严重慢性阻塞性肺疾病患者食管切除术围手术期并发症及处理

目的 探讨重度慢性阻塞性肺疾病简称慢阻肺病人食管切除术围手术期常见并发症及其处理。方法 45例重度慢阻肺的病人在全麻联合硬膜外阻滞下进行开胸食管切除手术，围手术期处理包括术前戒烟、胸部理疗、预防和控制呼吸道感染、解痉化痰、呼吸功能锻炼、营养支持和氧疗；术后硬膜外镇痛、早期锻炼、保持呼吸道通畅，部分病人予以呼吸支持。结果 术中3例出现低氧血症。术后所有病人PaO2均有不同程度的下降，6例出现肺部感染，6例行纤维支气管镜吸痰，2例通过气管插管给予呼吸机支持，2例行气管切开术，1例酸碱平衡紊乱使用盐酸精氨酸治疗。所有病人均痊愈出院。结论 重度慢阻肺病人并非开胸食管切除手术的绝对禁忌证，积极的术前准备和严格的术后管理可减少和控制术后急性发作，有助于确保此类病人的围手术期安全和康复。     

结直肠癌合并慢性阻塞性肺疾病患者的临床分析

目的 探讨结直肠癌合并慢性阻塞性肺疾病(COPD)患者手术治疗的危险性、手术耐受力及围手术期的处理.方法 收集广西医科大学第一附属医院2005年7月至2008年7月结直肠癌合并COPD患者的临床资料共40例.并收集无COPD的结直肠癌老年患者40例,对手术后常见并发症进行对比分析.结果 合并COPD与无COPD的结直肠癌患者出现伤口裂开分别为2例和1例、伤口感染为3例和7例,肺部感染14例和6例(P<0.05),呼吸衰竭8例和2例(P<0.05).术后住院时间:COPD组中＜ 14 d占5例,14～21 d占24例,＞21 d占7例.对照组中＜ 14 d占9例,14～21 d占29例,＞21 d占3例.结论 结直肠癌合并COPD患者手术危险性高,主要在术后,但术前、术中与术后进行适当的准备与处理,可降低术后并发症发生.     

肺保护性通气可减轻轻中度慢性阻塞性肺疾病老年患者围术期肺部感染

目的探讨肺保护性通气对全麻轻中度慢性阻塞性肺疾病(COPD)老年患者围术期肺部感染的影响。方法选择择期行全麻上腹部手术的轻中度COPD老年患者40例,男24例,女16例,年龄65~81岁,ASAⅠ~Ⅲ级,BMI 19~28kg/m~2,采用随机数字表分为肺保护性通气组(PV组)和常规通气组(CV组),每组20例。PV组行肺保护通气:IPPV,V_T 6ml/kg,PEEP 5~10cm H_2O,每隔30分钟进行手法肺复张;CV组行常规通气:IPPV,V_T 10 ml/kg,不使用PEEP及肺复张。于麻醉诱导前(T_1)、机械通气后2h(T_2)、术毕时(T_3)、术后6hT_4)和24h(T_5)采集静脉血检测IL-6和IL-8的浓度;记录麻醉前、术后第1、3、5、7天的临床肺部感染评分(CPIS)和术后肺部炎症发生情况。结果两组患者年龄、BMI、ASA分级、术中输液量、出血量、尿量、机械通气时间、手术方式、T_1~T_5时IL-6和IL-8浓度组间差异均无统计学意义。与T_1时比较,T_2~T_5时两组IL-6和IL-8浓度明显升高(P0.05)。与麻醉前比较,术后第1、3、5天CV组CPIS评分和术后肺部炎症发生率明显升高(P0.05);术后第1、3、5天PV组CPIS评分明显低于CV组(P0.05)。结论肺保护性通气不能降低开腹手术轻中度COPD老年患者围术期IL-6和IL-8浓度,但是可减少术后肺部炎症的发生,减轻术后5d内的肺部感染。     

肝移植围手术期肺部并发症的危险因素及相关防治

背景 肝移植围手术期各类肺部并发症发生率高,发病机制复杂,严重影响患者的预后.目的 分析肝移植围手术期肺部并发症的危险因素并提出具体防治措施以保护肺功能.内容 介绍肝移植术后急性肺损伤(acute lung injury,ALI)的机理;患者术前病理生理因素、麻醉因素以及非特异性因素与肺部并发症的关系;围手术期肺功能保护的措施.趋向 对相关机制和危险因素进行深入研究,并采取相应防治措施,有助于减少肝移植患者围手术期肺部并发症的发生.     

