1月至2017年7月在四川大学华西医院诊治的156例结直肠癌骨转移患者,收集临床病理及预后资料进行回顾性分析,单因素生存分析采用Kaplan-Meier法和Log-rank检验以及COX回归,多因素生存分析采用COX回归模型。结果：156例患者中直肠癌108例（69.2%）,结肠癌48例（30.8%）;同时性骨转移61例（39.1%）,异时性骨转移95例（60.9%）。确诊肠癌至出现骨转移的中位时间365天,其中异时性骨转移患者发生骨转移中位时间为784天。多发骨转移113例（72.4%）,单发骨转移43例（27.6%）。仅30例（19.2%）以骨转移为唯一远处癌转移灶,其余126例（80.8%）患者均存在骨以外的其他转移病灶,其中合并肺转移92例（59.0%）,合并肝转移77例（49.4%）。95例异时性骨转移患者中60例骨转移都不是初发,其中46例继发于肺转移。与同时性骨转移相比,癌胚抗原升高、骨痛、肺转移、淋巴结阴性、病理类型中-高分化的患者在异时性骨转移中更常见。结直肠癌...     

结直肠癌临床病理特征与预后的多因素回归分析

目的探讨结直肠癌的临床病理特征与预后的关系。方法应用单因素和多因素的分析方法,回顾性分析有完整临床病理资料和随访资料的761例结直肠癌患者的临床特点、病理特征及其对预后的影响。结果结直肠癌患者总的3,5年生存率分别为62.9％和60.7％,中位生存时间为1825 d。单因素分析显示,其预后与肿瘤的大体分型、侵袭程度、转移情况、分化等级、病理分期以及癌性肠梗阻均有相关性。应用Cox比例危险回归模型分析显示,肿瘤的大体分型、分化程度、肠壁的侵袭深度和病理分期是影响结直肠癌患者术后生存的独立因素。结论病理分期是影响结直肠癌患者预后最重要的一个指标(P<0.0005),对于指导手术治疗、术后辅助治疗和判断预后方面具有重要作用。     

PD-L1表达与结直肠癌预后及临床病理特征关系的Meta分析

目的 探讨PD-L1表达在结直肠癌（CRC）预后及临床病理特征中的意义。方法 系统检索PubMed、Embase、Web of Science、Cochrane Library、CNKI和万方数据库,检索有关PD-L1表达与CRC预后关系的文献。检索时间截止2018年6月。按纳入排除标准筛选文献及提取数据,用Stata SE12.0软件进行Meta分析。结果 纳入18篇文献,共5 724例CRC患者。结果显示：肿瘤组织PD-L1表达与CRC的总生存期（OS）（HR: 1.40, 95%CI: 1.02~1.93, P=0.039）和无复发生存期（RFS）（HR: 1.67, 95%CI: 1.27~2.20, P=0.000）显著下降有关,而与无疾病生存期（DFS）（P=0.933）无显著关联;且PD-L1表达还与肿瘤分化（P=0.016）和淋巴结转移（P=0.028）显著相关,与性别、肿瘤位置、TNM分期、浸润深度、血管侵犯、化疗、MSI状态和KRAS突变无显著相关性。亚组分析中,肿瘤细胞中PD-L1表达与OS（P=0.033）和RFS（P=0.001）显著下降相关,而肿瘤浸润免疫细胞中PD-L1表达与OS（P=0.991）和RFS（P=0.210）的关联比较差异无统计学意义。结论 肿瘤组织PD-L1表达提示结直肠癌预后不良,且肿瘤细胞中PD-L1与肿瘤浸润免疫细胞中PD-L1表达对结直肠癌预后的预测意义可能不一致。     

