Impact on physical fitness on cognitive aging

Cognitive vitality is one of the determining factors of autonomy in the elderly. Aging is often accompanied by important changes in the central nervous system, which may lead to cognitive decline. Several factors seem however to modulate the effect of aging on cognition. For instance, older adults who engage in regular physical activity have better performances in tests implying decision-making process, memory and problems solving. This article draws up a portrait of normal aging while being interested in the impact of the physical fitness on cognition in the elderly. Although further researches are needed to elucidate the mechanisms by which physical fitness enhance cognition in old age, recent studies have shown that improving physical fitness leads to better performances in tasks assessing a diversity of cognitive domains. Moreover, the impact of physical fitness appears to be heterogeneous, being of greater amplitude in tasks that tap executive functions. It thus seems that physical training could serve to enhance and maintain cognitive vitality in older adults.     

Associations of leisure time physical activity, self-rated physical fitness, and estimated aerobic fitness with serum C-reactive protein among 3,803 adults

OBJECTIVE: Serum C-reactive protein (CRP), a marker of systemic inflammation, is a risk factor for cardiovascular disease. Obesity and physical activity are associated with CRP, though population studies are sparse. METHODS AND RESULTS: We assessed the cross-sectional relationship of physical activity, self-rated fitness and estimated aerobic fitness with serum CRP among a population-based random sample of 3,803 Finnish adults aged 25-74 years. Conditioning, commuting and non-conditioning physical activity was measured by a recall and self-rated physical fitness by a questionnaire. A non-exercise test was used to estimate aerobic fitness. The combined association of aerobic fitness and waist-to-hip ratio (WHR) on CRP was also assessed. Self-rated fitness and aerobic fitness had inverse associations with CRP (adjusted for age, WHR, smoking, anti-hypertensive drugs, aspirin, diabetes, hypercholesterolemia, hormone replacement therapy and menopausal status) in both sexes (p < 0.001). An inverse age-adjusted association of conditioning and non-conditioning physical activity with CRP was found in both sexes. After further adjustments, associations remained significant in women for conditioning and non-conditioning activity (p < 0.001 and p = 0.010, respectively) and borderline significant in men (p = 0.074 and p = 0.070, respectively). Commuting physical activity was inversely associated with CRP among women only (p = 0.012). CONCLUSIONS: Physical activity and fitness may have an anti-inflammatory effect, which is independent of obesity.     

A method for identifying biomarkers of aging and constructing an index of biological age in humans

This study was conducted to identify biomarkers of aging and to construct an index of biological age in humans. Healthy adult men (n = 86) who had received an annual health examination from 1992 through 1998 were studied. From 29 physiological variables, five variables (forced expiratory volume in 1 second, systolic blood pressure, hematocrit, albumin, blood urea nitrogen) were selected as candidate biomarkers of aging. Five candidate biomarkers expressed substantial covariance along one principal component. The first principal component obtained from a principal component analysis was used to calculate biological age scores (BAS). Individual BAS showed high longitudinal stability of age-related changes. Age-related changes of BAS are characterized by three components: age, peak functional capacity, and aging rate. A logistic regression analysis suggested that aging rate was influenced by environmental factors, but peak functional capacity was almost independent of environmental factors.     

Adiposity,physical fitness and incident diabetes: the physical activity longitudinal study

Aims/hypothesis The purpose of this study was to investigate the relationships among adiposity, physical activity, physical fitness and the development of diabetes in a diverse sample of Canadians. Methods The sample included 1,543 adults (709 men and 834 women) from the Canadian Physical Activity Longitudinal Study who were free of diabetes at baseline (1988). Several indicators of adiposity (BMI, waist circumference, WHR, sum of skinfold thicknesses), musculoskeletal fitness (sit-ups, push-ups, grip strength, trunk flexibility), cardiorespiratory fitness (maximal metabolic equivalents [METs]) and leisure-time physical activity levels were measured at baseline. Participants were followed until 2002–2004 for the ascertainment of new cases of diabetes. Results The 15.5-year cumulative incidence of diabetes was 5.0% (5.2% in men, 4.9% in women). Adiposity and physical fitness, but not physical activity, were significant predictors of diabetes after adjustment for age, sex and several covariates. For each standard deviation of the indicators of adiposity, the risk of diabetes was 99–194% higher. Conversely, the risk was 70 and 61% lower for each standard deviation of maximal METs and composite musculoskeletal fitness score, respectively. Receiver operating characteristic curve analyses confirmed that neither adiposity nor physical fitness provided a superior prediction of incident diabetes. Conclusions/interpretation Adiposity and physical fitness were both important predictors of the development of diabetes in this cohort of Canadians.     

