肺毛霉菌病1例

患者男,82岁,因反复咳嗽、咳痰、喘息10年,加重6天入院。患者于10年前无明显诱因的出现咳嗽、咳痰,痰多为白色黏液性,偶有黏液脓性,伴喘息,每于感冒及寒冷季节发作,每年持续约3个月。近2年来出现活动性气促,曾在我科诊为慢性阻塞性肺疾病,多经抗感染、抗炎平喘等治疗,病     

Good综合征合并肺毛霉菌病1例

<正>患者,女,72岁。因咳嗽、咯痰伴发热5d于2009年7月2日收入院。既往史:2005年因广泛黏膜念珠菌病发现免疫缺陷、胸腺瘤,并发菌群失调、全身多系统真菌感染,经补充丙种球蛋白、抗真菌治疗在我科治愈后出院。2006年并发带状疱疹。平素患者定期复查免疫球蛋白,每月静脉补充丙种球蛋白     

肺毛霉菌病

1　临床资料1 1　一般资料　 14例中男性 9例 ,女性 5例。年龄最小 9个月 ,最大 90岁 ,平均 5 2岁。1 2　基础疾病与诱因　血液病 4例 ,肝硬化、肝坏死各 1例 ,药物中毒急性肾功衰竭 2例 ,尿毒症 1例 ,急性心梗多器官衰竭 1例 ,结核性支气管扩张 1例 ,糖尿病 1例。无基础病 2例。合并酸中毒 4例。进行化疗的 4例。13例先后用多种大量抗生素治疗 ,其中 1例治疗长达月余 ;10例并用激素治疗。1 3　临床与Ｘ线表现　发热 13例 (93 % ) ,其中 10例持续高热 ;咳嗽 13例 (93 % ) ,咯血痰 8例 (5 7% ) ,咯血时间最长1年多 ;胸痛 3例 (2 1% ) ,呼吸困…     

肺毛霉菌病l例

患者男,82岁,因“反复咳嗽、咳痰、喘息10年,加重6天”入院。患者于10年前无明显诱因的出现咳嗽、咳痰,痰多为白色黏液性,偶有黏液脓性,伴喘息,每于感冒及寒冷季节发作,每年持续约3个月。近2年来出现活动性气促,曾在我科诊为“慢性阻塞性肺疾病”,多经抗感染、抗炎平喘等治疗,病情可缓解。     

1例两性霉素B脂质体联合泊沙康唑治疗儿童糖尿病合并肺毛霉菌病并文献复习

目的:探索两性霉素B脂质体联合泊沙康唑治疗儿童糖尿病合并肺毛霉菌病的有效性和安全性。方法:回顾性分析1例儿童糖尿病合并肺毛霉菌病患者应用两性霉素B脂质体联合泊沙康唑治疗过程并文献复习。结果:支气管镜下发现左肺上叶段支气管痰栓堵塞和肉芽增生,支气管肺泡灌洗液涂片见毛霉菌,诊断肺毛霉菌病。予两性霉素B脂质体静脉治疗1周后复查胸部CT发现左上肺空洞样改变,加用泊沙康唑口服。两性霉素B治疗3周时患者出现窦性心动过缓伴室性早搏,停两性霉素B脂质体后好转。改为泊沙康唑序贯治疗至12周,患者左上肺空洞消失且未出现不良反应。结论:儿童糖尿病合并肺毛霉菌病少见且治疗困难,两性霉素B脂质体联合泊沙康唑治疗方案为临床治疗提供诊疗经验。     

肺毛霉菌病误诊为肺癌1例

肺毛霉菌病误诊为肺癌１例戴聪军，杨宗夫（临沂市胸科医院）关键词肺毛霉菌病；误诊；肿痛；肺肺毛霉菌病是肺霉菌病的一种，由条件致病菌毛霉科真菌感染肺部所致。我院收治１例，术前误诊为右中央型肺癌，现报告如下。患者，女性，３２岁。因咳嗽、多饮１年，加重３个月...     

