肝素表面修饰的亲水性丙烯酸酯人工晶状体在超声乳化联合小梁切除术中的应用

目的比较肝素表面修饰的亲水性丙烯酸酯人工晶状体和非肝素表面修饰的亲水性丙烯酸酯人工晶状体在晶状体超声乳化及人工晶状体植入联合小梁切除手术后的前房炎症反应。方法29例(29眼)施行晶状体超声乳化及后房型人工晶状体植入联合小梁切除手术者分为A组和B组:A组(15例)植入非肝素表面修饰的亲水性丙烯酸酯人工晶状体,B组(14例)植入肝素表面修饰的亲水性丙烯酸酯人工晶状体。于术后1d、7d、1月及3月随访观察。结果术后1d两组的房水闪光值和细胞计数均显著上升,术后7d下降明显,其后逐渐下降,术后3个月基本恢复至术前水平。两组间房水闪光值和细胞计数在术后1d和第7d差异有统计学意义(P<0.05),而术后第1月、3月两组间差异无统计学意义(P>0.05)。术后3个月,两组间最佳矫正视力及眼压的差异均无统计学意义(P>0.05)。结论肝素表面修饰的亲水性丙烯酸酯人工晶状体可改善人工晶状体的生物相容性,较非肝素表面修饰者更能减轻术后炎症反应,尤其有利于白内障联合青光眼术后早期阶段的视力康复。     

不同材料和设计的人工晶状体对白内障术后炎症反应的影响

目的观察不同材料和设计的人工晶状体(IOL)植入患眼后引起的前房炎症反应有无差异。设计病例系列研究。研究对象67例(67眼)行白内障超声乳化吸除术患者。方法将患者分成A(24例)、B(21例)、C(22例)三组,A组植入第三代硅凝胶IOL,B组植入亲水丙烯酸酯IOL,C组植入肝素表面修饰的亲水丙烯酸酯IOL。手术前及术后第1、7、28天用激光房水闪光细胞仪测量前房房水的闪光(flare)和细胞(cell)计数值,以判断前房炎症反应程度。主要指标激光房水闪光细胞仪测量的flare值、cell值。结果A、B、C三组术后第1天的flare值分别为(17.5±7.9)、(17.0±6.7)、(11.6±5.8)光子数/毫秒(pc/ms),cell值分别为(13.1±5.9)、(13.7±5.8)、(9.4±3.7)个/立方毫米(num/mm3);A、B、C三组术后第7天的flare值分别为(9.5±5.6)、(8.8±5.0)、(5.6±3.0)pc/ms,cell值分别为(6.5±4.6)、(5.6±2.9)、(3.6±2.9)num/mm3。术后第1、7天C组的flare和cell值明显小于A组和B组,差异有统计学意义(P<0.05),而A、B两组间差异无统计学意义。术前及术后第28天,三组之间flare和cell值均无统计学差异。结论植入肝素表面处理的人工晶状体者白内障术后早期炎症反应较其它两种轻,激光房水闪光细胞仪是定量测量白内障术后炎症反应安全有效的工具。     

肝素修饰人工晶体植入在抗青光眼术后白内障超声乳化术中的应用

目的观察肝素表面修饰折叠型人工晶体植入对抗青光眼术后白内障超声乳化吸除术后前房炎症反应的影响。方法对60例(88眼)抗青光眼术后白内障患者施行超声乳化吸除术,所有病例随机植入肝素表面修饰折叠型人工晶体或蓝光滤过折叠型人工晶体。应用激光闪光细胞检测仪(Laserflarecellmeter,LFCM)测量并比较术前及术后1天、7天、30天及90天房水的平均闪辉值,以评价前房炎症反应。并观察术前后的视力、眼压及滤过泡和角膜内皮计数情况。结果(1)术前,二组患者房水闪辉值没有显著性差异,植入肝素表面修饰折叠型人工晶体者,手术后7天内的房水闪辉值均明显低于蓝光滤过折叠型人工晶体植入组,而术后30、90天时两种人工晶体植入者之间差异无显著性。两组术后视力均明显提高,眼压控制稳定,角膜内皮功能正常。结论抗青光眼术后白内障手术后眼血-房水屏障功能受损,植入肝素表面修饰折叠型人工晶体能显著减轻白内障术后短期内的炎症反应,增加了手术安全性。     

