Ultrasound biomicroscopic study of ciliary body thickness in eyes with narrow angles

PURPOSE:To determine the ciliary body thickness and other biometric findings in eyes with narrow angles.METHODS:Eighteen otherwise normal eyes with narrow angles in 18 Japanese patients and 18 normal control eyes with open angles in 18 age-matched and sex-matched Japanese patients were studied. A-scan ultrasonography was performed to measure anterior chamber depth, lens thickness, axial length, and relative lens position. Ultrasound biomicroscopy was also performed to obtain measurements of the anterior ocular structures, including anterior chamber depth and ciliary body thickness at sites 1 mm and 2 mm posterior to the scleral spur (positions 1 and 2, respectively). RESULTS:Compared with normal control eyes, the narrow-angle eyes showed a shallower anterior chamber (narrow angle, 1.87 +/- 0.27 mm; control, 2.69 +/- 0.26 mm; P <.0001), a thicker lens (4.97 +/- 0.49 mm, 4.26 +/- 0.53 mm; P <.0001), a more anteriorly located lens (2. 21 +/- 0.13, 2.35 +/- 0.14; P <.0001), a shorter axial length (22.70 +/- 0.97 mm, 23.41 +/- 0.86 mm; P =.012), and a thinner ciliary body (position 1: 454 +/- 107 microm, 602 +/- 86 microm; P <.0001; position 2: 203 +/- 50 microm, 321 +/- 68 microm; P <.0001). Lens thickness was significantly correlated with ciliary body thickness at positions 1 (R(2) = 0.34; P =.0001) and 2 (R(2) = 0.43; P <.0001). Anterior chamber depth was significantly correlated with ciliary body thickness at positions 1 (R(2) = 0.48; P <.0001) and 2 (R(2) = 0.56; P <.0001).CONCLUSION:Thinning of the ciliary body may be one of the important factors associated with the anterior location of the lens, the increased lens thickness, and the decreased anterior chamber depth in eyes with a narrow angle.     

Iridociliary apposition in plateau iris syndrome persists after cataract extraction

PURPOSE: To evaluate the ultrasound biomicroscopic appearance of the anterior segment before and after cataract extraction in eyes with plateau iris syndrome and to determine the effect of postoperative zonular relaxation on ciliary body position. DESIGN: Interventional case series. METHODS: Eyes with plateau iris syndrome scanned before and after cataract extraction between January 1994 and September 2001 were enrolled. The iridociliary relationship and the anterior chamber depth at a distance of 3 mm from the scleral spur were assessed. RESULTS: We examined six eyes of six patients. Mean patient age was 74.2 +/- 6.4 years (standard deviation [SD]) (range, 65-81 years). Mean refractive error was + 1.0 +/- 3.9 diopters [D] (range, -5.75-+5.50), and mean axial length was 21.85 +/- 0.77 mm (range, 20.90-22.95 mm). All eyes had undergone laser iridotomy and argon laser peripheral iridoplasty before cataract extraction. Ultrasound biomicroscopy examination revealed a narrow angle and absence of a ciliary body sulcus in all eyes with focal areas of iridotrabecular apposition in three eyes. Following cataract extraction, the anterior chamber depth increased (P =.0006, paired t test), while the iridociliary contact remained unchanged. CONCLUSIONS: Iridociliary apposition persists after cataract extraction in plateau iris syndrome. Whether the cause is congenital or acquired, or both, remains to be determined.     

应用超声生物显微镜研究睫状肌麻痹剂对眼前节结构的影响

目的应用超声生物显微镜观察局部应用睫状肌麻痹剂前、后眼前节形态结构的改变及其与眼压的关系,同时对睫状体厚度、睫状体晶体赤道部距离进行观察。方法以４８只正常眼为研究对象,在局部应用２％后马托品前、后分别进行眼前节结构的超声生物显微镜定量测定,并测量眼压。对其结果进行统计学分析。结果用药后在反映房角改变的参数中,小梁虹膜夹角减小,房角开放距离２５０减小,虹膜厚度１增厚,前房加深,虹膜晶体接触距离缩短,差异均有显著性（Ｐ＜０．０５）;在反映睫状体改变的参数中,睫状体和睫状突的厚度减小,巩膜睫状体夹角增大,虹膜悬韧带距离减小,睫状体晶体距离增大,差异有显著性（Ｐ＜０．０５）。应用睫状肌麻痹剂后,眼压由２．３５±０．４６ｋＰａ（１ｋＰａ＝７．５ｍｍＨｇ）升高至２．４３±０．４７ｋＰａ,但差异无显著性（Ｐ＞０．０５）。结论局部应用睫状肌麻痹剂后,前房加深、房角变窄、睫状体变薄且向后运动、睫状体晶体距离增大。超声生物显微镜能动态观察眼前节结构的改变并行定量测定,在眼前节形态学研究中具有优越性。     

