共查询到20条相似文献,搜索用时 11 毫秒
1.
E. V. Semenov S. S. Krylov A. N. Petrov 《Bulletin of experimental biology and medicine》1977,84(3):1280-1283
The effect of the central cholinolytic benactyzine (40 mg/kg) and of the cholinomimetic arecoline (2.5 mg/kg) on activity of Mg2–-dependent ATPase was studied and the content of Ca2– and Mg2– ions determined in rat brain. Benactyzine and arecoline caused biphasic changes in the activity of the enzyme and content of the electrolytes. It is concluded that inhibition of the enzyme is linked with the accumulation of Ca2– ions and its activation with an increase in the concentration of Mg2– ions in brain tissue. It is suggested that benactyzine and arecoline exert their influence on the liberation and retention of neuromediators in the tissue depots through these effects.(Presented by Academician of the Academy of Medical Sciences of the USSR V. V. Zakusov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol.84, No. 9, pp. 306–309, September, 1977. 相似文献
2.
3.
4.
Zamai TN Titova NM Zamai AS Usol'tseva OS Yulenkova OV Shumkova DA 《Bulletin of experimental biology and medicine》2002,134(6):541-543
We studied the effect of 2-week alcohol intoxication on water exchange and activity of Na,K-ATPase and Ca-ATPase in rat brain. Alcohol intoxication increased water content in the brain due to cell hyperhydration. It is assumed that hyperhydration results from increased Na+ content in cells due to inhibition Na,K-ATPase activity, which in turn is caused by activation of lipid peroxidation under the effect of ethanol. A possible mechanism of Na,K-ATPase inhibition. 相似文献
5.
6.
G. A. Cherednichenko A. A. Moibenko I. A. Butovich S. A. Ogii 《Bulletin of experimental biology and medicine》1995,120(3):895-897
In thisin vitro study using a purified sarcolemmic fraction of guinea pig myocardium, the 13(S)-hydroperoxide of linoleic acid (13-HPODE)
increased in a dose-dependent manner the permeability of myocardial sarcolemma to Ca ions in concentrations above 10 μmol/liter,
stimulated Na/Ca exchange there in concentrations from 0.1 to 10 μmol/liter, and exerted a digitalis-like action on sarcolemmic
Na,K-ATPase in concentrations between 0.1 and 100 μmol/liter (IC50=20 μmol/liter). The results indicate that the linoleic acid hydroperoxide may be an effective modulator of sarcolemmic Ca2+ transport and of membrane-bound enzymes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
9, pp. 255–257, September, 1995
Presented by D. F. Chebotarev, Member of the Russian Academy of Medical Sciences 相似文献
7.
8.
V. V. Frol'kis B. V. Pugach A. L. Kobzar' 《Bulletin of experimental biology and medicine》1996,121(6):569-571
Myocardial hyperfunction is experimentally modeled by coarctation of the aorta in mature (6–8-month-old) and senescent (26–28-month-old)
Wistar rats. During the emergency phase of cardiac hyperfunction Na,K-ATPase activity is shown to rise reliably in mature
animals, while in old rats it remains unchanged. Cardiomyocyte cytosol and blood plasma from mature (but not old) rats with
experimental coarctation of the aorta activate Na,K-ATPase in membranes from the myocardium of both the mature and old rats.
It is assumed that the activation of Na,K-ATPase during the emergency stage of cardiac hyperfunction is mediated through synthesis
of specific invertors. In senescent animals the synthesis of invertors probably becomes insufficient, while membrane sensitivity
to them is preserved.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 6, pp. 631–633, June, 1996 相似文献
9.
V. V. Frol'kis A. L. Kobzar' O. V. Sokolova 《Bulletin of experimental biology and medicine》1996,122(1):655-657
Insulin, testosterone, and thyroxine activated the Na, K-ATPase of hepatocyte plasma membranes in adult rats. Incubation of
intact plasma membranes from rat hepatocytes with hepatocyte cytosol or blood serum from adult rats injected with one of the
three indicated hormones led to elevated Na, K-ATPase activity in the incubated plasma membranes. It is suggested that hormones
induced the appearance in liver cells and blood serum of a factor, called inverter, that is ultimately responsible for the
observed Na, K-ATPase activation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 7, pp. 9–11, July, 1996 相似文献
10.
11.
Experiments on isolated frog gall bladders showed that the addition of ouabain (1·10–4 M) or noradrenalin (3·10–6 M) to the incubation Ringer's solution from the side of the serous surface of the organ or replacement of the K+ in the solution by the equivalent Na+ concentration causes a decrease in the rate of absorption of fluid by the epithelium and a decrease in the Na,K-ATPase activity in its cells. Noradrenalin reduces Mg-ATPase activity also. Significant positive correlation was found between the rate of transport of isotonic fluid by the epithelium and the Na,K-ATPase activity in its cells.Department of Physiology of Water and Salt Metabolism, A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. (Presented by Academician of the Academy of Medical Sciences of the USSR N. N. Gorev.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 85, No. 5, pp. 515–517, May, 1978. 相似文献
12.
