江苏省昆山市2006~2013年胰腺癌发病与死亡趋势分析

[目的]分析昆山市2006～2013年胰腺癌发病与死亡趋势.[方法]胰腺癌发病资料来源于昆山市恶性肿瘤登记报告系统;死亡病例资料来源于人口死亡信息登记管理系统;计算胰腺癌粗发病(死亡)率与中国人口年龄标化发病(死亡)率(中标率);使用平均年度变化百分比(annual change percent,APC)评价胰腺癌发病率和死亡率在年份之间变化趋势.[结果]昆山市2006～2013年胰腺癌发病总例数744例,男性发病率明显高于女性.发病率历年有所波动,但未能发现有明显变化趋势,男性APC=2.9％(95％CI:-4.2％～10.6％),女性APC=5.7％(95％CI:-1.8％～13.6％).昆山市2006～2013年胰腺癌死亡总例数705例,胰腺癌男性死亡率明显高于女性.男性(APC=1.3％,95％CI:-3.0％～5.8％)、女性(APC=-1.2％,95％CI:-11.5％～10.4％)均未能发现胰腺癌粗死亡率呈现明显趋势变化.[结论]昆山市胰腺癌发病与死亡率水平较高,当前仍需加强疾病监测以探究其长期变化趋势.     

江苏省昆山市2006—2015年肺癌发病趋势分析北大核心CSCD

目的分析昆山市2006—2015年肺癌发病趋势并预测未来发病趋势。方法肺癌病例来源于昆山市肿瘤登记报告系统;使用中国2000年第五次人口普查的年龄结构计算分性别的年龄标化发病率(中标率)。使用年度变化百分比(annual percentage change,APC)评价肺癌发病率在年份之间的变化趋势。用时间趋势与自回归模型预测2016—2020年肺癌发病率。结果肺癌中标率在总人群(APC=3.1%,95%CI:2.0%~4.2%)、男性人群(APC=1.9%,95%CI:0.9%~2.9%)和女性人群(APC=6.1%,95%CI:3.7%~8.5%)中均明显上升。≥70岁年龄组中男性(APC=1.7%,95%CI:-0.1%~3.5%)和女性人群(APC=2.0%,95%CI:-1.8%~5.8%)肺癌年龄标化发病率无明显变化。而30~70岁年龄组中男性(APC=2.0%,95%CI:0.8%~3.2%)和女性人群(APC=8.6%,95%CI:5.4%~11.8%)肺癌年龄标化发病率持续上升。时间序列预测结果提示未来年份(2016—2020年)男性和女性人群中肺癌粗发病率均持续上升。结论昆山市肺癌30~70岁人群发病率在过去10年急剧上升,未来年份将继续上升;肺癌防治相关措施亟需开展,特别是30~70岁人群。     

江苏省昆山市2006~2015年膀胱癌发病趋势分析

[目的]分析江苏省昆山市2006～2015年膀胱癌的发病趋势.[方法]2006～2015年膀胱癌发病病例来源于昆山市肿瘤登记报告;计算历年膀胱癌粗发病率与年龄标化发病率(中标发病率).用平均年度变化百分比(APC)及其95％CI评价膀胱癌发病率在年份之间的变化趋势;用时间趋势与自回归模型结合的方法预测未来年份膀胱癌粗发病率.[结果] 2006～2015年登记膀胱癌519例,占同期新发恶性肿瘤的2.12％.膀胱癌中标发病率在男女合计(APC=1.6％,95％CI:-0.6％～3.8％)、男性(APC=1.3％,95％CI:-1.2％～3.8％)和女性(APC=5.3％,95％CI:-2.1％～12.7％)无明显趋势变化;但30～69岁人群膀胱癌中标发病率变化趋势在男女合计(APC =4.1％,95％CI:0.5％～7.7％)和女性(APC=9.5％,95％CI:1.0％～18.0％)人群中明显上升.时间趋势与自回归模型预测结果显示2016～2020年膀胱癌粗发病率在男性和女性人群中均呈现持续上升趋势.[结论]虽然膀胱癌中标发病率无明显趋势变化,但是膀胱癌发病数逐年增加,因膀胱癌造成的疾病负担逐年增加,特别在30～69岁女性人群中上升趋势最为显著.     