Narrowing of the anterior chamber angle during Valsalva maneuver: a possible mechanism for angle closure

PURPOSE: To evaluate changes at the anterior chamber angle during Valsalva maneuver in eyes suspected to have a primary adult glaucoma. METHODS: Seventy-six consecutive patients underwent recording of applanation tonometry, measurement of the anterior chamber angle recess, angle opening distance, angle recess area, scleral spur-iris root distance, iris thickness, iridociliary angle, ciliary body thickness, anterior chamber depth, and pupil size on ultrasound biomicroscopy before and during the Valsalva maneuver. The Valsalva maneuver was standardized to a pressure of 40 mmHg for 15 seconds, using a manometer. RESULTS: The mean baseline intraocular pressure changed from 19.5+/-4.1 mmHg to 29.5+/-4.8 mmHg during Valsalva (p<0.0001). The anterior chamber angle recess narrowed from 17.9+/-9.5 to 7.8+/-9.2 degrees (p=0.0001). The angle recess area diminished from 0.15+/-0.14 mm2 to 0.14+/-0.12 mm2 (p=0.03) and the scleral spur to iris distance decreased from 0.19+/-0.2 mm to 0.16+/-0.18 mm (p=0.0001). The iridociliary angle narrowed from 72.6+/-33.5 degrees to 62.5+/-32.8 degrees (p=0.04). There was a significant increase in the thickness of the ciliary body, from 0.99+/-0.19 mm to 1.12+/-0.16 mm (p=0.001) and in iris thickness from 0.47+/-0.07 mm to 0.55+/-0.09 mm (p=0.0001). There was no significant change in the angle opening distance, anterior chamber depth, or pupillary diameter. A significant narrowing of the angle to less than 5 degrees was seen in 37 eyes, with iridocorneal apposition present in 28 eyes. After multivariate regression analysis it was found that the baseline ciliary body thickness and angle recess were significant predictors of narrowing of the angle (R2=96.1%). CONCLUSIONS: Significant elevation of the intraocular pressure, narrowing of the anterior chamber angle recess, thickening of the ciliary body, and increase in the iris thickness is seen during the Valsalva maneuver. The Valsalva maneuver may lead to angle closure in eyes anatomically predisposed to primary angle closure glaucoma.     

Ultrasound biomicroscopic characteristics of the anterior segment in primary congenital glaucoma

PURPOSE: To evaluate qualitatively and quantitatively ultrasound biomicroscopic (UBM) features of the anterior segment in eyes with primary congenital glaucoma. METHODS: UBM of 45 eyes of patients with primary congenital glaucoma (39 previously operated and 6 unoperated eyes) and 28 control eyes were included in this study. UBM parameters were correlated with ocular biometry. Iris thickness, ciliary body thickness, ciliary body-lens distance, posterior chamber depth, and anterior chamber angle were measured and compared with control eyes. Other features of the anterior segment were qualitatively evaluated. RESULTS: A thin, stretched-out ciliary body and abnormal tissue at the iridocorneal angle were features seen in 90% of UBM scans. Iris thickness and stretched zonules correlated with the axial length (r = -0.6 and 0.58, respectively; p = 0.04) but not with the mean corneal diameter. Abnormal insertion of the ciliary body to the posterior surface of the iris was noted in eight eyes (17%). CONCLUSIONS: The present study documents characteristic anterior segment dysplasia and ciliary body anomalies in patients with primary congenital glaucoma.     

