Pinkus纤维上皮瘤1例

报告Pinkus纤维上皮瘤1例.患者女,61岁,右侧腹股沟区不规则黑褐色斑块2个月余,大小约为0.8 cm×1.2 cm,表面粗糙呈乳头瘤状,不伴疼痛及瘙痒.皮损组织病理:真皮内可见增生的与表皮相连的基底样细胞样条索,并含有色素,条索周边的细胞呈栅栏状排列,部分周边有收缩间隙,基质内见胶原纤维增生及黏液沉积.诊断:Pi...     

Pinkus纤维上皮瘤

报告1例左侧颈部Pinkus纤维上皮瘤。患者男,32岁。因左侧颈部丘疹2年就诊。皮肤科检查:左颈部一直径0.5cm球形丘疹,质地适中,无浸润感。皮损组织病理检查:表皮增生,棘层下方大量基底样细胞增生,呈条索状向真皮内延伸,相互交织成网状,细胞核大深染,胞质嗜碱性,无明显异形性。患者的临床表现、组织病理改变均符合Pinkus纤维上皮瘤的特点。将皮损手术切除,目前正在随访中。     

Pinkus纤维上皮瘤1例

Pinkus 纤维上皮瘤(fibroepithelioma of Pinkus)临床较少见,病理表现为基底样细胞增生,其与基底细胞癌的关系尚存争议,皮疹形态多样,但表现为外阴部多发丘疹、结节者极少见,现将我科诊治的1 例报告如下.     

Pinkus纤维上皮瘤一例

65岁男性患者,右大腿内侧结节10年余,逐渐增大.患者右大腿内侧可见一1.0 cm×0.5 cm大小暗紫红色结节,表面光滑有正常皮肤纹理,边界清楚,质地较硬.皮损组织病理见真皮内大量上皮样细胞组成的条索,与表皮相连,相互交织成网状,肿瘤细胞为核大深染的基底样细胞,下端细胞条索较为平齐,肿瘤周围结缔组织基质明显增生,毛细...     

Pinkus纤维上皮瘤

患者男,83岁.主诉:左下背部一蚕豆大黑褐色结节20余年.现病史:患者20多年前左下背部出现一黑褐色丘疹,无自觉症状.发病前皮损处无外伤史.自认为色素痣,未行任何治疗.后逐渐缓慢增至蚕豆大,平卧时局部有压迫不适感,遂于2009年4月9日来我科就诊.     

多发性Pinkus纤维上皮瘤

报造1例多发性Pinkus纤维上皮瘤。患者男,47岁。因两侧腰部褐色、淡红色斑8年,增大、增多半年就诊。皮肤科检查：两侧腰部褐色、淡红色斑,边缘褐色,稍隆起,可见扩张的毛囊口,中央淡红色、轻度萎缩,表面无糜烂、渗出,无浸润。组织病理检查显示为Pinkus纤维上皮瘤样改变。     

外阴Pinkus纤维上皮瘤

报告1例外阴Pinkus纤维上皮瘤。患者女,71岁。左大阴唇外侧斑块10余年。皮肤科检查见左大阴唇外侧一2cm×2cm灰黑色浸润性斑块．质地中等,边缘清楚,表面散在红色点状糜烂面,无明显渗液。皮损组织病理检查：棘层下方大量基底样细胞增生．增生的细胞呈条索状嵌入真皮增生的纤维间质中,彼此吻合形成网状,基底细胞胞核大而深染,胞质少,呈嗜碱性,表皮基膜完整,真皮内有以淋巴细胞为主的大量炎性细胞浸润。诊断：外阴Pinkus纤维上皮瘤。     

Pinkus纤维上皮瘤1例并文献复习

患者女,67岁,左肩肤色皮肤肿物3年。患者皮损呈扁平隆起斑块状,约4 cm×3 cm大小,表面大致呈正常肤色,无明显角质增生,不伴局部多毛。皮损组织病理示:病变与表皮相连,瘤细胞条索边缘处呈柱状栅栏样排列;细胞胞浆较透明淡染,胞核更为狭长,栅栏样排列更为明显。病变予5 mm边界完整切除后随访1年未见复发。     