Influence of dental occlusion on physical fitness decline in a healthy Japanese elderly population

The aim of this study was to clarify the relationship between dental occlusion and physical fitness by a longitudinal survey. A sample of 348 subjects (171 men and 177 women) aged 71 was investigated by Eichner index (EI) as an occlusal condition (Class A: no loss; Class B: partial loss; Class C: complete loss) and five types of physical fitness tests and were re-examined 8 years later. The upper 50% were sampled to analyze the correlation between each physical fitness decline and the EI at the baseline by logistic regression models. Logistic regression analyses revealed that leg extensor power (Class B vs. Class A; odds ratio = OR = 4.61, p = 0.010) and one-leg standing time with eyes open (Class C vs. Class A; OR = 4.27, p = 0.031) showed significant correlations with the EI at the baseline. In this study, partial or complete loss of occlusion was associated with a decline in leg extensor power or a decrease in one-leg standing time with eyes open. These findings suggest that maintenance of dental occlusion may prevent a decrease in activities of daily living in the elderly.     

Markers of inflammation are inversely related to physical activity and fitness in sedentary men with treated hypertension

BACKGROUND: Physical inactivity is an important risk factor for atherosclerotic disease. We studied the relationship between physical activity and physical fitness and soluble markers of atherosclerotic activity in men with drug-treated hypertension. METHODS: The participants (n = 177, 40 to 74 years of age), who were randomly recruited from the Hypertension High Risk Management Trial (HYRIM), were overweight and had sedentary lifestyles. The inflammatory markers high-sensitivity C-reactive protein (hs-CRP), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (SICAM-1) and soluble E-selectin (sE-selectin) and the hemostatic markers soluble thrombomodulin (sTM), von Willebrand factor (vWf), and tissue plasminogen activator antigen (tPAag) were measured. Physical activity was measured by use of a questionnaire. Time to exhaustion in a bicycle test was used as an expression of physical fitness. RESULTS: The hs-CRP showed a significant inverse relationship with physical fitness independent of major cardiovascular risk factors (P = .017) but was not related to physical activity. The sE-selectin was significantly related to physical activity, although only when other factors were taken into account (P = .033), and it had no significant association with physical fitness. In addition there were strong associations between hs-CRP and sICAM-1 and the Framingham Coronary Heart Disease risk score (P < .001). CONCLUSIONS: The observed inverse relations between physical fitness and hs-CRP and between level of physical activity and sE-selectin in drug-treated, hypertensive sedentary men indicates a beneficial effect of good fitness status as well as activity of low intensity on vessel wall inflammation.     

The influence of winter and summer seasons on physical fitness in aged population

Epidemiological studies have described the association between physical fitness and health. Few have reported the impact of seasonal variation on fitness determinants, in elderly. We investigated the effects of summer and winter environmental conditions on physical fitness, in both exercise and non-exercise elders. 371 non-institutionalized older adults (74.1% female; 78.4 ± 5.3 years) randomly recruited from a total sample of 1338 subjects from north of Portugal, were prospectively followed during 1 year and 3 assessments were performed – April (baseline), October (summer season) and April (winter season). Four groups were defined, according to reported habits of exercising: Exercise (EG); Winter Exercise (WG); and Summer Exercise (SG); non-Exercise (nEG). Muscle strength was assessed with handgrip and isometric knee extension test, and aerobic capacity with the 6 min walking test. Repeated measures ANOVA with two between-subjects factors were run for independent variables, considering a three Time points. Significance set at p < .05. Findings show that: (1) men were fitter than women; (2) EG showed better results than nEG (p = .000), but not different than WG or SG, (3) nEG physical fitness was not significantly different from WG and SG; (4) SG and WG showed similar results; (5) there was significant group-by-time interaction for all variables in study. Among elderly, the regular physical exercise determined better cardiorespiratory fitness and levels of strength compared to individuals that were not exercising, however, no season impact was observed. Independently of exercising mode, regular, seasonal or not exercising, the pattern of changes in physical fitness throughout the year was similar.     

