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1.
Urmila Chandran Gary Zirpoli Gregory Ciupak Susan E. McCann Zhihong Gong Karen Pawlish Yong Lin Kitaw Demissie Christine B. Ambrosone Elisa V. Bandera 《Cancer causes & control : CCC》2013,24(12):2217-2229
Purpose
Research on the role of red meat and poultry consumption in breast carcinogenesis is inconclusive, but the evidence in African-American (AA) women is lacking. The association between consuming meat and breast cancer risk was examined in the Women’s Circle of Health Study involving 803 AA cases, 889 AA controls, 755 Caucasian cases, and 701 Caucasian controls.Methods
Dietary information was collected using a Food Frequency Questionnaire. Odds ratios (OR) and 95 % confidence intervals (CI) were obtained from logistic regression models adjusting for potential covariates.Results
Comparing the fourth versus the first quartiles, among Caucasian women, processed meat (OR = 1.48; 95 % CI 1.07–2.04), unprocessed red meat (OR = 1.40; 95 % CI 1.01–1.94), and poultry intakes (OR = 1.42; 95 % CI 1.01–1.99) increased breast cancer risk. Risk associated with poultry intake was more dominant in premenopausal women (OR = 2.33; 95 % CI 1.44–3.77) and for women with ER? tumors (OR = 2.55; 95 % CI 1.29–5.03) in the Caucasian group. Associations in AA women were mostly null except for a significant increased risk trend with processed meat consumption for ER+ tumors (OR = 1.36; 95 % CI 0.94–1.97, p trend = 0.04).Conclusions
Overall, associations between breast cancer risk and consumption of red meat and poultry were of different magnitude in AA and Caucasian women, with further differences noted by menopausal and hormone receptor status in Caucasian women. This is the first study to examine racial differences in meat and breast cancer risk and represents some of the first evidence in AA women. 相似文献2.
Dagfinn Aune Eduardo De Stefani Alvaro Ronco Paolo Boffetta Hugo Deneo-Pellegrini Giselle Acosta Maria Mendilaharsu 《Cancer causes & control : CCC》2009,20(9):1605-1615
Background
Previous studies have suggested that a high intake of legumes may decrease the risk of stomach and prostate cancer and some other cancers. However, the evidence is still limited. To further explore the association between legume intake and cancer risk we conducted a case–control study of 11 cancer sites in Uruguay between 1996 and 2004, including 3,539 cancer cases and 2,032 hospital controls.Results
The highest versus the lowest tertile of legume intake was associated with a significant decrease in the risk of cancers of the oral cavity and pharynx (OR = 0.48, 95% CI: 0.34–0.68), esophagus (OR = 0.54, 95% CI: 0.38–0.77), larynx (OR = 0.55, 95% CI: 0.40–0.77), upper aerodigestive tract (OR = 0.50, 95% CI: 0.40–0.63), stomach (OR = 0.69, 95% CI: 0.49–0.97), colorectum (OR = 0.43, 95% CI: 0.32–0.59), kidney (OR = 0.41, 95% CI: 0.24–0.71), and all sites combined (OR = 0.68, 95% CI: 0.59–0.78). No significant association was observed between legume intake and cancers of the lung (OR = 1.03, 95% CI: 0.83–1.27), breast (OR = 0.89, 95% CI: 0.65–1.20), prostate (OR = 0.87, 95% CI: 0.64–1.18) or bladder (OR = 0.82, 95% CI: 0.57–1.17). Similar results were found for both beans and lentils.Conclusion
Higher intake of legumes was associated with a decreased risk of several cancers including those of the upper aerodigestive tract, stomach, colorectum, and kidney, but not lung, breast, prostate or bladder. Further investigations of these associations in prospective cohort studies are warranted. 相似文献3.
