Meta-analysis of smoking and the risk of gastric cancer among the Chinese population

OBJECTIVE To reevaluate the effect of tobacco smoking on the risk of developing gastric cancer among the Chinese population. METHODS Thirty articles from the literature both in Chinese and English from January, 1988 to present were identified and from which adjusted odd ratios （ORs） or relative risks （RRs） were combined by meta-analysis. Generalized least squares （GLS） for trend estimation of summarized dose-response data was carried out. All the analyses were performed using software of STATA version 10.0. RESULTS Comparing current smokers with subjects who have never smoked, the summary effect values on gastric cancer with a 95% confidence interval （CI） were 1.67 （1.43-1.96） for casecontrol studies and 1.52 （1.17-1.96） for cohort studies, respectively. The combined effect values with a 95%CI for the comparison of smoking quantity of current smokers with the referent group were 1.41 （1.15-1.72） for case-control studies and 1.24 （1.02-1.52） for cohort studies, respectively. The combined effect values with a 95%CI for the comparison of accumulative years smoked of current smokers with the referent group were 1.07 （0.89-1.28） for case-control studies and 1.28 （0.95-1.74） for cohort studies, respectively. Dose-response meta-analysis showed that the gastric cancer risk will increase 50% （OR = 1.50, 95%CI： 1.34-1.67） with each 20 cigarette per day increment and increase 14% （OR = 1.14, 95%CI： 1.10-1.18） with each 10 year increment of smoking. CONCLUSION The gastric cancer risk among the Chinese population is significantly associated with tobacco smoking and the smoking quantity per day. Smoking cessation should be more strongly advocated.     

The association of cigarette smoking with gastric cancer: the multiethnic cohort study

Purpose  

The purpose of this study is to investigate the association of cigarette smoking with gastric cancer.     

Clinicopathological analysis for recurrence of stage Ib gastric cancer (according to the second English edition of the Japanese classification of gastric carcinoma)

Background  

The prognosis for patients with stage Ib (second English edition of the Japanese classification of gastric carcinoma) gastric cancer is promising, with an expected 5-year survival of 90%. Despite this relatively high survival rate, the outcome for patients who experience recurrence is poor. To date, however, prognostic and recurrence factors for stage Ib gastric cancer are poorly understood, and appropriate adjuvant chemotherapy protocols have not been developed.     

The prognostic significance of isolated tumor cells in the lymph nodes of gastric cancer patients

Background  

The clinical significance of isolated tumor cells (ITC) detected immunohistochemically in the lymph nodes of gastric cancer patients is controversial. The aim of this study was to examine the prognostic impact of ITC in patients with gastric cancer.     

Coffee, black tea and risk of gastric cancer

Background  

To provide information about the association of coffee, black tea with gastric cancer risk.     

Retrospective analysis of prognostic outcome of gastric cancer in young patients

Background  

It has been suggested that gastric cancer in young patients has a worse prognosis than in older patients, but this is controversial. This retrospective investigation was undertaken to understand the clinicopathological features and identify the prognostic factors of gastric cancer in young patients.     

Novel prognostic score for patients with gastric carcinoma

Objective  

The lack of a simple criterion for gastric carcinoma creates a persistent challenge for clinicians trying to provide patients with useful prognostic information. The aim of this study was to identify baseline prognostic factors, and use this information to establish a simple criterion to predict outcome in gastric carcinoma.     

胃癌组织中HER2基因状态与p21蛋白表达的关系研究

Objective  

We aimed to analysis the HER2 gene status and its relationship with p21 protein expression in gastric carcinoma.     

Fish consumption and the risk of gastric cancer: systematic review and meta-analysis

Background  

Gastric cancer is the fourth most frequently occurring malignancy after lung, breast, and colorectal cancer, and the second most common cause of death from cancer worldwide. Epidemiologic studies have examined the possible association between fish consumption and gastric cancer, but the results were inconclusive. We conducted a systematic review and meta-analysis to examine the association between fish intake and the risk of gastric cancer.     

Clinical implications of metastatic lymph node ratio in gastric cancer

Background  

The 5-year survival rate in patients with gastric cancer is still poor, and lymph node metastasis is considered one of the most important prognostic factors. However, there are controversies in the classification of lymph node metastasis in gastric cancer. This study was carried out to investigate whether the metastatic lymph node ratio is a reliable classification of lymph node metastasis in gastric cancer in Chinese.     

Incidence of pulmonary thromboembolism in gastric cancer surgery using routine thromboprophylaxis

Background  

There is a lack of published data on the incidence of pulmonary thromboembolism (PTE) after resections for gastric cancer. We report the incidence of PTE after gastric cancer surgery with routine thromboprophylaxis from a highvolume center.     

No associations of Toll-like receptor 2 (TLR2) -196 to -174del polymorphism with the risk of Helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in Japanese

Background  

Recently, the association between gastric cancer risk and a functional polymorphism of Toll-like receptor 2 (TLR2), -196 to -174del, was reported for a Japanese population. This study aimed to confirm the associations of the polymorphism with the risk of gastric cancer, as well as Helicobacter pylori seropositivity and the risk of gastric atrophy in Japanese.     