江苏省昆山市2006~2014年卵巢癌发病率趋势分析

[目的]了解江苏省昆山市卵巢癌发病率趋势,预测2015～2020年发病率.[方法]2006～2014年卵巢癌病例来源于昆山市肿瘤登记数据,用中国2000年第5次人口普查年龄结构计算年龄标化发病率(中标率).使用年度变化百分比(annual change percentage,APC)评价发病率变化趋势;用时间趋势与自回归模型预测至2020年卵巢癌发病率.[结果]江苏省昆山市卵巢癌粗发病率从2006年的3.63/10万上升到2014年10.19/10万(APC=8.6％,95％CI:3.6％～13.6％);中标率从2006年的2.70/10万上升到2014年的7.19/10万(APC=7.1％,95％CI:1.7％～12.5％);年龄别发病率在30～60岁快速上升,60～64岁达到高峰.时间趋势与自回归模型预测结果显示2015～2020年卵巢癌预粗发病率分别为10.22/10万、10.76/10万、11.30/10万、11.84/10万、12.39/10万和12.93/10万.[结论]江苏省昆山市卵巢癌发病率明显上升,未来也将继续上升.     

江苏省昆山市1981~2014年肺癌死亡率时间序列分析

[目的]以时间序列分析方法探究江苏省昆山市1981～2014年肺癌死亡率.[方法]1981～2014年肺癌死亡病例来源于基于人群的死因监测,使用平均年度变化百分比(annual change percent,APC)及其95％可信区间(CI)评价1981～2014年肺癌粗亡率与年龄标化死亡率时间趋势;使用时间趋势与自回归模型结合的方法对昆山市1981～2014年肺癌死亡率进行时间序列分析.[结果]肺癌标化死亡率在男女合计(APC=0.9％,95％CI:0.6％～1.2％)、男性(APC=0.5％,95％CI:0.2％～0.8％)和女性(APC=1.5％,95％CI:0.8％～2.2％)人群中呈现上升趋势.时间趋势与自回归模型预测结果显示2015～2024年昆山市肺癌粗死亡率在男性和女性人群中依旧处于上升趋势.[结论]江苏省昆山市肺癌标化死亡率在过去33年间呈现上升趋势,未来10年依旧上升.     

2006－2013年江苏省昆山市居民结直肠癌发病与死亡趋势分析

目的：结直肠癌是影响居民健康的主要癌症之一,且发病率呈现明显上升趋势。本研究探讨江苏省昆山市2006－2013年结直肠癌发病与死亡趋势。方法江苏省昆山市2006－2013年结直肠癌发病和死亡病例来源于昆山市肿瘤登记报告;计算结直肠癌粗发病（死亡）率与发病（死亡）的年龄标化率（age standardized rate,ASR）;使用平均年度变化百分比（annual percent change,APC）及其95％CI,评价结直肠癌发病率和死亡率在年份之间变化趋势。结果江苏省昆山市2006－2013年结直肠癌发病 ASR 在女性人群中呈明显上升趋势,APC＝2．3％,95％CI 为0．5％～4．2％;结直肠癌发病率总体变化趋势（APC＝0．6％,95％ CI 为－0．8％～1．9％）与男性人群（APC＝－0．8％,95％ CI 为－3.5％～1．5％）差异无统计学意义。昆山市2006－2013年结直肠癌死亡 ASR 在总体（APC ＝－5．3％,95％CI 为－9．0％～－1．6％）和女性（APC ＝－9．1％,95％CI 为－16．2％～－2．0％）人群中呈下降趋势,差异有统计学意义;而男性人群中结直肠癌死亡 ASR 的变化差异无统计学意义,APC＝－2．1％,95％CI 为－6．2％～2．0％。结论虽然结直肠癌死亡率呈现下降趋势,但是结直肠癌发病数逐年增加。因结直肠癌造成的疾病负担逐年增加,在全人群中开展结直肠癌预防控制十分必要。     