Michelle C. Turner Daniel Krewski Bruce K. Armstrong Angela Chetrit Graham G. Giles Martine Hours Mary L. McBride Marie-Élise Parent Siegal Sadetzki Jack Siemiatycki Alistair Woodward Elisabeth Cardis 《Cancer causes & control : CCC》2013,24(5):949-960
Purpose
A history of allergy has been inversely associated with several types of cancer although the evidence is not entirely consistent. We examined the association between allergy history and risk of glioma, meningioma, acoustic neuroma, and parotid gland tumors using data on a large number of cases and controls from five INTERPHONE study countries (Australia, Canada, France, Israel, New Zealand), to better understand potential sources of bias in brain tumor case–control studies and to examine associations between allergy and tumor sites where few studies exist.Methods
A total of 793 glioma, 832 meningioma, 394 acoustic neuroma, and 84 parotid gland tumor cases were analyzed with 2,520 controls recruited during 2000–2004. Conditional logistic regression models were used to obtain odds ratios (ORs) and 95 % confidence intervals (CIs) for associations between self-reported allergy and tumor risk.Results
A significant inverse association was observed between a history of any allergy and glioma (OR = 0.73, 95 % CI 0.60–0.88), meningioma (OR = 0.77, 95 % CI 0.63–0.93), and acoustic neuroma (OR = 0.64, 95 % CI 0.49–0.83). Inverse associations were also observed with specific allergic conditions. However, inverse associations with asthma and hay fever strengthened with increasing age of allergy onset and weakened with longer time since onset. No overall association was observed for parotid gland tumors (OR = 1.21, 95 % CI 0.73–2.02).Conclusions
While allergy history might influence glioma, meningioma, and acoustic neuroma risk, the observed associations could be due to information or selection bias or reverse causality. 相似文献4.
Ji Hyun Song Young Sun Kim Sun Young Yang Su Jin Chung Min Jung Park Seon Hee Lim Jeong Yoon Yim Joo Sung Kim Hyun Chae Jung 《Cancer causes & control : CCC》2013,24(9):1717-1726
Purpose
To evaluate physical activity and other lifestyle risk factors in relation to the prevalence of colorectal adenomas in asymptomatic Koreans.Methods
A total of 1,526 asymptomatic subjects who underwent a colonoscopy were enrolled. Lifestyle factors such as physical activity and smoking data were obtained using a questionnaire. The subjects were grouped into three exposure levels by tertiles of metabolic equivalent hours per week. We evaluated the risk factors in subjects with adenomas by risk stratification (low-risk adenoma group vs. high-risk adenoma group) and by anatomic location (proximal colon, distal colon, rectum, and multiple locations). The high-risk adenoma group was defined as subjects with advanced adenomas or multiple (≥3) adenomas.Results
A total of 456 participants had colorectal adenomas, and 861 had no polyps. In multivariate analyses, higher levels of physical activity were associated with a significantly decreased risk of colorectal adenomas (OR = 0.56, 95 % CI 0.40–0.79). This inverse association was stronger for the risk of high-risk adenomas (OR = 0.39, 95 % CI 0.21–0.73) than for low-risk adenomas (OR = 0.62, 95 % CI 0.43–0.89). The negative relation of physical activity was significant for distal colon adenomas (OR = 0.54, 95 % CI 0.30–0.95) and the adenomas with multiple locations (OR = 0.39, 95 % CI 0.21–0.72).Conclusions
Increased physical activity is associated with a reduced prevalence of colorectal adenomas. The inverse association between physical activity and adenoma was stronger for the risk of advanced or multiple adenomas. 相似文献5.
Song Wang Yang Li Xiang-Dong Liu Chun-Xiong Zhao Kun-Qing Yang 《International journal of clinical oncology / Japan Society of Clinical Oncology》2013,18(4):666-669
Background
Previous studies have indicated a direct effect of μ-opioid receptors on tumor progression or recurrence. An A118G polymorphism in the μ-opioid receptor gene was believed to play an important role in this carcinogenic process. The aim of the present study was to investigate the association between the A118G polymorphism and the risk of esophageal squamous cell carcinoma (ESCC) in a Chinese population.Method
The case–control study included 260 cancer patients and 291 controls from a Chinese Han and Chinese TuJia population in Enshi region, China. Genotypes were determined by TaqMan platform. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated using multivariate unconditional logistic regression.Results
Compared with the G/G genotype, the A/A genotype exhibited a significantly elevated risk for ESCC (OR = 3.12, 95 % CI [1], 1.11–6.01). A significant interaction between the A118G polymorphism and age, smoking status, and family history of cancer was also found (OR = 2.25, 95 % CI 1.36–4.12; OR = 1.75, 95 % CI 1.23–2.32; OR = 3.14, 95 % CI 1.31–7.28, respectively).Conclusion
The A118G polymorphism in the μ-opioid receptor gene might be associated with the risk of ESCC in Chinese population. 相似文献6.
