腹腔镜联合胃镜治疗邻近贲门或幽门的胃间质瘤

目的探讨腹腔镜联合胃镜行胃楔形切除治疗邻近贲门或幽门的胃间质瘤的安全性和可行性。方法2006年9月～2008年11月对5例特殊部位的胃间质瘤（3例肿瘤距离贲门≤5cm,2例距离幽门≤5cm）采用腹腔镜联合胃镜进行胃楔形切除。切割闭合器切除肿瘤过程中,胃镜于胃腔内实时观察和调整切割缘位置,避免损伤贲门或者幽门,确保肿瘤完整切除且胃腔无狭窄。结果5例均成功完成腹腔镜联合胃镜胃楔形切除,肿瘤完整切除,无肿瘤破裂,无胃腔狭窄,无中转开腹。手术时间60～110min,平均84min;术中出血量10～50ml,平均30ml。术后中位排气时间3d,中位进流食时间术后3d。术后病理切缘均为阴性。1例术后出现粘连性肠梗阻（经保守治疗后缓解）,其余4例未出现手术相关并发症。术后3个月行胃镜以及钡餐造影,无胃腔狭窄。5例平均随访27.8月（8～34个月）,未发现肿瘤复发和转移。结论对于邻近贲门或幽门的胃间质瘤,腹腔镜联合胃镜行胃楔形切除是安全和可行的,符合胃肠道间质瘤的治疗原则,可以避免胃腔狭窄。     

腹腔镜胃楔形切除术治疗胃底部间质瘤

目的:总结腹腔镜胃底楔形切除术治疗胃底部间质瘤的可行性及其临床应用价值。方法:采用4孔法。手术主要步骤为肿瘤定位、网膜游离、胃底和脾上极分离、食管贲门连接处(esophagocardiac junction,ECJ)显露以及用内视镜切割吻合器楔形切除胃底间质瘤。结果:79例手术均获成功,手术时间平均为(60.1±6.6)min;术中平均出血(56.2±6.7)ml。无病灶遗漏,也无并发症和手术中转。术后平均住院(4.6±0.5)d。78.5%病人于术后36 h内恢复胃肠功能,并开始进食和下床活动。结论:腹腔镜胃腔外胃底楔形切除术对胃底,尤其是对后壁近ECJ黏膜下肿瘤的治疗是安全、简便和有益的,可以避免腹腔污染、脾脏损伤以及术后食管狭窄的发生;同时,胃的切除范围也不受限。     

双镜联合技术在胃间质瘤切除术中的应用

目的探讨腹腔镜与胃镜双镜联合手术治疗胃间质瘤的可行性和安全性。方法对2003年12月至2009年12月间采用腹腔镜与胃镜双镜联合行胃间质瘤切除手术的23例患者的临床资料进行回顾性分析,其中18例行经胃镜定位腹腔镜胃腔外胃部分切除术、1例行经胃镜定位腹腔镜胃腔内胃部分切除术、4例行胃镜下肿瘤切除联合腹腔镜胃壁修补缝合术。结果 23例手术均获成功,无中转开腹,无手术死亡和并发症。手术时间30～95min,平均(66.5±20.1)min,术中出血量1~20ml,平均(12.0±17.1)m1,术后平均住院日(4.9±1.8)d。术后病理结果示:极低度风险15例、低度风险8例。随访3～75个月,无肿瘤复发和远处转移。结论腹腔镜和胃镜双镜联合手术治疗胃间质瘤是安全可行的,近期疗效令人满意,远期结果有待进一步观察。     

