手部嗜中性皮病1例

<正>患者女,62岁。因双手斑块、脓疱,于2020年8月15日来我科就诊。患者2个月前无明显诱因于双手指、手背出现紫红色斑块,触之略有疼痛感,皮损表面逐渐出现少许坏死及脱屑,同时手背、手指及手掌出现多发小脓疱,20 d前皮损加重。患者既往体健,自发病以来无发热、咽痛等急性上呼吸道感染症状,无手部外伤史,无关节肿痛,否认银屑病、     

复发性手部嗜中性皮病1例

<正>1病历资料患者女,59岁。因左手背水肿性红斑伴疼痛20 d,于2017年1月3日来宁波市北仑区人民医院皮肤科就诊。患者20 d前无明显诱因左手背突然出现水肿性红斑,并逐渐增大、肿胀且疼痛明显,伴发热,体温最高38.9°C。当地医院给予抗生素治疗(具体不详),病情无明显好转。追问病史,患者2年前和1年前均有过一类     

急性发热性嗜中性皮病1例

患者女,52岁。因面部、颈部及四肢出现红色丘疹及斑块,不痛不痒1个月,于2007年8月8日至我院皮肤科就诊。患者于1个月前双上臂出现散在红色丘疹及斑块,无自觉症状,表面无鳞屑,未予治疗。嗣后皮损逐渐增多,面部、颈部及双下肢出现同样皮损,无疼痛、瘙痒及烧灼感,不伴发热,无关节疼痛。曾在外院就诊,疑诊为肉芽肿予以药物（具体用药不洋）治疗,皮损未见好转。     

急性发热性嗜中性皮病1例

急性发热性嗜中性皮病亦称斯威特(Sweeet)综合征。是一种原因不明的慢性易复发性红斑与结节性皮肤病，临床常见但泛发伴有水疱，表皮坏死者少见。我们发现1例报道如下。临床资料患者男，43岁，农民。因感冒发热，伴发扁桃体炎，在当地医院静脉滴注青霉素5天好转。3周后在颈部、面部及四肢相继出现淡红色至暗红色斑块和结节，自觉灼热疼痛，触痛明显以致病人有时不能忍受，下肢膝关节痛，上肢肘、腕关节痛。在当地医院按病毒感染性疱疹治疗(药物不详)，效果不佳，于2003年12月来我站就诊，     

以急性发热性嗜中性皮病为首发症状的急性髓系白血病1例

 报告以急性发热性嗜中性皮病为首发症状的急性髓系白血病1例。患者女,50岁,反复全身红色斑块伴疼痛4个月,加重2 d。皮肤科检查：颈部及双上肢分布大小不等红色斑块,皮损边缘略隆起于皮面,呈环状,未见水疱及破溃,触痛阳性。上唇少许糜烂面。组织病理符合急性发热性嗜中性皮病改变。入院后查血液系统异常,诊断急性髓系白血病,以急性发热性嗜中性皮病为首发症状。予EA方案预化疗。三个月后患者因严重脑出血死亡     

中性粒细胞胞外诱捕网与嗜中性皮病

中性粒细胞胞外诱捕网成分复杂,包括DNA和组蛋白及各种抗菌肽等,发挥的作用不仅限于宿主防御,还包括癌症、血管疾病、自身免疫性疾病等疾病.近年来,越来越多的研究发现,中性粒细胞胞外诱捕网的产生与嗜中性皮病的发生发展密切相关.本文主要围绕中性粒细胞胞外诱捕网的成分及作用、形成方式及参与嗜中性皮病的病理过程展开论述.     

急性发热性嗜中性皮病1例

患者女,34岁,反复颜面、上肢红色斑块、水疱4月,再发4天.皮肤科检查:前额、面部、左前臂、左腕部、右肘部、手背、指背关节处可见多发散在鲜红色、水肿性斑块,表面可见多发小脓疱、水疱.皮损以右面部为重,边缘稍隆起,表面结黄色浆液痂或脓痂.触之有浸润感,压痛.皮损组织病理检查:真皮乳头水肿,真皮浅、深层弥漫性中性粒细胞浸润...     