白内障术后人工晶状体混浊一例

患者,女,46岁,因"双眼并发性白内障"于6年前在我院先后行白内障超声乳化联合人工晶状体植入术,左眼植入亲水性丙烯酸酯人工晶状体,右眼植入肝素表面处理聚甲基丙烯酸甲酯人工晶状体,术后无特殊反应.6年来,右眼无明显异常,左眼自觉眼前有纱样物遮挡,渐进性加重.眼科检查:视力右眼1.0,左眼0.8;眼压右眼14mmHg,左眼15mmHg(1mmHg=0.133kPa).睑结膜无充血,角膜清,前房深浅可,房水细胞(-),瞳孔对光反应灵敏,人工晶状体居中.右眼人工晶状体透明;左眼人工晶状体光学部呈乳白色,袢透明(图1).     

肝素表面处理人工晶状体在并发性白内障手术中应用疗效观察

目的探讨肝素表面处理人工晶状体在并发性白内障患者手术中应用的疗效。方法106例(152只眼)并发性白内障患者中随机抽取98只眼为研究组(A),植入HQ-201HEP型肝素表面处理人工晶状体;54只眼为对照组(B),植入MA-60MB型人工晶状体。比较术后视力、眼压、前房闪辉、房水细胞、虹膜后粘连、后囊膜混浊等结果。结果研究组(A)中98只眼有前房闪辉30只眼(30.6%),房水细胞阳性26只眼(26.5%),虹膜后粘连17只眼(17.3%),后囊膜混浊2只眼(2.04%),高眼压2只眼(2.04%)。而对照组(B)54只眼有前房闪辉42只眼(77.8%),房水细胞阳性43只眼(79.6%),虹膜后粘连24只眼(44.4%),后囊膜混浊7只眼(12.7%),高眼压6只眼(11.1%)。结论临床研究发现肝素表面处理人工晶状体在减轻眼内炎症反应、异物反应、细胞在人工晶状体表面沉着(前房闪辉、房水细胞、虹膜后粘连、后囊膜混浊)等方面优于对照组,尤其对于有葡萄膜炎病史、青光眼术后、局部和全身应用类固醇激素者尤为适合,可减轻高眼压和前房出血的发生。     

葡萄膜炎并发白内障术中植入肝素修饰人工晶状体

目的评价葡萄膜炎并发白内障术中植入肝素表面修饰的PMMA人工晶状体的效果。方法98例（146眼）葡萄膜炎并发白内障行超声乳化吸出术,术中分别植入肝素修饰的PMMA人工晶状体56例（98眼）（肝素组）和未修饰PMMA人工晶状体42例（48眼）（对照组）。对两组术后视力、眼前段反应、后囊浑浊情况进行回顾性对比分析。结果矫正视力≥0．5者,肝素组86眼（87．76％）,对照组27眼（56．25％）,（P〈0．05）。眼前段反应：人工晶状体表面纤维素样渗出、房水细胞,均在术后1周时差异最显著（P〈0．05）,虹膜后粘连在6个月后两组差异最显著（P〈0．05）。后囊浑浊发生率6个月后对照组明显高于肝素组,分别为54．17％和12。24％（P〈0．05）。结论葡萄膜炎并发白内障术中植入肝素修饰人工晶状体能显著减轻术后眼前段的炎症反应,降低后囊浑浊的发生率。     

