Agricultural Leaders’ Influence on the Safety Culture of Workers

ABSTRACT

Most US farmers are small, independent owner-operators, many of whom are exempt from safety regulation and enforcement, as well as age restrictions relative to family members performing hazardous tasks. These smaller farms account for a disproportionate share of the total fatality and injury statistics from farming incidents, contributing to an agriculture-industry death rate that is seven times greater than all occupations combined. In contrast, large agricultural enterprises that employ larger numbers of non-family workers are more regulated and more highly incentivized by economic, supply chain, and societal factors to implement cultures of safety, and are more readily influenced by agricultural opinion leaders, agribusinesses, farm organizations, and agricultural media. These agricultural influencer institutions must find ways to play more significant roles in changing the culture on operations that use only family labor. They will find willing partners in safety organizations such as the Agricultural Safety and Health Council of America (ASHCA), Agricultural Extension, and other health and safety advocates, including the National Institute for Occupational Safety and Health (NIOSH)-funded agricultural research centers. The overall workplace injury statistics for agriculture remain alarming; however, with leadership from the larger farm operations, and help from ASHCA, academia, the healthcare community, and others, the current culture of workplace safety and health in agriculture can be impacted in positive ways.     

Determination of ²³⁹Pu airborne concentration alpha correction factor for a zinc sulfide detector via ambient ²²²Rn progeny air sampling

This research empirically determined the 23?Pu airborne concentration alpha correction factor for an ADM-300 zinc sulfide detection system via ambient 222Rn progeny air sampling using a RADeCO high volume air sampler. Radon progeny air samples were collected on a four inch glass fiber filter and evaluated on both a high purity germanium detector and the ADMē-300 simultaneously using the three count method. These data were analyzed to obtain a loss fraction in the glass fiber filter for the 21?Bi collected. The 21?Bi response then was used to estimate a loss fraction for 23?Pu. The 23?Pu airborne concentration alpha correction factor for the ADM-300 detection system was found to be 445 ± 47 dpm ft3 cpm?1 m?3 as compared to a previously published correction factor of 500 dpm ft3 cpm?1 m?3.     

Influence of the route of administration on immunomodulatory properties of bovine β-lactoglobulin-producing Lactobacillus casei

Because of their intrinsic immunomodulatory properties, some lactic acid bacteria were reported to modulate allergic immune responses in mice and humans. We recently developed recombinant strains of Lactobacillus casei that produce β-lactoglobulin (BLG), a major cow's milk allergen. Here, we investigated immunomodulatory potency of intranasal and oral administrations of recombinant lactobacilli on a subsequent sensitization of mice to BLG. Intranasal administration of the BLG-producing Lb. casei stimulated serum BLG-specific IgG2a and IgG1 responses, and fecal IgA response as well, but did not inhibit BLG-specific IgE production. In contrast, oral administration led to a significant inhibition of BLG-specific IgE production while IgG1 and IgG2a responses were not stimulated. After both oral and intranasal administrations, production of IL-17 cytokine by BLG-reactivated splenocytes was similarly enhanced, thus confirming the adjuvant effect of the Lb. casei strain. However, a mixed Th1/Th2 cell response was evidenced in BLG-reactivated splenocytes from mice intranasally pretreated, with enhanced secretions of Th1 cytokines (IFN-γ and IL-12) and Th2 cytokines (IL-4 and IL-5) whereas only production of Th1 cytokines, but not Th2 cytokines, was enhanced in BLG-reactivated splenocytes from mice orally pretreated. Our results show that the mode of administration of live bacteria may be critical for their immunomodulatory effects.     

Is the Influence of Social Support on Mental Health the Same for Immigrants and Non-Immigrants?