江苏省昆山市1981~2014年食管癌死亡趋势及率差分解分析

[目的]探究昆山市1981～2014年食管癌死亡趋势及定量估计影响因素.[方法]食管癌死亡病例来源于死因监测;计算食管癌粗死亡率与年龄标化死亡率;使用平均年度变化百分比(annual percent change,APC)评价食管癌死亡率变化趋势.以0～74岁累积死亡率来评价食管癌历年死亡风险.采用率差别分解法分析人口因素对食管癌死亡率变化的贡献.[结果] 1981～2014年食管癌年龄标化死亡率在男女合计(APC=-4.2％,95％CI:-4.8％～-3.6％)、男性(APC=-4.3％,95％CI:-4.9％～-3.7％)和女性(APC=-4.4％,95％CI:-5.1％～-3.7％)人群中均呈现明显下降趋势.食管癌0～74岁累积死亡率由1981年的2.85％下降到2014年的0.45％(APC=-5.0％,95％CI:-5.7％～-4.3％),食管癌死亡的风险在0～74岁年龄组逐渐降低.食管癌死亡率的下降是人口因素与非人口因素共同作用结果,其中人口因素贡献在男女合计、男性及女性人群中分别为-68.66％、-68.39％和-127.43％.[结论]昆山市1981～2014年食管癌死亡率在非人口因素作用下明显下降,但是这种下降趋势受到了人口因素的阻碍.     

江苏省昆山市2006~2014年白血病发病与死亡趋势分析

摘 要：［目的］ 探究昆山市2006~2014年白血病发病与死亡趋势。［方法］昆山市2006~2014年白血病发病和死亡病例来源于昆山市肿瘤登记报告;计算历年白血病粗发病率与粗死亡率,以及中国2000年人口年龄构成标化发病率和死亡率（age standardized rate,ASR）;使用年度变化百分比（annual percentage change,APC）及95%CI评价白血病发病率和死亡率在年份之间变化趋势。［结果］ 昆山市白血病中标发病率在男女合计、男性及女性人群分别为6.01/10万、6.70/10万、5.35/10万;2006~2014年白血病中标发病率趋势在男女合计（APC=4.3%,95%CI：0.5%~8.1%,P=0.0667）和男性（APC=6.4%,95%CI：1.9%~10.9%,P=0.0294）中明显上升,但是在女性人群中无明显变化趋势（APC=1.7%,95%CI：-4.6%~8.0%,P=0.6115）。白血病中标死亡率在男女合计、男性及女性人群分别为3.07/10万、3.19/10万、2.93/10万;昆山市2006~2014年白血病中标死亡率变化趋势在男女合计（APC=2.4%,95%CI：-0.7%~5.5%,P=0.1713）、男性（APC=4.2%,95%CI：-0.4%~8.8%,P=0.1169）及女性（APC=2.2%,95%CI：-4.4%~8.8%,P=0.5384）中无统计学意义。［结论］ 虽然昆山市白血病死亡率呈稳定趋势,但是白血病发病数逐年增加,在全人群中开展白血病预防控制十分必要。     

