共查询到20条相似文献，搜索用时 45 毫秒
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Giulia Gasparini M.D. Dr. Emine Meral Inelmen M.D. Giuliano Enzi M.D. Cristina Santoro M.D. Giuseppe Sergi M.D. Fabrizio Cardin M.D. Oreste Terranova M.D. 《Journal of gastrointestinal surgery》2006,10(3):395-401
The aim of the present study was to analyze the influence of various factors on the prognosis for elderly patients with gastric
carcinoma. Forty-eight patients aged =>65 years admitted to Padova General Hos-pital were divided into two groups by age (<75
or >75 years). They all had a histologically confirmed diagnosis of gastric adenocarcinoma. Information on their clinicopathological
characteristics was col-lected from the Padova Hospital medical records. On univariate analysis, significant prognostic factors
in the two age groups were gender, stage, histotype (Lauren’s intestinal type), Charlson index, and type of surgery (curative
resection, palliative resection, and no surgery). On multivariate analysis, inde-pendent prognostic factors were the Charlson
index, tumor stage, and age group. The 52-month survival rate was 72.7% for females and 12.5% for males for patients =>75
years (P = 0.01), while for the whole series of patients it was 67.5% for females and 29.9% for males (P = 0.003). The 17-month survival rate was 55.6% for surgically treated patients and 0% for the untreated cases in stage 4
(P = 0.03). Gastric cancer should be treated with conventional surgery even in the very elderly, since the survival rate for
this age group does not differ significantly from the figures for younger patients. 相似文献
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Oyeon Cho MD Young‐Taek Oh MD PhD Mison Chun MD PhD O‐Kyu Noh MD PhD Jae‐Sung Hoe MD Hwanik Kim MD 《Head & neck》2016,38(Z1):E1061-E1067
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BACKGROUND: The aim of this analysis was to evaluate the outcomes of patients with nasopharyngeal carcinoma (NPC) treated primarily by external beam irradiation (ERT) and to explore for possible ways to improve the treatment results. METHODS: One thousand seventy patients with nonmetastatic NPC treated from 1990 to 1998 were retrospectively analyzed. The distribution according to the Union Internationale Contre le Cancer (UICC) (1997 edition) staging system at initial diagnosis was as follows: stage I, n = 113; stage IIA, n = 38; stage IIB, n = 360; stage III, n = 306; stage IVA, n = 136; stage IVB, n = 117; T1, n = 284; T2a, n = 88; T2b, n = 398; T3, n = 149; T4, n = 151; N0, n = 321; N1, n = 393; N2, n = 238; N3a, n = 29; N3b, n = 89. Two hundred eight patients were given neoadjuvant chemotherapy. Ninety-seven patients were diagnosed with locally persistent disease and were salvaged with high dose rate intracavitary brachytherapy. Multivariate analysis was performed with the Cox regression proportional hazards model. RESULTS: The 5-year actuarial local failure-free survival, regional failure-free survival, distant metastasis-free survival, progression-free survival, cancer-specific survival, and overall survival rates were 80.9%, 93.3%, 77.2%, 62.7%, 71.4%, and 66.5%, respectively. Isolated distant metastasis occurred in 191 patients (18%). The distributions were as follow: stage I, 2.1% (two of 95); stage IIA, 5.7% (two of 35); stage IIB, 14.9% (45 of 302); stage III, 26.4% (62 of 235); stage IVA, 40% (40 of 100); stage IVB, 47.1% (40 of 85). Results of the multivariate analysis of various clinical endpoints were discussed. By studying these failure patterns, it is hoped that we could refine future treatments according to the failure patterns of patients with different risks of locoregional and distant failure. CONCLUSIONS: The 18% incidence of isolated distant metastasis is too high to be ignored. Maximizing the local control and minimizing the risk of distant metastasis and late complications should be the key objectives in designing future clinical trials. 相似文献
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BACKGROUND: Treatment of locoregionally recurrent nasopharyngeal carcinoma (NPC) is challenging because of prior radiotherapy, morbidities from disease recurrence, and limited therapeutic options available. METHODS: A retrospective study of patients with locoregionally recurrent NPC. RESULT: Between March 1994 and December 1999, there were 42 patients; most were Chinese (98%) men (81%) with undifferentiated NPC (86%). A repeat course of radiotherapy was feasible in 20 patients and given concurrently with cisplatin followed by adjuvant cisplatin/5-fluorouracil (PF) (group 1). The remaining 22 (group 2) received palliative chemotherapy (PF) with a response rate of 50%. Significant morbidities resulted from cranial nerve palsies. The 2-year progression-free survival of patients in group 1 was expectedly better (58% vs 38%). Six (14%) developed systemic metastases at 12 months (median) from first recurrence. CONCLUSION: Concurrent chemoradiotherapy for locoregional recurrent NPC seems promising. The morbidity experienced resulted from locoregional disease with few progressing to develop systemic involvement. 相似文献
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Charlene Lin BA Shih‐Wei Lin BPharm Shih‐Feng Weng PhD Yung‐Song Lin MD 《Head & neck》2014,36(2):203-208
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BACKGROUND: Carotid artery stenosis is a late complication of radiotherapy to the neck region. This complication has, however, a significant impact with increased risk of stroke causing mortality and morbidity. Clinicians' awareness of this complication and early detection is therefore important. METHODS: Eighty patients with nasopharyngeal carcinoma (NPC) who had received radiotherapy were recruited for color Doppler ultrasonography of the carotid arteries. fifty-eight patients with newly diagnosed NPC who had never received any radiotherapy were recruited as controls. All patients with significant carotid stenosis were referred to the neurology clinic for further assessment. RESULTS: Twenty-four patients were found to have more than 50% diameter reduction in the extracranial carotid artery. Clinical assessment by a neurologist showed 9 of 24 patients had a history of transient ischemic attack, amaurosis fugax, or stroke. Seven of these patients had clinically detectable neck bruit. CONCLUSIONS: Clinicians attending to patients after radiotherapy for head and neck cancers should be aware of this long-term complication of radiotherapy. A detailed clinical history and incorporation of auscultation of carotid arteries in routine follow-up of postradiotherapy patients are recommended. 相似文献
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鼻咽癌放疗病人的心理分析及护理 总被引：14，自引：2，他引：14
对９８例单纯放疗的初治鼻咽癌病人入院时应用ＳＣＬ－９０症状自评表进行测试，结果显示，调查对象ＳＣＬ－９０的９个因子分均值高于国内常模，经ｔ检验有非常显著性差异，表明研究对象存在着严重的心理。障碍。将病人随机分为两组，对照组５０例，接受常规护理，不作心理干预、实验组４８例，接受常规护理和心理治疗，治疗结束后两组研究对象再用相同的方法进行测试，结果显示，ＳＣＬ－９０的９个因子分均值经ｔ检验，大多数有显 相似文献
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Lei Zeng PhD Xia Yuan PhD Li Bai MD Taixiang Lu MD Yunming Tian MD Fei Han PhD 《Head & neck》2016,38(8):1152-1157
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Wen Bo Huang MD Stanley Thian Sze Wong PhD BSc Jimmy Yu Wai Chan MD MS PhD 《Head & neck》2018,40(2):369-376