糖尿病合并毛霉菌病研究进展

毛霉菌病是一种少见的威胁生命的侵袭性真菌感染,常见于糖尿病人。该病的发病率虽较低,但病情凶险,死亡率较高。鼻眶脑是毛霉菌病最主要的发病区域。本文通过回顾以往的文献,总结患糖尿病时毛霉菌病的流行病学、病理生理特征、临床表现以及治疗方法,为以后在临床上治疗糖尿病患者提供理论帮助。     

肺毛霉菌病一例

患者 ,男 ,39岁 ,农民。因反复咯血 10天伴低热 ,干咳 1周 ,于 2 0 0 0年 9月 2 6日入院。咯血量最多达 5 0 0ｍｌ/ｄ ,曾在外院治疗 ,咯血量减少后转入我院。体检无异常体征。外院胸部ｘ线示 :右下肺团块状密度增高影。外院胸部ＣＴ示 :右肺下叶后基底段见一 4.6 7ｃｍ× 5 .83ｃｍ× 5 .0 0ｃｍ大小、类圆形软组织样密度灶 ,密度较均匀 ,边缘呈高度分叶 ,并见短毛刺。纵隔内见许多小淋巴结 ,首先考虑肺癌。送痰液检查未见肿瘤细胞。行纤支镜检查未发现病变。入院诊断 :右下叶肺癌 ?于 2 0 0 0年 10月 16日行“右下肺叶切除术”。术中见肿…     

糖尿病合并肺毛霉菌病的临床特征及诊治分析

目的 探讨肺毛霉菌病(pulmonary mucormycosis,PM)的危险因素、临床表现和诊治方法,以期提高肺毛霉菌病的诊断率,降低死亡率.方法 收集2011年1月至2021年8月在昆明市延安医院呼吸与危重症医学一科经病理确诊的PM患者4例,分析其临床特征、临床症状、影像学表现及诊治方法、预后情况.结果 4例PM...     

疑诊为肺结核的肺毛霉菌病1例

目的 通过报道1例疑诊为肺结核的肺毛霉菌病患者的临床及影像特点,提高对肺毛霉菌病的认识。方法 分析1例疑诊为肺结核的肺毛霉菌病患者的临床特点以及胸部CT表现。结果 51岁男性患者,因少量咯血入院,有糖尿病及冠心病病史,胸部CT示双肺沿支气管分布斑片状实变影,伴树芽征,可见黏液栓征,抗感染治疗病灶增多,纤维支气管镜提示血疑块及白色坏死物堵塞支气管,病理确诊支气管肺毛霉菌病。结论 肺毛霉菌病一般具有基础疾病,症状可表现轻微,临床表现及影像学特点缺乏特异性,易误诊误治,确诊主要靠组织病理检查。     

人类巨细胞病毒感染致1型糖尿病机制的初步探讨

目的通过对1型糖尿病患者的HCMV感染标志物、空腹血糖、空腹C肽、胰岛素自身抗体及抗胰岛细胞抗体的研究,初步探讨HCMV致1型糖尿病的机制。方法检测1型糖尿病患者的HCMV感染标志物（包括HCMV—IgG及其相对含量、HCMV—IgM及HCMV—pp65）、空腹血糖、C肽、抗胰岛素自身抗体及抗胰岛细胞抗体并进行统计学分析。结果HCMV感染与1型糖尿病患者抗胰岛素自身抗体之间无明显相关性,但与1型糖尿病患者空腹血糖、空腹C肽、抗胰岛细胞抗体存在明显的相关性,HCMV—pp65阳性的1型糖尿病患者中其空腹血糖明显高于该指标阴性者;抗HCMV—IgG阳性的1型糖尿病患者空腹血糖水平、抗胰岛细胞抗体均显著高于抗HCMV—IgG阴性者,而空腹C肽水平则明显低于抗HCMV—IgG阴性者,且抗HCMV—IgG抗体指数在4．1以上者,其抗胰岛细胞抗体阳性率显著高于抗HCMV—IgG抗体指数在4．0以下者。结论HCMV感染可能通过直接损伤胰岛免疫病理反应损伤胰岛细胞最终导致1型糖尿病的发生。     