Fatima Isa Li-Ping Xie Zhiquan Hu Zhaohui Zhong Marjolein Hemelt Raoul C. Reulen Y. C. Wong Po-Chor Tam Kai Yang Chao Chai Xing Zeng Yilan Deng Wei-De Zhong Maurice P. Zeegers 《Cancer causes & control : CCC》2013,24(5):885-895
Background
The epidemiologic evidence on the role of dietary consumption on the risk of bladder cancer in the Chinese population is limited. We investigated the role of dietary consumption and diet diversity on the risk of developing bladder cancer within a Chinese population.Methods
A case–control study of 487 cases and 469 controls was conducted in four hospitals in China. A food frequency questionnaire was used to gather information on the consumption of 35 food items. Unconditional logistic regression models were used to derive odds ratios (ORs) and corresponding 95 % confidence intervals (95 % CI) for the relationship between dietary factors, dietary diversity scores, and bladder cancer.Results
The ORs of bladder cancer for red meat (OR = 1.8, 95 % CI:1.1–3.0;p trend = 0.01), organ meat (OR = 1.6, 95 % CI:0.9–2.9;p trend = 0.04), leafy vegetables (OR = 2.9, 95 % CI:1.6–5.4;p trend = 0.003), bulb vegetables (OR = 2.3, 95 % CI:1.3–4.0;p trend = 0.003), and preserved vegetables (OR = 2.3, 95 % CI:1.2–4.2;p trend = 0.02) were significantly increased when comparing the highest to lowest level of consumption. The ORs for white fresh fish (OR = 0.5, 95 % CI:0.3–0.9;p trend = 0.004), citrus fruits (OR = 0.4, 95 % CI:0.3–0.8;p trend = 0.007), stone fruits (OR = 0.4, 95 % CI:0.2–0.6;p trend < 0.001), vine fruits (OR = 0.5, 95 % CI:0.2–1.0;p trend = 0.02), flower vegetables (OR = 0.3, 95 % CI:0.2–0.6;p trend < 0.001), potatoes (OR = 0.4, 95 % CI:0.2–0.9;p trend = 0.005), or dairy products (OR = 0.4, 95 % CI:0.3–0.7;p trend < 0.001) were significantly decreased when comparing the highest to lowest level of consumption. Subjects with the highest total diet diversity (OR = 0.4, 95 % CI:0.2–1.1;p trend = 0.02) and fruit diversity (OR = 0.1, 95 % CI:0.0–0.3;p trend < 0.001) had reduced ORs of and compared to subjects with the lowest diversity.Conclusion
Our results indicate that a diet with higher total diet diversity and in particular fruit diversity may reduce the risk of bladder cancer. 相似文献7.
X.-P. Guo Y. Wang H. Zhao S.-D. Song J. Zhou Y. Han 《Clinical & translational oncology》2014,16(7):623-629
Objectives
To investigate the relationship of the MTHFR polymorphisms (C677T) and the risk of CRC by meta-analysis.Methods
Relevant literatures concerning the association between the MTHFR C677T polymorphism and the risk of CRC were searched using the electronic database PubMed, EMBASE, Cochrane and China National Knowledge Infrastructure (CNKI). Odds ratio (ORs) and 95 % confidence intervals (CIs) were determined to assess the gene–disease association using fixed or random effect models, according to the heterogeneity among included studies.Results
The study shows that the MTHFR 677 TT homozygous genotype significantly decreases the risk of CRC in Asians (TT vs. CC: OR = 0.82, 95 % CI 0.73–0.92; TT vs. CT: OR = 0.84, 95 % CI 0.75–0.94; TT vs. CC+TT: OR = 0.83, 95 % CI 0.75–0.93).Conclusion
This meta-analysis indicated that the MTHFR 677 TT homozygous genotype decreased the risk of CRC in Asians, while the MTHFR 677 CT heterozygous genotype did not contribute to CRC susceptibility. 相似文献8.