结直肠癌肝转移预后临床及病理相关因素研究进展

结直肠癌是消化系统最常见恶性肿瘤之一,其发病率每年以2%的速度上升。肝脏是结直肠癌远处转移的最常见部位,约有25%的结直肠癌患者首次就诊已出现肝转移,术后5年内50%会出现肝转移,其中80%~90%发生在术后3年内。有研究发现与其他肿瘤不同,20%~35%的结肠癌患者肝脏是其唯一转移脏器。目前,结直肠癌肝转移预后相关因素的研究文献报道显示,原发瘤分化程度、有无淋巴结转移、血清CEA、肝转移出现时间、肝转灶情况、有无肝外转移、肝转移灶治疗方法以及患者一般状况与肝转移预后相关。作者就结直肠癌肝转移预后临床及病理相关因素研究进展进行总结,为临床医师选择合理而有效的治疗方法提供参考。     

202例高龄结直肠癌患者临床特征及预后分析

目的 分析高龄(年龄≥75岁)结直肠癌患者的临床特征及预后情况.方法 选取202例年龄≥75岁的高龄结直肠癌患者,对所有患者进行为期5年的随访,以总生存(OS)为随访终点,高龄结直肠癌患者OS的影响因素采用Cox风险比例回归模型分析.结果 202例结直肠癌患者中Ⅰ期43例,Ⅱ期84例,Ⅲ期75例,不同TNM分期患者的3年OS率分别为90.70％、84.52％、57.33％,5年OS率分别为79.07％、60.71％、46.67％.单因素分析结果显示,不同肿瘤最大径、术前癌胚抗原(CEA)水平、术前肠梗阻情况、手术方式、T分期、N分期、TNM分期、分化程度、病理类型为印戒细胞癌/黏液腺癌、神经/脉管侵犯情况、术后化疗情况高龄结直肠癌患者3、5年OS率比较,差异均有统计学意义(P﹤0.05).Cox风险比例回归模型分析,结果显示,年龄增加、术前白蛋白水平降低、术前CEA水平﹥5 ng/ml、病理类型为印戒细胞癌/黏液腺癌、神经/脉管侵犯、N分期为N2期和术后未化疗均是高龄结直肠癌患者5年OS的独立危险因素.结论 高龄结直肠癌患者仍能从以手术为主、化疗为辅的综合治疗中获益,但术后化疗意愿低,判断预后时除N分期外还要综合考虑患者的年龄、术前白蛋白水平、术前CEA水平、病理类型是否为印戒细胞癌/黏液细胞癌、神经/脉管侵犯情况等.     

结直肠癌临床病理分期与预后的关系

结直肠癌的预后受诸多因素的影响,其中TNM分期是最为重要的因素。TNM分期的提出是根据肿瘤发展的生物学规律总结出来的,而大宗的临床统计分析数据促成了TNM分期的不断完善和更新。文章就新近的几个大宗临床荟萃分析结果作一综述,阐述结直肠癌TNM分期与预后的关系。     

脉管瘤栓在Ⅱ期结直肠癌中的临床价值研究

目的 探讨脉管瘤栓在Ⅱ期结直肠癌中的临床意义.方法 系统性搜集行手术治疗的Ⅱ期结直肠癌患者临床资料和随访资料,分析患者脉管瘤栓情况与临床特征的关系和其对预后的影响.结果 共纳入305例Ⅱ期结直肠癌病例,其中伴有脉管瘤栓者67例(22.0％).脉管瘤栓情况在年龄、分化程度、pT分期和神经侵犯情况方面比较,差异均具有统计学...     

Correlation of c-MET expression with clinical characteristics and the prognosis of colorectal cancer

BackgroundThe proto-oncogene c-MET (mesenchymal-epithelial transition factor gene) plays a critical role in cellular proliferation, survival, migration, and invasion in cancers. The aim of this study is to explore the relationship between c-MET expression and the clinicopathological characteristics of colorectal cancer (CRC) patients.MethodsA total of 337 enrolled patients were collected in present study. Here, the c-MET and EGFR expression were detected by immunohistochemistry (IHC). The mutational statuses of KRAS in exons 2, 3, and 4, NRAS in exons 2, 3, and 4, and BRAF in exon 15 from formalin-fixed sections were detected by direct DNA sequencing.ResultsOur results showed that high c-MET expression was significantly associated with tumor perineural invasion (P=0.007) and gender (P=0.016). High level c-MET expression (c-MET-high) in the primary tumors was observed in 68.2% of patients. In the 337 enrolled patients, 43.2% of patients had KRAS mutations, 3.3% of patients had NRAS mutations, and 4.7% of patients had BRAF mutations. However, KRAS, NRAS, and BRAF gene mutations had no association with c-MET protein levels in primary tumors. Additionally, c-MET protein expression had a strong correlation with EGFR expression (P=0.002). The survival time was not significantly longer for patients with c-MET-high primary tumors than for those with c-MET-low primary tumors.Conclusionsc-MET immunohistochemistry was significantly higher in primary tumors with perineural invasion, female gender, and EGFR high expression. However, c-MET-high in the primary tumors was not significantly associated with longer survival compared with c-MET-low tumors. Further studies are required to investigate c-MET as potential molecular marker of progression and to test the possibility of its incorporation as a new therapeutic target.     