1-脱氧野尻霉素减轻2型糖尿病小鼠的肝纤维化

Objective To investigate the effect of 1-deoxynojirimycin (DNJ) for improving diabetic liver fibrosis and explore the underlying mechanism. Methods Mouse models of type 2 diabetes were established in 10 Kunming mice by high-fat diet feeding for 8 weeks and intraperitoneal injection of STZ, with 5 mice receiving intraperitoneal injection of citrate buffer solution with normal feeding as the control group. The mouse models were randomized into two groups (n=5) for further high-fat feeding (model group) and additional treatment with 10% DNJ in drinking water (200 mg · kg- 1 per day; DNJ group) for 8 weeks. The mice were monitored for changes in body weight (BW), blood glucose, serum total cholesterol (TC), triglyceride (TG) and superoxide dismutase (SOD) levels. The pathological changes in the liver tissue were observed using HE and Sirius Red staining, and the solubility of collagens in the liver tissues was determined. The expression levels of MCP-1, TNF-α, IL-1β and TGF-β1 mRNA were detected with real-time PCR, and the protein expressions of α-SMA and collagen2 (ColA2) were determined with Western blotting. In the in vitro experiment, mouse fibroblasts L929 cells were pretreated with DNJ (10 μg/ mL) or PBS for 30 min followed by culture in high-glucose medium for 24 h, and the level of ROS production was measured using dihydroethidium (DHE) staining. Results In the mouse model of type 2 diabetes, DNJ treatment significantly lowered serum level of glucose, TC, and TG (P<0.05) and increased serum SOD activity (P<0.05). DNJ obviously attenuated liver fibrosis in the diabetic mice, as shown by alleviated cross-linking of collagens and reduced contents of pepsin-solubilized collagen (PSC) and total collagen (P<0.05). DNJ treatment also significantly reduced the overexpression of the pro-inflammatory cytokines and fibrosis-related cytokines induced by diabetes (P<0.05). In L929 cells exposed to high glucose, pretreatment with DNJ significantly lowered the intensity of red fluorescence in DHE staining. Conclusion DNJ can attenuate type 2 diabetes-induced liver fibrosis in mice through its hypoglycemic, anti-inflammatory and anti-oxidative effects.     

儿童1型糖尿病103例临床特点及疗效分析

目的 回顾分析儿童1型糖尿病(T1DM)的发病状况,探讨其临床特点及诊治方法.方法 对2002年2月至2010年8月成都市妇女儿童中心医院住院的T1DM患儿103例的临床资料进行回顾性分析,并将其中不同的胰岛素给药方法的31例学龄期糖尿病酮症酸中毒患儿分为基础-餐时胰岛素治疗组和胰岛素泵治疗组,进行疗效分析,比较其血糖达标所需时间、低血糖发生情况、血糖波动情况、治疗达标时空腹血糖、餐后2 h血糖水平、每日胰岛素用量、尿酮体消失时间、住院时间等.结果 103例T1DM患儿年龄38 d至15岁4个月,平均(8±3)岁;初发病例78例(75.7%),男孩多见(57例,55.3%),发病年龄以7～10岁最多(47例,占45.6%),冬春季发病51例(49.5%),合并感染67例(65.2%),以呼吸道感染(27例)和消化道感染(15例)多见.而62例(60.2%)以酮症酸中毒就诊,并发脑水肿者4例(3.9%).部分患儿合并桥甲炎、甲状腺功能亢进、系统性红斑狼疮等自身免疫性疾病.不同的胰岛素给药方法患儿治疗后空腹血糖及餐后血糖均明显下降,差异无统计学意义(P＞0.05).胰岛素泵治疗组酸中毒纠正时间短、尿酮体消失快(P＜0.01),血糖达标时间短(P＜0.01),血糖波动幅度小、持续时间短,胰岛素用量少,住院时间短,与基础-餐时胰岛素治疗组比较差异有统计学意义(P＜0.05).结论 儿童T1DM起病临床表现不典型,易合并酮症酸中毒,感染可能是患儿出现糖尿病酮症酸中毒的重要诱因之一.胰岛素泵治疗可较好控制血糖,使用方便,是目前儿童T1DM较佳治疗方法.     

儿童及青少年1型糖尿病患儿生存质量分析

目的 了解儿童及青少年1型糖尿病患者生存质量,探讨其影响因素。方法 收集住院的儿童及青少年1型糖尿病患儿38例,分为血糖控制良好组（21例）和血糖控制不佳组（17例）,采用儿童生存质量测定量表（PedsQL4.0）进行问卷调查,对数据进行分析,评价患儿的生命质量,并采用Pearson相关对影响患儿生命质量的因素进行多元线性逐步回归分析。结果血糖控制不佳组患儿的生理功能、心理社会功能、生存质量总分较血糖控制良好组低,两组比较差异均有统计学意义（均P＜0.05）。患儿的生存质量与空腹血糖（FPG）、糖化血红蛋白（HbA1c）、餐后2h血糖（2hPG）、糖类抗原19-9（CA19-9）、血清β羟丁酸呈负相关（P＜0.05或0.01）,FPG、血清β羟丁酸为最相关影响因素（P＜0.05或0.01）。结论加强血糖控制,积极预防糖尿病酮症发生,监测CA19-9变化,有利于改善儿童及青少年1型糖尿病患儿生存质量。     