Development of models for predicting biological age (BA) with physical, biochemical, and hormonal parameters

Individual differences are the hallmark of aging. Chronological age (CHA) is known that fails to provide an accurate indicator of the aging but biological age (BA) estimates the functional status of an individual in reference to his or her chronological peers on the basis of how well he or she functions in comparison with others of the same CHA. Therefore, we developed models for predicting BA that can be applicable in clinical practice settings. This was a community-based cross-sectional study. Subjects were recruited from the health promotion center in Korea from 2001 to 2005. Among these, data obtained from the 3575 participants (1302 men and 2273 women) was used for clinical evaluation and statistical analysis. For our test battery we selected 25 parameters among the routine tests. For males, the best models were developed using 15, 7, 5, and 4 of the 25 chosen parameters for total, physical, biochemical and hormonal characteristics, respectively (R(2)=0.62, 0.38, 0.33, and 0.36, respectively). Similar to males, for the females, 14, 6, 8, and 3 parameters were developed as the models (R(2)=0.66, 0.40, 0.42, and 0.37, respectively). Our BA prediction models may be used as supplementary tools adding knowledge in the evaluation of aging status.     

Relationship between dental occlusion and physical fitness in an elderly population

BACKGROUND: The relationship between physical fitness and dental health status in elderly adults is still unknown. The purpose of the present study is to examine the relationship between physical fitness and occlusal condition of natural teeth in the elderly population. The sample consisted of 591 individuals aged 70 years and 158 aged 80 years selected from the registry of residents in Niigata city. METHODS: Hand grip strength (kg), leg extensor strength (kg), leg extensor power (watts), stepping rate (time per 10 seconds), and one-leg standing time with eyes open (seconds) were measured. The Eichner index was used as a measurement of occlusal condition. It was based on existing natural tooth contacts between maxilla and mandible in the bilateral premolar and molar regions and determined the three groups of classification used. In comparing physical fitness with Eichner index, multiple regression models were developed to adjust for variables such as age, gender, height, body weight, past medical history, blood pressure, serum albumin concentration, presence of lower back pain, smoking habit, marital status, and education. RESULTS: Multiple regression analyses revealed that leg extensor power (R(2) =.627, p <.05), stepping rate (R(2) =.159, p <.05), and one-leg standing time with eyes open (R(2) =.179, p <.05) showed significant correlations with the Eichner index. CONCLUSIONS: Leg extensor power, stepping rate, and one-leg standing time with eyes open are useful indicators in evaluating lower extremity dynamic strength, agility, and balance function, respectively. These findings suggest that dental occlusal condition is associated with lower extremity dynamic strength, agility, and balance function in elderly adults.     

Physical fitness related to disability in older persons

BACKGROUND: In today's aging society, preventing or reducing disability is important. Physical activity may serve this goal. Generally, physical activity aims to enhance physical fitness, which in turn may prevent disability. The relationship between physical fitness and disability has been much less explored than the relationship between physical activity and physical fitness. OBJECTIVE: To investigate the relationship between separate components of physical fitness and disability. METHODS: The subjects were a community-based sample of 176 men and 233 women aged 65 years or older. Physical fitness was assessed with performance-based tests. Disability and potential confounders were assessed during face-to-face interviews. RESULTS: Independently of other fitness components, walking endurance, grip strength, manual dexterity and balance contributed significantly to the prediction of disability for both men and women. Flexibility of the hip and spine, flexibility of the shoulder and reaction time were not independent predictors of disability for men or women. Physical fitness explained a greater percentage of variance in disability for women (31-48%) than for men (14-34%). Although depressive symptoms, cognitive functioning (men), number of chronic conditions (women) and age (women) explained additional variance in disability, these variables did not confound the relationship between physical fitness and disability. CONCLUSION: Walking endurance, grip strength and manual dexterity are important unique predictors of disability. Physical activity programs should be directed at these fitness components.     

Measurement of physical capacities in the elderly: a secondary analysis of the Quebec longitudinal study NuAge

OBJECTIVE: To assess the validity of a battery of functional capacity tests in community-living elderly Canadians. MATERIAL AND METHODS: Design: cross-sectional study. Study population: baseline data from 1793 men and women aged 74.4 +/- 4.1 participating in the NuAge longitudinal study were collected from December 2003 to April 2005 and used for the analyses. A global score measuring functional capacities (BFC) was constructed as the sum of four tests according to a method proposed by Guralnik [Timed Up and Go, walking speed (4 m), chair stands (five times), standing balance]. Multivariate linear regression analysis was used to study the relationship between age, sex, and physical activity, and BFC score. RESULTS: The global functional capacities score had an internal consistency of 0.74. It was significantly associated with age, sex and measures of mental and physical health status including: cognitive function (< 0.001), depressive symptoms (< 0.001), nutritional risk (< 0.001), burden of disease (< 0.001), and level of physical activity (< 0.001) thus supporting the construct validity of the global score. Age related differences in BFC were consistent and similar among men and women. CONCLUSION: The global score of functional capacity tests provided a valid assessment of physical capacities in the community-living elderly. While men had higher global BFC scores than women, among both sexes the best performance was observed in the youngest age group and in those reporting more physical activity.     