Accommodative ciliary body and lens function in rhesus monkeys, I: normal lens, zonule and ciliary process configuration in the iridectomized eye

PURPOSE: The underlying causes of presbyopia, and the functional relationship between the ciliary muscle and lens during aging are unclear. In the current study, these relationships were studied in rhesus monkeys, whose accommodative apparatus and age-related loss of accommodation are similar to those in humans. METHODS: Centripetal ciliary body and lens equator movements were measured during accommodation in 28 eyes of 21 rhesus monkeys (ages, 5.7-26 years) by goniovideography. Ultrasound biomicroscopy was performed in 21 eyes of 17 monkeys. Narrowing of the angle between the anterior aspect of the ciliary body and the inner aspect of the cornea was used as a surrogate indicator of forward ciliary body movement during accommodation. RESULTS: Average centripetal ciliary body movement in older eyes (age > or =17 years, n = 16) was approximately 20% (0.09 mm) less than in young eyes (age, 6-10 years, n = 6), but not enough to explain the 60% (0.21 mm) loss in centripetal lens movement nor the 76% (10.2 D) loss in accommodative amplitude. Average forward ciliary body movement was 67% (49 degrees ) less in older (n = 11) versus young (n = 6) eyes. Maximum accommodative amplitude correlated significantly with the amplitude of centripetal lens movement (0.02 +/- 0.003 mm/D; n = 28; P < 0.001) and with forward ciliary body movement (3.34 +/- 0.54 deg/D; n = 21; P = 0.01). CONCLUSIONS: Decreased lens movement with age could be in part secondary to extralenticular age-related changes, such as loss of ciliary body forward movement. Ciliary body centripetal movement may not be the limiting component in accommodation in the older eye.     

闭角型青光眼中虹膜睫状体囊肿的发病情况

目的:观察闭角型青光眼中虹膜睫状体囊肿的发病情况,虹膜睫状体囊肿与前房轴深、房角的关系。方法:利用超声生物显微镜(UBM)对闭角型青光眼患者740例1057眼进行眼前节检查。结果:闭角型青光眼740例1057眼中检出合并虹膜睫状体囊肿者42例60眼,占被检眼数的5.68%。60眼虹膜睫状体囊肿中虹膜睫状沟囊肿56眼(93.33%),睫状冠囊肿4眼(6.67%);其中单发囊肿33眼(55.00%),多发囊肿27眼(45.00%)。不伴有虹膜睫状体囊肿的患者前房轴深1.16～2.37(平均1.843)mm;合并有虹膜睫状体囊肿的患者前房轴深1.67～2.78(平均2.297)mm。伴有及不伴有虹膜睫状体囊肿的闭角型青光眼患者房角粘连>2个象限的比率分别为66.67%和44.59%。结论:虹膜睫状体囊肿在闭角型青光眼中的发病率较高,多为虹膜睫状沟囊肿,对前房轴深影响不大,但可以增加房角粘连范围,引起闭角型青光眼。     

Variability of axial length, anterior chamber depth, and lens thickness in the cataractous eye

PURPOSE: To review and evaluate the biometry measurements in 750 eyes (first eye developing cataract) of 750 consecutive patients with no retinal pathology. SETTING: Private practice, Lynwood, California, USA. METHODS: All measurements were performed with the I3 system A-scan (Innovative Imaging, Inc.) using an immersion technique. The axial length (AL), anterior chamber depth (ACD), and lens thickness (LT) measurements were evaluated in relation to each other and in relation to age, sex, and keratometric readings. RESULTS: The mean AL was 23.46 mm +/- 1.03 (SD), the mean ACD was 2.96 +/- 0.45 mm, and the mean LT was 4.93 +/- 0.56 mm. Men presented for surgery at an earlier age than women (mean 73 +/- 9.41 years versus 75 +/- 8.55 years) with a longer AL (23.76 +/- 1.00 mm versus 23.27 +/- 1.01 mm). The AL tended to be longer in younger patients (r = -0.127; P<.001); the ACD tended to be deeper in younger patients (r = -0.250; P<.001) and in longer eyes (r = 0.423; P<.001). The LT tended to be thicker in older patients (r = 0.385; P<.001) and in shorter eyes (r = -0.179; P<.001), with large scatter in the distribution. CONCLUSIONS: There was a positive correlation between AL and ACD and an inverse correlation between AL and LT. Also, AL was inversely correlated with age and corneal power.     

A case of angle closure glaucoma caused by plateau iris and adie's pupil

PURPOSE: To describe a case of plateau iris associated with bilateral Adie's pupil. DESIGN: Interventional case report. METHODS: A 54-year-old woman presented with pain in her right eye and headache. Intraocular pressure was 34 mm Hg in the right eye. Light reflex was defective bilaterally. RESULTS: Ultrasound biomicroscopic imaging revealed normal anterior chamber depth and narrow angle. The ciliary processes were situated anteriorly. The eyes showed supersensitivity to 0.125% pilocarpine. The patient was diagnosed as having bilateral angle-closure glaucoma induced by Adie's pupil and plateau iris. CONCLUSION: Mild pupillary dilation caused by Adie's pupil may have played a role in the development of angle closure in the plateau iris configuration of our patient.     