单面修饰疏水性人工晶状体表面细胞黏附实验研究

目的：观察乙烯基吡咯烷酮接枝前表面修饰疏水性丙烯酸酯人工晶状体植入兔眼后的表面细胞黏附的光镜改变,分析其单面修饰提高人工晶状体的生物相容性。

方法：健康新西兰白兔13只26眼随机分组。9眼植入前表面乙烯基吡咯烷酮接枝修饰人工晶状体,8眼植入前表面二氧化钛修饰人工晶状体,9眼植入未修饰的疏水性丙烯酸酯人工晶状体。于术后90d摘除眼球并取出人工晶状体进行光镜分析。

结果：单面乙烯基吡咯烷酮接枝修饰后的人工晶状体表面黏附细胞数量和面积、蛋白膜的形成均低于对照组。

结论：疏水性人工晶状体经乙烯基吡咯烷酮接枝单面修饰后可明显提高人工晶状体的葡萄膜生物相容性。     

前房注射甲强龙在晶状体超声乳化人工晶状体植入联合房角分离术中的应用

目的 探讨前房注射甲强龙在控制急性闭角型青光眼晶状体超声乳化房角分离术后前房炎症反应的效果.方法 对合并白内障的原发性急性闭角型青光眼行超声乳化人工晶状体植入联合房角分离术.实验组(23例,24眼).术毕即刻给予0.5 mg甲强龙前房内注射,对照组(24例,25眼)不注射.比较术后1d、3d、1周、2周前房炎症反应及视力、眼压、角膜、瞳孔.结果 术后不同时间比较:对照组房水闪光较实验组程度重且吸收慢.结论 前房内注射甲强龙能有效控制急性闭角型青光眼晶状体超声乳化房角分离术后前房炎症反应.     

表面修饰疏水性丙烯酸酯人工晶状体表面超微结构的观察

目的　改变疏水性丙烯酸酯人工晶状体的前表面性能,并进行改性后观察人工晶状体表面超微结构。方法　采用表面修饰技术对疏水性丙烯酸酯人工晶状体前表面进行乙烯基吡咯烷酮单体以及氧化钛单面修饰并观察其表面形貌;修饰人工晶状体植入兔眼,于术后９０ｄ摘出修饰人工晶状体行扫描电镜观察。结果　扫描电镜结果表明,与未修饰人工晶状体相比,改性处理后的人工晶状体表面更均匀光滑。未修饰人工晶状体植入兔眼术后９０ｄ,人工晶状体表面黏附有细胞以及蛋白膜附着物,黏附细胞多为大小及形态多样的巨噬细胞,主要集中于人工晶状体周边。修饰人工晶状体表面黏附细胞少于未修饰人工晶状体,乙烯基吡咯烷酮单体修饰人工晶状体表面黏附细胞更少。结论　表面修饰的疏水性丙烯酸酯人工晶状体提高了人工晶状体的葡萄膜生物相容性。     

三种不同折叠式人工晶状体术后的血房水屏障功能的评价

超声乳化白内障吸除联合人工晶状体植入术切口较小，术后反应较轻，是目前白内障手术的主流。但是，手术带来的对血房水屏障功能的影响目前仍没有完全解决，而血房水屏障功能的紊乱会导致延长术后恢复时间以及用药时间，并且也会增加术后并发症，如青光眼、黄斑囊样水肿、瞳孔粘连等的发生率。要减少手术对血房水屏障的扰动，目前所需的工作主要集中于两方面：一是进一步改进手术技巧，减少手术本身对前葡萄膜的刺激；二是改进人工晶状体的材料和设计，减轻其对血房水屏障功能的干扰，加快血房水屏障功能的恢复。目前国内外比较各种人工晶状体术后血房水屏障功能恢复过程的研究尚不多，尤其是采用激光闪光细胞检测仪（laser flare cell meter，LFCM）对术后血房水屏障功能量化测定的研究更少，其中主要的研究几乎都在欧洲，对于国人的研究尚为空白。激光闪光细胞检测仪利用前房蛋白浓度与蛋白颗粒散射的光粒子数成线性相关的原理，直接测定光粒子数，从而能够快捷、精确、敏感和非侵入地定量前房蛋白浓度，测定正常人眼和人工晶状体眼的房水闪光值和细胞值，从而评价血房水屏障功能。故我们应用激光闪光细胞检测仪对目前国内临床上常规使用的3个同类设计不同材料的折叠式人工晶状体的术后血房水屏障恢复过程进行了研究，现报告如下。     