老年男性慢性阻塞性肺疾病与骨质疏松的关系

目的探索老年男性慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者骨密度(bone mineral density,BMD)水平及骨质疏松(osteoporosis,OP)发生率,进而探讨COPD与OP可能存在的联系。方法选取2013年1月至2017年9月期间入我院的60周岁以上共94名老年男性作为研究对象,并分为COPD组52名和对照组42名,利用双能X线骨密度仪测量不同部位的骨密度T值(腰椎TL2-4、股骨颈TNeck、髋部TTotal);肺通气功能仪测量肺通气指标值(FEV1%、FEV1/FVC%、VC%、MVV%)。计量资料采用独立样本t检验或曼-惠特尼U检验,计数资料采用χ2检验,多因素分析采用二分类Logistic回归分析。结果老年男性COPD患者的骨密度指标值(TNeck、TTotal)及肺通气各项指标值(FEV1%、FEV1/FVC%、VC%、MVV%)均显著低于对照组,差异具有统计学意义。老年男性COPD组与对照组的骨质疏松、骨量减少和骨量正常构成比分别为21.2%、55.8%、23.1%和9.5%、42.9%、47.6%,差异具有统计学意义。老年男性COPD的影响因素包括身高、体重、BMI指数、TNeck及FEV1/FVC%。结论老年男性COPD患者的股骨颈及髋部BMD显著低于对照组、骨质疏松的发生率显著高于对照组;老年男性患者股骨颈BMD值越高,COPD发生的风险越低。     

肺切除术后肺部并发症发生的危险因素分析

目的分析肺切除术后肺部并发症(PPC)发生的危险因素,尽可能减少术后PPC的发生,降低病死率。方法回顾性分析2007年1月至2009年12月在我科行肺切除术302例患者的临床资料,其中男228例,女74例;年龄23～91岁,平均年龄63.38岁。统计术后各种肺部并发症的发生率,并收集术前、术中及术后相关资料和数据,采用logistic多元回归分析肺切除术后PPC发生的独立危险因素。结果围术期共死亡22例(7.28%),75例(24.83%)发生110例次PPC,最主要的PPC为胸膜腔持续漏气/支气管胸膜瘘(8.94%,27/302),院内肺炎(6.95%,21/302)和急性呼吸衰竭(6.29%,19/302)。logistic多因素分析结果显示:ASA分级≥3级(OR=2.400,P=0.020)、术后即刻气管内插管机械通气时间延长(OR=1.620,P=0.030)是肺切除术后发生PPC的独立危险因子。结论以患者一般情况和各器官功能状态为基础的ASA分级和术后机械通气时间是肺切除术后PPC的独立预测因子。对高危患者需特别注意完善术前准备,改善患者各器官功能状况,保护肺功能,术后尽量缩短机械通气时间,尽可能减少PPC的发生。     

胸腔镜部分肺切除术后肺部并发症的危险因素

目的探讨胸腔镜部分肺切除术后肺部并发症(PPCs)的危险因素。方法回顾性分析2018年1—12月首次行胸腔镜解剖性部分肺切除手术患者896例,年龄18～79岁,ASAⅠ—Ⅲ级,术前所有患者肺功能正常。收集患者性别、年龄、BMI、合并症、术中出入量及PPCs等围术期资料。采用单因素分析及多因素Logistic回归分析法筛选胸腔镜部分肺切除PPCs的危险因素。结果有220例(24.6%)患者发生PPCs(并发症组),其中最常见的肺炎有135例(15.1%)。单因素分析显示,并发症组患者术前白蛋白35 g/L、右肺手术、多肺叶肺段手术的比例明显高于无并发症组(P0.05),单肺通气时间明显长于无并发症组(P0.05),液体入量明显少于无并发症组(P0.05)。多因素Logistic回归分析显示,单肺通气时间2 h(OR=1.605,95%CI 1.113～2.314,P=0.011)、白蛋白35 g/L(OR=1.806,95%CI 1.094～2.981,P=0.021)、右肺手术(OR=1.443,95%CI 1.043～1.998,P=0.027)、多肺叶肺段手术(OR=1.998,95%CI 1.348～2.932,P=0.001)是胸腔镜部分肺切除PPCs的独立危险因素。结论单肺通气时间延长(2 h)、低白蛋白血症(白蛋白35 g/L)、右肺手术及接受多肺叶肺段手术可作为胸腔镜部分肺切除PPCs的独立危险因素。     