腹腔镜手术治疗胃间质瘤的临床研究

目的:探讨腹腔镜技术在胃间质瘤手术治疗中的临床应用价值。方法:回顾性分析2004年6月至2011年1月我院行腹腔镜胃间质瘤切除术68例病人的临床资料。包括手术时间、术中出血量、术后排气时间、术后住院天数、并发症、术后病理和随访等。结果:本组研究68例病人中,均在腹腔镜下顺利完成手术。腹腔镜胃楔形切除术34例(50%),腹腔镜经胃肿瘤外翻切除术32例(47.1%),腹腔镜辅助远端胃大部切除术1例(1.47%),腹腔镜辅助近端胃大部切除术1例(1.47%)。瘤体平均直径(3.2±1.6)cm,手术平均时间(83.0±27.5)min,术后平均出血量(29.0±23.7)mL,术后平均住院天数(7.5±1.4)d。并发症3例(4.4%),随访63例(92.6%),中位随访时间27个月,63例均无复发及远处转移,1例术后其他原因死亡。总生存率98.5%。结论:腹腔镜手术是治疗胃GIST安全、微创、有效的方法。     

腹腔镜胃间质瘤切除术32例报告

目的总结腹腔镜胃间质瘤切除术的手术要点。方法2005年9月～2007年9月,应用腹腔镜行胃间质瘤切除术32例。19例肿瘤位于胃体、胃底部前壁,术中胃镜定位,线形切割吻合器（Endo-GIA）在距肿瘤边缘2～3cm处将肿瘤从胃壁完整切除;8例肿瘤位于胃体或胃底后壁,术中胃镜定位,在肿瘤对应的前壁打开胃腔,与胃镜配合找到肿瘤后,将后壁肿瘤从胃前壁切口提出,用Endo-GIA在距肿瘤2～3cm处切除;2例肿瘤位于胃前壁,距贲门口〈2cm,直径分别约3.0cm、2.5cm,术中胃镜定位,打开对应的胃前壁浆膜,将肿瘤切除;1例肿瘤位于胃窦部前壁,直径约5.0cm,行腹腔镜辅助远端胃次全切除术;2例肿瘤位于胃体上段小弯侧,距贲门口〈2cm,直径分别约6.0cm、4.0cm,行腹腔镜辅助全胃切除术。结果32例均手术成功,平均手术时间82min（52～185min）,平均出血量60ml（30～210ml）,无中转开腹。手术标本病理切缘均为阴性,其中5例肿瘤最大直径〉5cm,术后病理报告为胃恶性间质瘤,余27例病理均为胃间质瘤、低度恶性倾向。术后平均随访12个月（8～25个月）,X线、B超及CT检查均无复发及远处转移。结论术前行胃镜、超声胃镜和CT等检查,以确定肿瘤来源、大小、部位。术中用胃镜、腹腔镜联合定位,根据肿瘤部位及大小不同,采用不同术式,以取得最好的疗效。     

腹腔镜手术治疗胃间叶源性肿瘤的临床研究

目的:探讨腹腔镜手术治疗胃间叶源性肿瘤的临床应用价值。方法:回顾性分析2008年3月至2010年10月间接受腹腔镜手术的35例胃间叶源性肿瘤病人的临床资料,包括手术方式、手术时间、术中出血量、术后住院时间、并发症、术后病理及随访结果等。结果:所有手术均在腹腔镜下完成,其中使用内镜下线型切割闭合器行腹腔镜胃部分切除术27例,腹腔镜辅助远端胃大部切除术4例,腹腔镜辅助近端胃大部切除术4例。8例手术采用术中胃镜的双镜治疗。无一例中转开腹手术。中位手术时间90(60~160)min,术中平均出血量(42.1±23.6)(10~200)mL,肿瘤平均大小(35.4±13.5)(10~62)mm,肿瘤切缘术中冷冻及术后石蜡病理均为阴性。术后病理胃间质瘤26例、胃神经鞘瘤5例、胃平滑肌瘤2例、胃脉管瘤1例、胃纤维母/肌纤维母细胞瘤1例。术后平均住院时间(6.3±1.3)(4~10)d,无术后并发症。术后中位随访时间22(12~43)个月,所有病人均无肿瘤复发及远处转移。结论:腹腔镜手术切除胃间叶源性肿瘤是安全、微创、有效的,应作为此类肿瘤治疗的首选方法。     