Inflammation after phacoemulsification in diabetic retinopathy. Foldable acrylic versus heparin-surface-modified poly(methyl methacrylate) intraocular lenses

PURPOSE: To evaluate inflammation after cataract surgery in patients with nonproliferative diabetic retinopathy (NPDR) and compare results with 2 intraocular lenses (IOLs): a foldable hydrophobic acrylic and a heparin-surface-modified (HSM) poly(methyl methacrylate) (PMMA). SETTING: Department of Ophthalmology, University of Vienna, Vienna, Austria. METHODS: Patients with NPDR were randomized for implantation of an HSM PMMA IOL (811C, Pharmacia) through a 6.0 mm sclerocorneal incision (30 patients) or a foldable hydrophobic acrylic IOL (AcrySof, Alcon) through a 4.0 mm sclerocorneal incision (32 patients). Both IOLs had 6.0 mm optics. All patients were treated according to a standardized protocol. The degree of flare in the anterior chamber was measured with the Kowa 1000 laser flare-cell meter 1 day preoperatively and 1 day, 1 week, and 1 and 3 months postoperatively. RESULTS: In both IOL groups, flare was highest on the first postoperative day and decreased to preoperative levels by 3 months after surgery. There was no statistically significant difference in relative flare values between the 2 groups. CONCLUSION: There was no difference in postoperative inflammation in eyes with a foldable hydrophobic acrylic IOL implanted through a small incision and those with a rigid HSM PMMA IOL. Postoperative inflammation results indicate that the lenses are equally suitable for the use in patients with diabetic retinopathy.     

Inflammation after implantation of hydrophilic acrylic,hydrophobic acrylic,or silicone intraocular lenses in eyes with cataract and uveitis: comparison to a control group

PURPOSE: To compare the course of inflammation after small-incision cataract surgery with implantation of 1 of 3 types of foldable intraocular lenses (IOLs) in eyes with uveitis. SETTING: Department of Ophthalmology, University of Vienna, Vienna, Austria. METHODS: Seventy-four eyes with uveitis and cataract and 68 control eyes with cataract were prospectively selected to receive a foldable hydrophilic acrylic (Hydroview, Bausch & Lomb), hydrophobic acrylic (AcrySof, Alcon), or silicone (CeeOn 911, Pharmacia) IOL. All surgery was performed by the same surgeon using a standardized protocol: clear corneal incision, capsulorhexis, phacoemulsification, and in-the-bag IOL implantation. Preoperative and postoperative inflammation was evaluated by measuring aqueous flare preoperatively and 1, 3, 7, 28, 90, and 180 days after surgery using the Kowa FC-1000 laser flare-cell meter. All uveitic eyes were in remission for at least 3 months before surgery. RESULTS: In the uveitic eyes, there was no statistically significant difference in the postoperative course of flare and cell among the 3 IOL groups. Six months after surgery in uveitic eyes, flare values reached preoperative levels and the cell count was lower than preoperatively in all 3 IOL groups. Relative flare values were higher in the eyes with uveitis and a CeeOn 911 IOL; however, the difference between this group and the 2 acrylic IOL groups was not significant. CONCLUSIONS: There were no significant differences in inflammation after implantation of foldable IOLs in uveitic eyes. Although absolute flare values and cell counts in eyes with uveitis were higher than in control eyes, primarily because of a damaged blood-aqueous barrier (BAB), BAB recovery was similar between the 2 groups. The changes in the BAB indicate that foldable IOL implantation is safe in uveitic eyes.     