Wei Wang Lei Liu Zhiwei Wang Xiaopeng Lu Min Wei Tianlong Lin Yixin Zhang Songqi Jiang Qiang Wang Ziang Cao Minxin Shi 《Cancer causes & control : CCC》2014,25(10):1369-1377
Purpose
The association between ABO blood group and the risk of esophageal carcinoma (EC) in previously published studies is uncertain and conflicting. The aim of the current study was to determine the correlation of ABO blood group with EC risk via a case–control study and meta-analysis.Methods
We performed a population-based case–control study of 3,595 cases and 41,788 controls in Chinese population to evaluate the association between ABO blood group and EC risk. Then, a comprehensive meta-analysis combining our original data and previously published data was conducted to clearly discern the real relationship. The strength of association was measured by odds ratios (ORs) with 95 % confidence intervals (CI).Results
In our case–control study, the risk of EC in blood group B was significantly higher than that in non-B groups (A, O, and AB) (OR = 1.15, 95 % CI 1.09–1.21). Compared with non-O groups (A, B, and AB), individuals with blood group O demonstrated a reduced risk of EC (OR = 0.90, 95 % CI 0.85–0.94). The meta-analysis also indicated that blood group B was associated with significantly higher EC risk (OR = 1.20, 95 % CI 1.10–1.31), and people with blood group O had a decreased EC risk (OR = 0.94, 95 % CI 0.90–0.99). Neither the case–control study nor the meta-analysis produced any significant association of blood group A or AB with EC risk.Conclusion
Results from our case–control study and the followed meta-analysis confirmed that there was an increased risk of EC in blood group B individuals, whereas a decreased risk of EC was observed in blood group O individuals. 相似文献9.
Background
To investigate the associations between serum concentrations of carotenoids and the presence of colorectal polyps and cancers in Japanese using a cross-sectional study.Methods
893 subjects who underwent colorectal endoscopy between 2001 and 2002 provided serum samples and information on lifestyle factors. Serum concentrations of six carotenoids were compared among patients with polyps, cancers, and controls.Results
In males, high serum zeaxanthin was associated with decreased rates of polyps [odds ratio (OR) = 0.48, 95 % confidence interval (CI) 0.27–0.87] and cancer (OR = 0.35, 95 % CI 0.12–1.06), adjusting for age, body mass index, serum cholesterol, smoking status, and alcohol intake. In females, zeaxanthin (OR = 0.25, 95 % CI 0.07–0.82), lutein (OR = 0.30, 95 % CI 0.10–0.94), alpha-carotene (OR = 0.30, 95 % CI 0.10–0.90), and beta-carotene (OR = 0.27, 95 % CI 0.09–0.85) showed significant inverse associations with cancer development. These associations were consistent with findings of inverse associations between the ingestion of green–yellow vegetables (OR = 0.44, 95 % CI 0.23–0.84), carrots and pumpkins (OR = 0.46, 95 % CI 0.25–0.86), and fruits (OR = 0.53, 95 % CI 0.30–0.94) and polyp in males, and between carrots and pumpkins (OR = 0.30, 95 % CI 0.09–0.99), legumes (OR = 0.14, 95 % CI 0.04–0.44), and seaweed (OR = 0.23, 95 % CI 0.07–0.75) and cancer development in females.Conclusions
These results provide further support for the protective effects of carotenoids contained in green–yellow vegetables and fruits against colorectal neoplasm in Japanese.10.