The association between social support and mental health across immigrant groups were examined in this study. A population-based sample was extracted from a 2009/10 Canadian community health survey. Self-reported mood or anxiety disorders and a standardized social support scale were used as outcome and explanatory variables. The association between these variables was measured using logistic regression controlling for sex, age, marital status, education, self-rated health and perceived stress. Stratified analyses were performed to test if the strength of association differed by immigrant status. In comparison with individuals who had moderate levels of social support, individuals with low social support had higher odds of reporting mental disorders and this association appeared strongest among recent immigrants. Using the same comparison group, individuals with high social support had lower odds of reporting mental disorders and this association appeared stronger among long-term immigrants. Findings were discussed within the context of immigration stress and acculturation strategies.     

Influence of different upper age limits on the “years of potential life lost” index

The use of 65, 70 or 75 years as upper age limits for the Years of Potential Life Lost index (YPLL) could influence the relative importance assigned to different causes of premature death. Data from a representative year (1987) in Catalonia (Spain), show that health priorities and comparability among studies are not affected by the use of these upper age limits.Corresponding author.     

Influence of dietary spices on the in vivo absorption of ingested β-carotene in experimental rats

Animal studies were conducted to evaluate the influence of dietary spice compounds, piperine, capsaicin and ginger, on the absorption of orally administered β-carotene and its conversion to vitamin A. In rats maintained on these spice-containing diets for 8 weeks, concentrations of β-carotene and retinol were determined in the serum, liver and intestine 4 h after a single oral administration of β-carotene. β-Carotene concentration was significantly increased in the serum, liver and intestine of piperine- and ginger-fed rats, suggesting improved absorption of β-carotene. However, retinol concentration was not significantly changed in these animals, suggesting that the bioconversion of β-carotene to vitamin A was not similarly influenced. Between the two enzymes involved in the bioconversion of β-carotene to vitamin A, the activity of intestinal and hepatic β-carotene 15,15'-dioxygenase was either unaffected or lowered by these spice treatments. The activity of intestinal and hepatic retinal reductase was unaffected by the dietary spices. Activities of these two enzymes involved in the bioconversion of β-carotene to retinal were inhibited by the test spices in vitro, thus corroborating with the in vivo observation. Although the bioconversion of β-carotene was not promoted, increased absorption and tissue levels of β-carotene by the dietary spices may contribute to a higher antioxidant protection.     

Does a Medical Home Influence the Effect of Low Birthweight on Health Outcomes?

The objective of this study was to investigate the possible modifying effect of medical home on the association between low birthweight and children’s health outcomes. The analytic sample included children 5 years and under from the 2007 National Survey of Children’s Health whose mothers were the primary respondents and who had non-missing covariate information (n = 19,356). Controlling for sociodemographic factors, logistic and ordinal regression models estimated the presence of developmental, mental/behavioral or physical health outcomes, condition severity, and health status by birthweight, medical home, and their interaction. Prevalence estimates of physical, developmental, mental/behavioral and severe conditions among those with any conditions as well as fair/poor overall health were 8.9, 6.8, 2.4, 41.6, and 2.5 %, respectively. Overall, low compared to normal birthweight children had a higher prevalence of physical and developmental conditions and fair/poor health (15.2 vs. 8.3 %, 11.1 vs. 6.4 %, 4.5 vs. 2.3 %, respectively). Medical home did not significantly modify the effect of birthweight on health outcomes; however, prevalence of all outcomes was higher for children without a medical home. Adjusted models indicated that low birthweight children were almost twice as likely as normal birthweight children to have a physical or developmental condition and poorer overall health, regardless of having a medical home. Having a medical home was associated with equally improved health outcomes among normal and low birthweight children. Adequacy and frequency of medical home care should be investigated further, especially among low birthweight children.     

Cumulative catalytic effects of some physiologically active ions on the rate of nitrosation of N‐methylaniline in vitro

There is increasing evidence that foodstuffs and human body fluids containing various amounts of thiocyanate and iodide ions, may significantly increase human exposure to carcinogenic N‐nitrosamines by catalyzing their formation in the digestive tract. We have found that both thiocyanate and iodide ions at physiological concentrations have pronounced cumulative catalytic influence on the in vitro formation of N‐methyl‐N‐nitrosaniline (NMNA).     