胸腔镜肺切除术患儿术后肺部并发症的危险因素

目的 分析患儿胸腔镜下肺切除术后肺部并发症（PPCs）的危险因素。
方法 回顾性分析行胸腔镜肺切除术566例患儿的临床资料，男334例，女232例，年龄≤6岁，ASA Ⅰ或Ⅱ级。根据患者术后7 d内是否发生PPCs分为两组：PPCs组和非PPCs组。将单因素分析中P≤0.2以及临床认为可能有意义的协变量纳入多因素Logistic回归分析。绘制受试者工作特征（ROC）曲线并计算曲线下面积（AUC）。
结果有123例（21.7%）发生PPCs。多因素Logistic回归分析显示，单肺通气时间长、单肺通气时呼吸频率快、手术医师经验不足是PPCs的独立危险因素，术中最大PEEP升高（最大为7 cmH₂O）是保护因素。预测模型为Logit（P）=-4.410+0.006×单肺通气时间+0.063×单肺通气呼吸频率+0.569×手术医师经验不足（赋值为1）-0.160×最大PEEP值，该模型预测患儿胸腔镜肺切除术PPCs发生率的AUC为0.682（95%CI 0.631～0.734），敏感性76.4%，特异性69.6%。
结论单肺通气时间长、单肺通气时呼吸频率快、手术医师经验不足是患儿胸腔镜肺切除术PPCs的危险因素，术中最大PEEP升高是PPCs的保护因素。     

心脏外科术后肺部并发症的危险因素

目的 分析心脏外科术后肺部并发症（PPCs）的危险因素。
方法 回顾性分析2017年1月至2020年12月行心脏外科手术患者的病历资料,根据患者是否发生PPCs分为两组：并发症组（n=271）和无并发症组（n=331）。提取性别、年龄、ASA分级、高血压病史、糖尿病病史、慢性阻塞性肺疾病（COPD）病史、脑血管病史、手术史、术前房颤、肺动脉高压、心功能指标、凝血功能指标、肝肾功能指标、乳酸脱氢酶、血糖、手术时间、心肺转流（CPB）时间、术中药物使用情况、术中输血量、术中液体输注量、术中尿量、术后肝肾功能指标、心电图等临床指标,采用单因素分析评估上述指标与PPCs的相关性。将组间差异有统计学意义的单因素纳入Logistic回归模型,分析心脏外科PPCs的独立危险因素。
结果 与无并发症组比较,并发症组年龄、左心房直径明显增大,ASA分级、糖尿病和术前房颤比例、肺动脉高压分级、淋巴细胞含量、尿素氮、球蛋白、总蛋白、乳酸脱氢酶、AST浓度明显升高（P＜0.05）;手术时间和CPB时间明显延长,术中输注血小板比例明显升高,晶体液输注量明显增多（P＜0.05）;术后尿素氮、肌酐浓度明显升高,引流量明显增多（P<0.05）。多因素Logistic回归分析结果显示,ASA Ⅳ级（OR=1.886,95%CI 1.030～3.456,P=0.040）、术前房颤（OR=1.526,95%CI 1.031～2.257,P=0.034）、CPB时间≥2 h（OR=2.418,95%CI 1.692～3.456,P＜0.001）是心脏外科PPCs的独立危险因素。
结论 术前房颤、ASA Ⅳ级、CPB时间≥2 h是心脏外科PPCs发生的独立危险因素。     