The effect of cataract extraction on the contractility of ciliary muscle

PURPOSE: To evaluate the changes in the pilocarpine-induced contractility of the ciliary muscle in eyes with presbyopia before and after cataract extraction using ultrasound biomicroscopy (UBM). DESIGN: Prospective interventional case series. METHODS: A clear corneal phacoemulsification and posterior chamber intraocular lens (AcrySof SA60AT; Alcon Laboratories, Fort Worth, Texas, USA) was implanted in 23 eyes in 15 subjects. UBM was performed with and without instilling 2% pilocarpine, as well as before and two months after cataract extraction. The mean (+/- standard deviation) age was 65.33 +/- 6.09 years (range, 56 to 75 years). The increase in the axial length of the ciliary body (CBAXL) was used as a surrogate indicator of the centripetal ciliary muscle contraction during accommodation. Images of the ciliary body were compared visually using Adobe Photoshop 7.0 (Adobe Systems Inc., San Jose, California, USA). RESULTS: The CBAXL value with and without pilocarpine before cataract extraction was 1.708 +/- 0.165 mm and 1.689 +/- 0.187 mm, respectively, which was not significantly different (P = .261). The CBAXL value with and without pilocarpine after cataract extraction was 1.998 +/- 0.375 mm and 1.675 +/- 0.279 mm, respectively, which was significantly different (P < .001). The visually compared configurations of the changes in the ciliary body were compatible with the analysis of the measured parameters. CONCLUSIONS: Pilocarpine induced only subtle movement of the ciliary body before cataract surgery. However, after cataract extraction, it induced significant centripetal movement of the ciliary body compared with that without pilocarpine. This shows that a lenticular sclerotic component may influence both lens movement and the contractility of the ciliary muscle, and is believed to be related to the presbyopia.     

Implantation of a new accommodative posterior chamber intraocular lens

PURPOSE: A new, potentially accommodative posterior chamber lens (PCIOL) was designed based on principles elaborated by Hanna using finite element computer simulation methods. We report 3-month postoperative results in patients. METHODS: In a prospective study, 12 eyes of 12 patients (age 45 to 87 yr) underwent phacoemulsification for cataracts and PCIOL implantation. The PCIOL, 1 CU, has haptics designed for anterior optic movement following ciliary muscle contraction. Patients were examined postoperatively after 1 and 2 days, 1, 2 and 6 weeks, and 3 months, and results were compared with a control group of 12 eyes that received standard PMMA or acrylic PCIOLs. RESULTS: Surgery was uncomplicated and all PCIOLs were well-tolerated and stable with good centration in the capsular bag. The results were (mean +/- SD [range] and median; 1 CU versus control PCIOL): near visual acuity (Birkh?user reading chart at 35 cm) with best distance correction 0.34 +/- 0.17 (0.2 to 0.6), 0.3 (J10-J1, median J7) versus 0.15 +/- 0.07 (0.1 to 0.3), 0.15 (J16-J7, median J13), P=.001; subjective near point 59 +/- 10 cm (40 to 100 cm), 53.5 cm versus 93 +/- 20 cm (64 to 128 cm), 86 cm, P=.004; retinoscopic accommodative range 1.2 +/- 0.4 D (0.63 to 1.5 D), 1.2 D versus 0.2 +/- 0.19 D (-0.25 to 0.5 D), 0.25 D, P < .001; decrease of anterior chamber depth after 2% pilocarpine 0.63 +/- 0.16 mm (0.40 to 0.91 mm), 0.63 mm versus 0.15 +/- 0.05 mm (0.08 to 0.20 mm), 0.17 mm, P < .001. CONCLUSIONS: The new PCIOL appears to be safe at short to medium term. Our results indicate pseudophakic accommodation secondary to focus shift with this PCIOL. Additional larger and long-term studies are necessary for exact evaluation of safety and accommodative power of this new PCIOL.     