Course of postoperative inflammation after implantation of 4 types of foldable intraocular lenses.

PURPOSE: To compare the course of postoperative inflammation after small incision cataract surgery with implantation of 4 types of foldable intraocular lenses (IOLs). SETTING: Department of Ophthalmology, University Hospital of Vienna, Austria. METHODS: One hundred twenty eyes were prospectively randomized to receive a foldable silicone (Pharmacia 920), hydrogel (Bausch & Lomb Hydroview), methyl methacrylate/hydroxyethyl methacrylate (Mentor MemoryLens), or acrylic (Alcon AcrySof) IOL. All surgery was performed by the same experienced surgeon using a standardized surgical protocol: clear corneal incision, capsulorhexis, phacoemulsification, and in-the-bag implantation of the IOL. All patients received standardized postoperative medication and follow-up. Postoperative inflammation was evaluated by measuring aqueous flare preoperatively and 1, 3, 7, 14, 28, 90, and 180 days after surgery using the Kowa 1000 laser flare-cell meter. RESULTS: Except on the first day after surgery, when the AcrySof group had higher flare values than the other groups (P = .0265), no significant differences were found up to 6 months. Re-establishment of the blood-aqueous barrier was similar in eyes with the AcrySof, Hydroview, and MemoryLens IOLs; the course of postoperative inflammation was different in eyes with the silicone IOL. CONCLUSION: Comparison of postoperative flare values after implantation of 4 foldable IOLs showed no clinically relevant differences in the course of postoperative inflammation.     

类风湿关节炎患者晶状体超声乳化及人工晶状体植入术

目的评价类风湿关节炎患者白内障晶状体超声乳化吸出及人工晶状体植入术的效果，探讨类风湿关节炎活动性指标与术后前房反应的关系。方法类风湿关节炎活动性指标不同的白内障22例（22眼），术后1周、1个月、3个月测量房水闪光和细胞计数值。结果手术无并发症发生。术后除1例老年黄斑变性外，其余患者矫正视力≥0．6，术前房水闪光均值为（1．7±0．5）pc／ms，细胞计数均值为（0．5±0．08）num／mm^3，术后1周、1个月、3个月的房光闪光均值分别为（14．4±2．0）pc／ms，（5．8±1．4）pc／ms，（2．1±0．4）pc／ms，细胞计数值分别为（10．7±2．1）mm／mm^3，（4．5±1．2）num／mm^3，（0．7±0．07）mm／mm^3，3个月时二者均降至术前水平。术后前房反应与术前类风湿因子滴度、血沉、C反应蛋白、葡萄糖6磷酸异构酶、抗环瓜氨酸肽抗体等指标之间无统计学意义的相关性。结论类风湿关节炎的白内障患者行白内障手术安全有效；术后前房反应的程度和持续时间与既往病情活动度无关。     

Effect of heparin in the irrigation solution on postoperative inflammation and cellular reaction on the intraocular lens surface.