Elizabeth C. Lowcock Michelle Cotterchio Beatrice A. Boucher 《Cancer causes & control : CCC》2013,24(4):813-816
Purpose
To investigate the association between intake of flaxseed—the richest source of dietary lignans (a class of phytoestrogens)—and breast cancer risk.Methods
A food frequency questionnaire was used to measure the consumption of flaxseed and flax bread by 2,999 women with breast cancer and 3,370 healthy control women who participated in the Ontario Women’s Diet and Health Study (2002–2003). Logistic regression was used to investigate associations between consumption of flaxseed and flax bread and breast cancer risk. Confounding by established and suspected breast cancer risk factors, as well as dietary factors, was assessed.Results
Flaxseed or flax bread was consumed at least weekly by 21 % of control women. None of the 19 variables assessed were identified as confounders of the associations between flaxseed or flax bread and breast cancer risk. Consumption of flaxseed was associated with a significant reduction in breast cancer risk (odds ratio (OR) = 0.82, 95 % confidence interval (CI) 0.69–0.97), as was consumption of flax bread (OR = 0.77, 95 % CI 0.67–0.89).Conclusions
This Canadian study is, to our knowledge, the first to report on the association between flaxseed alone and breast cancer risk and has found that flaxseed intake is associated with a reduction in breast cancer risk. As dietary intake of flaxseed is modifiable, this finding may be of public health importance with respect to breast cancer prevention. 相似文献11.
Melissa N. Eliot Dominique S. Michaud Scott M. Langevin Michael D. McClean Karl T. Kelsey 《Cancer causes & control : CCC》2013,24(7):1315-1322
Purpose
The purpose of this study was to examine associations between oral hygiene, including history of periodontal disease and mouthwash use, and risk of head and neck squamous cell carcinoma (HNSCC).Methods
We measured history of oral hygiene and dental care on 513 HNSCC cases and 567 controls from a population-based study of HNSCC. Logistic regression was used to estimate odds ratios (ORs) and 95 % confidence intervals (95 % CI).Results
Periodontal disease was associated with a slightly elevated risk of HNSCC (OR = 1.09, 95 % CI: 1.02, 1.16). Using any type of mouthwash at least once per day was associated with increased risk compared to never using mouthwash (OR = 1.11, 95 % CI: 1.02, 1.20). HNSCC was associated with frequent use of non-alcoholic mouthwash compared to using any kind of mouthwash rarely or never (OR = 1.24, 95 % CI: 1.05, 1.47).Conclusions
Our results support an association between periodontal disease and HNSCC. Our data suggest that mouthwash use is associated with HNSCC, but we noted no difference between the effects of alcohol-containing and non-alcoholic mouthwashes. 相似文献12.
Michelle K. McHugh Sumesh Kachroo Mei Liu Anthony M. D’Amelio Jr. Qiong Dong Waun Ki Hong Anthony J. Greisinger Margaret R. Spitz Carol J. Etzel 《Cancer causes & control : CCC》2010,21(12):2157-2164
Background
We investigated environmental and occupational exposures and smoking history (while controlling for demographics) in a population of Mexican–American lung cancer cases and controls from the Houston metropolitan area.Methods
Data were collected between 1991 and 2005 as part of an on-going multi-racial/ethnic, lung cancer case–control study. Cases included 212 Mexican–American lung cancer cases from UT MD Anderson Cancer Center. Controls (n = 328) were recruited from Houston’s largest multispecialty group practice and frequency matched to the cases by age (±5 years), sex, and ethnicity. Environmental and occupational factors were analyzed and odds ratios and 95% confidence intervals were calculated using logistic regression.Results
We detected elevated risks of lung cancer associated with pesticide exposure and found conventional and antimicrobial (e.g., sterilizers, disinfectants, antiseptics) pesticides were associated with an increased risk of lung cancer in Mexican–Americans (conventional pesticides and antimicrobial pesticides combined: OR = 1.80, 95% CI 1.13–2.86; conventional pesticides: OR = 2.05, 95% CI 1.23–2.39; antimicrobial pesticides: OR = 2.48, 95% CI 1.46–4.21).Conclusions
Although we found over a two-fold increased risk of lung cancer among Mexican–Americans for pesticides, we could not identify individual pesticides. Our findings are an important preliminary step in identifying factors that are specifically associated with lung cancer risk among Mexican Americans. 相似文献13.