儿童1型糖尿病32例临床分析

目的: 探讨儿童1型糖尿病(type1 diabetesmellitus,T1-DM)的临床特点,以提高对儿童1型糖尿病的诊治和管理水平。方法: 回顾分析32例1型糖尿病患儿的临床资料,并观察10例糖尿病酮症酸中毒(diabetes ketoaacdosis,DKA)患儿的诊治效果。结果: 10例儿童1型糖尿病首发症状为酮症酸中毒,4例以呼吸道感染、3例以呕吐、1例以腹痛为首发表现;小剂量胰岛素短时静脉滴注治疗DKA效果好。结论: 儿童1型糖尿病起病往往隐匿,临床表现不典型,以酮症酸中毒及呼吸、消化系统疾病为首发表现就诊者,易误诊误治;胰岛素治疗有效。     

Predictors of acute complications in children with type 1 diabetes

CONTEXT: Diabetic ketoacidosis and severe hypoglycemia are acute complications of type 1 diabetes that are related, respectively, to insufficient or excessive insulin treatment. However, little is known about additional modifiable risk factors. OBJECTIVE: To examine the incidence of ketoacidosis and severe hypoglycemia in children with diabetes and to determine the factors that predict these complications. DESIGN, SETTING, AND PARTICIPANTS: A cohort of 1243 children from infancy to age 19 years with type 1 diabetes who resided in the Denver, Colo, metropolitan area were followed up prospectively for 3994 person-years from January 1, 1996, through December 31, 2000. MAIN OUTCOME MEASURES: Incidence of ketoacidosis leading to hospital admission or emergency department visit and severe hypoglycemia (loss of consciousness, seizure, or hospital admission or emergency department visit). RESULTS: The incidence of ketoacidosis was 8 per 100 person-years and increased with age in girls (4 per 100 person-years in < 7; 8 in 7-12; and 12 in > or =13 years; P<.001 for trend). In multivariate analyses, sex-adjusted and stratified by age (<13 vs > or =13 years), the risk of ketoacidosis in younger children increased with higher hemoglobin A(1c) (HbA(1c)) (relative risk [RR], 1.68 per 1% increase; 95% confidence interval [CI], 1.45-1.94) and higher reported insulin dose (RR, 1.40 per 0.2 U/kg per day; 95% CI, 1.20-1.64). In older children, the risk of ketoacidosis increased with higher HbA(1c) (RR, 1.43; 95% CI, 1.30-1.58), higher reported insulin dose (RR, 1.13; 95% CI, 1.02-1.25), underinsurance (RR, 2.18; 95% CI, 1.65-2.95), and presence of psychiatric disorders (for boys, RR, 1.59; 95% CI, 0.96-2.65; for girls, RR, 3.22; 95% CI, 2.25-4.61). The incidence of severe hypoglycemia was 19 per 100 person-years (P<.001 for trend) and decreased with age in girls (24 per 100 patient-years in < 7, 19 in 7-12, and 14 in > or =13 years). In younger children, the risk of severe hypoglycemia increased with diabetes duration (RR, 1.39 per 5 years; 95% CI, 1.16-1.69) and underinsurance (RR, 1.33; 95% CI, 1.08-1.65). In older children, the risk of severe hypoglycemia increased with duration (RR, 1.34; 95% CI, 1.25-1.51), underinsurance (RR, 1.42; 95% CI, 1.11-1.81), lower HbA(1c) (RR, 1.22; 95% CI, 1.12-1.32), and presence of psychiatric disorders (RR, 1.56; 95% CI, 1.23-1.98). Eighty percent of episodes occurred among the 20% of children who had recurrent events. CONCLUSIONS: Some children with diabetes remain at high risk for ketoacidosis and severe hypoglycemia. Age- and sex-specific incidence patterns suggest that ketoacidosis is a challenge in adolescent girls while severe hypoglycemia continues to affect disproportionally the youngest patients and boys of all ages. The pattern of modifiable risk factors indicates that underinsured children and those with psychiatric disorders or at the extremes of the HbA(1c) distribution should be targeted for specific interventions.