江苏省昆山市1981年-2015年肺癌死因对期望寿命和潜在减寿年影响分析

背景与目的 肺癌发病率和死亡率在男性和女性人群持续上升,但是有关肺癌所致的潜在减寿年和去肺癌死因可增加期望寿命时间变化趋势的研究较少.本研究旨在探究江苏省昆山市1981年-2015年去肺癌死因可增加期望寿命和肺癌所致的潜在减寿年时间趋势.方法 1981年-2015年肺癌死亡病例来源于死因监测,以计算去肺癌死因可增加期望寿命和潜在减寿年.用中国2000年第五次人口普查的年龄结构计算分性别的年龄标化潜在减寿年.使用年度变化百分比(estimate annual percentage change,eAPC)评价去肺癌可增加期望寿命和潜在减寿年在年份之间变化趋势.结果 总人群中去肺癌死因可增加期望寿命由1981年的0.34岁上升到2015年的0.86岁,上升趋势有统计学意义(APC=3.2％,95％CI:2.8％-3.6％);男性人群(APC=3.0％,95％CI:2.5％-3.5％)和女性人群中(APC=3.6％,95％CI:3.0％-4.2％)去肺癌死因可增加期望寿命也呈现上升趋势.肺癌所致的标化潜在减寿年在总人群(APC=-0.1％,95％CI:-0.6％-0.4％)和男性人群(APC=-0.5％,95％CI:-1.1％～0.1％)无明显趋势变化,而女性人群中明显上升(APC=1.5％,95％CI:0.3％-2.7％).结论 虽然因肺癌所致的过早死亡没有趋势变化,而肺癌死因对全人群期望寿命的影响在持续上升,有针对性的肺癌预防控制措施亟需开展.     

上海市金山区2002～2013年恶性肿瘤发病时间趋势分析

[目的]了解近年来上海市金山区恶性肿瘤发病变化趋势,为政府部门制定肿瘤防治策略和措施提供参考依据.[方法]利用基于居民健康档案的肿瘤登记报告系统采集辖区居民肿瘤发病个案信息,并计算2002～2013年金山区不同性别、不同年龄组及不同类别恶性肿瘤的粗发病率、标化发病率和年度变化百分比(APC)等指标.[结果]2002～2013年,金山区男性恶性肿瘤粗发病率APC=4.58％ (P＜0.01),标化发病率APC=0.98％(P＞0.05).女性恶性肿瘤粗发病率APC=7.06％ (P＜0.01),标化发病率APC=4.38％ (P＜0.01);男性除65岁及以上年龄组外,其余0～14岁组、15～44岁和45～64岁组肿瘤发病率均随时间呈上升趋势(APC=1 1.03％、3.47％、1.54％,P＜0.05),女性则除0～14岁组外,其余年龄段肿瘤发病率也呈上升趋势(APC=8.77％、4.56％、3.54％,P＜0.01).12年间,男性肺癌、胃癌、膀胱癌、脑肿瘤、白血病标化发病率无明显变化趋势(APC=-0.22％、-1.55％、-0.93％、-1.42％和1.13％,P＞0.05),结直肠癌、胰腺癌和前列腺癌标化发病率呈上升趋势(APC=4.94％、4.08％和8.96％,P＜0.05),肝癌标化发病率则呈下降趋势(APC=-3.70％,P＜0.01).同期,女性乳腺癌、肺癌、甲状腺癌、子宫癌、脑肿瘤标化发病率随时间呈上升趋势(APC=5.34％ 、4.17％、20.75％、10.12％和5.59％,P＜0.05),肝癌标化发病率则呈下降趋势(APC=-4.86％,P＜0.01),结直肠癌、胃癌、胰腺癌和胆囊癌则随时间未呈现出明显变化趋势(APC=2.66％、-2.07％、1.66％和-1.97％,P＞0.05).[结论]上海市金山区不同性别、年龄组人群和各类肿瘤发病变化趋势各有特点,应根据不同特征人群、不同类别肿瘤的发病趋势特点制定相应的肿瘤防控策略与措施.     

广东省中山市2012年恶性肿瘤发病分析

[目的]分析2012年中山市恶性肿瘤发病概况,为中山市恶性肿瘤防治提供科学依据.[方法]收集整理2012年中山市恶性肿瘤发病资料,分析其发病数、粗率、中标率、世标率及构成比等指标.[结果]2012年中山市恶性肿瘤新发病例4279例,其中男性2428例,女性1851例,男、女性世标率分别为261.85/10万和179.57/10万.男性发病前5位恶性肿瘤依次是肺、肝、鼻咽、食管、结肠癌,女性依次是乳腺、肺、宫体、结肠和脑及神经系统恶性肿瘤,鼻咽癌分别居中山市同期男、女性恶性肿瘤发病顺位的第3位和第10位.男、女性年龄别发病率均从40～岁组开始迅速上升,但男、女性年龄别发病模式不同.[结论]2012年中山市恶性肿瘤发病总体居国内中等水平,鼻咽癌和女性宫体癌发病居国内较高水平,应加强防治.     