带虹膜隔人工晶状体植入术治疗白内障合并虹膜缺损的疗效观察

目的　评价带虹膜隔人工晶状体植入术治疗白内障合并虹膜缺损的疗效 ,探讨术后并发症的发生机制。方法　收集 2 5例 (2 7只眼 )行带虹膜隔人工晶状体植入术患者 ,分析手术疗效和并发症的发生情况 ,同时应用房角镜和超声生物显微镜 (UBM)观察术后发生继发性青光眼患者的房角结构和人工晶状体襻位置。术后随访时间 3～ 18个月。结果　术后患者畏光症状明显减轻或完全消失 ;术后视力较术前提高≥ 2行 2 0只眼 (74 1% ) ,变化 <1行 5只眼 (18 5 % ) ,下降 >2行 2只眼(7 4 % )。术后并发症包括继发性青光眼 10只眼 (37 0 % )、散光度数≥ 2 0 0D 17只眼 (6 3 0 % )、角膜失代偿 2只眼 (7 4 % )、前房出血 2只眼 (7 4 % )、玻璃体出血 3只眼 (11 1% )、视网膜脱离 1只眼(3 7% )。在继发性青光眼 10只眼 2 0只人工晶状体襻中 ,9只襻准确固定在睫状沟内 ,其他位置包括前房角、睫状突及睫状突后。房角改变包括房角后退、残留虹膜根部前粘连、房角关闭。结论　带虹膜隔人工晶状体植入术可有效治疗白内障合并虹膜缺损 ;术后继发性青光眼主要与房角损伤有关 ,人工晶状体襻位置异常、眼内出血、持续性炎性反应也参与其发生。     

Ocular structure changes during vacuum by the Hansatome microkeratome suction ring

PURPOSE: To evaluate whether the vacuum of a microkeratome suction ring induces ocular structure changes. METHODS: A prospective case series using A-scan ultrasonography to measure anterior chamber depth, lens thickness, vitreous body, and axial length was performed. Measurements before and during application of a Hansatome microkeratome suction ring were performed on 69 eyes of 39 consecutive patients scheduled to undergo a first-time LASIK procedure with mechanical creation of a corneal flap. RESULTS: Mean patient age was 43 +/- 12.1 years. Of the 69 eyes, 63 (91.3%) had refractive myopia with a mean spherical equivalent refraction of -2.93 +/- 1.56 diopters (D) and 6 (8.7%) had refractive hyperopia with a mean spherical equivalent refraction of 1.37 +/- 0.31 D. Overall, the mean spherical equivalent refraction of all eyes was -2.56 +/- 1.94 D. Ultrasound measurements during suction revealed a decrease in the anterior chamber depth of -0.06 +/- 0.36 mm (P < .05) and lens thickness by -0.14 +/- 0.45 mm (P < .05) whereas the vitreous body increased 0.25 +/- 0.36 mm (P < .05). Although insignificant, a trend toward increasing axial length was noted. No measurements changed over time during the application of vacuum. CONCLUSIONS: Vacuum by a microkeratome suction ring induced a compression of the anterior chamber and lens with commensurate expansion of the vitreous body. The assessment of vacuum effects during LASIK suggests that measurements of intraocular compartments are more informative than axial length.     

葡萄膜炎的超声生物显微镜图像特征

目的：探讨葡萄膜炎超声生物显微镜(ultrasound biomicroscopy,UBM)的图像特征及其应用价值。方法：应用UBM对20例36只眼在我中心诊断为葡萄膜炎的患者进行眼前段检查,包括前房、前房角、后房、睫状体及玻璃体基底部,并对其图像进行分析。结果：20例36只眼的UBM图像可显示不同的改变,主要有前房点状高反射回声影;虹膜前粘连或部分虹膜前粘连,房角关闭;虹膜后粘连、高度膨隆、瞳孔闭锁;后房团片状回声影;睫状体水肿、平坦部“雪堤样”片状回声影;玻璃体基底部点、线状高反射回声影。结论：UBM可显示葡萄膜炎眼前段不同的病理改变,可为葡萄膜炎的临床诊断提供客观依据。     