Influence of the addition of different ingredients on the bioaccessibility of glucose released from rice during dynamic in vitro gastrointestinal digestion

Abstract

Rice represents a primary source of carbohydrates in human nutrition. Upon its consumption, the released sugars are mostly absorbed, categorising rice as a high glycemic index food. Addition of ingredients is common practice when cooking rice, which may affect rice digestibility and influence nutrients absorption in the gastrointestinal (GI) tract, enabling a controlled glucose release. In this sense, rice formulations were submitted to a dynamic in vitro GI model, constituted by reactors that simulates peristalsis coupled to filtration membranes, to evaluate carbohydrates hydrolysis and bioaccessibility. Addition of quinoa and wholegrains reduced carbohydrates hydrolysis (i.e. 38.5?±?5.08% and 57.98?±?1.91%, respectively) and glucose bioaccessibility (i.e. 25.92?±?5.70% and 42.56?±?1.39%, respectively) when compared with brown rice (i.e. 63.86?±?2.96% hydrolysed and 44.33?±?1.88% absorbed). Addition of vegetables significantly decreased sample chewiness and resulted in superior hydrolysis (71.75?±?7.44%) and glucose absorption (51.61?±?6.25%).     

Influence of nutrition on acid-base balance – metabolic aspects

BACKGROUND: Nutrition has long been known to strongly influence acid-base balance. Recently, we have shown that it is possible to appropriately estimate the renal net acid excretion (NAE) of healthy subjects from the composition of their diets. AIM OF THE STUDY: 1) To briefly present a physiologically based calculation model that allows a reasonable estimation of the analytically determined urinary NAE, 2) to summarize the underlying metabolic mechanisms and 3) to study the specific effect of protein on ammoniagenesis which may counteract, to a small degree, the primary acid load-increasing potential of protein. METHODS: The calculation model and the algorithm for predicting the dietary acid load are summarized, major metabolic (and intestinal) pathways of acid and base equivalents are explained, and urinary excretion rates of ammonium and NAE were specifically examined with special regard to the respective protein intake levels. For the latter examinations, data from diet experiments in adults and epidemiological data from children (protein intake; NAE, pH, and ammonium excretion in 24-h urine samples) were analyzed. RESULTS: The paper shows that the diet-induced generation of acidity and alkalinity is not only determined by the metabolism (oxidation) of sulfur-containing amino acids and organic acid anions of alkali salts, respectively. The intestine is also directly involved in the generation of food-derived acid or alkali loads which is due to the considerably different intestinal absorption rates of relevant food components, i. e., protein and minerals. Further analyses of the interrelation between diet and acid-base status revealed that increasing protein intake (despite its potential to increase NAE) also significantly improves the capacity for renal net acid excretion by stimulating urinary ammonium excretion. CONCLUSION: An adequate concept to estimate renal NAE and potential renal acid loads from dietary intakes must consider the specific bioavailability of the individual nutrients. Furthermore, an increased protein intake does not necessarily result in an accordingly increased use of endogenous acid excretion capacity for two reasons: 1) additional alkali loads in an appropriately composed diet can compensate for the protein-related raised acid production and 2) protein itself moderately improves the renal capacity to excrete net acid by increasing the endogenous supply of ammonia which is the major urinary hydrogen ion acceptor.     

Disentangling the Relative Influence of Schools and Neighborhoods on Adolescents’ Risk for Depressive Symptoms