Perineural invasion is a prognostic factor in stage II colorectal cancer but not a treatment indicator for traditional chemotherapy: a retrospective cohort study

BackgroundPerineural invasion (PNI) is considered a risk factor of survival but does not yet inform treatment decisions, and has not been studied separately in stage II colorectal cancer (CRC) patients whose postoperative traditional chemotherapy is controversial. This cohort study aimed to assess the association of PNI with basic clinicopathological features and patient outcomes after curative resection and the effects of PNI on responses to adjuvant chemotherapy in stage II CRC.MethodsThe clinical data of 371 stage II CRC patients who underwent curative-intent surgery at the National Cancer Center/Cancer Hospital in 2014 were retrospectively reviewed. The adjuvant chemotherapy data were acquired from follow-up information. PNI status was examined, and the overall survival (OS) and disease-free survival (DFS) rates were analyzed.ResultsPNI was detected in 82 of the 371 patients (22.1%) and was closely correlated with preoperative serum carcinoembryonic antigen (CEA) levels (P=0.030), gross tumor type (P=0.010), tumor differentiation (P=0.010), p stage (P<0.001), and extramural vascular invasion (EMVI) (P<0.001). The median follow-up time was 71 months. The 5-year OS was 84.1% and 96.5% (P<0.001), and the 5-year DFS was 75.6% and 91.3% (P<0.001) for PNI-positive (+) and PNI-negative (−) patients, respectively. The multivariate regression analyses identified PNI as an independent negative prognostic factor for DFS [hazard ratio (HR): 2.95; 95% confidence interval (CI), 1.546–5.626; P=0.001] and OS (HR: 3.966; 95% CI, 1.642–9.575; P=0.002). Among PNI (+) patients, DFS and OS were positively correlated with CEA levels (P=0.005 and P=0.004, respectively). Postoperative chemotherapy failed to improve DFS (P=0.480 and P=0.267, respectively) and OS (P=0.940 and P=0.077, respectively) regardless of whether the patients were PNI positive or not.ConclusionsIn stage II CRC patients, PNI was a poor independent predictor for DFS and OS. Among PNI (+) patients, CEA levels were positively correlated with DFS and OS. Traditional postoperative adjuvant chemotherapy does not improve outcomes of PNI (+) patients. Therefore, as to the active role of PNI and vacancy for treatment in allusion to PNI, follow-up of PNI (+) patients with elevated CEA level should be strengthened and further research on drug conducted on PNI deserve to be carried on.     

LINC00178 promotes cell growth,migration, and invasion in colorectal cancer in vitro and in vivo