Gabriella M. Anic Melissa H. Madden Reid C. Thompson L. Burton Nabors Jeffrey J. Olson Renato V. LaRocca James E. Browning John D. Brockman Peter A. Forsyth Kathleen M. Egan 《Cancer causes & control : CCC》2013,24(12):2051-2058
Purpose
Iron is essential for oxygen transport and oxidative metabolism; however, elevated iron stores can trigger overproduction of reactive oxygen species and induce DNA damage. Little is known about the association between body iron stores and glioma risk. This study examined the associations of iron levels measured in toenails and genetic variants linked to body iron stores with risk of glioma in a clinic-based case–control study.Methods
Samples were collected a median of 24 days following glioma diagnosis in the cases (10th–90th percentile, range: 10–44 days). Nail iron levels were measured in 300 cases and 300 controls using neutron activation analysis. A total of 24 genetic variants associated with iron status were genotyped in 622 cases and 628 controls. Logistic regression was used to estimate odds ratios (OR) and 95 % confidence intervals (CI) for glioma risk according to toenail iron and the examined genotypes.Results
No association was observed between toenail iron and glioma risk when restricting to cases with nails collected within ~3 weeks of diagnosis (OR = 0.93; 95 % CI 0.46, 1.87 comparing those with high (≥14 μg/g) vs. low (<6 μg/g) iron levels). In contrast, an inverse association with increasing iron was observed after restricting to cases with a delay of 3 weeks or greater (OR = 0.42; 95 % CI 0.19, 0.95), reflecting potentially insidious effects of advancing disease on iron levels among the cases. No associations were observed for any of the examined genetic variants.Conclusion
The results do not support a role for body iron stores as a determinant of glioma risk. 相似文献14.
Magdalena Lagerlund Jessica M. Sontrop Sophia Zackrisson 《Cancer causes & control : CCC》2013,24(9):1687-1694
Purpose
To determine whether reproductive and hormonal risk factors for breast cancer associate with mammography attendance.Methods
We linked data from the Malmö Diet and Cancer Study to the Malmö mammography register (Sweden, 1992–2009). We analyzed 11,409 women (age 44–72) who were free of breast cancer at study entry and a total of 69,746 screening invitations. Generalized Estimating Equations were used to account for repeated measures within subjects. Models were adjusted for age and other sociodemographic factors.Results
In this study cohort, mammography screening attendance ranged from 87.6 to 94.5 % between calendar years, with an average attendance of 92 %. Higher attendance was found among women who had given birth to fewer than three children (ORs ranging between 1.15 and 1.37) and had used oral contraceptives (OC) within the last decade (OR = 1.22, 95 % CI 1.07–1.38) and for a longer period (OR = 1.13, 95 % CI 1.01–1.27). A lower odds of attendance was found among post-menopausal women (OR = 0.86, 95 % CI 0.77–0.96). Age <13 at menarche, age ≥30 at first childbirth, age ≥55 at menopause, age <20 at first OC use, nulliparity, breastfeeding, and hormone replacement therapy were not associated with mammography attendance.Conclusion
Reproductive and hormonal risk factors for breast cancer have little effect on mammography screening attendance. This may indicate a potential for under-screening of some women at higher risk. 相似文献15.
Christina B. Rasmussen Mette T. Faber Allan Jensen Estrid Høgdall Claus Høgdall Jan Blaakær Susanne K. Kjaer 《Cancer causes & control : CCC》2013,24(7):1459-1464
Purpose
The aim of the study was to examine the potential association between a history of pelvic inflammatory disease (PID) and risk of epithelial ovarian cancer or ovarian borderline tumors.Methods
In a population-based case–control study in Denmark, we included 554 women with invasive ovarian cancer, 202 with ovarian borderline tumors, and 1,564 controls aged 35–79 years. The analyses were performed in multiple logistic regression models.Results
We found a significantly increased risk of ovarian borderline tumors among women with a history of PID (OR = 1.50; 95 % CI 1.08–2.08) but no apparent association between PID and risk of invasive ovarian cancer (OR = 0.83; 95 % CI 0.65–1.05). We found no effect of age at time of first PID or time since first PID on the risk for either condition.Conclusion
Our results suggest that a history of PID is associated with an increased risk of ovarian borderline tumors, which may support the hypothesis that inflammation is an etiological factor. The lack of an association between previous PID and invasive ovarian cancer may indicate an etiological difference between ovarian borderline tumors and invasive ovarian cancer. However, an important limitation of the study is the use of self-reported PID. 相似文献16.