Impact of tumor infiltration pattern into the surrounding tissue on prognosis of the subserosal gastric cancer (pT2b)

Background

The aim of this study was to clarify the impact of infiltration pattern on prognosis in patients with gastric carcinoma invading subserosa.

Methods

Clinicopathologic findings in patients with ssγ pattern (n = 144) were compared with those in patients with ssα/ssβ cancers (n = 222). Prognostic factors of pT2b patients were analyzed by univariate and multivariate analysis.

Results

Compared with the ssα/β group, ssγ gastric cancer exhibited more frequent undifferentiated histology, disseminated lymph node metastasis and perineural invasion. Frequency of postoperative peritoneal recurrence was significantly higher in ssγ gastric cancer (P < 0.05). The 5-year survival rate for patients with ssγ gastric cancer was significantly lower compared with ssα/β group (63.2% vs. 74.8%, respectively; P < 0.05). Lymph node metastasis, vein invasion and infiltrative pattern (ssγ) were significant independent prognostic factors affecting survival in pT2b patients.

Conclusion

In patients with gastric cancer invading the subserosa, infiltrative type growth pattern is closely related to carcinomatosis and poorer prognosis.     

Systematic review of feasibility and safety of laparoscopic gastrectomy for gastric cancer

Objective  

The purpose of the present study was to retrospectively and systematically evaluate the feasibility and safety of laparoscopic gastrectomy for gastric cancer.     

Trends in characteristics of surgically treated early gastric cancer patients after the introduction of gastric cancer treatment guidelines in Japan

Background  

The gastric cancer treatment guidelines (Guidelines) of the Japanese Gastric Cancer Association allow endoscopic treatment and a modified gastrectomy for the treatment of early gastric cancer (EGC). Endoscopic treatment is indicated for EGC with a minimal chance of nodal metastasis. Consequently, surgeons will likely treat an increasing number of EGC patients with greater chance of nodal metastasis using a reduced extent of lymphadenectomy. The aim of this study was to investigate the trends in characteristics and long-term oncological outcomes of surgically treated EGC patients after the introduction of the Guidelines.     

The flow angle beneath the gastrojejunostomy predicts delayed gastric emptying in Roux-en-Y reconstruction after distal gastrectomy

Background

Delayed gastric emptying without mechanical obstruction after Roux-en-Y reconstruction has been defined as Roux stasis syndrome. It occurs in 10–30% of patients after such reconstruction. So far, the cause of this stasis has not been completely identified. This study aimed to reduce Roux stasis using surgical techniques.

Methods

From November 2007 to October 2010, we performed 101 distal gastrectomies with Roux-en-Y reconstruction. All the gastrojejunostomies were performed with end-to-end anastomoses. Roux stasis was analyzed with respect to tumor location, extent of the dissection, tumor progression, operation time, antecolic/retrocolic reconstruction, and the shape of the gastrojejunostomy. The shape of the gastrojejunostomy was evaluated by contrast gastroradiography 4?days after the operation.

Results

Roux stasis syndrome was observed in 17 of the 101 patients. There was no relationship between the extent of the dissection, tumor progression, or operation time and the occurrence of Roux stasis. There was no difference in the incidence of Roux stasis between antecolic and retrocolic reconstructions. However, the group that displayed a straight anastomotic shape on contrast radiography demonstrated an apparently lower incidence of Roux stasis (p?=?0.0003). In addition, Roux-en-Y reconstruction following gastric cancer was more frequently followed by Roux stasis in the antrum than in the midstomach (p?=?0.0036). Cases of Roux stasis occurred 11.8?days after surgery on average and resolved within 2?weeks on average.

Conclusions

Our findings demonstrate the substantial benefits of a straight anastomosis of the gastrojejunostomy for the prevention of Roux stasis syndrome.     

Prognostic factor analysis of third-line chemotherapy in patients with advanced gastric cancer

Background  

Almost all patients with advanced gastric cancer will eventually develop progressive disease after first-line chemotherapy. However, the role of subsequent salvage chemotherapy remains controversial. The purpose of this study was to evaluate prognostic factors for the survival of patients with advanced gastric cancer who received third-line chemotherapy.     

Quality of life in patients with gastric cancer: translation and psychometric evaluation of the Iranian version of EORTC QLQ-STO22

Background  

Disease and treatment related events, can adversely affect the quality of life of patients with cancer. The purpose of this study was to translate and validate a gastric cancer specific health related quality of life questionnaire (EORTC QLQ-STO22) for Iranian patients suffering from gastric cancer.     

Association of circulating VacA-neutralizing antibodies with gastric cancer and duodenal ulcer

Objective  

To study the association between anti-VacA antibodies and pre-neoplastic lesions (IM), gastric cancer (GC), and duodenal ulcer (DU).     

直径小于2厘米胃癌预制因素分析

Objective  

The aim of our study was to identify clinicopathological characteristics as predictive factors for gastric cancer tumours of less than 2 cm in diameter.