The possibility of dietary protective factors in duodenal ulcer. II. An investigation into the effect of pre-feeding with different diets and of instillation of foodstuffs into the stomach on the incidence of ulcers in pylorus-ligated rats.

Rats pre-fed on a South Indian diet show a much higher incidence of ulceration of the stomach after pyloric ligation than those on a North Indian diet. Removing vegetables and pulses from the North Indian diet deprives it of its protective effect. Staple foodstuffs with a high buffer content (unmilled rice, unrefined wheat and a millet [ragi]) placed in the stomach after pyloric ligation are also protective, but those with a low buffer content (milled rice, tapioca, sorghum and maize) are not protective. Refined wheat, however, gives protection despite its low buffer content. The significance of these findings in relationship to the distribution of duodenal ulcer in India and Africa is discussed.     

十二指肠溃疡合并穿孔的危险因素分析

目的:探究十二指肠溃疡合并穿孔的危险因素,为穿孔的早期诊断提供辅助检查依据.方法:回顾性分析290例十二指肠溃疡患者的临床资料,根据穿孔发生与否分为穿孔组(n=41)和未穿孔组(n=249).单因素和多因素Logistic回归分析十二指肠溃疡合并穿孔的危险因素,受试者工作特征曲线(ROC)分析各独立危险因素及联合检测对十二指肠溃疡合并穿孔的诊断效能.结果:十二指肠溃疡合并穿孔发生41例(14.14％).单因素和多因素Logistic回归分析显示,幽门螺杆菌(Hp)感染(OR=6.961)、溃疡直径较大(OR=5.950)、溃疡位于十二指肠前壁(OR=5.202)、服用非甾体抗炎药(NSAIDS)(OR=5.019)、血清降钙素原(PCT)(OR=1.331)及血清胃泌素(Gas)水平(OR=1.030)升高为十二指肠溃疡合并穿孔的独立危险因素(P<0.05).十二指肠溃疡合并穿孔的回归方程式为Logistic(P)=-16.752+1.940 Hp感染+1.783溃疡直径+1.649溃疡位置+1.613服用NSAIDs+0.286 PCT+0.029 Gas,联合检查(Logistic回归模型)诊断的曲线下面积(AUC=0.808)、灵敏度(0.829)、特异度(0.807)、约登指数(0.636)均高于各因素单独诊断(P<0.001).结论:Hp感染、溃疡直径较大、溃疡位于十二指肠前壁、服用NSAIDS、血清PCT及Gas升高为十二指肠溃疡合并穿孔的独立危险因素;上述独立危险因素的联合检查可进一步提高十二指肠溃疡合并穿孔的诊断效能.     

心理社会因素与十二指肠溃疡之相关研究

心理社会因素与十二指肠溃疡之相关研究Ｃｏｒｒｅｌａｔｉｏｎｓｔｕｄｙｂｅｔｗｅｅｎｐｓｙｃｈｉｃｓｏｃｉａｌｆａｃｔｏｒｓａｎｄｄｕｏｄｅｎａｌｕｌｃｅｒｄｉｓｅａｓｅ￥／／张卫中，尚景瑞，赵瑞敏，季卫东，朱玉萍，张新农随着生物医学模式向生物、心理社...