非小细胞肺癌合并慢性阻塞性肺疾病患者围手术期综合管理有效性和安全性的系统评价及Meta分析

目的系统评价围手术期综合管理措施对非小细胞肺癌(non-small cell lung cancer,NSCLC)合并慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者的有效性及安全性。方法计算机检索PubMed、EMbase、The Cochrane Library、中国生物医学文献数据库、中国知网、万方数据库,纳入所有关于NSCLC合并COPD的临床研究。检索时间为数据库建库至2017年11月1日。由2位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Rev Man 5.3和Stata 14.0软件进行Meta分析。结果共纳入20个研究1 079例NSCLC合并COPD患者。Meta分析结果表明:在肺功能方面,围手术期综合管理可改善患者第一秒用力呼气量(FEV1)、用力肺活量(FVC)、最大自主通气量(MVV)、预计术后一秒率(ppoFEV1%)、肺一氧化碳弥散量(DLCO)和第一秒用力呼气率(FEV1%),且与治疗前的差异有统计学意义[分别为:MD=–0.47,95%CI(–0.62,–0.32),P<0.000 01;MD=–0.17,95%CI(–0.22,–0.11),P<0.000 01;MD=–4.24,95%CI(–5.37,–3.11),P<0.000 01;MD=–7.54,95%CI(–8.33,–6.76),P<0.000 01;MD=–1.33,95%CI(–2.16,–0.50),P=0.002;MD=–6.93,95%CI(–9.45,–4.41),P<0.000 1],但一氧化碳弥散率(DLCO%)和最大负荷量通气(VEmax)方面差异无统计学意义[MD=–2.91,95%CI(–11.31,5.50),P=0.5;MD=0.18,95%CI(–2.23,2.58),P=0.89];在心功能方面,综合管理可改善患者最大摄氧量(VO2max)、6分钟步行距离(6MWD)和无氧阈值(AT),且与治疗前的差异有统计学意义[MD=–2.28,95%CI(–3.41,–1.15),P<0.000 1;MD=–57.77,95%CI(–77.90,–37.64),P<0.000 1;MD=–2.71,95%CI(–3.30,–2.12),P<0.000 1];和常规治疗相比,综合治疗可明显减少术后肺部短期并发症,明显缩短住院时间[OR=0.39,95%CI(0.26,0.58),P<0.000 01;MD=–2.38,95%CI(–3.86,–0.89),P=0.002]。结论围手术期综合管理可明显改善NSCLC合并COPD患者的肺功能,减少术后肺部短期并发症,缩短住院时间,具有良好的有效性及安全性。     

Perioperative rehabilitation and physiotherapy for lung cancer patients with chronic obstructive pulmonary disease

Objective: The purpose of this study was to investigate the impact of pulmonary rehabilitation on surgical morbidity and lung function in lung cancer patients with chronic obstructive pulmonary disease (COPD). Methods: Prospectively, 22 lung cancer patients with COPD who underwent lobectomy between 2000 and 2003 were enrolled for this study as a rehabilitation group (Rehab. Group). The criteria of COPD were preoperative forced expiratory volume in 1 second (FEVl)/forced vital capacity (FVC) ≦70% and more than 50% of low attenuation area in a computed tomography. Preoperatively patients performed aggressive pulmonary exercise for two weeks and received chest physiotherapy postoperatively. As a historical control, 60 patients with lung cancer who fulfilled the same criteria but did not receive rehabilitation between 1995 and 1999 (control group) were entered in this study. Results: Patient backgrounds were all equivalent between the two groups. However, FEV1 and FEV1/FVC were significantly lower in the Rehab. Group (p<0.05). Prolonged oxygen supplement and tracheostomy tended to be more frequent in the control group. The ratio of actual postoperative to predicted postoperative FEV1 was significantly better in the Rehab. Group (p=0.047). Furthermore, postoperative hospital stay was significantly longer in the control group (p=0.0003). Conclusion: Despite lower FEV1 and FEV1/FVC in the Rehab. Group, postoperative pulmonary complications and long hospital stay could be effectively prevented and FEV1 was well preserved by rehabilitation and physiotherapy.     

Increased risk of chronic obstructive pulmonary diseases in coke oven workers: interaction between occupational exposure and smoking

BACKGROUND: Coke oven workers are regularly exposed to coke oven emissions (COE) and may be at risk of developing lung diseases. There is limited evidence for the link between exposure to COE and chronic obstructive pulmonary diseases (COPD). The aim of this study was to explore the dose-response relationship between COE exposure and COPD and to assess the interaction with cigarette smoking. METHODS: Seven hundred and twelve coke oven workers and 211 controls were investigated in southern China. Benzene soluble fraction (BSF) concentrations as a surrogate of COE were measured in representative personal samples and the individual cumulative COE exposure level was quantitatively estimated. Detailed information on smoking habits and respiratory symptoms was collected and spirometric tests were performed. RESULTS: The mean BSF levels at the top of two coking plants were 743.8 and 190.5 microg/m3, respectively, which exceed the OSHA standard (150 microg/m3). After adjusting for cigarette smoking and other risk factors, there was a significant dose-dependent reduction in lung function and increased risks of chronic cough/phlegm and COPD in coke oven workers. The odds ratio for COPD was 5.80 (95% confidence interval 3.13 to 10.76) for high level cumulative COE exposure (> or =1714.0 microg/m3-years) compared with controls. The interaction between COE exposure and smoking in COPD was significant. The risk of COPD in those with the highest cumulative exposure to COE and cigarette smoking was 58-fold compared with non-smokers not exposed to COE. CONCLUSION: Long term exposure to COE increases the risk of an interaction between COPD and cigarette smoking.     