PURPOSE: To evaluate the influence of heparin sodium in the irrigation solution on postoperative inflammation and cellular reaction on the anterior surface of a hydrophilic intraocular lens (IOL). SETTING: Department of Ophthalmology, University of Vienna, Vienna, Austria. METHODS: This randomized prospective single-surgeon study included 50 patients with senile cataract only. Half the patients received 1 mL of heparin sodium (concentration 10 IU/mL) in addition to the regular irrigating solution. In all other respects, the procedure was standardized: clear corneal incision, phacoemulsification, and implantation of a Hydroview foldable hydrogel IOL (Bausch & Lomb). The parameters of inflammation-anterior chamber flare and cells-were evaluated with the pupil dilated in a masked fashion using a Kowa FC-1000 laser flare-cell meter 1, 3, 7, 14, and 28 days and 3, 6 and 12 months postoperatively. The cellular reaction was semiquantitatively examined and analyzed by specular microscopy. RESULTS: In both groups, flare and cell values increased on the first postoperative day and successively decreased thereafter. In the first week, the flare and cell values were significantly higher in the group without heparin sodium in the irrigating solution. Subsequently, there were no differences between the 2 groups in flare or cells. At 1 day, the heparin sodium group had statistically significantly fewer IOLs with no cells on the surface. Subsequently, no differences in cellular reaction on the IOL were observed. CONCLUSIONS: Heparin sodium added to the standard irrigating solution reduced disturbances of the blood-aqueous barrier in the early postoperative period. There seemed to be no long-term effect, especially on cellular reaction, on the hydrophilic IOL surface.     

Blood-aqueous barrier after phacoemulsification with posterior chamber lens implantation; foldable acrylate lens vs PMMA lens-- a clinical study on 46 eyes

BACKGROUND: Cataract surgery leads to a more or less pronounced postoperative inflammation due to breakdown of the blood-aqueous barrier. This alteration of the blood-aqueous barrier can be reduced by minimally invasive surgery. The purpose of this study was to quantify the early course of the postoperative alteration of the blood-aqueous barrier following phacoemulsification with implantation of conventional PMMA posterior chamber lens (IOL) in comparison with foldable acrylic lens implantation. PATIENTS AND METHODS: Forty-six eyes of 46 patients (age 63 +/- 8.8 years) without preexisting deficiences of the blood-aqueous-barrier or previous intraocular surgeries were divided into two groups: group 1 (24 patients): phacoemulsification with one-piece-PMMA-IOL implantation (6.5 mm corneoscleral tunnel incision); group 2 (22 patients): phacoemulsification with foldable acrylic-IOL implantation (3.5 mm incision, 15 patients with corneoscleral tunnel and 7 patients with clear cornea incision). All surgical procedures were performed by one surgeon. The postoperative treatment was standardized. Alteration of the blood-aqueous barrier was quantified by the laser flare-cell meter (Kowa, FC-1000) preoperatively and on the first and the second day after surgery. RESULTS: Preoperative aqueous flare values (photon counts/ms) were comparable in both groups (6.7 +/- 2.7 versus 5.6 +/- 2.7 respectively, p = 0.1). On day 1, aqueous flare in group 1 (9.7 +/- 2.9) was not statistically significantly higher than in group 2 (9.2 +/- 2.2, p = 0.2) and remained relatively constant on day 2 after surgery (9.3 +/- 3.3), whereas the aqueous flare values in group 2 decreased statistically significant (6.7 +/- 2.3, p = 0.01). Postoperatively, there was no statistically significant difference of aqueous flare values between eyes with corneoscleral tunnel incision and eyes with clear corneal incision (p = 0.7) in group 2. CONCLUSIONS: Our study shows that phacoemulsification with foldable IOL implantation leads to a mild and short-lasting alteration of the blood-aqueous barrier. Thus, implantation of foldable IOL may be useful in eyes especially with preexisting alteration of the blood-aqueous-barrier.     

