腹腔镜Roux-en-Y胃旁路术与腹腔镜袖状胃切除术对改善肥胖患者血脂的Meta分析

目的:比较腹腔镜Roux-en-Y胃旁路术(LRYGB)与腹腔镜袖状胃切除术(LSG)对肥胖症的减重效果及对血脂的影响。方法:检索相关数据库,以获取比较LRYGB与LSG治疗肥胖患者及改善血脂的相关中、英文文献,检索时间自建库至2022年9月,对纳入文献进行质量评价、提取数据及数据统计分析。结果:共纳入15篇文献,其中LRYGB组4 033例,LSG组4 859例。与LSG组相比,LRYGB组术后甘油三酯水平较低[MD=-0.19,95%CI(-0.33,-0.04),P<0.05],总胆固醇水平较低[MD=-0.61,95%CI(-0.95,-0.28),P<0.05],低密度脂蛋白水平较低[MD=-0.54,95%CI(-0.85,-0.24),P<0.05];两组术后体质指数[MD=-0.10,95%CI(-0.23,0.02),P>0.05]、高密度脂蛋白[MD=-0.12,95%CI(-0.40,0.15),P>0.05]、血脂异常缓解率[RR=1.14,95%CI(0.99,1.30),P>0.05]差异无统计学意义。结论:LRYGB与L...     

腹腔镜袖状胃切除术对肥胖患者血清尿酸水平的影响

目的:探讨腹腔镜袖状胃切除术对肥胖患者血清尿酸水平的影响.方法:回顾分析2016年1月至2019年1月接受腹腔镜袖状胃切除术的83例肥胖患者的临床资料.依照血清尿酸水平的高低分为尿酸正常(NUA)组(n=41)与合并高尿酸血症(HUA)组(n=42).统计分析两组患者术前与术后人体测量学指标、部分生化指标的变化情况.采...     

腹腔镜袖状胃切除术后远期效果分析

目的:评价腹腔镜袖状胃切除术治疗病态肥胖症的远期临床效果.方法:2005年9月至2009年9月为47例单纯性肥胖症患者施行腹腔镜袖状胃切除术,术后随访2年,观察体重指数变化和超重体重下降百分比.结果:术后患者均随访12个月以上,无严重并发症发生及营养不良,43例患者减重效果理想.结论:腹腔镜袖状胃切除术减重效果显著,远...     

腹腔镜袖状胃切除术的疗效分析

目的:探讨腹腔镜袖状胃切除术治疗肥胖症的临床疗效及其相关并发症。方法:回顾分析2014年4月至2017年1月为28例肥胖症患者行腹腔镜袖状胃切除术的临床资料。术后随访患者体重、体重指数、血糖、糖化血红蛋白、血脂、血红蛋白、维生素B_(12)、叶酸等指标,计算多余体质量下降百分比。结果:28例患者均顺利完成手术,无中转开腹。随访3~36个月,术后患者体重、体重指数明显下降。2例患者减重效果欠佳,多余体质量下降百分比分别为47.2%与42.9%。10例患者合并2型糖尿病,其中8例仅靠生活及饮食可控制空腹血糖;术后血脂及其他相关肥胖并发症均得到明显缓解。2例合并胃食管反流病,术后未见缓解。无营养不良。结论:腹腔镜袖状胃切除术是高效、安全的减重手术,可明显缓解肥胖症患者的体重及相关肥胖并发症。     