Central corneal thickness: congenital cataracts and aphakia

PURPOSE: To evaluate central corneal thickness (CCT) in normal children (controls) and in those with cataracts, pseudophakia, and aphakia. DESIGN: Prospective, observational case series. METHODS: CCT was measured in 369 eyes of 223 children. Subjects with glaucoma, anterior segment abnormalities, or intraocular pressure of more than 30 mm Hg were excluded. Group means were compared for controls and for eyes with pediatric cataracts, pseudophakia, and aphakia. RESULTS: The mean CCT of eyes with cataracts was more than that of controls (574 +/- 54 microm [n = 46] and 552 +/- 38 microm [n = 230], respectively; P = .001). After excluding from the cataract group those eyes with aniridia, Down syndrome, Marfan syndrome, or glaucoma surgery, the mean CCT (564 +/- 34 microm [n = 36]) was no longer greater than that of controls (P = .07). The mean CCT of pseudophakic eyes (598 +/- 56 microm [n = 29]) was greater than the mean CCT of controls (P < .001) and was similar to the mean CCT of eyes with cataracts (P = .06). The mean CCT of aphakic eyes (642 +/- 88 microm [n = 64]) was greater than the mean CCT of controls (P < .001), eyes with cataracts (P < .001), and eyes with pseudophakia (P = .003). CONCLUSIONS: In the absence of factors known to affect CCT (Down syndrome, Marfan syndrome, and aniridia), CCT is similar in eyes with pediatric cataracts and normal controls and increases after cataract surgery.     

Does an iridotomy provide protection against narrowing of the anterior chamber angle during Valsalva maneuvre in eyes with primary angle closure

PURPOSE: To evaluate changes at the anterior chamber angle during Valsalva manoeuver, in eyes having primary angle closure (PAC) and a patent laser peripheral iridotomy. METHODS: Twenty-three eyes of 23 consecutive patients underwent a recording of applanation tonometry, measurement of the anterior chamber angle recess, angle opening distance, iris thickness, anterior chamber depth, and pupil size on ultrasound biomicroscopy before and during the Valsalva maneuver. The Valsalva manoeuver was standardized to a pressure of 40 mmHg for 15 s, using a manometer.RESULTS:The mean baseline intraocular pressure changed from 18.86+3.79 to 26.73+4.73 mmHg during Valsalva, (P<0.0001). The anterior chamber angle recess narrowed from 16.62+6.24 to 6.5+4.02 degrees (P<0.0001). There was a significant increase in the thickness of the ciliary body from 0.92+0.25 to 1.17+0.31 mm (P=0.0006) and in the iris thickness from 0.47+0.17 to 0.57+0.11 mm (P=0.007). A significant increase in pupillary diameter (P=0.008) and a decrease in the angle opening distance (P<0.0001) also occurred during Valsalva, whereas there was no significant change in the anterior chamber depth (P=0.056). The angle recess during Valsalva had a positive correlation with the baseline anterior chamber angle (r=0.41, P=0.05) and a negative correlation with the ciliary body thickness (r=-0.52, P=0.046).CONCLUSIONS: The induction of Valsalva maneuver in day-to-day activities can lead to significant anterior segment angle shallowing and can lead to progression from the PAC stage to primary angle closure glaucoma in such predisposed eyes. The presence of a patent laser iridotomy may not prevent irido trabecular apposition during the Valsalva maneuver.     

虹膜睫状体囊肿对后房型人工晶状体位置的影响

目的:用超声生物显微镜(ultrasound biomicroscopy,UBM)研究虹膜睫状体囊肿对后房型人工晶状体位置的影响。方法:在北京大学眼科中心行白内障超声乳化吸出人工晶状体植入术的患者,无角膜手术史,在白内障人工晶状体植入手术前行UBM检查,发现合并虹膜睫状体囊肿者20例(26眼),其中,双眼合并囊肿者6例(12眼),这12眼中只有8眼行白内障人工晶状体植入术,设无虹膜睫状体囊肿者17例(22眼)为对照组,白内障人工晶状体植入术后1mo,对这两组患者复行UBM检查,测量角膜内皮到人工晶状体前表面中央的距离,以及人工晶状体光学部外周12∶00,6∶00,3∶00,9∶00分别到角膜内皮的距离,人工晶状体襻的位置,虹膜睫状体囊肿的位置、大小。并且于术后1mo对这两组患者进行旋光视力检查。应用成组t检验方法分别对数据进行分析。结果:(1)虹膜睫状体囊肿的20例(22眼)和对照组白内障人工晶状体植入术后1mo旋光视力均数分别为4.78±0.15,4.89±0.10,(t=-2.30,P=0.03)。(2)虹膜睫状体囊肿患者20例(22眼)中,其人工晶状体外周12∶00,6∶00,3∶00,9∶00分别到角膜内皮的距离差值(最长与最短距离之差)的均数为(0.52±0.29)mm,对照组中人工晶状体光学部外周12∶00,6∶00,3∶00,9∶00分别到角膜内皮的距离差值的均数为(0.28±0.18)mm,两组t=2.26,P=0.03。(3)两组中虹膜后表面到人工晶状体前表面周边12∶00,6∶00的距离差值均数分别为(0.18±0.09)mm,(0.06±0.06)mm,(t=3.51,P=0.002)。(4)虹膜睫状体囊肿的20例(22眼)和对照组术后1mo的角膜内皮到人工晶状体前表面的中央距离均数分别为(3.77±0.10)mm,(3.66±0.29)mm,(t=1.34,P=0.20)。(5)本组虹膜睫状体囊肿大小不一,最大的囊肿矢状面面积为1.592mm2(最大矢状面面积),最小的囊肿矢状面面积为0.081mm2(最大矢状面面积)。1例(1眼)术前合并囊肿者,术后囊肿消失。结论:虹膜睫状体囊肿,对人工晶状体位置有一定影响,对术后患者的旋光视力有一定影响,对术后中央前房深度没有影响,囊肿术后可以消失。     