合并慢性阻塞性肺病的老年直肠癌患者围手术期处理

目的探讨合并慢性阻塞性肺病(COPD)的老年直肠癌患者的围手术期处理。方法对40例中度以上COPD直肠癌患者进行静态肺功能评估,并进行正确的围手术期处理,研究其对患者术后的影响。结果术后心律失常4例,COPD症状加重8例,肺部感染6例,二重感染4例,呼吸功能衰竭2例,内科治疗后均缓解;伤口感染5例,无围手术期死亡。结论虽然合并COPD患者增加了手术风险,但正确内科治疗及处理,可以降低手术并发症发生率。     

Video-assisted lobectomy for a lung cancer patient with chronic obstructive pulmonary disease

Objectives: This retrospective study was conducted to see whether a video-assisted lobectomy is beneficial in lung cancer patients with chronic obstructive pulmonary disease regarding preservation of pulmonary function compared to lobectomy by standard thoracotomy.Subjects and Methods: Between 1982 and 2002, 67 patients who underwent lobectomy for primary lung cancer showed 55% or less of preoperative forced expiratory, volume in one second/vital capacity. Among them, 25 patients were enrolled in this retrospective study. The remaining 42 patients were excluded because of no presence of a postoperative pulmonary function test. Nine of 25 patients underwent a video-assisted lobectomy between 1994 and 2002 and the remaining 16 patients who underwent a lobectomy by standard thoractomy between 1982 and 1994 were employed as a historical control. Perioperative conditions and changes in pulmonary function were compared between two groups.Results: A parameter of chest wall damage was minor in video-assisted lobectomy compared to that in lobectomy by standard thoracotomy. Changes between pre- and postoperative percent of vital capacity, forced expiratory volume in one second and maximal ventilatory volume showed significantly minor deterioration or even improvement in video-assisted lobectomy patients. Predicted postoperative pulmonary function tended to be underestimated for postoperative values in video-assisted lobectomy patientsConclusions: Video-assisted lobectomy seemed to be profitable in preservation of pulmonary function in lung cancer patients with chronic obstructive pulmonary disease. Prediction of postoperative pulmonary function should be revised due to the underestimation for postoperative values in video-assisted lobectomy, which could offer profitable surgical treatment for lung cancer patients with chronic obstructive pulmonary disease.     

慢性阻塞性肺疾病患者睡眠质量及影响因素调查

目的了解慢性阻塞性肺疾病(COPD)患者睡眠状况及风险因素。方法便利抽取COPD患者和健康体检对照人群各100例为研究对象,采用匹兹堡睡眠质量指数量表(PSQI)、睡眠信念与态度量表(DBAS)、焦虑自评量表(SAS)、呼吸困难量表(MMRC)、圣乔治呼吸问卷(SGRQ)进行调查,采集一般资料、行肺功能等检查。结果 COPD组和对照组睡眠障碍发生率分别为72.92%和42.86%,两组比较,差异有统计学意义(P0.01)。COPD组的PSQI总分及各维度得分显著高于对照组(P0.05,P0.01)。睡眠障碍组患者与无睡眠障碍组患者在年龄、夜间治疗、第1秒用力呼气量占预计值的百分比、呼吸困难分级、SAS评分、SGRQ评分及DBAS评分方面的差异有统计学意义(P0.05,P0.01)。呼吸困难分级、DBAS、SGRQ是影响睡眠质量的主要因素(P0.05,P0.01)。结论 COPD患者睡眠质量较差。呼吸困难程度、睡眠认知、躯体症状、心理状况等是影响睡眠质量的主要因素,积极治疗原发病、改善呼吸功能和躯体症状,建立有效的睡眠认知是提高睡眠质量的关键。     

Respiratory mechanics in anaesthetised patients after neostigmine-atropine. A comparison between patients with and without chronic obstructive pulmonary disease