BackgroundThis study aimed to determine the role of LINC00178 in colorectal cancer (CRC) cell invasion and migration by examining its expression in CRC cells and tissues.MethodsCancer tissues and corresponding adjacent tissue specimens were collected from 45 patients who experienced radical CRC resection in the hospital from March to September 2021. The expression of LINC00178 was measured in both CRC cells and tissues and normal human colorectal mucosal cells using quantitative fluorescence polymerase chain reaction (QF-PCR). Cell Counting Kit-8 (CCK-8), clonogenic, and transwell assays were used to assess the impact of LINC00178 overexpression or knockdown on the CRC cells invasion and proliferation. In addition, the expression levels of vimentin, E-cadherin, and N-cadherin in CRC cells were determined after either LINC00178 knockdown or overexpression was performed using western blotting.ResultsThe experiments revealed that LINC00178 was over expressed in CRC cells and tissues. Over-expression of LINC00178 could significantly promote the propagation, clone formation, invasion, and transportation of CRC, whereas knockdown of LINC00178 had the opposite function. When LINC00178 was expressed at high levels, it suppressed the vimentin and N-cadherin expression and prevented the upregulation of E-cadherin. In vivo (nude mouse) studies showed that the over expression of LINC00178 could significantly promote the propagation in CRC cells.ConclusionsLINC00178 is overexpressed in CRC cells and tissues. In vivo and in vitro experiments showed that LINC00178 can significantly promote the propagation of CRC cells, so it may develop a potential biological site for targeted therapy of CRC patients.     

Neural cell adhesion molecule and perineural invasion in gallbladder cancer

To clarify the role of neural cell adhesion molecule (NCAM) in perineural invasion, NCAM expression was studied by immunohistochemical staining in 26 cases with gallbladder cancer. In gallbladder cancer, the incidence of perineural invasion and that of positive NCAM expression was 42% and 31%, respectively, which are less frequent than those of bile duct cancer in our previous report. Perineural invasion was observed in 88% of the patients with positive expression of NCAM and in 22% of those with negative expression. The former is similar to that of bile duct cancer but the latter is significantly lower. Eighty percent of the cancer cells that invaded the perineural space were positive for NCAM, when the primary tumor was positive for NCAM expression. Therefore, in gallbladder cancer, positive cells in NCAM expression likely invade the perineural spaces. However, the perineural invasion of negative cells in NCAM expression is not likely to occur as compared to bile duct cancer. In conclusion, perineural invasion in gallbladder cancer is not as common as in bile duct cancer, but the role of NCAM in perineural invasion is more important in gallbladder cancer than in bile duct cancer. © 1995 Wiley-Liss, Inc.     

High expression of MAGE-C1 gene in colorectal cancer is associated with its poor prognosis

BackgroundThe aim of this study was to explore the relationship between melanoma antigen gene C1 (MAGE-C1) expression and the prognosis for colorectal cancer (CRC), and to establish a mathematical model to comprehensively evaluate the prognosis of patients with CRC.MethodsMAGE-C1 was selected by bioinformatics for its greater expression differences in CRC patients. Immunohistochemistry (IHC) was used to detect the expression level of MAGE-C1 in tissue samples of 156 patients with CRC. Kaplan-Meier analysis was employed to assess the relationship between MAGE-C1 and the prognosis of patients with CRC. Univariate and multivariate Cox regression models analyzed the factors affecting the prognosis of CRC patients. Also, the clinicopathological characteristics of patients and genes with clinical concern were integrated to establish a model to comprehensively predict the prognosis of patients with CRC.ResultsMAGE-C1 was found to be highly expressed in 28.8% of CRC patients. MAGE-C1 expression was associated with tumor size, number, and metastasis. Survival analysis showed that CRC patients with high expression of MAGE-C1 had a poor prognosis. Regression analysis demonstrated that MAGE-C1 protein status, T stage, differentiation, Kirsten rat sarcoma (KRAS) status, and v-RAF murine sarcoma viral oncogene homolog B1 (BRAF) status were the independent factors influencing the overall survival of patients with CRC. Meanwhile, MAGE-C1 combined with clinicopathological characteristics and hotspot gene mutations could be used to evaluate the prognosis of CRC.ConclusionsOur study shows that MAGE-C1 is differentially expressed in patients with CRC and affects the prognosis of patients. The combination of MAGE-C1, clinicopathological characteristics, and genes with clinical concern can be used to assess the prognosis of CRC.     