双镜联合治疗胃神经鞘瘤4例临床分析

目的:探讨腹腔镜联合胃镜治疗胃神经鞘瘤的临床应用。方法:回顾分析4例胃神经鞘瘤患者临床及诊疗资料。结果:4例患者术前均行胃镜及腹部CT检查(肿瘤直径均<3 cm),仅1例诊断为胃神经鞘瘤;联合腹腔镜及胃镜切除肿瘤,术中快速病理报告均诊为胃间质瘤;手术均顺利完成,手术平均时间(83±15)min;术中平均出血量(43±10)m L;无出血、狭窄等并发症;随访未出现复发及转移。术后病理诊断均为胃神经鞘瘤。结论:腹腔镜联合胃镜对直径<3 cm的胃神经鞘瘤是安全可行的,但术前诊断率仍有待提高。     

胃间质瘤的早期诊断及微创治疗

目的探讨胃镜、超声内镜、腹腔镜联合应用在小的胃间质瘤(直径5cm)诊断和治疗中的作用和价值。方法自2004年8月至2009年12月,对胃镜发现的胃黏膜下隆起性病变43例,进行超声内镜检查,初步诊断胃间质瘤29例(直径0.89~3.85cm,平均1.78cm)。随后在胃镜辅助定位下,行腹腔镜胃部分切除术。术后长期随访有无局部复发及远处转移。结果手术全部成功,手术时间35~90min,平均55min,无术后并发症及死亡病例。术后胃肠功能恢复时间18~36h,平均28h。住院时间3~5d,平均3.6d。术后病理诊断间质瘤者28例,神经鞘瘤1例,术前诊断符合率96.5%。28例胃间质瘤患者术后随访2~64个月,平均30个月,未发现肿瘤局部复发和转移。结论胃镜联合超声内镜有助于发现和诊断小的胃间质瘤,并可在术前初步判定其可切除性。在胃镜辅助定位下,行腹腔镜胃部分切除术治疗小的胃间质瘤安全、有效、预后良好。     

腹腔镜手术治疗胃间质瘤的疗效分析

目的:探讨腹腔镜手术治疗胃间质瘤的可行性及临床应用价值。方法:回顾分析2011年6月至2014年9月腹腔镜治疗胃间质瘤43例患者的临床资料。结果:1例发生肿瘤破裂、1例切口感染。无中转开腹及围手术期死亡病例,均未发生明显胃出血、吻合口狭窄、胃瘫及吻合口漏等严重并发症。其中腹腔镜胃楔形切除术21例,腹腔镜经胃肿瘤外翻切除术15例,腹腔镜辅助远端胃大部切除术4例,腹腔镜辅助近端胃大部切除术3例。手术时间50~192 min,平均(85.3±53.6)min;术中出血量20~150 ml,平均(80.6±42.3)ml;术后住院7~15 d,平均(9.1±4.7)d。肿瘤直径2.0~6.3 cm,平均(3.6±2.9)cm,切缘均阴性。免疫组化染色提示:CD117阳性41例,CD34阳性36例,DOG-1阳性42例。Fletcher风险分级:极低复发危险25例,低度复发危险13例,中度复发危险4例,高度复发危险1例。术后随访10~49个月,1例复发,余者均无肿瘤局部复发、远处转移。结论:在严格掌握适应证、丰富的开腹手术经验及熟练的腹腔镜手术技术基础上,腹腔镜手术治疗胃间质瘤是安全、可行的。     

腹腔镜胃间质瘤切除术23例

目的:探讨腹腔镜下胃间质瘤切除术的可行性及临床应用价值。方法:回顾分析23例腹腔镜下胃间质瘤切除术的手术方式、术中处理原则以及术后相关指标。结果:23例手术全部成功,平均手术时间(133±68)min,平均出血量40mL,术后平均肠道功能恢复时间(36.6±16.2)h,平均住院(8.1±3.0)d。结论:腹腔镜下胃切除术治疗胃间质瘤是安全、可行的,不同位置手术难易程度相差较大,位于后壁及近贲门部较大的间质瘤应格外慎重。     