Quality of life, nutritional status, physical activity, and their interrelationships of elderly living on an underpopulated island in Japan

Background:   The objectives of this study were to assess the quality of life (QOL), nutritional and health status, physical fitness and daily physical activity level (PAL) of elderly residents living on a remote island in Japan and to reveal factors associated with QOL scores and PAL.
Methods:   This was a cross-sectional study that targeted elderly residents dwelling on an island whose population is aging and rapidly decreasing. Fifty-two subjects (20 men and 32 women; mean age, 74 years) were evaluated for anthropometry (nutritional status), blood pressure (health status) and handgrip strength (physical fitness). QOL was investigated using the World Health Organization-QOL questionnaire. In addition, 24-h acceleration monitoring was conducted in eight subjects on 3 consecutive days to determine PAL.
Results:   Women tended to be obese compared with men (BMI, 25.6 vs 23.6 kg/m², P  < 0.05). Of the four QOL domains, the score for "social relationships" was significantly higher in women. Significant correlations were found between handgrip strength and QOL scores. A significant negative relationship was found between BMI and PAL ( r _s =−0.90, P  < 0.005). In contrast, a positive association was observed between handgrip strength and PAL ( r _s = 0.77, P  < 0.05).
Conclusion:   The results suggest that social communication is an important factor for a high QOL of women in the remote island society. The results of the correlation analyses suggest that walking, maintaining an ideal body weight and promoting physical fitness have important roles in maintaining and increasing PAL in the elderly.     

Increasing physical fitness does not proportionally decrease circulating C-reactive protein level in men with varying fitness

Several studies have shown that low physical fitness is associated with high levels of C-reactive protein (CRP), a marker of future cardiovascular events. However, whether increasing physical fitness proportionally decreases the circulating CRP level has not been evaluated. We first evaluated the basic relationship between physical fitness, assessed by running velocity, and circulating CRP level along with cardiovascular risk factors in 1065 healthy middle-aged men. Afterward, we examined the association between annual change in fitness and changes in CRP level in 482 subjects who had the same parameters measured 1 year later without any intervention. In the cross-sectional study, physical fitness was significantly correlated with circulating CRP level (r=0.28, P<.0001). This significance still remained after adjustment for other cardiovascular risks (beta=-.12, P=.0004). In the follow-up study, several variables, including CRP, were significantly improved (CRP geometric mean, from 0.35 to 0.26 mg/L; P<.001). Improvements in fitness did not reach statistical difference (P=.067). Annual change in CRP was significantly correlated with creatinine kinase level 1 year later (r=0.16, P=.004) and with annual changes in some other risks, but not with annual change in fitness. When follow-up subjects were divided into tertiles according to increase in fitness, the greatest reduction in CRP was found in subjects with mildly increased fitness and favorable risk profiles (n=159; CRP geometric mean, from 0.35 to 0.21 mg/L; P<.0001), but not in those with moderately to highly increased fitness (n=113; geometric mean, from 0.36 to 0.28 mg/L; P=.03). In conclusion, although physical fitness was significantly associated with circulating CRP level in a cross-sectional study, increasing fitness did not proportionally decrease circulating CRP level. Improving coincidental risks, relieving intensity of exercise-induced muscle damage, or both, in addition to increasing fitness, might be important to effectively reduce CRP level.     

Association of age and comorbidity with physical function in HIV-infected and uninfected patients: results from the Veterans Aging Cohort Study

HIV clinical care now involves prevention and treatment of age-associated comorbidity. Although physical function is an established correlate to comorbidity in older adults without HIV infection, its role in aging of HIV-infected adults is not well understood. To investigate this question we conducted cross-sectional analyses including linear regression models of physical function in 3227 HIV-infected and 3240 uninfected patients enrolled 2002-2006 in the Veterans Aging Cohort Study-8-site (VACS-8). Baseline self-reported physical function correlated with the Short Form-12 physical subscale (ρ?=?0.74, p?相似文献   

Blood pressure and physical fitness in a population of children--the Odense Schoolchild Study

This cross-sectional study examined the association between blood pressure and physical fitness in 1,369 children (81.5% of the eligible population) aged 8-10 years participating in the first phase of a primary intervention study with physical training. An inverse correlation between BP and physical fitness was demonstrated, and significant differences have been found between quartiles of distribution of physical fitness in girls with regard to systolic BP and in boys and girls with regard to diastolic BP respectively. Important determinants of physical fitness seemed to be dependent on confounding variables representing body mass index, height, heart rate and age. Our observations suggest that the contribution of confounding variables may explain the relationship between BP and physical fitness in childhood.     