重度肥胖患者应用腹腔镜下袖状胃切除术与胃旁路术治疗前后肺功能及血脂水平变化分析

目的对比腹腔镜下袖状胃切除术(LSG)与胃旁路术(LRYGB)对重度肥胖患者肺功能及血脂水平的影响。 方法回顾性分析2014年11月至2017年11月2个医院收治的重度肥胖(BMI≥35kg/m²)患者90例,患者接受LSG(n＝48)或LRYGB(n＝42)治疗。采用SPSS 19.0进行统计学分析,一般资料、肺功能指标、生理指标、血脂水平的比较采用( ±s),组间比较采用独立t检验或单因素方差分析;计数资料采用χ²检验。P<0.05表示统计学差异显著。 结果LSG组手术时间与麻醉时间均低于LRYGB组,差异有统计学意义(P<0.05),两组术中出血量比较无明显统计学意义(P>0.05);术前两组肺功能的比较差异无统计学意义。术后两组PaO₂、FVC、FEV1和MMF均较术前明显下降(P<0.05)。术后48 h,上述指标均较术后24 h改善(P<0.05),但仍较术前水平低(P<0.05); LSG组术后24 h、48 h的上述指标均较LRYGB组高,差异有统计学意义(P<0.05)。与术前比较,两组术后6个月体重、BMI、腰围、臀围、空腹血糖和餐后2 h血糖均明显下降(P<0.05);与术前比较,两组术后6个月TG、CH、LDL水平均明显下降,而HDL水平明显升高(P<0.05),组间比较差异均无统计学意义(P>0.05)。(P>0.05)。 结论LRYGB和LSG减肥疗效相当,对血脂的改善无明显差异,但是LSG对患者短期肺功能和氧合的影响较LRYGB小。     

腹腔镜袖状胃切除术治疗肥胖及其并发症20例报告

目的:探讨腹腔镜袖状胃切除术治疗肥胖及其并发症的可行性。方法:回顾分析2020年5月至2021年5月接受腹腔镜袖状胃切除术治疗的20例肥胖患者的临床资料,整理术前(性别、年龄、体重、体重指数、糖化血红蛋白、甘油三脂及血压)、术中(出血量、手术时间)、术后(术后胃残端瘘、出血、死亡例数及术后6个月随访时患者的体重、体重指数、糖化血红蛋白、甘油三酯及血压)相关指标,并进行统计学分析。结果:20例患者均成功完成腹腔镜袖状胃切除术,术中出血量平均(25.65±7.04)mL,手术时间平均(63.85±13.81)min;术后2例患者出现消化道出血,无术后胃瘘及围手术期死亡病例。术后6个月随访,患者体重较术前平均下降(22.15±8.37)kg,体重指数平均下降(7.55±2.21)kg/m²,血脂水平均降至正常,7例高血压患者中5例收缩压完全降至正常,另2例血压较术前不同程度降低;2例2型糖尿病患者的糖化血红蛋白较术前均下降。结论:腹腔镜袖状胃切除术治疗肥胖及其相关并发症安全、有效,可作为常规术式在基层医院开展。     

腹腔镜袖状胃切除术对胃食管反流病的影响

胃食管反流病在肥胖患者中的发病率较高,而代谢减重手术是重度肥胖患者的重要治疗手段。其中腹腔镜袖状胃切除术作为现阶段最流行的减重手术,其对胃食管反流病的影响也受到越来越多的关注。由于袖状胃手术对胃食管反流病的影响争议较大,本文现总结胃食管反流病的病理生理基础、袖状胃手术对胃食管反流病影响的相关文献及袖状胃术后胃食管反流病的治疗方案,以期为临床实践提供帮助。     

腹腔镜袖状胃切除术的饮食管理

目的:探讨腹腔镜袖状胃切除术的饮食管理,以保证患者围手术期的安全在体重减轻的同时减少营养物质缺乏及相关并发症的发生。方法:为2013年3月至2015年5月施行腹腔镜袖状胃切除术的30例減重患者进行规范的饮食管理,术后定期进行营养随访教育。结果:患者均顺利康复出院,并进行至少12个月的术后随访,体质量下降显著,相关合并症亦有不同程度改善。随访期内1例患者出现脱发症状,经饮食、维生素调整后得到缓解;未按要求进食者2例,其中1例出现较严重的脱水,另1例出现腹痛均再次住院治疗均未见其他明显营养相关并发症发生。结论:规范合理的饮食管理是保证手术疗效、減少并发症、避免术后营养相关并发症、提高患者生活质量的重要因素,值得临床推广应用。     