Functional gastric bypass with an adjustable gastric band

Background: To create a bond between the technique proposed and the patient, flexibility and adaptability are indispensable.Thus, we devised the functional gastric bypass, which can be activated and deactivated by inflating or deflating the Lap-Band^?. Methods: The Lap-Band^? was positioned according to the standard technique, with the addition of a hand-sewn side-to-side gastroenterostomy between the gastric pouch and the intestine in the form of an Omega loop. Inflation or deflation of the Lap-Band^? allows activation or deactivation of the bypass. From October 1995 to December 2001, 545 Lap-Band^? operations were carried out. Between January 2001 and December 2001, functional gastric bypass was performed on 7 patients. Indications were: 1) prior failed Lap-Band^? treatment; 2) the first-choice operation for patients where non-restrictive surgery may be indicated. Results: There was no morbidity or mortality.The functioning bypass was confirmed radiologically and clinically. Conclusion: In morbid obesity characterized by a variable relationship with food, the flexibility of the functional bypass allows adaptation to changes in the pathology itself and in the individual patient, which other surgical techniques cannot do. Surgical indications, proven feasibility, safety and efficacy await long-term documentation.     

Metastatic ossified gastric carcinoid with hypergastrinemia associated with gastric and thyroid autoantibodies

A 42-year-old white woman was seen by her physician because of somatic complaints of the neck and right arm discomfort, difficulty in swallowing, and "heartburn." Findings of the workup led to the diagnosis of metastatic ossified gastric carcinoid. Review of the literature suggests that this is the third report of ossified gastric carcinoid. However, this is the only case in which such a tumor was associated with hypergastrinemia, gastric (antiparietal cell), and thyroid (antimicrosomal) autoantibodies.     

Clinical aspects with prognostic value in gastric cancer--analysis of 468 cases with gastric adenocarcinoma

The aim of this study is to assess clinico-pathological parameters and find out the correlation between them and their possible prognostic value. We made a retrospective analysis of a group of 468 patients with gastric adenocarcinoma which were operated in the 3rd Surgical Clinic--Cluj Napoca--01.01.1998-31.12.2003. The median age was 62 years. Patients in pTNM 0 stage were significantly younger than the rest of patients, with an average of 7.5 years. The male/female ratio was 1.7:1, this ratio being significantly higher in cases with proximal gastric cancers. There was not found any significant correlation between the interval : onset of symptoms and surgery, and pTNM stage. The most frequent signs and symptoms were epigastric pain, weight loss, indigestion, fatigue, pallor and loss of appetite, each of them were found in more than 40% patients. Multivariate analysis of symptoms showed that weight loss (p=0.00638) was independently correlated to advanced pTNM stages. The number of signs and symptoms was significantly correlated to advanced pTNM stages (p=0.000026). This significant group of patients studied has maintained characteristics encountered in populations with higher incidence of gastric adenocarcinoma, men being more frequently affected, distal localization and intestinal histologic type being encountered more frequently.     

Effectiveness of gastric devascularization and splenectomy for patients with gastric varices

BACKGROUND: Bleeding from gastric varices is difficult to control and has a high mortality rate. Recently, newly developed treatments for this serious lesion have been used, but surgical intervention is still advocated by several studies. We report our experience with gastric devascularization and splenectomy and its effectiveness for patients with gastric varices. STUDY DESIGN: Gastric devascularization and splenectomy was successfully performed to treat patients with isolated gastric varices (n = 42). The patients included 27 men and 15 women who ranged from 29 to 73 years of age (average 53.7 years). We analyzed the findings of gastric varices using endoscopy, the results of gastric devascularization and splenectomy, and survival after the operation. RESULTS: No patient had tortuous varices (F1). Twenty-seven patients (64.3%) had nodular varices (F2) and 15 (35.7%) had tumorous varices (F3). Twenty-five patients (59.5%) had large varices that occupied two or more areas. Twenty-nine patients (69.0%) had varices with a positive red color sign. No major complications during or after the operation were observed, and peri-operative death did not occur. Gastric varices were eradicated in all 42 patients. Survival rates were 97.6% after 1 year, 88.1% after 3 years, 76.2% after 5 years (mean followup period, 46 months). CONCLUSIONS: This study showed that gastric devascularization and splenectomy provides satisfactory results for patients with gastric varices that are likely to bleed and that it can be performed even on patients who have had other treatments.     

