电针对摇头丸滥用者^99mTc—ECD脑灌注显像及服功能活动的影响

目的：用单光子发射计算机断层扫描（SPECT）脑灌注显像，观察电针（EA）对摇头丸滥用者局部脑血流量（rCBF）及脑功能活动的影响。方法 17例摇头丸滥用者和20例健康志愿者（对照组）在电针治疗前后进行SPECT检查，用服血流功能变化率（BCFR％）数学模型进行定量分析，评价电针对上述观察指标的影响。结果：与对照组比，17例摇头丸滥用者的大脑皮质额叶、颞叶、服岛、基底栉均存在局部服血流量不同程度的降低，而脑岛、基底节区功能亢进的病理表现；电针治疗可显著增加或调整局部服血流量，并改善大服的功能活动（P＜0．01，P＜0．001）。结论 摇头丸滥用可以导致大脑血液供应减少或病理性增加，进而引起中枢神经系统的功能异常；针刺治疗对此有显著改善作用，提示针刺可以作为一种简便、有效、无副作用的方法用于治疗摇头丸滥用所导致的服部病理损害。     

自发性脑出血后局部脑血流量动态变化及影响因素的相关研究

为研究自发性脑出血后局部脑血流（rCBF）动态变化规律及影响因素，应用单光子发射计算机断层扫描（SPECT）rCBF断层显像，依据ROI比值法分别测定66例脑出血患者急性期、亚急性期及慢性期的比值。结果：急性期rCBF显著减少，其程度与血肿量及出血部位有关，以后随时间推移rCBF逐步增加。影响脑出血后rCBF变化的因素主要是血肿量及出血部位。     

潘生丁负荷~(99m)Tc-MIBI心肌断层显像对冠心病心肌缺血的诊断价值

目的　评价潘生丁负荷 99m Tc- MIBI心肌断层显像用于冠心病心肌缺血诊断的可行性和临床价值。方法　静脉注入潘生丁 0 .14 mg· kg- 1 · min- 1 ,共 4 min,1min后注射 99m Tc- MIBI 74 0 MBq,1h后行心肌断层显像。结果　潘生丁负荷心肌断层显像诊断冠心病心肌缺血的灵敏度为 92 .5 % ,特异性为 92 .1%。潘生丁注入后引起的副作用轻微且较短暂。结论　潘生丁负荷 99m Tc- MIBI心肌断层显像用于诊断冠心病心肌缺血有较高的准确性     

~(99m)Tc-TRODAT-1脑SPECT显像在诊断早期帕金森病中的应用

帕金森病(PD)是一种慢性、渐进性中枢神经系统变性疾病,早期对PD患者作出正确诊断对临床治疗及预后均有很大的意义。本研究通过99mTc-TRODAT-1脑单光子发射计算机体层摄影术(SPECT)显像对早期PD诊断的临床价值。1对象与方法1.1研究对象:选择临床按照CAPIT标准[1]诊断为早期PD的     

3,4-亚甲二氧基苯丙胺对空间学习记忆功能的急性影响

目的 探讨3,4-亚甲二氧基苯丙胺(MDMA)对大鼠空间学习记忆功能的急性影响。方法 对照组(A)腹腔注射等体积生理盐水,实验组(B、C、D、E)分别腹腔注射MDMA 3、5、10、20 mg·kg-1;两组分别于用药后第7天行Morris水迷宫实验。结果 无论是定向航行实验、还是空间探索实验,对照组与实验组(MDMA 3、50、10、20 mg·kg-1)大鼠在逃避潜伏期和穿原平台所在位置的次数上均无统计学差异。结论 MDMA对成年大鼠的学习记忆功能无明显影响。     

~(99m)TC-MIBI SPECT心肌显像评价麝香保心丸治疗恶化型劳累性心绞痛的疗效

为评价麝香保心丸治疗恶化型劳累性心绞痛的疗效,将46例患者随机分组:治疗组26例,在常规治疗的基础上加用麝香保心丸;对照组20例,采用常规治疗。对两组进行临床疗效对比观察,并采用~(99m)TC-MIBISPECT心肌显像靶心图分析,定量评价缺血心肌面积变化。结果显示:治疗组临床疗效总有效率(88.5％)明显高于对照组(55.0％),P<0.05,治疗后心肌显像心肌缺血面积组间对比有显著性差异(19.2％±8.6％及26.8％±9.3％,P<0.05),再发性心绞痛和心脏事件治疗组少于对照组。表明麝香保心丸治疗冠心病恶化劳累型心绞痛有一定疗效。     