腹腔镜袖状胃切除术后胃漏2例诊疗体会

目的:探讨腹腔镜袖状胃切除术后胃漏的发生原因及治疗方法。方法:回顾分析2015年5月至2018年12月接受LSG术后发生胃漏的2例患者的临床资料。结果:病例1男性,33岁,BMI 34.68 kg/m~2,术前诊断为原发性肥胖症及胃间质瘤,行腹腔镜袖状胃切除术+腹腔镜胃间质瘤切除术,为第15例LSG患者,术后第7天发生胃漏;病例2为女性,28岁,BMI 53.65 kg/m~2,术前诊断为代谢综合征及食管裂孔疝,行腹腔镜袖状胃切除术+食管裂孔疝修补术,为第30例LSG患者,术后第8天患者出院,第22天发生胃漏。采用三腔喂养管,同时行胃肠减压、胃瘘口冲洗及肠内营养,并予以黎氏管腹腔冲洗引流,2例胃漏患者分别于治疗后63 d及17 d复查上消化道造影,提示治愈。结论:应用三腔喂养管行胃瘘口冲洗及肠内营养、黎氏管腹腔持续冲洗引流,可有效控制腹腔感染,提高胃漏治愈率,操作简单、易行,效果确切、安全,值得临床推广。     

Laparoscopic revisional surgery after Roux-en-Y gastric bypass and sleeve gastrectomy

BackgroundFailure of primary bariatric surgery is frequently due to weight recidivism, intractable gastric reflux, gastrojejunal strictures, fistulas, and malnutrition. Of these patients, 10–60% will undergo reoperative bariatric surgery, depending on the primary procedure performed. Open reoperative approaches for revision to Roux-en-Y gastric bypass (RYGB) have traditionally been advocated secondary to the perceived difficulty and safety with laparoscopic techniques. Few studies have addressed revisions after RYGB. The aim of the present study was to provide our experience regarding the safety, efficacy, and weight loss results of laparoscopic revisional surgery after previous RYGB and sleeve gastrectomy procedures.MethodsA retrospective analysis of patients who underwent laparoscopic revisional bariatric surgery for complications after previous RYGB and sleeve gastrectomy from November 2005 to May 2007 was performed. Technical revisions included isolation and transection of gastrogastric fistulas with partial gastrectomy, sleeve gastrectomy conversion to RYGB, and revision of RYGB. The data collected included the pre- and postoperative body mass index, operative time, blood loss, length of hospital stay, and intraoperative and postoperative complications.ResultsA total of 26 patients underwent laparoscopic revisional surgery. The primary operations had consisted of RYGB and sleeve gastrectomy. The complications from primary operations included gastrogastric fistulas, refractory gastroesophageal reflux disease, weight recidivism, and gastric outlet obstruction. The mean prerevision body mass index was 42 ± 10 kg/m². The average follow-up was 240 days (range 11–476). The average body mass index during follow-up was 37 ± 8 kg/m². Laparoscopic revision was successful in all but 1 patient, who required conversion to laparotomy for staple line leak. The average operating room time and estimated blood loss was 131 ± 66 minutes and 70 mL, respectively. The average hospital stay was 6 days. Three patients required surgical exploration for hemorrhage, staple line leak, and an incarcerated hernia. The overall complication rate was 23%, with a major complication rate of 11.5%. No patients died.ConclusionLaparoscopic revisional bariatric surgery after previous RYGB and sleeve gastrectomy is technically challenging but compared well in safety and efficacy with the results from open revisional procedures. Intraoperative endoscopy is a key component in performing these procedures.     