磷酸甘油酸变位酶1在结直肠癌组织中的表达及其对患者预后和癌细胞恶性生物学行为的影响

目的：探讨结直肠癌（CRC）组织中磷酸甘油酸变位酶1（PGAM1）的表达及其与患者预后的关系,研究PGAM1 对CRC细胞增殖、迁移和侵袭的影响。方法：选择2003 年3月至2008 年11月间在天津医科大学肿瘤医院手术切除的30例CRC患者的肿瘤组织标本及临床资料,采用免疫组织化学染色法检测CRC组织中PGAM1蛋白的表达,分析PGAM1表达与患者临床病理特征的关系,Kaplan-Meier 生存分析法比较PGAM1 高表达与低表达患者的OS、PFS 来评价PGAM1 表达与患者预后的关系。利用RNA干扰技术分别将si-PGAM1及si-NC 质粒转染至HCT-116和SW480 细胞,WB法检测转染细胞中PGAM1蛋白的表达水平,CCK-8、Transwell 实验分别检测敲低PGAM1对CRC细胞增殖、迁移和侵袭的影响。结果：30 例CRC组织中PGAM1阳性染色定位于CRC细胞的细胞质,其中33.3%（10/30 例）呈高表达。虽然PGAM1高表达与CRC患者年龄、性别、组织学类型、肿瘤大小、淋巴结转移、远处转移及临床TNM分期无关（均P>0.05）,但是PGAM1 高表达与低表达患者相比其OS、PFS 显著缩短。在CRC 细胞中敲低PGAM1 后,细胞的增殖、迁移和侵袭能力均显著降低（均P<0.05）。结论：CRC 组织中PGAM1 呈高表达,PGAM1高表达的患者预后较差;敲低PGAM1后细胞的增殖、迁移及侵袭能力均显著降低,提示PGAM1可能是CRC患者预后的生物标志物。     

Intramural and extramural vascular invasion in colorectal cancer: prognostic significance and quality of pathology reporting

BACKGROUND:

Blood vessel invasion has been associated with poor outcome in colorectal cancer (CRC), whereas the prognostic impact of lymphatic invasion is less clear. The authors of this report evaluated venous and lymphatic invasion as potential prognostic indicators in patients with CRC focusing on lymph node‐negative patients and compared routine and review pathology diagnoses.

METHODS:

In total, 381 tumors from randomly selected patients were retrospectively reviewed. The presence of vascular invasion was related to disease‐free and cancer‐specific survival using the Kaplan‐Meier method. For multivariable analysis, Cox proportional hazards regression models were performed.

RESULTS:

Lymphatic invasion and venous invasion were observed in 126 patients (33%) and 87 patients (23%), respectively, and were associated significantly with tumor classification, lymph node status, American Joint Committee on Cancer/International Union Against Cancer (AJCC/UICC) disease stage, tumor differentiation, pattern of invasion, and extent of tumor budding. The detection of vascular invasion was related to the number of examined tissue blocks. Venous and lymphatic invasion proved to be significant prognostic variables in univariable and multivariable analyses. Extramural vascular involvement was of particular significance. When the analysis was restricted to patients with (AJCC/UICC) stage II disease, venous invasion, but not lymphatic invasion, was identified as an independent prognostic variable. Review pathology diagnoses differed significantly from routine diagnoses with respect to prognostic impact.

CONCLUSIONS:

Venous and lymphatic invasion proved to be significant prognostic variables in patients with CRC. The detection of vascular invasion and, consequently, risk stratification of affected patients were related to the quality of pathology workup, ie, the number of examined tissue blocks. Observed differences between review and routine pathology diagnoses illustrated the need for high‐quality pathology reporting and also for standardized quality control. Cancer 2012;. © 2011 American Cancer Society.     

转凝蛋白在结直肠癌组织中的表达及其对SW480细胞恶性生物学行为的影响

目的:探讨转凝蛋白(transgelin,TAGLN)在结直肠癌(colorectal cancer,CRC)组织中的表达及其对SW480细胞增殖、迁移及侵袭的影响.方法:选取郑州大学附属肿瘤医院2015年5月至2016年8月收治的97例CRC患者的癌及配对的癌旁组织标本,以及人CRC细胞系SW620、SW480、HC...     