Epidemiology of the breast cancer patients registered at Institute of Radiotherapy and Nuclear Medicine, Peshawar, Pakistan

In Pakistan, malignant diseases are increasing day by day, but no epidemiological cancer study on large scale has been designed. The main objective of this study was to provide a baseline data on frequency, morphological types, gender and age distribution etc., of breast cancer in North-West Frontier Province and Federally Administered Tribal Areas of Pakistan, and to compare it with the published data. In this context, 2134 breast cancer patients (2059 female and 75 male) registered at Institute of Radiotherapy and Nuclear Medicine, Peshawar from 1995 to 2001, were studied. Crude incidence, standardized incidence ratios (SIR, world) and age-specific incidence rates (ASIR) were determined both for male and female patients. Same morphological distribution was found in both genders. Moreover, breast cancer was found to be the most common malignancy among the women (96.49%). Male to female breast cancer ratio was found to be 3.5 times higher than the reported data. The highest ASIR of ∼10.6/100 000 per year among women was observed in the age group of 55–59 years. In men, the highest ASIR of 0.84/100 000 per year was observed in the age group of 65–69 years. The SIR (world) for women was 3.15/100 000 per year, while for male this was 0.13/100 000 per year.     

Cambodian cancer incidence rates in California and Washington, 1998-2002

BACKGROUND.

Among the many diverse Asian ethnic groups living in the US, Cambodian immigrants comprise a small fraction (1.8%) of the total Asian population. Because of their small numbers, Cambodian vital statistics are often combined into Southeast Asian (SA) cancer data consisting of Vietnamese, Thais, Laotians, and Hmong.

METHODS.

The 2000 Census counts were used for 2 Cambodian populations, Cambodians alone and Cambodians alone and in combination with any other racial/ethnic group for California and for Seattle (Puget Sound area), Washington. Then the cancer incidence rates were calculated using cancer cases from the California and Puget Sound cancer registries between 1998–2002. The 1998–2002 annual age‐adjusted incidence rates, upper bound rates (based on the Cambodian alone population), lower bound rates (based on the Cambodians alone or in combination population) are reported and compared with the rates in the non‐Hispanic White (NHW) population in these regions.

RESULTS.

The top 5 cancers in Cambodian males are lung and bronchus, liver, prostate, colorectal, and stomach cancers. The sites where the rates are higher in male Cambodians than NHW males are (in ascending rank) nasopharynx, liver, stomach, myeloma, and lung and bronchus. The top 5 cancers for female Cambodians are breast, lung, colon and rectum, cervix, and thyroid. The sites where female rates are greater than NHW female rates are (in ascending rank) nasopharynx, liver, stomach, cervix uteri, oral cavity, and thyroid.

CONCLUSIONS.

The challenges to address the health issues of Cambodians are complicated by historical events that caused their emigration to the US. Many of the immigrants are survivors of the holocaust in Cambodia. Health programs for Cambodians must deal with the consequences of these issues as well as cultural issues of language and religion in helping Cambodians to reduce their cancer disparities. Cancer 2007. © 2007 American Cancer Society.     

