共查询到20条相似文献,搜索用时 62 毫秒
1.
2.
杀菌/通透性增加蛋白对休克大鼠肺组织细胞因子mRNA表达的影响 总被引:5,自引:0,他引:5
作者在大鼠失血性休克(4kPa,180分钟)模型上,观察了重组杀菌/通透性增加蛋白(BPI)对肺组织肿瘤坏死因子(TNF)、白介素-6(IL-6)mRNA表达及急性肺损伤的影响,并对肠源性内毒素血症与炎症细胞因子诱发的关系进行了探讨。结果显示:失血性休克可导致血浆内毒素含量显著升高,肺组织TNF、IL-6mRNA表达分别在复苏后2、8小时明显增多(P<0.05~0.01);给予BPI治疗则完全中和休克所致内毒素血症,并不同程度地抑制肺组织TNF、IL-6mRNA的表达(P<0.05~0.01);肺毛细血管通透性与髓过氧化物酶活性均明显降低。作者认为,BPI可有效防止失血性休克诱发的急性肺损伤,其作用机制可能与抑制肠源性内毒素血症所介导的局部组织炎症细胞因子基因表达有关。 相似文献
3.
1,6—二磷酸果糖对内毒素休克犬TNF,MDA,SOD的影响 总被引:1,自引:0,他引:1
目的:观察1,6-二磷酸果糖对内毒素休克犬血浆TNF,MDA水平和RBC-SOD活性的影响,为FDP治疗ET休克提供实验依据。方法:12只犬随机分成两组,内毒素休克组和内毒素休克1,6-二磷酸果糖治疗组,每组6例,外周静脉注射灭活大肠杆菌30分钟、90分钟后、FDP组输入7.5%FDP375mg/kg,ET组输入等容量平衡盐液。注ET前及注后2、4、6、8小时测CO及血浆TNF、MDA水平和RBC 相似文献
4.
脾切除及大肠杆菌内毒素攻击对大鼠血浆内毒素、TNF和NO水平的影响 总被引:1,自引:0,他引:1
本实验动态观察了大鼠脾切除及粗制大肠杆菌内毒素攻击后血浆内毒素、肿瘤坏死因子(TNF)和NO-2/NO-3水平的变化。结果发现:脾切除组较假手术组血浆上述因子均明显升高(P<0.05或P<0.01),且和单纯腹腔注射大肠杆菌内毒素后所引起的改变非常类似。注射内毒素后,切脾前后血浆上述因子无明显差异,但均处在较高水平上,秩相关分析表明:血浆NO-2/NO-3与内毒素及TNF水平有一定相关性(rs分别为0422及0721,P均<001),其中与TNF高度相关。作者认为:脾切除后机体免疫力下降,可能导致肠道细菌或毒素移位,诱导产生TNF等细胞因子,并协同激活体内Larg:NO通路。这也可能是脾切除后凶险性感染(OPSI)发生机制之一。 相似文献
5.
6.
严重烧伤后休克期切痂对肠道细菌和内毒素移位的影响 总被引:8,自引:1,他引:7
为探讨严重烧伤休克期切痂与肠源性细菌感染的关系,作者采用SPF大鼠150只,随机分成三组:休克期切痂组(B组)与常规切痂组(C组)均致30%TBSAⅢ度烫伤,伤后1小时开始补液治疗,分别于伤后24小时、5天切痂植皮。另设单纯植皮组(A组),不烫伤,仅植皮对照。结果显示,B组切痂前、后血浆LPS及TNF含量均明显低于C组,但高于A组(P<0.05~0.001),痂下菌量(1.5×103±0.3×10cfu/g组织)也明显低于C组(4.3×106±1.7×10cfu/g组织)(P<0.001)。B组内脏细菌检出率显著低于C组(P<0.05~0.01)。结果表明,休克期切痂可以减轻肠源性内毒素血症,及其细菌和毒素移位。内毒素在肠道内细菌和毒素移位中起重要作用。 相似文献
7.