~(18)F-脱氧葡萄糖与~(99)Tc~m-亚甲基二膦酸盐骨扫描显像探测恶性肿瘤全身骨转移病灶的对比分析

<正>99Tcm-亚甲基二膦酸盐(MDP)全身骨显像是检测恶性肿瘤骨转移的常规方法,而18F-脱氧葡萄糖(FDG)正电子发射型计算机断层显像(PET)显像可显示具有葡萄糖高代谢水平的骨骼转移病灶。本研究目的是比较18F-FDG hPET(hybird PET)/CT显像与99Tcm-MDP全身骨显像检测恶性肿瘤骨骼病灶的异同点,探讨18F-FDG hPET/CT显像诊断恶性肿瘤骨转移病灶的临床价值。1资料与方法1.1临床资料:选取本院2009年12月至2013年10月收治     

彩超及彩超联合~(99m)TcO~(-4)甲状腺静态显像对甲状腺结节诊断价值的对比分析

目的探究彩超与彩超联合~(99m)TcO~(-4)甲状腺静态显像对甲状腺结节诊断的效果对比分析。方法选择2017年1月至2018年1月行甲状腺结节检查的患者80例为研究对象,根据诊断方式的差异将其分为对照组与观察组,对照组给予彩超检查,观察组在此基础上给予甲状腺静态显像诊断,比较两组患者的正确诊断率。结果观察组正确诊断率显著高于对照组,同时特异度与敏感度也高于对照组,差异有统计学意义(P <0.05)。结论彩超联合甲状腺~(99m)TcO~(-4)静态显像诊断甲状腺结节的准确率高,能有效提高甲状腺结节的良恶性,值得临床推荐。     

淫羊藿甙扩张脑血管作用的研究

本实验用麻醉家兔和狗以电磁流量计测定了淫羊藿甙(EI)对脑血流的作用,结果表明,动脉和静脉给予EI均能显著增加脑血流量,降低腑血管阻力。EI增加脑血流的作用与罂粟碱(Pap)相似,作用强度虽弱于Pap,但作用时间较Pap长。     

葛根素对急性心肌缺血狗区域性心肌血流与心脏血流动力学的作用

麻醉开胸狗ⅳ葛根素(puerarin)可减慢心率(HR)、降低主动脉压(MAP),用同位素标记微球法测得的缺血区侧枝冠脉血流量并不减少。从狗的右室旁路制备的心脏血流动力学实验发现葛根素明显减低张力一时间指数(TTI)与左室压力升高速度(LV dp/dt)。当MAP调整到给药前的水平时,TTI与LV dp/dt恢复,进入缺血区的侧技血流增加,非缺血区的冠脉血流量(CBF)亦增加。葛根素减低冠脉血管阻力(CVR)的作用比减低全身血管阻力(SVR)的作用更显著。葛根素不影响心肌收缩力,但增加局部心肌缺血时的侧枝血流并减少与心肌氧消耗有关的血流动力学参数。这些结果提示葛根素有益于治疗心肌缺血。     

维拉帕米改善实验性沙土鼠脑缺血后LCBF和脑水份含量

利用沙土鼠脑缺血再灌注模型,于缺血前或缺血后静脉注入钙通道阻滞剂维拉帕米0.5mg/kg,结果表明,维拉帕米显著地改善沙土鼠脑缺血后低灌注现象,增加缺血区脑血流量(P<0.01),同时减轻脑水份含量(P<0.01),对脑缺血后神经细胞将起保护作用,值得进一步研究及临床验证。     

间尼索地平与尼索地平对清醒兔血流动力学和局部血流量的影响

应用放射性生物微球技术观察间尼索地平(m-Nis)和尼索地平(Nis)对清醒兔血流动力学和局部血流量的影响。m-Nis 1μg/kg·min~(-1)×10min iv显著增加清醒兔CO、CI、SV和LVSW;等剂量Nis增加CO及CI不显著;两药对清醒兔MABP、HR和脑、心、肾、脾等局部血流量影响相似,对这些器官的血流分布及心输出量分布无明显影响。     

电针对家兔细胞免疫功能的影响

应用淋巴细胞转化试验和混合淋巴细胞培养试验观察电针对家兔细胞免疫功能的影响。经ＳＤ纯系大鼠胸腺匀浆致敏的２０只家兔分为实验组和对照组。实验每日电针足三里，三阴交３０ｍｉｎ共１５ｄ。对照组只针刺不通电。     