Pinkus纤维上皮瘤一例

患者男,56岁。因左侧股部及膝关节处皮肤斑块50余年,破溃半年余就诊。患者自幼左膝关节上方有鸡蛋大小暗红色斑块,质脆,外伤后易破溃流血。因无自觉症状,未影响日常生活,故未系统诊治。皮损逐渐扩大,增厚明显,以近10年为著。半年前,于外伤后左膝关节内侧出现一溃疡,起初溃疡面积约2.0 cm × 2.0 cm,不易愈合……     

基底细胞上皮瘤1例

患者男,47岁,左大腿伸侧黑色结节30年,增大3年伴渗液1周。于2002年9月9日来本科就诊。患者30年前,发现右侧大腿前出现一黑色皮损,约绿豆大,不痛不痒,未予治疗。3年前,发现无明显原因结节增大,摩擦后有不适感,且逐渐增大至鸽蛋大。1周前,皮损处碰撞后有血性分泌物流出,并感疼痛,但仍未就诊。后因皮损处间断有淡黄色液体流出,自行用手挤压致渗液增多,疼痛加剧,才来我院求治,     

Fibroepithelioma of Pinkus induced by radiotherapy

Fibroepithelioma of Pinkus (FEP) is a rare cutaneous neoplasm. Evidence supports classification as a variant of either basal cell carcinoma (BCC) or trichoblastoma. Reports of FEP arising in sites of preceding radiation therapy have been documented in the literature, but the relationship between radiotherapy and the development of FEP has not yet been defined. We report a case of FEP following radiation therapy for testicular cancer.     

Fibroepithelioma of Pinkus is a true basal cell carcinoma developing in association with a newly identified tumour-specific type of epidermal hyperplasia

Background Fibroepithelioma of Pinkus (FEP) has long been viewed as a subtype of basal cell carcinoma (BCC). Recently, however, the proposal has been made that FEP represents a fenestrated trichoblastoma/trichoepithelioma. One of the main arguments is the presence of Merkel cells in FEP, which typically do not occur in BCC. Objectives As the new stem cell marker, PHLDA1 (TDAG51), labels trichoepithelioma but not BCC, our aim was to characterize its staining pattern in FEP. Because adnexal tumours have been viewed as recapitulating embryogenesis, we also examined PHLDA1 immunoreactivity in the skin of human embryos and fetuses. Methods We studied immunohistochemically PHLDA1 staining in 31 FEPs, 14 BCCs and 16 trichoepitheliomas and compared this with its staining pattern in embryonic skin and with the distribution of Merkel cells. Results In FEP, PHLDA1 labels the anastomosing network of thin cellular strands but not the basaloid nubbins. During embryogenesis, PHLDA1 stains the basal cell layer of the epidermis, as long as adnexal structures develop. Immunoreactivity for PHLDA1 correlates positively with the presence of Merkel cells. Conclusions We propose that the thin anastomosing network of PHLDA1‐positive cells represents a type of epidermal hyperplasia specific to FEP. The multifocal BCCs that are PHLDA1‐negative develop from this network which becomes incorporated into the tumour. Viewing the anastomosing network as a tumour‐specific form of epidermal hyperplasia explains the hitherto enigmatic presence of Merkel cells in FEP.     

Fibroepithelioma of pinkus

An 88-year-old woman presented with an 8-year history of a slowly enlarging growth on the suprapubic area. A shave excision of this lesion demonstrated fibroepithelioma of Pinkus (FEP). Fibroepithelioma of Pinkus is an indolent growing tumor that traditionally has been classified as a variant of the basal cell carcinoma. More recent evidence favors the classification of FEP as a variant of trichoblastoma. In this case report, we identified a large FEP with benign histologic features suggestive of a follicular origin as demonstrated in part by CK 20 staining and the presence of scattered Merkel cells within the tumor. The pathogenesis of FEP remains enigmatic, and the genetic basis has yet to be fully elucidated. Complete surgical resection is considered curative.