Objectives. Although schools and neighborhoods influence health, little is known about their relative importance, or the influence of one context after the influence of the other has been taken into account. We simultaneously examined the influence of each setting on depression among adolescents.Methods. Analyzing data from wave 1 (1994–1995) of the National Longitudinal Study of Adolescent Health, we used cross-classified multilevel modeling to examine between-level variation and individual-, school-, and neighborhood-level predictors of adolescent depressive symptoms. Also, we compared the results of our cross-classified multilevel models (CCMMs) with those of a multilevel model wherein either school or neighborhood was excluded.Results. In CCMMs, the school-level random effect was significant and more than 3 times the neighborhood-level random effect, even after individual-level characteristics had been taken into account. Individual-level indicators (e.g., race/ethnicity, socioeconomic status) were associated with depressive symptoms, but there was no association with either school- or neighborhood-level fixed effects. The between-level variance in depressive symptoms was driven largely by schools as opposed to neighborhoods.Conclusions. Schools appear to be more salient than neighborhoods in explaining variation in depressive symptoms. Future work incorporating cross-classified multilevel modeling is needed to understand the relative effects of schools and neighborhoods.Depression is one of the most serious public health problems among adolescents in the United States. Large epidemiological studies estimate that 12% of young people meet lifetime diagnostic criteria for major depression or dysthymia1 and that 29% of high school students report having felt sad or hopeless nearly every day during the preceding 2 weeks.2 Given that adolescent-onset depression is associated with many short- and long-term consequences, including suicidal thoughts and behaviors3,4; cigarette, alcohol, and drug use5–7; and recurrent episodes of depression in adulthood,8,9 there is an urgent need to understand the etiology of depression in adolescence.Interest in the social determinants of depression—or how features of the broader social context in which adolescents are embedded affect their risk for depression—has increased in the past decade. Neighborhood social environments have been primarily examined to date.10–14 Research in this area suggests that a neighborhood’s racial/ethnic and socioeconomic composition and culture (e.g., levels of social cohesion, norms related to relationships between neighbors) are associated with individual mental health outcomes, even after individual-level factors have been taken into account. Although schools are gaining more interest from public health researchers,15,16 research on the role of schools in depression is lacking outside of a small number of studies. These studies, which have primarily focused on school connectedness and school socioeconomic status (SES), have shown that higher levels of each of these elements are associated with lower levels of depressive symptoms among students.17–25 In addition, most school-related studies have focused on individual-level rather than multilevel associations.26–32Not only are schools understudied on their own, but their role in relation to neighborhoods is also poorly understood.33 Studies involving cross-classified multilevel modeling techniques, which explicitly allow researchers to disentangle the unique effects on health of multiple nonnested contexts (e.g., school and neighborhood environments),34,35 are rare. This is especially true for mental health outcomes. As a result, it remains unclear whether each context is important independent of the other and, if so, whether schools or neighborhoods are equally important determinants of adolescent depression or one context is more salient than the other.A case could be made for the importance of both schools and neighborhoods. Schools are likely to be important determinants of depression because they serve more than 95% of the nation’s young people for approximately 6 hours per day (or upward of 40% of students’ waking time during the school year) and at least 11 continuous years of their lives.36 Schools are also well-defined social institutions providing access to a range of supportive relationships that promote mental health.30,37,38 Neighborhoods, by contrast, may be important because they are the setting where unstructured social activity occurs outside of school and during the summer.39,40 Neighborhoods may also have a more direct influence on parents’ capacity to raise their children through shaping of community norms, supervision and monitoring, collective efficacy, and reductions in the burdens and stressors associated with caregiving.41,42Studies that examine the salience of schools relative to neighborhoods (and vice versa) are needed, given that schools and neighborhoods have increasingly become nonnested contexts in the United States. Indeed, a growing number of young people are attending schools outside of their neighborhoods as a result of the popularity of school choice (e.g., charter schools, federal vouchers to attend private school) and the desire to close low-performing schools.43,44 Thus, in the case of many young people, schools and neighborhoods are no longer hierarchically nested; for example, adolescents may attend non-neighborhood-based schools that have demographic features different from those of their neighborhood of residence.Our objective was to address these gaps in the literature by providing an understanding of the relative importance of neighborhoods and schools in levels of youth depressive symptoms. Specifically, we set out to determine the unique proportion of variance in depressive symptoms attributable to schools and neighborhoods (i.e., the random effects of each context) and examine the association between youth depression and sociodemographic characteristics (e.g., SES, race/ethnicity) at the individual, school, and neighborhood levels (i.e., fixed effects).     