Nephrolithiasis after bariatric surgery: A comparison of laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy

IntroductionLaparoscopic Roux-en-Y gastric bypass (LRYGB) is known to increase risk for calcium oxalate nephrolithiasis due to hyperoxaluria; however, nephrolithiasis rates after laparoscopic sleeve gastrectomy (LSG) are not well described. Our objective was to determine the rate of nephrolithiasis after LRYGB versus LSG.MethodsThe electronic medical records of patients who underwent LRYGB or LSG between 2001 and 2017 were retrospectively reviewed.Results1,802 patients were included. Postoperative nephrolithiasis was observed in 133 (7.4%) patients, overall, and 8.12% of LRYGB (122/1503) vs. 3.68% of LSG (11/299) patients (P < 0.001). Mean time to stone formation was 2.97 ± 2.96 years. Patients with a history of UTI (OR = 2.12, 95%CI 1.41–3.18; P < 0.001) or nephrolithiasis (OR = 8.81, 95%CI 4.93–15.72; P < 0.001) were more likely to have postoperative nephrolithiasis.ConclusionThe overall incidence of symptomatic nephrolithiasis after bariatric surgery was 7.4%. Patients who underwent LRYGB had a higher incidence of nephrolithiasis versus LSG. Patients with a history of stones had the highest risk of postoperative nephrolithiasis.     

代谢手术治疗肥胖合并代谢综合征的Meta分析——袖状胃切除术与胃旁路术疗效比较

目的 比较袖状胃切除术及RouX-en-Y胃旁路术对肥胖伴有代谢综合征的近期疗效的循证支持.方法 以英文关键词“metabolic surgery”“bariatric surgery"“Roux-en-Y gastric bypass"“sleeve gastrectomy”“obesity”“T2DM”,及中文关键词“代谢手术”“减重手术”“胃旁路术”“袖状胃切除术”“肥胖”“2型糖尿病”等为检索词检索PubMed、EMBASE、Cochrane library、万方、CNKI数据库数据库检索自2011年1月-2016年6月间中英文袖状胃切除术及Roux-en-Y胃旁路术治疗合并肥胖的代谢综合征患者疗效相关文献,设立纳入与排除标准筛选文献,进行质量评价、提取数据和数据统计分析.结果 纳入Meta分析标准的文章有13篇,其中5篇为随机对照试验,8项病例对照研究涉及袖状胃切除术与Roux-en-Y胃旁路术疗效比较,共纳入病例18 850例:其中袖状胃切除术组2 559例,Roux-en-Y胃旁路术组16 291例.袖状胃切除术与Roux-en-Y胃旁路术术后1年2型糖尿病缓解率分别为78.7％和83.0％,二者差异无统计学意义(RR =0.94,95％CI:0.81 ～1.09,P＞0.05),但短期随访Roux-en-Y胃旁路术手术体重指数降低效果显著优于袖状胃切除术(MD=-2.03,95％ CI:-3.25 ～-0.81,P＜0.05).上述2种术式均能改善高血脂及高血压的发生率,但二者间差异并无统计学意义.结论 两种术式均为治疗肥胖合并代谢综合征的有效措施,均可降低包括T2DM、高血压、高血脂的发病率,并明显降低体重,Roux-en-Y胃旁路术治疗肥胖的疗效优于袖状胃切除术.     

Changes in the lipid profile 5 years after bariatric surgery: laparoscopic Roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy

Background

Few studies have compared mid-term results of laparoscopic Roux-en-Y gastric bypass (LRYGB) versus laparoscopic sleeve gastrectomy (LSG), and none have focused on lipid profile.