小剂量氯胺酮吗啡及氯胺酮-吗啡配伍用于硬膜外腔术后镇痛作用的比较小剂量氯胺酮吗啡及氯胺酮-吗啡配伍用于硬膜外腔术后镇痛作用的比较 总被引:1,自引:0,他引:1
目的:探讨氯胺酮、吗啡硬膜外腔术后镇痛效应和伍用后是否可提高镇痛效果并减少副作用。方法:50例硬膜外腔麻醉下行骨科手术的患者,随机分为5组,每组10例。A组:吗啡0.01mg/kg;B组:氯胺酮0.4mg/kg;C组氯胺酮0.6mg/kg;D组:A+B;E组:A+C。于术后4、8、12、24、48、72h记录疼痛评分(VAPS)及副作用的发生情况。结果:A组VAPS评分平均为2.95,有效镇痛7例,平均持续时间为52.0h;B组镇痛效果差,VAPS评分平均为7.26,有效镇痛3例,与A组比较有统计学显著差异(P<0.01);C组VAPS评分平均为3.60,与A组比较无统计学差异,有效镇痛7例,平均持续时间为44.4h;D组VAPS平均评分为2.73,与A组比较无统计学差异,平均持续时间为50.8h;E组平均VAPS评分为1.58,与A组比较有统计学显著差异(P<0.01),持续时间为58.1h。结论:1.氯胺酮0.4mg/kg硬膜外腔术后镇痛效果差,剂量增至0.6mg/kg镇痛效果与吗啡0.01mg/kg相近,恶心、呕吐发生较少,无精神方面的副作用;2.氯胺酮与吗啡配伍,随着氯胺酮剂量增加到0.6mg/kg 相似文献
8.
血浆内毒素和细胞因子在腹腔感染致多系统器官功能障碍早期的变化 总被引:6,自引:0,他引:6
为观察腹腔感染(IAI)致多系统器官功能障碍(MSOD)早期血浆内毒素和细胞因子的变化,在制作IAI致MSOD动物模型的基础上,对感染组(行盲肠结扎加穿孔手术)及对照组(行盲肠探查术)兔在实验0、1、2、3、4、5、6及24小时不同时相的血浆内毒素和细胞因子包括肿瘤坏死因子(TNF)、白细胞介素1和6(IL1,IL6)进行了检测,并记录动物死亡情况和生存时间。结果显示:感染组血浆内毒素和TNF水平在实验后1小时、IL6在实验后2小时开始显著升高,IL1无显著变化。感染组兔于1周内均死亡,平均生存时间为84.1±39.0小时,对照组兔1周时均存活,两组比较有显著性差异(P<0.05)。本实验所观测到的IAI时血浆内毒素及细胞因子的早期变化特点为临床防治研究提供了实验基础。 相似文献
9.
通下法抗急性坏死性胰腺炎肺损害的实验研究 总被引:15,自引:0,他引:15
为研究肿瘤坏死因子(TNF)在急性坏死性胰腺炎(ANP)所致肺损害中的作用,14只家犬随机分成三组。中药组(n=5):ANP模型+大承气汤治疗;盐水组(n=5):ANP模型+生理盐水治疗;假手术组(n=4)。术后测定血清、支气管肺泡灌洗液(BALF)的TNF活性及血清内毒素水平等指标。结果:1.BALF中TNF活性升高较血清中升高更明显。2.中药组术后6、12小时血清及BALF中TNF活性低于盐水组(P<0.01)。3.术后12小时中药组肺损害程度明显轻于盐水组。4.盐水组血清TNF活性与内毒素水平呈正相关(P<0.05)。结论:TNF的过度分泌是ANP致肺损害的重要因素;通里攻下法治疗能够减轻TNF介导的肺损害程度。 相似文献
10.
尼卡地平伍用芬太尼减轻气管插管时心血管副反应的研究 总被引:9,自引:1,他引:8
36例ASAI级择期手术患者,随机分为三组,每组12例。全麻诱导均静脉注射硫喷妥钠8mg/kg和琥珀胆碱2mg/kg.诱导前5分钟组I静注生理盐水4ml,组Ⅱ静注尼卡地平0.01mg/kg,组Ⅲ静注尼卡地平0.01mg/kg和芬太尼3μg/kg。结果显示组Ⅲ在插管后SBP、HR和RPP变化最小。表明静注尼卡地平0.01mg/kg和芬太尼3μg/kg是减轻气管插管时心血管副反应的有效方法。 相似文献
11.
12.