Influence of income on the association between cognitive impairment and polypharmacy: Bambuí Project

OBJECTIVE: To evaluate the prevalence of polypharmacy and the influence of income on the association between medication use and cognitive impairment among elderly people. METHODS: Out of the 1,606 baseline members of the Bambuí cohort of elderly people, which started in 1997, 1,554 took part in the study. The Mini-Mental State Examination was applied to all the participants. The association between cognitive impairment and polypharmacy was tested by means of multivariate ordinal regression, performed for the whole population and for each of the income strata. RESULTS: The prevalence of polypharmacy (two or more medications consumed) was 70.4% and the number of medications used presented an independent negative association with cognitive impairment (OR=0.72; 95% CI: 0.55;0.95). When this was stratified according to personal income (<2 minimum monthly salaries versus >or= 2 minimum monthly salaries), a negative association was observed between medication use and cognitive impairment among elderly people with lower income (OR=0.64; 95% CI: 0.48;0.86), but not among those with higher income (OR=1.74; 95% CI: 0.81;3.74). CONCLUSIONS: With regard to the association between cognitive impairment and number of medications consumed, the results indicate social inequality in the use of medications. It is possible that these elderly people are not consuming the medicines needed for appropriate treatment of their health problems.     

Effect of dietary γ-aminobutyric acid on the brain protein synthesis rate in hypophysectomized aged rats

The purpose of this study was to determine whether the regulation of brain protein synthesis was mediated through changes in the plasma concentration of growth hormone (GH) when dietary γ-aminobutyric acid (GABA) treatment was manipulated in hypophysectomized or sham-operated aged rats. Experiments were done on four groups of hypophysectomized and sham-operated (24-wk-old) male rats given 0% or 0.5% GABA added to a 20% casein diet. The concentrations of plasma GH and fractional rates of protein synthesis in the brains increased significantly with the 20% casein+0.5% GABA compared with the 20% casein diet alone in the sham-operated rats. However GABA treatment to the basal diet did not affect the rates of protein synthesis in the hypophysectomized rats. In the cerebral cortex and cerebellum, the RNA activity [g protein synthesized/(g RNA·d)] significantly correlated with the fractional rate of protein synthesis. The RNA concentration (mg RNA/g protein) was also related to the fractional rate of protein synthesis in these organs. The results suggest that treatment with GABA is likely to increase the concentrations of GH and the rate of brain protein synthesis in sham-operated rats only, not in hypophysectomized rats, and that the GABA-induced increase in the concentration of GH may be primarily responsible for changes in the brain protein synthesis. The RNA activity is at least partly related to the fractional rate of brain protein synthesis.     

Influence of Behavioral and Environmental Factors on the Development of Obesity in Three-year-old Children —A Case-Control Study Based on Toyama Study—

Obesity in children seems to be a risk factor for chronic diseases in adulthood. From the viewpoint of preventive medicine, factors influencing the development of obese children should be removed early in life. The purpose of this study was to the elucidate relationship between obesity in 3-year-old children and both behavioral and environmental factors by conducting a case-control study. Subjects were selected from the Toyama study. Matched-pair comparisons were performed between obese children whose Kaup’s index was 18 or more (N=117) and control children (N=234) . Multivariate stepwised logistic regression analysis also applied to assess influence of confounding factors. The results indicated that the following 6 factors significantly influenced the development of obese 3-year-old children in exact Fisher’s method analysis (p<0.05): person other than the mother responsible for taking care of the child, short sleep duration (9 hours or less), physical inactivity, eating snacks irregularly, overweight father (BMI≥24), and overweight mother (BMI≥24). For both sexes, after adjusting for confounders by multivariate stepwise logistic analysis, overweight mother (OR 2.54, 95 % CI 1.64-3.95), birth overweight (birth weight≥3,500g; OR 1.76, 95 % CI 1.15-2.69), the mother not responsible for taking care of the child (OR 1.65, 95% CI 1.10-2.48), overweight father (OR 1.62, 95%CI 1.09-2.40), eating snacks irregularly (OR 1.56, 95% CI 1.04-2.33), and gender (female;OR 0.51, 95% CI 0.34-0.77) had significant relationships with obesity in childhood. For boys, overweight mother (OR 2.53, 95 % CI 1.47-4.35), birth overweight (OR 2.03, 95%CI 1.22-3.39), eating snacks irregularly (OR 1.94, 95 %CI 1.19-3.18), and birth month (36-41 months; OR 0.47, 95 % CI 0.23-0.96) had significant relationships. For girls, overweight mother (OR 2.62, 1.28-5.35), and short sleep duration (OR 2.24, 1.11-4.52) had significant relationships. In neither Fisher’s exact method nor multivariate logistic models, time to wake up, bedtime, duration of playing outdoors, regularity of meals, care about salty food, or frequency of eating snacks had significant relations with obesity in 3-year-old children (p<0.05).     