Leiomyoma of the ciliary body extending to the anterior chamber: clinicopathologic and ultrasound biomicroscopic correlation

Leiomyoma of the ciliary body is a rare tumor that often causes a diagnostic dilemma. Sclerouvectomy has been found to be beneficial in the management of iris and ciliary body leiomyoma. We treated a case of leiomyoma of the ciliary body presenting as a fleshy mass in the anterior chamber, removed by partial lamellar sclerouvectomy. Ultrasound biomicroscopic and histopathologic features, including light microscopic, immunohistochemistry, and transmission electron microscopic features, were studied and the literature was reviewed.     

原发性房角关闭眼激光虹膜切除术后UBM测量参数比较

目的:比较激光虹膜切开术前后原发性房角关闭(primary angle closure,PAC)眼超声生物显微镜(ultrasound biomicroscopy,UBM)参数。方法:对46例74眼PAC患者进行了一项前瞻性临床试验。平均年龄58,04±11.33(24.0-82.0)岁。所有病例行完整的眼科检查,前房角镜A超生物测量和超声生物显微镜检查(Vu-max,SonomedInc.,NY,USA)及24-2标准无色差视野检查(SAP,Humphrey Visual Field Analyzer-II i,Carl Zeiss Meditec Inc.,Dublin,CA,USA)。使用配对t检验评估基准和随访的平均值之间的变化。结果:激光周边虹膜切除术(laser peripheral iridotomy,LPI)术后,平均房角从8.02±4.61(0.10-19.60)度增加到17.66±6.39(0.10-32.70)度(P=0.000),房角开放距离500(angle opening distance 500,AOD500)从0.11±0.06(0.01-0.30)mm增加到0.23±0.07(0.13-0.50)mm(P=0.000),平均虹膜厚度(iris thickness,IT)从0.58±0.11(0.33-0.99)mm下降到0.52±0.10(0.25-0.77)mm(P=0.000)。小梁睫状突距离,虹膜睫状突距离和睫状体厚度均未发现显著统计学差异。结论:LPI术后PAC的白种人眼睛的AOD500,虹膜晶体距离和前房角增加,IT和虹膜晶体高度减少。这说明LPI解除了瞳孔阻滞,加深了前房,扩大了房角,减少了虹膜前凸和增厚。     

Ultrasound biomicroscopy in traumatic aniridia 2 years after phacoemulsification

A 45-year-old man with retinitis pigmentosa experienced total aniridia in the left eye due to direct blunt trauma 2 years after uneventful bilateral phacoemulsification via a 3.5 mm clear corneal incision. Ultrasound biomicroscopy (UBM) of the left eye revealed no missing or stretched zonular fibers extending from the ciliary body to the anterior capsule, a few iris root remnants, a normal ciliary body, an in-the-bag acrylic intraocular lens, and Descemet's membrane dehiscence at the corneal tunnel through which the iris extruded. The eye recovered 20/25 visual acuity after 1 week. Transient hyphema and a rise in intraocular pressure were recorded. This is the first report of traumatic aniridia 2 years after phacoemulsification with UBM evidence of undamaged zonular apparatus. A UBM examination may be clinically helpful, especially when blood prevents accurate slitlamp examination of the anterior segment.