20例急性发热性嗜中性皮病临床病理分析

对２０例ＡＦＮＤ进行临床病理分析，该病临床皮损主要表现为疼痛性水肿性红色斑块，皮损好发于面、颈部及四肢，多数伴有发热和中性多核粒细胞增多，病理特点主要在真皮内可见以中性多核粒细胞为主的弥漫性浸润。     

嗜中性药疹

药疹可以模拟多种皮肤病,包括几种“经典”的嗜中性皮肤病,其中最常见的Sweet综合征,其它还包括急性泛发性发疹性脓疱病、坏疽性脓皮病、溴疹、碘疹、嗜中性小汗腺炎等。本文就嗜中性药疹的情况做一概述。     

急性发热性嗜中性皮病

<正>1病历摘要患者女,52岁。因面部水肿性红斑伴终末血尿3个月,复发1个月就诊。患者3个月前无明显诱因左侧面颊部皮肤出现一水肿性红斑,色鲜红,边缘略隆起,伴终末血尿。未重视,未予以治疗。随着病情发展,皮损逐渐扩大。于当地门诊按"皮炎"对症治疗(具体用药不详)后皮损消退,终末血尿症状无缓解,先后于妇科、泌     

Neutrophilic dermatosis of the dorsal hands in a farmer

Neutrophilic dermatosis of the dorsal hands is a recently described disorder, which is similar to Sweet's syndrome. It is characterized by erythematous plaques, pustules and haemorrhagic bullae located solely on the dorsal surface of the hands. We describe a 57-year-old man with neutrophilic dermatosis of the dorsal hands that occurred following exposure to a chemical fertilizer. There are few cases reported in the literature regarding neutrophilic dermatosis and the aetiology remains unclear. For the present case, we propose that neutrophilic dermatosis of the dorsal hands might have been induced by the chemical fertilizer.     

Neutrophilic dermatosis of the hands: presentation of eight cases and review of the literature

Pustular dermatosis of the dorsal hands is a peculiar variant of Sweet's syndrome described by Strutton et al. Nevertheless, not all authors accept this entity. We present a retrospective study of eight cases of neutrophilic vasculitis of the hands. Three patients presented with lesions only on the dorsal hands, three with lesions on the palmar surface and two with lesions on the dorsal and palmar surfaces of the hands. The patients with lesions on the dorsal surface presented a pustular aspect, and the histopathological examination revealed a high degree of vascular damage with presence of vasculitis and, in one case, with fibrinoid necrosis. Therefore, the term pustular vasculitis of the dorsal hands introduced by Strutton et al. should probably be conserved. Our cases may have demonstrated a peculiar clinicopathological disease with its own entity.     

Neutrophilic dermatosis of the dorsal hand

Neutrophilic dermatosis of the dorsal hands (NDDH) was originally described as pustular vasculitis (PV) of the hands. Recent debate focuses on categorizing this disorder in the family of neutrophilic dermatoses (ND), as opposed to a primary vasculitis. We present a case of NDDH with clinical and histologic features consistent with ND, and discuss the major concerns for this disease's reclassification.     

Neutrophilic dermatosis of the dorsal hands related to cocaine abuse

Neutrophilic dermatoses encompass a wide spectrum of diseases characterized by a dense infiltration mainly composed of neutrophils. Neutrophilic dermatosis of the dorsal hands is currently considered a localized variant of Sweet syndrome. Cocaine abuse has been related to a wide range of mucocutaneous manifestations, including neutrophilic dermatoses such as pyoderma gangrenosum. The authors of this study present a patient with neutrophilic dermatosis of the dorsal hands, in which cocaine abuse was identified as a probable trigger.     

Erosive pustular dermatosis of the leg: report of three cases

Erosive pustular dermatosis of the leg is a distinct form of spongiform amicrobial pustulosis. The disorder typically affects the lower limbs of elderly patients presenting with chronic venous insufficiency and stasis dermatitis, and has a chronic course. Three elderly patients with chronic venous ulcers are described, who developed pustules and moist eroded lesions on the leg. The clinical and histological features were typical for erosive pustular dermatosis. The lesions rapidly responded to topical treatment with either tacrolimus or corticosteroids. Of note, this condition was associated with a diverticular disease in two patients, while in another patient an epidermoid carcinoma of the tongue was present. Erosive pustular dermatosis of the leg is an uncommon but distinct skin disorder typically associated with trophic changes of the lower limbs. Our observations raise the question of the relation of erosive pustular dermatosis of the leg with the group of neutrophilic dermatoses. Topical immunotherapy with tacrolimus may constitute a novel therapeutic option for this frequently recalcitrant condition.     

Neutrophilic dermatosis of the dorsal hands

Neutrophilic dermatosis of the dorsal hands is a recently described disorder. It is still debatable if it constitutes a separate entity, a variant of Sweet syndrome or pyoderma gangrenosum or an overlap disorder of both. We report the clinical features, histopathological findings, and evolution of a 35-year-old patient with the diagnosis of neutrophilic dermatosis of the dorsal hands and distant lesions on the forehead.