Plasminogen activator,urokinase enhances the migration,invasion, and proliferation of colorectal cancer cells by activating the Src/ERK pathway

BackgroundThis paper aims to explore the effects of plasminogen activator, urokinase (PLAU) expression on the migration, invasion, and proliferation of colorectal cancer (CRC) cells and to preliminarily analyze its possible mechanism, thereby laying a foundation for the research on potential biological targets of CRC.MethodsCRC-related mRNA was screened in Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/gds/). Differentially expressed genes (DEGs) were obtained for functional enrichment analysis. The enriched pathway and key involved functional gene were screened for further in vitro and in vivo analysis CRC cells were transfected with PLAU-NC (negative control), PLAU-mimic, and PLAU-inhibitor for 48 h and divided into the above groups for later studies. The migration, invasion, and proliferation capacities of CRC cells were detected using wound healing, Transwell, and colony formation assays, respectively. The Src inhibitor saracatinib (AZD0530) was added to the PLAU-NC and PLAU-mimic groups, and the expression levels of Src/extracellular signal-regulated kinase (ERK) pathway-, migration-, invasion-, and proliferation-related proteins were detected by Western blotting.ResultsThe results showed that after upregulation of PLAU, the number of CRC cells (SW480) that migrated to the center of the wound significantly increased, the number of cells that migrated and invaded through the basement membrane increased in the PLAU-mimic group, and the number of colonies also increased. These results suggest that increasing PLAU expression promotes the migration, invasion, and proliferation of CRC cells. At the same time, the molecular mechanism of PLAU in CRC cells was investigated by downregulating the protein expression of Src combined with the results of the bioinformatics analysis. Western blotting revealed that the protein expressions of phosphorylated Src (p-Src) and phosphorylated ERK (p-ERK) in SW480 and SW620 cells increased significantly in the PLAU-mimic group compared with the PLAU-NC group, while the results were the opposite in the PLAU-inhibitor group. After being treated with saracatinib, we observed significantly decreased protein levels of p-ERK, matrix metallopeptidase 2 (MMP-2), MMP-3, MMP-9, Cyclin D1, and Cyclin A2 in the SW480 cells.ConclusionsIn conclusion, PLAU affects the migration, invasion, and proliferation of CRC cells by activating the Src/ERK pathway.     

Effect of the systemic immune-inflammation index on postoperative complications and the long-term prognosis of patients with colorectal cancer: a retrospective cohort study

BackgroundColorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract. Surgery is the main way to cure CRC, but the postoperative complication rate and recurrence rate remain high. The systemic immune-inflammation (SII) index reflects a patient’s systemic inflammatory state and immune state. Postoperative recurrence and the occurrence of complications are closely related to the inflammatory state and immune state. Thus, the SII index may have some value in predicting postoperative complications and the long-term prognosis of CRC patients, but relevant studies are currently lacking. The present study sought to examine the effect of the SII index on the postoperative complications and long-term prognosis of patients with CRC.MethodsFrom January 2014 to January 2017, the data of 440 patients with CRC who had been admitted to the Affiliated Hospital of Guangdong Medical University were retrospectively collected, and the patients were equally divided into the high and the low SII groups according to their preoperative SII index levels. The postoperative complication rate and postoperative progression-free survival (PFS) and mortality between the 2 groups were compared.ResultsCompared to the low SII group, the incidence of postoperative infection in the high SII group was significantly increased (15.45% vs. 9.09%, P=0.042), mortality was significantly increased at 5 years postoperatively (20.91% vs. 7.27%, P<0.001), and PFS was significantly shortened (P<0.001). The SII index had certain predictive value for postoperative infection in CRC patients, and the area under the curve (AUC) was 0.645 [95% confidence interval (CI): 0.559–0.731, P=0.001]. The SII index also had certain predictive value for the progression of CRC patients within 5 years of surgery, and the AUC was 0.670 (95% CI: 0.610–0.729, P<0.001). Additionally, the SII index had certain predictive value for death within 5 years of surgery in patients with CRC, and the AUC was 0.660 (95% CI: 0.593–0.726, P<0.001). CRC patients with postoperative infection had a significantly shorter PFS period than those who did not develop postoperative infection (P=0.029).ConclusionsThe SII index has certain predictive value for the diagnosis of postoperative infectious complications and the long-term prognosis of CRC patients.