广东省中山市2013年恶性肿瘤发病分析

[目的]分析2013年中山市恶性肿瘤发病概况,为中山市恶性肿瘤防治提供科学依据.[方法]收集整理2013年中山市恶性肿瘤发病资料,统计分析其发病数、粗率、中国与世界标化率、构成比等指标.[结果] 2013年中山市共有恶性肿瘤新发病例4405例,其中男性2508例,女性1897例,男女世界标化发病率分别为258.11/10万与177.33/10万,男性发病前5位恶性肿瘤依次是肺、肝、鼻咽、食管和结肠癌,女性依次是肺、乳腺、宫体、甲状腺和结肠癌.鼻咽癌分别占中山市同期男女恶性肿瘤发病顺位的第3和第10位.2013年中山市男女恶性肿瘤年龄别发病模式和不同镇区恶性肿瘤发病水平均不同.[结论] 2013年中山市恶性肿瘤发病总体居国内和广东省中上水平,鼻咽癌和女性宫体癌发病居国内较高水平,而男性前列腺癌和女性甲状腺癌发病上升,提示中山市应加强上述肿瘤的防治.     

Cancer prevalence in United States,Nordic Countries,Italy, Australia,and France: an analysis of geographic variability

Background:

The objectives of this study were to quantitatively assess the geographic heterogeneity of cancer prevalence in selected Western Countries and to explore the associations between its determinants.

Methods:

For 20 cancer sites, 5-year cancer prevalence, incidence, and survival were observed and age standardised for the mid 2000s in the United States, Nordic European Countries, Italy, Australia, and France.

Results:

In Italy, 5-year crude prevalence for all cancers was 1.9% in men and 1.7% in women, while it was ∼1.5% in all other countries and sexes. After adjustment for the different age distribution of the populations, cancer prevalence in the United States was higher (20% in men and 10% in women) than elsewhere. For all cancers combined, the geographic heterogeneities were limited, though relevant for specific cancers (e.g., prostate, showing >30% higher prevalence in the United States, or lung, showing >50% higher prevalence in USA women than in other countries). For all countries, the correlations between differences of prevalence and differences of incidence were >0.9, while prevalence and survival were less consistently correlated.

Conclusion:

Geographic differences and magnitude of crude cancer prevalence were more strongly associated with incidence rates, influenced by population ageing, than with survival rates. These estimates will be helpful in allocating appropriate resources.     

Past Trends and Future Estimation of Annual Breast Cancer Incidence in Osaka,Japan

Background: Although the breast cancer incidence rate in Japan is lower than in western countries, the age-specific rates have markedly increased in recent years, along with the problems of declining birth rate and an aging population. Materials and Methods: We examined past trends of age-specific breast cancer incidence using data from the Osaka Cancer Registry from 1976 to 2010, and estimated future trends until 2025 based on the changes observed and population dynamics using a log linear regression model. Results: The age-specific breast cancer incidence rate has increased consistently from the 1970s, and the rates have caught up with those of Japanese-Americans in the US. Assuming the increasing tendency of age-specific breast cancer incidence to be constant, the average annual incidence of breast cancer will increase 1.7-fold from 2006-2010 to 2021-2025. Furthermore, the number of patients aged 80 years should increase 3.4-fold. Conclusions: The medical demand for breast cancer care in Japan may increase explosively in the future, particularly among the elderly. We need to prepare for such a future increase in demand for care, although careful monitoring is needed to confirm these results.     

Trends in prognostic factors and survival from cutaneous melanoma in Yorkshire, UK and New South Wales, Australia between 1993 and 2003

The aim of this study was to compare trends in prognostic factors and survival from cutaneous melanoma between 1993 and 2003 in 2 populations with dramatically different underlying incidence rates [Yorkshire, UK, and New South Wales (NSW), Australia] and to look at whether the greater investment in melanoma prevention and early detection in Australia has resulted in any relative differences in survival. Patients diagnosed with invasive melanoma between 1993 and 2003 in Yorkshire (n = 4,170) and NSW (n = 30,520) were identified from cancer registry databases and prognostic information (age, sex, socioeconomic background, tumour site and Breslow thickness) was extracted. Age-standardised incidence rates, 5-year relative survival and relative excess risk of death were calculated. Between 1993-1995 and 2001-2003, the incidence of melanoma increased in both areas. These increases were mainly seen in tumours with thickness 相似文献   

Nasopharyngeal carcinoma in Indonesia:epidemiology,incidence,signs,and symptoms at presentation