Evaluation of balance and physical fitness in diabetic neuropathic patients

AIM: The main aim was to evaluate balance and physical fitness in diabetic neuropathic patients. METHODS: Sixty voluntary adults of both sexes from Kutahya, Turkey, were divided into two groups: a Type 2 diabetic neuropathic group (DG), mean age 57.6+/-3.9 (50-65; n=30); and a nondiabetic control group (CG), mean age 55.6+/-6.1 (51-64; n=30). The CG was selected to match the diabetic group characteristics, such as age, body mass, and sex. Standing on dominant and nondominant leg, functional reach and physical fitness tests were used for assessment. RESULTS: Static and dynamic standings on one leg test were significantly lower in DG (P<.01). Considering CG results, maximal balance reduction in DG was found in the dynamic test on the dominant leg with the eyes open and head rotation (63.1%) and the lowest was on the static test on dominant leg with eyes open (19.7%). The result of the functional reach test was determined to be significantly lower in DG, with 21.3% balance reduction (P<.01). In all physical fitness tests, DG made significantly lower repetitions in 1 min (P<.01). Functional reach (34 cm) and one-leg standing (42 s) test results had shown our participants' low-risk falling, considering literature studies (15 cm and 30 s). CONCLUSION: The data show that the diabetic neuropathy disturbed especially the balance on the dominant leg and decrease physical fitness. In this situation, further studies that show the difference between dominant and nondominant leg balance and new risk of falling profile in diabetic neuropathic participants are needed.     

Physical fitness and physical activity in fatigued and non-fatigued inflammatory bowel disease patients

Abstract

Objective. To assess physical fitness and physical activity in inflammatory bowel disease (IBD) patients and whether fatigue is associated with impaired physical fitness and impaired physical activity. Materials and methods. Ten patients with quiescent IBD and fatigue (fatigue group [FG]) based on the Checklist Individual Strength-Fatigue score of ≥35 were matched for age (±5 years) and sex with a non-fatigue group (NFG) with IBD. Physical fitness was measured with a cyclo-ergometric-based maximal exercise test, a submaximal 6-min walk test, and a dynamometer test to quantify the isokinetic muscle strength of the knee extensors and flexors. Level of physical activity was measured with an accelerometer-based activity monitor. Results. The patients in both groups did not differ in regard to medication use, clinical characteristics, and body composition. However, medium-to-large effect sizes for impaired physical fitness (both cardiorespiratory fitness and muscle strength) and physical activity were seen between the patients in the FG and the NFG. Especially, intensity of physical activity was significantly lower in the FG patients compared with the NFG patients (effect size: 1.02; p = 0.037). Similar results were seen when outcomes of the FG and NFG were compared with reference values of the normal population. Conclusion. Fatigued IBD patients show an impaired physical fitness and physical activity compared with non-fatigued IBD patients. This gives directions for a physical component in fatigue in IBD patients. Therefore, these new insights into fatigue indicate that these patients might benefit from an exercise program to improve physical fitness and physical activity.     

Executive functions,physical fitness and mobility in well-functioning older adults

The objective of this study was to examine the relationships between executive functions, physical fitness and mobility in well-functioning older adults. Forty-eight well functioning older adults (70.5 ± 5.3 years old; 20 men, 28 women) were included in this study. Two median splits were conducted based on each individual's performance for the 10MWT and TUG. Comparisons between groups of slower and faster individuals were made with regard to executive functions and physical fitness parameters. A correlational approach was used to assess the association between variables.     

Does negative information about aging influence older adults’ physical performance and subjective age?

This study investigated the way negative stereotypes influence older adults’ physical performance and how old they feel mentally and physically. Sixty-four older adults aged 65 years and older performed different physical tasks using a 3D optoelectronic system under a low or high stereotype threat condition. Self-perceptions of aging were considered as a moderator of the effects of threat. Overall, the effects of threat on physical performance were mostly not significant across tasks. However, threat condition influenced older adults' mental subjective age after they had performed the physical tests; people in the high-threat condition felt closer to their chronological age. Threat also influenced participants' physical subjective age, and this effect was moderated by self-perceptions of aging. More precisely, participants in the high-threat condition felt 7% physically older than their chronological age when they had more negative self-perceptions, while participants in the low-threat condition felt 13% younger. No differences emerged for participants who had more positive self-perceptions. The present findings suggest that performing physical tests under stereotype threat might worsen older people’s subjective experience of their own aging by making them feel older.