共查询到19条相似文献,搜索用时 46 毫秒
1.
临床资料患者,女,34岁。主因躯干、四肢褐色斑8年,于2012年9月17日就诊。8年前患者无明显诱因躯干、四肢出现红色粟粒至黄豆大小红色斑疹、斑丘疹,伴轻度瘙痒,消退后遗留褐色斑,持续存在,不能消退。遇冷后出现红色风团。曾就诊于当地医院,具体诊断及治疗 相似文献
2.
目的 介绍 1例大疱性色素性荨麻疹的临床资料并探讨该病的最新研究进展。方法 取臀部新发皮损做皮肤组织病理和Giemsa染色检查真皮内肥大细胞。结果 表皮大致正常 ,表皮下水疱形成 ,真皮内有大量大小一致的、圆形、胞浆淡染的、单一核细胞 ,Giemsa染色示胞浆内有紫红色颗粒 ,证明是肥大细胞。结论 大疱性色素性荨麻疹是肥大细胞增生症的一个特殊类型。 相似文献
3.
患儿女,4个半月。全身色素斑4个月,起水疱10天。查体:全身弥漫性灰褐色色素斑,表面见较多水疱、大疱及糜烂结痂,尼氏征阴性,Darier征阳性。皮损组织病理检查显示真皮浅层及血管周围见较多单一核细胞浸润,G iem sa染色阳性。诊断为大疱性色素性荨麻疹。 相似文献
4.
大疱性色素性荨麻疹1例 总被引:1,自引:1,他引:1
患儿女,1岁,躯干、四肢反复起斑丘疹、水疱1年伴痒。全身可见褐色斑丘疹,部分斑丘疹上见水疱,摩擦斑丘疹后局部出现风团样损害,即Darier征(+)。皮损组织病理示:表皮下大疱形成,真皮浅层可见大量肥大细胞浸润,Gimsa染色阳性,直接免疫荧光阴性。 相似文献
5.
患者,女,23岁。全身浅褐色斑片4年,皮肤划痕征(+),Darier征(-)。皮损组织病理示:真皮乳头层和真皮浅层血管周围可见灶状分布的圆形和梭形肥大细胞。甲苯胺蓝染色(+)。诊断:色素性荨麻疹。 相似文献
6.
色素性荨麻疹(Urticaria pigmentosa,UP)属于皮肤肥大细胞增生症的一种,病因不明,其发病率为1:8000~1:1000之间,男女发病率相当。大多数患者为儿童,成人发病不常见。本文报道1例典型的成人色素性荨麻疹。 相似文献
7.
8.
9.
回顾性分析38例色素性荨麻疹患者的临床表现及组织病理.患者皮损多表现为躯干、四肢圆形或类圆形的色素性斑丘疹.真皮内可见肥大细胞不同程度浸润,Giemsa染色阳性.色素性荨麻疹的临床和组织病理具特征性,Giemsa染色可帮助确诊. 相似文献
10.
11.
Cutaneous mastocytosis (CM) or urticaria pigmentosa is characterized by abnormal proliferation and accumulation of mast cells. Clinically, CM usually presents as symmetrically distributed red-brown macules or papules that develop weals, erythema and often pruritus on stroking (Darier's sign). The histological hallmark of the disease is an increase in oval to spindle-shaped mast cells in the dermis located around blood vessels and skin appendages. We describe three patients with a new clinicopathological type of CM, which clinically mimics a histiocytic disorder and histologically mimics leucocytoclastic vasculitis (LV). Three infants (two boys and one girl) developed generalized reddish-yellow-brown macules of 3-10 cm with occasional scaling and crusting on the trunk and extremities without further symptoms or organ involvement except variable itching. Histology revealed diffuse and dense dermal infiltrates of eosinophils, neutrophils and nuclear debris with perivascular accentuation, imitating LV. This infiltrate masked large epithelioid cells, positive for macrophage markers, which by special histochemical stains for metachromatic granules turned out to be mast cells. This is the first report of this new variant of CM, which may cause considerable diagnostic difficulties both clinically and histopathologically. 相似文献
12.
13.
14.
皮肤白细胞碎裂性与淋巴细胞性血管炎某些粘附分子表达的比较研究 总被引:1,自引:0,他引:1
目的:比较细胞粘附分子ICAM-1、VCAM-1和ELAM-1在皮肤白细胞碎裂性和淋巴细胞性血管炎的表达及其意义。方法:采用免疫组化方法研究两型血管料的粘附分子表达情况。结果:角质形成细胞ICAM-1在淋巴细胞性血管炎(85.71%)表达明显高于白细胞碎裂性血管炎(11.11%(P〈0.0001),ICAM-1、VCAM-1、ELAM-1在两型血管炎血管内皮中表达无区别(P值分别为1,0.068,0.46)。结论:无论在白细胞碎裂性还是淋巴细胞性血管炎、粘附分子表达均上调。两种血管炎粘附分子表达率的不同反应了局部细胞因子释放的不同,这对揭示血管炎发病机理将具有重要意义。 相似文献
15.