Qian Li Qing Lan Yawei Zhang Bryan A. Bassig Theodore R. Holford Brian Leaderer Peter Boyle Yong Zhu Qin Qin Stephen Chanock Nathaniel Rothman Tongzhang Zheng 《Cancer causes & control : CCC》2013,24(10):1875-1884
Purpose
Genetic polymorphisms in one-carbon metabolizing pathway genes have been associated with risk of malignant lymphoma. However, the results have been inconsistent. The objectives of this study were to examine the potential relationship between gene–nutrient interactions and the risk of non-Hodgkin lymphoma (NHL).Methods
We examined 25 polymorphisms in 16 one-carbon metabolism genes for their main effect and gene–nutrient interactions in relation to NHL risk among 518 incident cases and 597 population-based controls of Connecticut women enrolled between 1996 and 2000.Results
A significantly reduced risk of NHL was associated with the homozygous TT genotype in CBS (rs234706, Ex9+33C>T) (OR = 0.51, 95 % CI 0.31–0.84), the homozygous CC genotype in MBD2 (rs603097, ?2176C>T) (OR = 0.37, 95 % CI 0.17–0.79), the heterozygote AG genotype in FTHFD (rs1127717, Ex21+31A>G) (OR = 0.73, 95 % CI 0.55–0.98), and a borderline significantly reduced risk of NHL was observed for the homozygous CC genotype in MTRR (rs161870, Ex5+136T>C) (OR = 0.23, 95 % CI 0.05–1.04). The reduced risk of NHL associated with these genotypes was predominately in those with higher dietary vitamin B6 and methionine intakes, as well as with higher dietary folate intake although results were less stable. A borderline significantly increased risk of NHL was also observed for CBS (rs1801181, Ex13+41C>T), FTHFD (rs2305230, Ex10?40G>T), SHMT1 (rs1979277, Ex12+138C>T), and SHMT1 (rs1979276, Ex12+236T>C), and these associations appeared to be contingent on dietary nutrient intakes.Conclusion
Our results suggest that variation in several one-carbon metabolizing pathway genes may influence the risk of NHL through gene–nutrient interactions involving dietary nutrient intakes. 相似文献17.
Andrew Rundle Kathryn M. Neckerman Daniel Sheehan Michelle Jankowski Oleksandr N. Kryvenko Deliang Tang Benjamin A. Rybicki 《Cancer causes & control : CCC》2013,24(2):297-303
Purpose
Higher socioeconomic status (SES) men are at higher risk of prostate cancer (PCa) diagnosis, an association commonly interpreted as a function of higher rates of prostate screening among higher SES men. However, the extent to which screening explains this association has not been well quantified.Methods
Within a Detroit area cohort of 6,692 men followed up after a benign prostate procedure, a case–control study was conducted of 494 PCa cases and controls matched on age, race, duration of follow-up, and date of initial benign finding; 2000 Census data were used in a principal component analysis to derive a single factor, labeled the neighborhood SES index (NSESI), representing zip code-level SES.Results
Among cases, higher SES was associated with a younger age at initial biopsy: ?1.48 years (95 % CI, ?2.32, ?0.64) per unit NSESI. After adjustment for confounders and duration of follow-up, higher SES was associated with more PSA tests and DRE during follow-up; 9 % (95 % CI, 2, 16) and 8 % (95 % CI, 1, 15) more respectively, per unit NSESI. Higher SES was associated with a higher risk of PCa diagnosis during follow-up, multivariable adjusted OR = 1.26 per unit increase in NSESI (95 % CI, 1.04, 1.49). Further adjustment for screening frequency somewhat reduced the association between SES and PCa risk (OR = 1.19 per unit NSESI, 95 % CI, 0.98, 1.44).Conclusions
Differences in screening frequency only partially explained the association between higher zip code SES and PCa risk; other health care-related factors should also be considered as explanatory factors. 相似文献18.
