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非核苷类逆转录酶抑制剂奈韦拉平 总被引:11,自引:0,他引:11
艾滋病是严重威胁人类健康的传染性疾病,它是由HIV引发,特别是HIV-1。奈韦拉平是一种新型的非核苷类逆转录酶抑制剂,该药与核苷类逆转录酶抑制剂或蛋白酶抑制剂合用可用于治疗艾滋病,单独用药可用于预防HIV感染和母婴传播。 相似文献
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Sévigny G Stranix B Tian B Dubois A Sauvé G Petropoulos C Lie Y Hellmann N Conway B Yelle J 《Antiviral research》2006,70(2):17-20
The HIV protease inhibitor P-1946 is a member of a novel family of l-Lysine derivatives. The compound is a specific HIV-1 protease inhibitor that has potent and selective in vitro antiviral activity (EC50 152 nM) against a range of isolates resistant to commercially available protease inhibitors. The presence of at least four primary and four secondary drug resistance mutations is required to achieve greater than four-fold resistance to P-1946. P-1946's favorable resistance profile makes it a good lead for the development of new agents active against existing PI-resistant virus in treatment-experienced patient. 相似文献
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Targeting HIV: antiretroviral therapy and development of drug resistance 总被引:10,自引:0,他引:10
Menéndez-Arias L 《Trends in pharmacological sciences》2002,23(8):381-388