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基层药监稽查任务面广量大,管理相对人情况复杂,稽查人员缺乏,执法装备、执法手段相对落后,面对如此现状,切实提高稽查办案效果,对于有效打击各类涉药违法犯罪行为、教育警示广大群众、降低行政执法成本、树立药监执法部门权威有着重要的意义。笔者认为,提高基层药监稽查办案效果,应把握以下八个方面。 相似文献
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行政执法作为贯彻执行国家意志的有效手段,其基本目的,一是要维护公共利益,二是要服务社会。依法治国的根基在依法行政。药品监督管理的行政执法是国家依法行政的重要组成部分。药品监督管理机关作为行政执法机构,直接代表国家行使药品监督管理职能,在我国建设社会主义法治国家的进程中,理应围绕保证药品质量、确保人民用药安全有效这个根本职能严格依法行政。药监部门的一切工作必须依照法定权限和程序履行职责,既不失职,又不越权,做到有法可依、有法必依、执法必严、违法必究,有权必有责、有权受监督、侵权要赔偿,在依法监管过程中全面推进各项工作向依法行政、依法规范、依法运行转变。 相似文献
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马生荣 《中国食品药品监管》2005,(12)
药品监督执法人员的法律意识是指执法人员 对于相关法律和法规现象的态度、思想、观点和 心理的总称。是其法律素质和依法行政能力中最 重要最基本的要求。基层药监执法人员身处执法 第一线,承担着繁重的执法任务。如果不具备与 其法律职权相应的法律意识,就会影响到整个药 监执法队伍适用法律的能力和水平,相应地也会 影响到法律的尊严和政府部门的意识。因此,有 目的的培养并提高基层药监执法人员的法律意 识,是药监工作依法行政的现实需要,也是药监 执法人员提高构建社会主义和谐社会能力的必然 要求。 相似文献
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基层药品监管部门如何在监管中真正做到依法行政是关系到能否履行使命,能否不负重托的问题,也关系到药监部门的形象问题。本文试就这一问题谈一点个人的认识。 相似文献
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《中国食品药品监管》2004,(4)
近年来,随着法制建设步伐的加快,全国推进规范化执法工作不断深入。然而目前的药品行政执法工作与我国依法治国、依法行政的总要求还存在一定的差距,因此笔者认为分析当前药监行政执法工作中存在的问题,研究解决问题的方法,具有十分重要的意义。 相似文献
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食品药品监管部门担负着保障人民群众饮食用药安全的重要职责。在新的历史条件下,如何创新执法理念,落实科学发展观,进一步规范行政执法行为,履行好食品药品监管职责,是摆在我们面前的一个严峻课题。笔者认为,开展行政执法监督,目的是保证药品管理法律法规得以实现,防止和纠正药监行政违法行为,为此,要从源头抓起.坚持标本兼治,严格责任追究,建立和完善药监行政执法内部监督制约机制.促进药监部门依法行政。 相似文献
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在行政执法办案中,细节往往决定着办案质量。药监机关查办的案件能否件件成为经得起诉讼的铁案,这关系到药监机关的执法权威和形象,因此,应当注重细节。办案实践中容易被忽略的细节主要有如下几点: 相似文献
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The concept that oestrogen replacement therapy is cardioprotective has been challenged recently by the negative results of randomized clinical trials in coronary heart disease. These data have come at a time of rapid advances in our understanding of the cellular mechanisms of oestrogen. In particular, the cloning of the classical oestrogen receptor (ERalpha), the identification of a novel ER isoform (ERbeta), the availability of specific ERalpha and ERbeta knockout mice models, and the elucidation of receptor functions and signalling pathways linked to non-genomic actions of oestrogen are helping to unravel this complex biology. In this article, these advances will be discussed with particular emphasis on the regulation of nitric oxide synthesis by oestrogen. Furthermore, the puzzling issues that have emerged and the potential for development of novel and specific therapeutic approaches will be highlighted. 相似文献
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The history of ketamine and phencyclidine from their development as potential clinical anaesthetics through drugs of abuse and animal models of schizophrenia to potential rapidly acting antidepressants is reviewed. The discovery in 1983 of the NMDA receptor antagonist property of ketamine and phencyclidine was a key step to understanding their pharmacology, including their psychotomimetic effects in man. This review describes the historical context and the course of that discovery and its expansion into other hallucinatory drugs. The relevance of these findings to modern hypotheses of schizophrenia and the implications for drug discovery are reviewed. The findings of the rapidly acting antidepressant effects of ketamine in man are discussed in relation to other glutamatergic mechanisms.Tables of Links