Clinical application of laser flare-cell meter

Clinical application of the laser flare-cell meter was described. The instrument was developed for concurrent quantitative determinations of the flare and number of cells in the aqueous humor. Diurnal variations were demonstrated in the aqueous flare, and also an increase in the flare with increasing age. The effects of drugs on aqueous humor dynamics were also studied. Orally administered 500 mg of carbonic anhydrase inhibitor reduced the aqueous humor formation by one-third. Concurrent study with the laser flare-cell meter and slit-lamp microscopy in uveitis cases has revealed that the former instrument is superior to the latter in making a quantitative evaluation of inflammation in the anterior segment of the eye. A follow-up study of postoperative inflammation was performed in patients undergoing extracapsular cataract extraction with posterior chamber intraocular lens implantation. Cases with uneventful postoperative course showed intense flare on the first postoperative day followed by a rapid decrease. Cases with inflammation and fibrin had high aqueous flare which showed an increase even before detection of fibrin in the aqueous by slit-lamp microscopy. Topical 0.5% indomethacin treatment was shown to be effective in suppressing the postoperative increase in aqueous flare but had little effect on cell count. In cases undergoing Argon laser trabeculoplasty, the aqueous flare in the treated eyes was determined to be significantly higher than that in the fellow eyes for four weeks postoperatively (P less than 0.05). The laser flare-cell meter has made it possible to determine the flare and number of cells in the aqueous humor quantitatively. This capability differentiates the instrument from the slit-lamp microscope as well as the instruments previously developed for similar purposes. The laser flare-cell meter is a newly developed useful tool to investigate the pathophysiology of the eye.     

Postsurgical inflammation after phacoemulsification and extracapsular extraction with soft or conventional intraocular lens implantation.

A one-year prospective study was conducted in 120 patients to assess the time course of changes in intraocular inflammation after three cataract surgery procedures: planned extracapsular extraction with poly(methyl methacrylate) (PMMA) intraocular lens (IOL) implantation (11 mm incision group), phacoemulsification with PMMA IOL implantation (7 mm incision group), and phacoemulsification with foldable silicone single-piece IOL implantation (4 mm incision group). Each group was carefully matched for patients' ophthalmologic and systemic backgrounds. Patients with hard nuclei were excluded. The degree of inflammation was evaluated by quantitating aqueous flare intensity and cell count with the laser flare-cell meter. In the early postoperative period, both aqueous flare intensity and cell count were highest in the 11 mm incision group followed, in decreasing order, by the 7 mm and 4 mm incision groups. Significant between-group differences were observed at one, two, and seven postoperative days for flare and one day through one week for cells. Both parameters in each group decreased to a similar level one month after surgery, but flare intensity in all groups remained significantly higher than that of age-matched normal controls up to six months postoperatively.     

Postoperative inflammatory response to phacoemulsification and implantation of 2 types of foldable intraocular lenses in pseudoexfoliation syndrome

BACKGROUND: Patients with pseudoexfoliation syndrome (PEX) are known to have a greater degree of inflammation after cataract surgery when compared to patients with senile cataract in otherwise healthy eyes. We performed a randomised, prospective study to compare the influence of the intra-ocular lens (IOL) material of two different IOLs on the postoperative inflammation of the anterior chamber. PATIENTS AND METHODS: 28 eyes of 27 patients with PEX and cataract and 29 eyes of 29 control patients were included in this study. The IOLs used were the hydrophilic, acrylic lens: Bausch&Lomb-Hydroview and the hydrophobic, acrylic Alcon Acrysof MA60 lens. The patients were examined preoperatively as well as on day 1, 3, 7 and 1, 3, and 6 months after surgery using the Laser flare-cell meter (LFCM) KOWA FC 1000. RESULTS: The preoperative flare and cell values were significantly higher in PEX eyes as compared to the control group. The values decreased after about 1 month to reach values comparable to those in the control group. Over the six months period there was no significant difference between the values of both lenses in the PEX group except on the first postoperative day where the flare and cell values were higher in the Acrysof-lens group. When comparing both groups with the Hydroview-lens there was also no significant difference, except on day 7, between the PEX group and the control group up to 6 months after surgery. When comparing both groups with the Acrysof-lens, there was a significant difference between the PEX group and the control group until 1 month after surgery. CONCLUSION: Although PEX-eyes had higher flare and cell values up to one month after surgery, we could not determine a significant difference, except on the first postoperative day, between both IOLs. A significant difference was evident between the PEX and control group in eyes with an Acrysof-lens. Using this clinical model, the LFCM highlights only certain aspects of biocompatibility of different lens types.