应激状态下胃黏膜损伤与胃排空及胃酸分泌的关系

目的 研究胃黏膜损伤的确切原因和具体过程,为临床防治胃黏膜损伤、胃炎、胃溃疡及胃癌提供新的理论依据.方法 以水浸-束缚应激(WRS)大鼠的方法,将144只Wistar大鼠随机分为9组,每组16只,A、B、c 3组用放射性核素99mTc灌胃测定大鼠胃液相排空率;D、E、F 3组采用手术清除胃内容物并幽门结扎测定胃酸分泌率;G、H、I 3组为手术不清除胃内容物并幽门结扎,评估胃黏膜损伤溃疡指数(UI);分析胃排空率、胃酸分泌和胃黏膜损伤之间的关系.结果 随着wRs时间延长,大鼠胃排空速率明显下降,B组(WRS 2 h)和c组(WRS 4 h)的胃排空速率与A组(正常对照组)相比,差异均有统计学意义(P＜0.01);C组与B组比较,差异有统计学意义(P＜0.01).大鼠胃酸分泌受到显著抑制,E组(WRS 2 h)和F组(WRS 4 h)的胃酸分泌率与D组(正常对照组)相比,差异均有统计学意义(P＜0.01);F组与E组比较,差异无统计学意义(P＞0.05).胃黏膜损伤随着应激时间的延长而加重,清除胃内容物可以有效防治应激引起的胃黏膜损伤,手术对本实验无明显影响.B、C组与A组的胃黏膜损伤UI比较,差异有统计学意义(P＜0.01);C组与B组比较,差异也有统计学意义(P＜0.01);A、D、E、F、G组大鼠未出现胃黏膜损伤,H与E组比较,差异有统计学意义(P＜0.01);I与F组比较,差异也有统计学意义(P＜0.01);A、D、E、F、G组间比较,差异无统计学意义(P＞0.05).H组与B组之间和I组与C组之间比较,差异有统计学意义(P＜0.01).结论 WRS可导致胃排空障碍、胃酸分泌减少和胃黏膜损伤.     

应激状态下胃黏膜损伤与胃排空及胃酸分泌的关系

目的研究胃黏膜损伤的确切原因和具体过程，为临床防治胃黏膜损伤、胃炎、胃溃疡及胃癌提供新的理论依据。方法以水浸-束缚应激（WRS）大鼠的方法，将144只Wistar大鼠随机分为9组，每组16只，A、B、C3组用放射性核素99m^Tc灌胃测定大鼠胃液相排空率；D、E、F3组采用手术清除胃内容物并幽门结扎测定胃酸分泌率；G、H、I3组为手术不清除胃内容物并幽门结扎，评估胃黏膜损伤溃疡指数（uI）；分析胃排空率、胃酸分泌和胃黏膜损伤之间的关系。结果随着WRS时间延长，大鼠胃排空速率明显下降，B组（WRS2h）和C组（WRS4h）的胃排空速率与A组（正常对照组）相比，差异均有统计学意义（P〈0．01）；C组与B组比较，差异有统计学意义（P〈0．01）。大鼠胃酸分泌受到显著抑制，E组（WRS2h）和F组（WRS4h）的胃酸分泌率与D组（正常对照组）相比，差异均有统计学意义（P〈0．01）；F组与E组比较，差异无统计学意义（P〉0．05）。胃黏膜损伤随着应激时间的延长而加重，清除胃内容物可以有效防治应激引起的胃黏膜损伤，手术对本实验无明显影响。B、C组与A组的胃黏膜损伤UI比较，差异有统计学意义（P〈0．01）；C组与B组比较，差异也有统计学意义（P〈0．01）；A、D、E、F、G组大鼠未出现胃黏膜损伤。H与E组比较，差异有统计学意义（P〈0．01）；I与F组比较，差异也有统计学意义（P〈0．01）；A、D、E、F、G组间比较，差异无统计学意义（P〉0．05）。H组与B组之间和I组与c组之间比较。差异有统计学意义（P〈0．01）。结论WRS可导致胃排空障碍、胃酸分泌减少和胃黏膜损伤。