Horseshoe lung is an uncommon congenital malformation in which the bases of the right and the left lungs are fused to each other by a narrow isthmus posterior to the cardiac apex. So far 22 cases have been described: most of these were associated with right lung hypoplasia and the scimitar syndrome. A horseshoe lung anomaly with left lung hypoplasia is described. 相似文献
13.
14.
Technetium-fibrinogen lung scanning in canine lung contusion 总被引:3,自引:0,他引:3
E Geller B A Khaw H W Strauss A C Carvalho B Rajagopalan R Jones W M Zapol 《The Journal of trauma》1984,24(7):611-618
To detect experimentally induced acute lung contusion in anesthetized dogs, serial radionuclide images of the lung were recorded following intravenous infusion of 99mTc-labelled human fibrinogen (Tc-HF). The accumulation of Tc-HF in canine lungs was serially quantitated for up to 20 hours after lung contusion. A contusion (#1) was produced in one lung, Tc-HF was injected IV after 15 minutes, and 75 minutes later a contralateral lung contusion (#2) was produced in a series of 14 dogs. At autopsy the excised lungs were scanned, sectioned, and counted for radioactivity. Radiolabelled fibrinogen accumulated within 2-4 minutes of contusion #2 and remained stable over the next 20 hours in 14 dogs; contusion #1 was barely visible in four dogs. Lung Tc-HF activity in the central region of contusion #2 remained sixfold higher than in normal lung tissue. These data suggest that following lung contusion, fibrinogen deposition occurs rapidly and remains stable over a 20-hour interval of observation. 相似文献
15.
16.
17.
G H Clowes Jr E Hirsch L Williams E Kwasnik T F O''Donnell P Cuevas V K Saini I Moradi M Farizan C Saravis 《Annals of surgery》1975,181(5):681-692
Two series of patients were studied by serial measurements of blood gas exchange and pulmonarmonary dysfunction and to evaluate the dangers of respiratory failure in post traumatic patients. There were 27 patients who had sustained profound hemorrhagic shock and massive blood replacement averaging 9.7 liters and 38 patients who suffered general peritonitis or other forms of fulminating nonthoracic sepsis. All were supported by endotrachael intubation and volume controlled ventilators. The overall mortality for the post shock patients without sepsis was 12% while in the septic patients it was 35%. The maximal pulmonary arteriovenous shunt encountered in the post hemorrhagic shock patients at 36 hours averaged 20 plus or minus 8% and was accompanied by high cardiac indices (average 5.1 plus or minus 1.3 L/M-2/min) but no significant rise of pulmonary arterial pressure or peak inspiratory pressure (PIP). Severe pulmonary dysfunction subsequently occurred only in those patients who later became septic. The studies on the septic patients were divided according to the magnitude of the cardiac indices (the high indices averaged 4.8 plus or minus 1.6L/M-2/min) and thelow indices averaged 1.9 plus or minus 1.0 L/M-2/min. In the former, the average maximal shunt of 30 plus or minus 6% was sustained for 4 or more days, accompanied by an elevation of PIP to 36 plus or minus 6 cm H2O and by Pa pressure of 28 plus or minus 5 mm Hg. The patients in low output septic shock usually had an associated bronchopneumonia and had an average venous admixture of 34 plus or minus 8% and PIP values of 41 plus or minus 8 cm H2O. The mean Pa pressure in this group was 29 plus or minus 6 mm Hg. 相似文献
18.
19.
Date H Yamane M Toyooka S Okazaki M Oto T Sano Y Goto K 《Kyobu geka. The Japanese journal of thoracic surgery》2007,60(11):1005-1009
The rate of infection among lung transplant recipients is several times higher than that among recipients of other organs and is most likely related to the exposure of the allograft to the external environment. Meticulous peri-operative management is mandatory in performing living-donor lobar lung transplantation for patients with infectious lung diseases. All 5 patients with end-stage infectious lung diseases are currently alive for 17-104 months after receiving living-donor lobar lung transplantation at Okayama University Hospital. 相似文献
20.
Makoto Sonobe Tomohiro Handa Kiminobu Tanizawa Masaaki Sato Toshihiko Sato Fengshi Chen Mitsugu Omasa Toru Bando Hiroshi Date Michiaki Mishima 《General thoracic and cardiovascular surgery》2014,62(6):376-382