Background Urticaria pigmentosa is a cutaneous disorder involving infiltration of the skin with mast cells. Histologically the papillary dermis has an increased number of mast cells with an increase in basal layer pigmentation. In addition to possible systemic symptoms, patients with urticaria pigmentosa can suffer emotionally from the cosmetic nature of this skin disease. Objective The purpose was to investigate the use of a diode‐pumped Nd:YAG laser at 532 nm for the treatment of the cosmetic comorbidity of urticaria pigmentosa lesions. Methods A 19‐year‐old white male with urticaria pigmentosa had multiple lesions on the dorsum of the hands and forearms. A test site on the right inner arm was treated with a DioLite? 532 nanometer laser. Because of satisfaction with the treatment of the test site lesions, multiple lesions on the dorsal hands and forearms were also treated with the DioLite? 532 nanometer laser. Results There was a dramatic clinical reduction in the amount of lesions on the dorsum of the hands and forearms. The test site lesions on the right inner arm had not recurred. Conclusion The diode‐pumped Nd:YAG laser at 532 nanometers should be considered part of a dermatologist's armamentarium for the treatment of a patient's cosmetic concerns with lesions of cutaneous mastocytosis. 相似文献
16.
M Akiyama 《The Journal of dermatology》1990,17(6):347-355
In 21 cases of urticaria pigmentosa (UP), clinical and histological observations and evaluation of mast cell (MC) volume density in the lesions using a morphometric point counting method were performed. The mutual correlations between clinical and histological findings were statistically assessed by a method of multiple regression analysis. Clinical items employed in the analyses were as follows: sex, the age of onset, the age of biopsy, the biopsy, the duration of lesions, the type of skin lesions, sites involved, the presence or absence of Darier's sign of Darier's sign and symptoms, and serum histamine level. Histological items included the localization and infiltration pattern of MC, the level of basal melanosis, the presence or absence of inflammatory cell infiltration, and the MC volume density in the lesions. Statistical significance of the partial regression coefficients was obtained for 6 pairs of the criteria (p = 0.05), including the age of onset and the age of biopsy, the age of onset and the level of basal melanosis, the duration of lesions and the level of basal melanosis, and the type of skin lesions and the level of basal melanosis. No significant correlations were observed between the MC volume density in the lesions and any of the other items. These results suggest that the basal melanosis in a UP lesion may not be a direct reaction to the transitory massive infiltration of MC, but rather be due to a relatively long-term effect of MC infiltration. Furthermore, the MC volume density in the lesion is not likely to be an important factor in determining the clinical manifestations of a UP lesion. 相似文献
17.
A 12-year-old male presented with an 8-year history of five firm cream colored papules on the right vertex of the scalp. A biopsy showed a dense infiltrate of monomorphous mast cells involving the dermis and extending into the subcutis. A relatively well-circumscribed cluster of larger cells showed pleomorphic nuclei with bilobed and multilobed morphology. Both mast cell populations had an eosinophilic cytoplasm filled with granules ranging in size from small to giant forms. By immunohistochemistry, the cells expressed CD117, tryptase and CD68, and were negative for AE1/AE3, CD1a, CD2 and CD25. S-100 staining revealed only faint cytoplasmic positivity and myeloperoxidase had an inhomogeneous patchy pattern, with an overall staining of less than 5% of the cells. A diagnosis of cutaneous mastocytosis was made and after 6 months follow-up, no progression observed. Clinical correlation and awareness of these unusual morphologic features as being part of the spectrum of cutaneous mastocytosis are important to avoid an erroneous diagnosis of malignancy. Although pleomorphic, multilobed nuclear morphology and giant cytoplasmic granules have not been associated with an aggressive behavior or systemic mastocytosis, close clinical observation is warranted in this context. 相似文献
18.
Lack of c-kit mutation in familial urticaria pigmentosa 总被引:1,自引:0,他引:1
J L Rosbotham N M Malik P Syrris S Jeffery A Bedlow S Gharraie V A Murday C A Holden & N D Carter 《The British journal of dermatology》1999,140(5):849-852
Somatic mutations within c-kit have been reported in individuals with mastocytoses, including urticaria pigmentosa (UP). We have identified three siblings with UP. We aimed to determine whether the c-kit proto-oncogene was playing a part in the aetiology of UP in these three siblings. Using seven microsatellite repeat markers spanning an 8-cM interval encompassing the c-kit gene we followed the transmission of the c-kit gene in this family. Furthermore, single-strand conformation polymorphism analysis was used to scan exon 17 of the c-kit gene for mutations in genomic DNA of all family members and somatic DNA extracted from skin of the eldest affected sibling, the proband. No mutations were found in exon 17 in either genomic DNA of all family members or somatic DNA of the proband. Patients with UP have been shown to possess somatic mutations of the c-kit gene. However, this locus has been excluded as playing a part in the three siblings examined here in whom a second gene locus must be determining their UP. Therefore, this study emphasizes genetic heterogeneity in UP. Future study to identify primary molecular determinants of UP should include affected sib-pair studies. 相似文献
19.
NB Sánchez IF Canedo PE García-Patos P de Unamuno Pérez AV Benito AM Pascual 《Journal of the European Academy of Dermatology and Venereology》2004,18(6):731-735
The association between vasculitis and cancer has been widely reviewed in recent decades. The existence of malignancies in patients with vasculitis has been estimated at about 4.5-8%, haematological neoplasms being the most frequently observed. The haematological malignancies most frequently described are lymphoproliferative diseases such as hairy cell leukaemia and lymphomas. On the contrary, the incidence of paraneoplastic vasculitis in patients with myeloma is low; up to now, we have found nine cases reported on this subject. We report the case of a 73-year-old woman who in 1 year showed three outbreaks of acutely painful, purpuric and ulceronecrotic lesions, localized on the lower extremities. Histopathological study demonstrated thrombosis in the arterioles and leucocytoclastic vasculitis. Complementary tests revealed the presence of multiple myeloma. 相似文献