4'-甲基立可定对冠脉血流和家兔实验性心肌梗塞的影响

实验表明4′-甲基立可定具有增加家免冠脉血流量和小白鼠心肌营养性血流量的作用,但对家兔心肌收缩力和心率无明显影响。通过对家兔实验性心肌梗塞疗效的观察,证明4′-甲基立可定可改善结扎冠脉后引起的心电图变化,表现为∑ST明显降低,NST和TO显著减少,NBT染色法也证明用药后梗塞心肌的重量明显减轻。与立可定进行对比研究指出,二者作用基本相似,唯后者增加心肌营养性血流的作用不够明显。     

EFFECT OF LIGNOCAINE ON CORONARY BLOOD FLOW, SYSTOLIC MYOCARDIAL FUNCTION AND MYOCARDIAL HIGH ENERGY PHOSPHATE STORES IN SWINE

1. To investigate the effect of lignocaine upon coronary blood flow, myocardial systolic wall function and high energy phosphate stores, lignocaine was administered as a rapid intravenous injection to 14 open chest anaesthetized swine. 2. Before and after injection, measurements were made of coronary blood flow by electromagnetic flow probe, per cent wall thickening by ultrasonic crystals, adenosine triphosphate (ATP) and creatine phosphate (CP) content by myocardial biopsy, and arterial pressure by central aortic catheter. The animals were divided into two groups based on whether or not they received a continuous low-dose infusion of lignocaine prior to the study. Group I received the continuous low-dose infusion of lignocaine and group II did not. 3. With a 2 mg/kg lignocaine injection, peak diastolic coronary flow rose significantly in groups I and II by 27 +/- 7 and 29 +/- 7% respectively. This was followed by a significant decline in per cent wall thickening in groups I and II of -11 +/- 2 and -19 +/- 6% respectively. In group I myocardial CP content decreased after lignocaine injection by 58 +/- 6% and ATP tended to rise even though systolic and diastolic pressure did not change significantly. In group II neither CP nor ATP changed significantly, but systolic and diastolic blood pressure decreased significantly. 4. Repeat lignocaine injections were given over a wider dosage range (0.5-4.0 mg/kg) to determine dose-response for lignocaine versus coronary blood flow. Coronary blood flow increased and per cent wall thickening decreased as doses of lignocaine were increased. 5. It was concluded that rapid intravenous lignocaine injection appeared to cause a dose-dependent coronary dilatation and systolic dysfunction. Pre-treatment with low-dose continuous infusion of lignocaine appeared to result in a decrease in CP and a rise in ATP when compared with no pre-treatment--despite a similar effect on myocardial function and coronary blood flow.     

重组链激酶对大鼠凝血功能的影响及其毒性

重组链激酶以６、３０、１５０万ＩＵ／ｋｇ的剂量水平给大鼠腹腔注射，观察毒性反应。给药２８ｄ时，除各给药组凝血功能与对照组相比有不同程度的降低之外，其他无明显的毒性反应。凝血功能改变与剂量有关，并在停药１４ｄ后恢复，结果表明重组链激是一个毒性低的溶栓药。     

EFFECTS OF AE0047 ON CEREBRAL ISCHAEMIA AND OEDEMA AFTER MIDDLE CEREBRAL ARTERY OCCLUSION IN CATS

1. AE0047 is a new dihydropyridine calcium antagonist with protective effects against cerebral ischaemia and the occurrence of stroke in several animal models. 2. In the present study we investigated whether AE0047 would improve the reduced cerebral blood flow (CBF) and oedema formation in cats subjected to middle cerebral artery (MCA) occlusion and compared it for efficacy with other dihydropyridine calcium antagonists with different moieties, such as nilvadipine an. nicardipine. 3. Middle cerebral artery occlusion reduced local CBF (1CBF), as measured by the hydrogen clearance method, while dry weight measurement showed that water content in the cortical tissues surrounding each 1CBF measurement electrode had increased after 4 h ischaemia. 4. Both AE0047 (10 μg/kg) and nilvadipine (30 μg/kg), given intravenously 20min after MCA occlusion, produced an approximate 10. hypotensive response and significantly increased 1CBF in severely and moderately ischaemic regions, grouped according to the initial reduced flow values. However, nicardipine (5 μg/kg bolus followed by infusion of 3 μg/kg per min for 60 min) failed to mitigate the reduction in 1CBF despite an increase in the ICBF of the contralateral cortex. In addition, AE0047 tended to prevent an increase in cortical water content in severely ischaemic regions, whereas water content in both nilvadipine- and nicardipine-treated groups tended to increase. 5. These results suggest that dihydropyridine calcium antagonists act differently on cerebral ischaemia and oedema formation in a manner dependent on their side-chain structures and that AE0047 effectively attenuates ischaemic brain damage without aggravatin. oedema.