María Elena Martínez Scarlett L. Gomez Li Tao Rosemary Cress Danielle Rodriguez Jonathan Unkart Richard Schwab Jesse N. Nodora Linda Cook Ian Komenaka Christopher Li 《Breast cancer research and treatment》2017,166(1):185-193
Purpose
To assess tumor subtype distribution and the relative contribution of clinical and sociodemographic factors on breast cancer survival between Hispanic and non-Hispanic whites (NHWs).Methods
We analyzed data from the California Cancer Registry, which included 29,626 Hispanic and 99,862 NHW female invasive breast cancer cases diagnosed from 2004 to 2014. Logistic regression was used to assess ethnic differences in tumor subtype, and Cox proportional hazard modeling to assess differences in breast cancer survival.Results
Hispanics compared to NHWs had higher odds of having triple-negative (OR = 1.29; 95% CI 1.23–1.35) and HER2-overexpressing tumors (OR = 1.19; 95% CI 1.14–1.25 [HR?] and OR = 1.39; 95% CI 1.31–1.48 [HR+]). In adjusted models, Hispanic women had a higher risk of breast cancer mortality than NHW women (mortality rate ratio [MRR] = 1.24; 95% CI 1.19–1.28). Clinical factors accounted for most of the mortality difference (MRR = 1.05; 95% CI 1.01–1.09); however, neighborhood socioeconomic status (SES) and health insurance together accounted for all of the mortality difference (MRR = 1.01; 95% CI 0.97–1.05).Conclusions
Addressing SES disparities, including increasing access to health care, may be critical to overcoming poorer breast cancer outcomes in Hispanics.19.
Constance M. Johnson Caimiao Wei Joe E. Ensor Derek J. Smolenski Christopher I. Amos Bernard Levin Donald A. Berry 《Cancer causes & control : CCC》2013,24(6):1207-1222
Purpose
Demographic, behavioral, and environmental factors have been associated with increased risk of colorectal cancer (CRC). We reviewed the published evidence and explored associations between risk factors and CRC incidence.Methods
We identified 12 established non-screening CRC risk factors and performed a comprehensive review and meta-analyses to quantify each factor’s impact on CRC risk. We used random-effects models of the logarithms of risks across studies: inverse-variance weighted averages for dichotomous factors and generalized least squares for dose–response for multi-level factors.Results
Significant risk factors include inflammatory bowel disease (RR = 2.93, 95 % CI 1.79–4.81); CRC history in first-degree relative (RR = 1.80, 95 % CI 1.61–2.02); body mass index (BMI) to overall population (RR = 1.10 per 8 kg/m2 increase, 95 % CI 1.08–1.12); physical activity (RR = 0.88, 95 % CI 0.86–0.91 for 2 standard deviations increased physical activity score); cigarette smoking (RR = 1.06, 95 % CI 1.03–1.08 for 5 pack-years); and consumption of red meat (RR = 1.13, 95 % CI 1.09–1.16 for 5 servings/week), fruit (RR = 0.85, 95 % CI 0.75–0.96 for 3 servings/day), and vegetables (RR = 0.86, 95 % CI 0.78–0.94 for 5 servings/day).Conclusions
We developed a comprehensive risk modeling strategy that incorporates multiple effects to predict an individual’s risk of developing CRC. Inflammatory bowel disease and history of CRC in first-degree relatives are associated with much higher risk of CRC. Increased BMI, red meat intake, cigarette smoking, low physical activity, low vegetable consumption, and low fruit consumption were associated with moderately increased risk of CRC. 相似文献20.
Brigid M. Lynch Kerry S. Courneya Christine M. Friedenreich 《Cancer causes & control : CCC》2013,24(6):1257-1262