Among all head and neck (HN) cancers,nasopharyngeal carcinoma (NPC) represents a distinct entity regarding epidemiology,clinical presentation,biological markers,carcinogenic risk factors,and prognostic factors.NPC is endemic in certain regions of the world,especially in Southeast Asia,and has a poor prognosis.In Indonesia,the recorded mean prevalence is 6.2/100 000,with 13 000 yearly new NPC cases,but otherwise little is documented on NPC in Indonesia.Here,we report on a group of 1121 NPC patients diagnosed and treated at Dr.Cipto Mangunkusumo Hospital,Jakarta,Indonesia between 1996 and 2005.We studied NPC incidence among all HN cancer cases (n=6000) observed in that period,focusing on age and gender distribution,the ethnic background of patients,and the disease etiology.We also analyzed most prevalent signs and symptoms and staging of NPC patients at first presentation.In this study population,NPC was the most frequent HN cancer (28.4%),with a male-to-female ratio of 2.4,and was endemic in the Javanese population.Interestingly,NPC appeared to affect patients at a relatively young age (20% juvenile cases) without a bimodal age distribution.Mostly,NPC initiated in the fossa of Rosenmuller and spreaded intracranially or locally as a mass in the head.Occasionally,NPC developed at the submucosal level spreading outside the anatomic limits of the nasopharynx.At presentation,NPC associated with hearing problems,serous otitis media,tinnitus,nasal obstruction,anosmia,bleeding,difficulty in swallowing and dysphonia,and even eye symptoms with diplopia and pain.The initial diagnosis is difficult to make because early signs and symptoms of NPC are not specific to the disease.Early-age Epstein-Barr virus (EBV) infection combined with frequent exposure to environmental carcinogenic co-factors is suggested to cause NPC development.Undifferentiated NPC is the most frequent histological type and is closely associated with EBV.Expression of the EBV-encoded latent membrane protein 1(LMP1) oncogene in biopsy material was compared between NPC patients of 30 years old and those of ≥30 years old,matched for sex and tumor stage.Higher LMP1 expression in patients of 30 years old was observed,which was related to more locoregional progressivity.Increased medical awareness of prevailing early stage signs and symptoms coupled to use of EBV-related diagnostic tumor markers may lead to down-staging and timely treatment to improve survival of patients with this aggressive disease.     

温州市鹿城区2003～2005年新发肿瘤发病分析

目的了解温州市鹿城区居民恶性肿瘤发病情况与流行特征。方法对2003~2005年恶性肿瘤新发病例报告资料进行分析,计算发病率、标化发病率、标化截缩率(是指35~64岁截缩人口标化率)等。结果2003~2005年鹿城区恶性肿瘤年平均发病率为368.68/10万,标化发病率为243.05/10万,≥40岁恶性肿瘤发病率为211.88/10万,以肺癌、肝癌和胃癌多见,女姓以乳腺癌、肺癌和大肠癌为主。结论恶性肿瘤防治工作的重点应放在≥40岁人群,男性肺癌发病水平高,而乳腺癌对中壮年女性的生命健康危害大。加强肺癌等主要肿瘤危险因素研究,开展女性乳腺癌筛查具有重要意义。     

广西扶绥县2009年恶性肿瘤发病分析

[目的 ]评价2009年扶绥县恶性肿瘤的发病状况,为恶性肿瘤防控策略提供参考。[方法 ]通过对扶绥县肿瘤登记处2009年肿瘤登记数据进行统计分析,计算恶性肿瘤发病率、年龄别发病率、标化率、构成比、累积率等。[结果]2009年扶绥县恶性肿瘤粗发病率为170.82/10万;中标率为124.74/10万;世界标化率为157.53/10万;35~64岁截缩率为325.50/10万;0~74岁累积率为18.16%。肝癌、胃癌、肺癌、结直肠癌、乳腺癌居恶性肿瘤发病前5位。[结论]扶绥县恶性肿瘤防控的重点是肝癌、胃癌、肺癌。