袖状胃切除术与胃旁路术治疗GK大鼠疗效的比较研究

目的:对比袖状胃切除术与胃旁路术治疗大鼠非肥胖2型糖尿病的疗效。方法:30只GK大鼠随机分为袖状胃切除术组(SG组)、胃旁路术组(RYGB组)、假手术组(SO组),每组10只。观察术后各组存活情况,并根据情况检测各组术前及术后第1、4、8周的体质量、空腹血糖、口服糖耐量试验峰值、糖化血红蛋白比值及血清胰岛素水平。结果:SG组大鼠手术存活率100%,RYGB组手术存活率90%,SO组大鼠全部健康存活,3组手术存活率比较差异无统计学意义(P=0.305)。术后8周时,各组体质量均超过术前,RYGB组明显低于SO组和SG组(P0.05)。空腹血糖在SG组和RYGB组术后第1周即有下降趋势,术后8周时SG组较SO组降低,差异有统计学意义(P0.05),RYGB组较SO组明显降低(P0.01),RYGB组与SG组比较差异亦有统计学意义(P0.05)。口服糖耐量试验峰值在SG组和RYGB组术后1周即有下降,术后8周时SG组较SO组虽有降低但差异无统计学意义(P0.05),RYGB组较SO组明显降低(P0.01)。术前各组糖化血红蛋白比值差异无统计学意义,术后8周时SG组较SO组降低(P0.05),RYGB组较SO组明显降低(P0.01),RYGB组与SG组差异亦有统计学意义(P0.05)。8周后胰岛素水平SO组与SG组比较差异无统计学意义(P0.05),RYGB组在8周后升高明显,与前2组比较差异具有统计学意义(P0.05)。结论:袖状胃切除术与胃旁路术术后存活率相近,但胃旁路术治疗GK大鼠的疗效优于袖状胃切除术。     

Two-step conversion surgery after failed laparoscopic adjustable gastric banding. Comparison between laparoscopic Roux-en-Y gastric bypass and laparoscopic gastric sleeve

BackgroundDespite its worldwide popularity, laparoscopic adjustable gastric banding (LAGB) requires revisional surgery for failures or complications, in 20–60% of cases. The purpose of this study was to compare in terms of efficacy and safety, the conversion of failed LAGB to laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy. (LSG).MethodsThe bariatric database of our institution was reviewed to identify patients who had undergone conversion of failed LAGB to LRYGB or to LSG, from November 2007 to June 2012.ResultsA total of 108 patients were included. Of these, 74 (68.5%) underwent conversion to LRYGB and 34 to LSG. All of the procedures were performed in 2-stage and laparoscopically. The mean follow-up for the LRYGB group was 29.1±17.9 months while for the LSG patients was 24.2±14.3 months. The mean body mass index (BMI) prior LRYGB and LSG was 45.6±7.8 and 47.5±5.6 (P = .09), respectively. Postoperative complications occurred in 16.2% of the LRYGB patients and in 2.9% of the LSG group (P = .04). Mean percentage of excess weight loss was 59.9%±16.2% and 70.2%±16.7% in LRYGB, and it was 52.2%±11.4% and 59.9%±14.4% in LSG at 12 months (P = .007) and 24 months (P = .01) after conversion.ConclusionIn this series, LRYGB and LSG are both effective and adequate revisional procedure after failure of LAGB. While LRYGB seems to ensure greater weight loss at 24 months follow-up, LSG is associated with a lower postoperative morbidity.     

Systematic review on sleeve gastrectomy or Roux-en-Y gastric bypass surgery for refractory gastroparesis

Management of refractory gastroparesis is challenging after diet, prokinetics, and long-term nutritional support have failed. In this review, the efficacy and safety of surgical interventions (sleeve gastrectomy and Roux-en-Y gastric bypass surgery) are evaluated systematically in patients with refractory gastroparesis. The PubMed, Embase, and Scopus databases were searched to identify relevant studies published up to June 2021. Outcome of interest was symptom improvement and gastric emptying. Nineteen studies with 222 refractory gastroparesis patients (147 Roux-en-Y gastric bypass, 39 sleeve gastrectomy, and 36 subtotal gastrectomy) were included. All studies reported symptom improvement postoperatively, particularly vomiting and nausea. Gastric emptying improved postoperatively in 45% up to 67% for sleeve gastrectomy and 87% for Roux-en-Y gastric bypass. The findings of our systematic review suggest that sleeve gastrectomy and Roux-en-Y gastric bypass surgery improve symptoms and gastric emptying in patients with refractory gastroparesis. Surgery may be effective as treatment for a small group of patients when all other therapies have failed.