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Open in a separate windowThese Tables list key protein targets and ligands in this article which are hyperlinked to corresponding entries in http://www.guidetopharmacology.org, the common portal for data from the IUPHAR/BPS Guide to PHARMACOLOGY (Pawson et al., 2014) and are permanently archived in the Concise Guide to PHARMACOLOGY 2013/14a,b,c,dAlexander et al., 2013a,b,c,d,,,). 相似文献
TARGETS | |
---|---|
GPCRsa | Ligand-gated ion channelsb |
κ receptor | AMPA receptors |
μ receptor | GluN2A |
ACh receptors (muscarinic) | GluN2B |
Cannabinoid receptors | GluN2C |
D2 receptor | GluN2D |
Metabotrophic glutamate receptors | Kainate receptors |
Enzymesd | NMDA receptors |
Cholinesterases | Nicotinic ACh receptors |
GAD-67 | |
GSK-3 | Ion channelc |
mTOR | HCN1 |
PKB (Akt) |
LIGANDS | ||
---|---|---|
5-HT | Dopamine | Morphine |
ACh | Ethylketocyclazocine | Naloxone |
AMPA | HA-966 | NMDA |
Amphetamine | Ifenprodil | Noradrenaline |
Bicuculline | Kainate | Pentazocine |
Chlorpromazine | Ketamine (CI-581) | Phencyclidine |
Cyclazocine | Levorphanol | Pregnenolone |
D-AP5 | LSD | Quisqualate |
Dextromethorphan | Memantine | U50488H |
Dizocilpine (MK-801) |
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医院以及医院药学的定位和服务方式转变 总被引:3,自引:0,他引:3
本文以新一轮医药卫生体制改革的内容为切入点,分析我国现有医院与医院药学的现状,并与国外医疗体系做对比;提出了公立医院的定位问题及如何发挥医院药学在医院中的作用,转变服务方式,加强药师队伍建设等问题。 相似文献
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Hydrogen sulfide is rapidly gaining ground as a physiological mediator of inflammation, but there is no clear consensus as to its precise role in inflammatory signaling. This article discusses the disparate anti-inflammatory ('the good') and proinflammatory ('the bad') effects of endogenous and pharmacological H(2)S in disparate animal model and cell culture systems. We also discuss 'the ugly', such as problems of using wholly specific inhibitors of enzymatic H(2)S synthesis, and the use of pharmacological donor compounds, which release H(2)S too quickly to be physiologically representative of endogenous H(2)S synthesis. Furthermore, recently developed slow-release H(2)S donors, which offer a more physiological approach to understanding the complex role of H(2)S in acute and chronic inflammation ('the promising') are discussed. 相似文献
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Klopack TG 《Drug discovery today》2000,5(4):157-160
Pharmaceutical research organizations can benefit from outsourcing discovery activities that are not core competencies of the organization. The core competencies for a discovery operation are the expertise and systems that give the organization an advantage over its competition. Successful outsourcing ventures result in cost reduction, increased operation efficiency and optimization of resource allocation. While there are pitfalls to outsourcing, including poor partner selection and inadequate implementation, outsourcing can be a powerful tool for enhancing drug discovery operations. 相似文献