The Influence of Everyday Interpersonal Communication on the Medical Encounter: An Extension of Street’s Ecological Model

Street’s ecological model has shaped the research-examining communication during medical encounters for over a decade. Although the model accounts for the variety of contexts that shape the conversations in which patients and health-care providers engage, the model does not adequately address the way that everyday conversations about health carry over into patient–provider interactions. In this essay, we propose an extension of Street’s model that adds the context of everyday communication about health as a contributing factor in the medical encounter. We support the need for this extension by discussing research that points to the ways these conversations with our social network influence communication during the medical encounter and propose new areas for research based on this extension.     

Does Type of Harm Matter? A Factorial Survey Examining the Influence of Child Neglect on Child Protection Decision-making

Child maltreatment remains a serious social problem, with neglect arguably the most pernicious manifestation. Neglect is characterised by a chronic failure to provide for a child's basic needs and often co-exists with other forms of maltreatment. It usually occurs in a complex social environment where socio-economic disadvantage is rife and the family experiences numerous concurrent risk factors. The consequences of child neglect are pervasive and profound. However, there is little research on child protection decision-making as it relates to child neglect. The aim of this study was to explore social workers’ decision-making and intervention levels according to type of maltreatment with a particular focus on neglect. The study involved secondary analysis of factorial survey data. Fictitious vignettes (n = 327) with randomly assigned variables were rated by social workers. Multiple regression was used to examine the effect that the type of harm had on decision-making about risk, service provision, home visits and family contact. Social workers responded differently when the harm was child neglect. The respondents attributed a lower level of risk, a less intense service provision and fewer contact hours compared with when the harm was physical abuse or sexual abuse. In conclusion, neglect is the most common form of substantiated maltreatment. Child protection workers responding to vignettes respond to the maltreatment of neglect less intensively despite the preponderance of knowledge about the harmful effects of child neglect. This research indicates that further examination of decision-making in cases of child neglect is warranted.     

Influence of elemental impurities in aluminum hydroxide adjuvant on the stability of inactivated Japanese Encephalitis vaccine,IXIARO®

Aluminum hydroxide is a critical raw material in the production of many vaccines. It is used as an adjuvant in the formulation of the final bulk vaccine, and for this it must meet the specifications of the European Pharmacopeia Monograph. We investigated whether vaccine stability was affected by the presence of trace amounts of elemental impurities in commercially available aluminum hydroxide. The content of residual elemental impurities in commercially available aluminum hydroxide was determined by selective and sensitive inductively coupled-plasma mass spectrometry and inductively coupled plasma atomic emission spectroscopy. We found significant differences between different suppliers, but also between different lots from the same supplier. Inactivated Japanese encephalitis vaccine, IXIARO^®, was used to study the effect of residual metals in aluminum hydroxide on antigen stability. We propose that antigen degradation occurred via a pathway involving the metal-catalyzed, auto-oxidation of a process-related impurity (sulfite). Thus, sulfite auto-oxidation resulted in antigen degradation when residual Cu was present at elevated concentrations in aluminum hydroxide.