Acute generalized exanthematic pustulosis induced by cefaclor and acetazolamide.

We report a case of acute generalized exanthematic pustulosis induced by 2 different drugs, cefaclor and acetazolamide. The diagnosis was confirmed by challenge tests, and these 2 drugs respectively were proven to be responsible for the patient's pustular eruptions.     

Ichthyosiform erythroderma associated with generalized pustulosis

Two unrelated boys are described who were born as collodion babies and subsequently developed non-bullous ichthyosiform erythroderma and flares of generalized sterile pustulosis, similar to generalized pustular psoriasis. Both patients had a good response to treatment with oral retinoids.     

Acute generalized exanthematic pustulosis. An atypical case due to nadoxolol?

A 74-year-old woman developed a generalized pustular dermatosis with erythema-multiforme-like and vesiculobullous lesions 10 days after beginning a treatment by nadoxolol. Despite the clinical polymorphism of the eruption, histology constantly revealed the presence of subcorneal pustules, even within the epidermis overlying subepidermal bullae. The eruption spontaneously healed after discontinuation of nadoxolol.     

Clopidogrel-associated acute generalized exanthematous pustulosis

Acute generalized exanthematous pustulosis (AGEP) is a skin eruption of rapid onset and progression that is characterized by the formation of numerous sterile pustules on an erythematous background. Other features may include fever and leukocytosis, with resolution usually in less than 15 days. We present an 83-year-old woman with an erythematous pustular eruption following placement of a bare metal coronary stent and initiation of anticoagulation with clopidogrel. She was diagnosed with AGEP after a biopsy was performed and other possible causes of a pustular eruption were excluded. Two medications--carvedilol and rosuvastatin--were initially viewed as possible culprits and were temporarily discontinued. However, the patient's rash continued to worsen. Additionally, she had a persistent low-grade fever, leukocytosis, and a slow rise in her creatinine level. Clopidogrel was discontinued and replaced with ticlopidine on day 7 of hospitalization. Within 48 hours her temperature, white blood cell count, and creatinine level began to improve. Her skin subsequently desquamated and she was sent home on day 20. We discuss drug-induced AGEP and a desensitization protocol that has allowed patients to resume use of clopidogrel following a prior cutaneous reaction to this medication.     

Ibuprofen-induced acute generalized exanthematous pustulosis

Acute generalized exanthematous pustulosis is a rare condition characterized by an acute pustular eruption involving most of the body, usually precipitated by drugs. It can occur after the use of a variety of medications but there have been no previous reports of ibuprofen as an etiological agent.     

Clindamycin-induced acute generalized exanthematous pustulosis

Acute generalized exanthematous pustulosis is a rare but distinctive entity that may be associated with various etiologies. Drug exposure is the most common cause. We present the first report of acute generalized exanthematous pustulosis induced by the drug clindamycin.