The aim of this study was to compare the effects of pharmacological reversal of neuromuscular blockade on static compliance and resistance in patients with and without chronic obstructive pulmonary disease (COPD). Twenty patients were studied: 12 patients were free of respiratory disease (NCOPD) and had normal pulmonary function tests. Eight subjects (COPD) had a clinical history of chronic bronchitis and a FEV1 < 70% of the predicted value. All patients were anaesthetised with a continuous infusion of methohexitone and alfentanil. Airway pressure (Paw) was recorded continuously. Static compliance (Crs) was calculated from the relationship between 21 syringe volume (250 ml step) and Paw. Total respiratory resistance (Rrs) was measured at two levels of inspiratory flow and tidal volume. These measurements were made before vecuronium (control), after injection of vecuronium to abolish the first neuromuscular response to train of four, 5 and 15 min after administration of neostigmine 40 μgkg^-1 and atropine 10 μg kg^-1. In COPD patients Crs and Rrs were significantly greater (1450 ± 580 ml kPa^-1 and 1.06 ± 0.68 kPa l^-1 -s^-1) than in normal patients (1000±380 ml-kPa^-1 and 0.58 ± 0.22 kPa-1^-l-s^-1) (P < 0.01). In both groups Crs and end-expiratory pulmonary volume were similar before injection of vecuronium and after neostigmine-atropine administration. In both groups, Rrs was not altered significantly by neostigmine-atropine for the two inspiratory flows. These results suggest that neostigmine-atropine mixture is associated with small changes in respiratory mechanics, and the changes are similar in COPD compared with normal patients.     

Pre-operative optimisation for chronic obstructive pulmonary disease: a narrative review

Chronic obstructive pulmonary disease is a condition commonly present in older people undergoing surgery and confers an increased risk of postoperative complications and mortality. Although predominantly a respiratory disease, it frequently has extra-pulmonary manifestations and typically occurs in the context of other long-term conditions. Patients experience a range of symptoms that affect their quality of life, functional ability and clinical outcomes. In this review, we discuss the evidence for techniques to optimise the care of people with chronic obstructive pulmonary disease in the peri-operative period, and address potential new interventions to improve outcomes. The article centres on pulmonary rehabilitation, widely available for the treatment of stable chronic obstructive pulmonary disease, but less often used in a peri-operative setting. Current evidence is largely at high risk of bias, however. Before surgery it is important to ensure that what have been called the ‘five fundamentals’ of chronic obstructive pulmonary disease treatment are achieved: smoking cessation; pulmonary rehabilitation; vaccination; self-management; and identification and optimisation of co-morbidities. Pharmacological treatment should also be optimised, and some patients may benefit from lung volume reduction surgery. Psychological and behavioural factors are important, but are currently poorly understood in the peri-operative period. Considerations of the risk and benefits of delaying surgery to ensure the recommended measures are delivered depends on patient characteristics and the nature and urgency of the planned intervention.     

Six-minute walking and pulmonary function test outcomes during the early period after lung cancer surgery with special reference to patients with chronic obstructive pulmonary disease

Objective: To evaluate physical dysfunction during the early period after lung resection in patients with lung cancer and coexisting chronic obstructive pulmonary disease (COPD), we examined the relationship between the ratio of the forced expiratory volume in 1 second to the forced vital capacity (FEV₁/FVC%) and the results of a 6-minute walk (6MW) test before and after surgery. Methods: Eighty-three patients who underwent lobectomy for lung cancer were classified into three groups according to their preoperative FEV₁/FVC: more than 70% (non-COPD, n=61), 60–69% (mild COPD, n=15), and 40–59% (moderate COPD, n=7). The 6MW and pulmonary function tests were performed before surgery and repeated 1 and 2 weeks after surgery. During the 6MW test, the distance covered during a 6MW test (6MWD) and the decrease in oxygen saturation (SpO₂) were measured. Results: During both the preoperative and postoperative 6MW tests, the decrease in SpO2 correlated significantly with the preoperative FEV₁/FVC% (p<0.001). The percentage decrease in 6MWD at 1 and 2 weeks after surgery correlated significantly with the preoperative FEV₁/FVC% (p<0.001 and p=0.04, respectively), but not with the concomitant percentage reduction in vital capacity (VC). The differences of the decreases in postoperative 6MWD and SpO₂ during the 6MW test were significant between the moderate and mild COPD patients and between the mild COPD and non-COPD patients (p<0.01–0.001). Conclusion: The decreases in 6MWD and SpO₂ after surgery were significantly influenced by the preoperative FEV₁/FVC%, but not by the decrease in VC. COPD patients have a limited capacity for walking during the early period after surgery due to significant oxygen desaturation.