A. A. Boldyrev E. R. Bulygina G. G. Kramarenko 《Bulletin of experimental biology and medicine》1996,121(3):253-256
The susceptibility of Na,K-ATPase from bovine brain to various compounds containing active oxygen radicals is assessed. Sodium
nitroprusside slightly inhibits Na,K-ATPase, while light-induced NOo radicals (controlled by the rate of ascorbate oxidation) have no effect on the enzyme. When added in concentrations equally
effective in the ascorbate oxidation assay, hydrogen peroxide and sodium hypochlorite inhibit Na,K-ATPase by 70 and 25–30%,
respectively. The Fe-dinitrosyl-cysteine complex is the most potent (K0.5=20 μM) inhibitor of Na,K-ATPase. It is demonstrated that different free oxygen radicals accumulated in the ischemic brain
cause different kinds of damage to Na,K-ATPase.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
3, pp. 275–278, March, 1996
Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences 相似文献
13.
14.
T. G. Sazontova 《Bulletin of experimental biology and medicine》1996,121(4):348-351
Na,K-ATPase activity is shown to be lowered more than twice 2 hours after emotional pain stress in comparison with the initial
level, remaining practically unchanged during the subsequent 24 hours. Adaptation to repeated stress results in a 50% activation
of Na,K-ATPase. A protective effect is demonstrated in long-term stress against the background of preadaptation. Adaptation
to periodic hypoxia inhibits liver Na,K-ATPase to the same extent as does acute stress. Against the background of preadaptation
to periodic hypoxia, stress does not aggravate the drop of Na,K-ATPase activity. Adaptation to stress inhibits accumulation
of products ofin vitro-induced lipid peroxidation in the heart 1.4-fold and does not affect it in the liver, whereas adaptation to hypoxia sharply
accelerates the accumulation of oxidized products in both organs, which probably explains the activation of liver Na,K-ATPase
in adaptation to stress and its inhibition in adaptation to hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 4, pp. 383–386, April, 1996
Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences 相似文献
15.
16.
E. V. Semenov 《Bulletin of experimental biology and medicine》1978,86(3):1168-1170
The effect of the central cholinolytic benactyzine and the cholinomimetic arecoline on the uptake of45Ca by rat brain synaptosomes was studied in vitro. Benactyzine was shown to cause biphasic changes (a decrease followed by an increase) in the intensity of uptake of the isotope, whereas arecoline led to a rapid initial increase in45Ca uptake. Benactyzine was shown to depress the effect of arecoline and depolarization on uptake of the isotope. It is concluded that the increase in45Ca uptake through the action of arecoline is connected with activation of Nachannels. Benactyzine, on the other hand, reduces the permeability of the these channels for45Ca and activates the Ca-channels proper.(Presented by Academician of the Academy of Medical Sciences of the USSR S. S. Golikov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 9, pp. 301–304, September, 1978. 相似文献
17.
A. M. Golenda G. N. Kryzhanovskii V. K. Lutsenko O. P. Sakharova R. N. Glebov 《Bulletin of experimental biology and medicine》1978,86(2):988-990
Activity of Na,K-ATPase, acetylcholinesterase (AChE), and glutamate decarboxylase (GDC) was investigated in fractions of the rat brain and spinal cord during and 5 and 30 min after a single electric shock. GDC activity of the brain synaptosomes was reduced but not significantly, whereas activity of AChE, Na,K-ATPase and, probably, proteolytic enzymes was increased 5 min after electric shock and returned to normal after 30 min. It is suggested that inhibition of Na,K-ATPase activity in the synaptosomes of the rat cerebral cortex may play a role in the pathogenesis of convulsions.Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. Kemerovo Medical Institute. (Presented by Academician of Medical Sciences of the USSR G. N. Kryzhanovskii.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 8, pp. 139–142, August, 1978. 相似文献
18.
I. A. Zhuravin E. F. Derkachev A. K. Dobrylko I. V. Mindukshev A. I. Krivchenko 《Bulletin of experimental biology and medicine》1993,116(1):781-783
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N
o
7, pp. 19–21, July, 1993 相似文献
19.
R. N. Glebov A. M. Golenda G. N. Kryzhanovskii 《Bulletin of experimental biology and medicine》1979,87(3):188-190
The phenomenon of inactivation of Na,K-ATPase of the unpurified synaptosomal fraction from rat cerebral cortex in electric shock may be connected with modification of the potassium combining site of the enzyme. The anticonvulsant diazepam, if injected intramuscularly, also inhibits the Na,K-ATPase of the brain membranes, but diazepam followed by electrical stimulation of the brain in vivo activates Na,K-ATPase by comparison with the control. Diazepam also abolishes clonic convulsions following electrical stimulation of the brain. Meanwhile diazepam does not abolish the compensatory changes in acetylcholinesterase activity of brain and spinal cord synaptosomes of rats with electric shock. The results are discussed in connection with the view that inhibition of Na,K-ATPase activity of the nerve ending membranes may be the pathogenetic mechanism of seizure activity.Laboratory of General Pathology of the Nervous System, Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. Department of Biochemistry. Kemerovo Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR A. M. Chernukh.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 87, No. 3, pp. 204–207, March, 1979. 相似文献
20.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny Vol. 115, N
o
2, pp. 219–221, February, 1993 相似文献