伊曲康唑治疗浅部真菌病的报告

伊曲康唑治疗浅部真菌病的报告宋宁静杨风清孙红宋兆友（指导）（蚌埠市皮肤病防治研究所２３３０００）我所于１９９３年元月～１９９６年元月，采用伊曲康唑治疗浅部真菌感染病１００例，现将临床观察报告如下：１临床资料１００例均为临床和真菌学检查确诊的门诊病例。...     

中华医学会学术会务部与西安杨森制药有限公司举办“伊曲康唑临床研究奖”

为进一步提高临床医生特别是中青年医生对甲癣及真菌病、浅部真菌感染、霉菌性阴道炎、系统及深部真菌感染的诊断及治疗水平,推动中国抗真菌领域的不断发展,特此,中华医学会学术会务部与西安杨森制药有限公司组织了“伊曲康唑临床研究奖”的活动,具体要求如下: 1、用伊曲康唑治疗甲癣及甲真菌病的病例不少于15例,能提供8例病人治疗前后清晰照片的医生优先考虑。     

伊曲康唑治疗浅部真菌病临床疗效观察

伊曲康唑治疗浅部真菌病临床疗效观察吴建华①廖万清①我科自１９９５年３月开始应用伊曲康唑治疗各种常见真菌病，收到满意的效果。现将应用伊曲康唑治疗皮肤浅部真菌病５３例患者的资料总结报告如下。１资料和方法１．１试验目的：（１）观察伊曲康唑治疗浅部真菌病（手...     

伊曲康唑治疗儿童真菌感染有效

伊曲康唑是一种广谱口服抗真菌制剂,已用于治疗成人的真菌感染,用于儿童同样有效。 伊曲康唑5mg/kg/d治疗儿童皮肤癣菌病安全而有效。安全性同儿童应用灰黄霉素和酮康唑比较更令人满意。与酮康唑不同的是,伊曲康唑并不干扰哺乳类动物类固醇产生。     

五种新型唑类抗真菌药物

唑类药物是目前治疗浅部和深部真菌感染的一线用药.按照其结构的不同,该药可以分为咪唑类和三唑类.3种咪唑类新药卢立康唑、拉诺康唑和氟曲乌唑已在国外上市,外用治疗皮肤癣菌等浅部真菌病疗效明显且局部无明显不良反应.2种三唑类新药普拉康唑和雷夫康唑则仍在临床试验阶段,但从目前研究来看,两者用于治疗浅部和深部真菌感染亦较安全有效...     

伊曲康唑治疗皮肤浅部真菌病80例

伊曲康唑治疗皮肤浅部真菌病８０例陈可（江苏淮安市人民医院皮肤科，２２３２００）关键词：伊曲康吐，治疗，皮肤浅部真菌病我科于１９９４年４月开始使用伊曲康唑胶囊（商品名：斯皮仁诺），治疗８０例皮肤浅部真菌病，获良好之效果，现将结果报告如下。一、临床资料：...     

婴儿及儿童多剂量服用伊曲康唑口服液的药代动力学

血液恶性疾病或肝移植患儿并发真菌感染(大多为念珠菌或曲霉感染 )已成为发病率及死亡率不断上升的原因。伊曲康唑为一广谱抗真菌药物 ,在体外有抗曲霉活性 ,可用于预防和治疗免疫功能低下儿童粘膜及侵入性真菌感染。由于婴儿和儿童服用胶囊有困难 ,为方便给药 ,作者开发了以羟丙 β-环糊精为助溶剂的伊曲康唑口服液 (标示量 1 0ｍｇ/ｍｌ,羟丙 β-环糊精40 0ｍｇ/ｍｌ)用于儿童。成年白血病患者以每日5ｍｇ/ｋｇ剂量给药 ,血清药峰浓度大于 2 5 0ｎｇ/ｍｌ,高于肺部抗曲霉感染的有效浓度。但儿童服用伊曲康唑后的药代动力学数据很有限 ,且…     

五种新型唑类抗真菌药物

唑类药物是目前治疗浅部和深部真菌感染的一线用药。按照其结构的不同,该药可以分为咪唑类和三唑类。3种咪唑类新药卢立康唑、拉诺康唑和氟曲马唑已在国外上市,外用治疗皮肤癣菌等浅部真菌病疗效明显且局部无明显不良反应。2种三唑类新药普拉康唑和雷夫康唑则仍在临床试验阶段,但从目前研究来看,两者用于治疗浅部和深部真菌感染亦较安全有效,有望作为新型抗真菌药应用于临床。     

伊曲康唑消化道反应的临床分析和对策

在2003年～2007年间使用伊曲康唑（斯皮仁诺、西安杨森制药有限公司）治疗浅部真菌病的700多例患者中，对服药后出现消化道反应，且愿意作相关检查的38例患者，进行消化系统病史的回顾分析，探讨伊曲康唑消化系统反应的对策。     

伊曲康唑治疗皮肤肿瘤的研究进展

伊曲康唑为三唑类抗真菌药物,对浅表真菌及深部真菌感染均有显著疗效,在皮肤科得到广泛应用。近年来,越来越多的研究发现伊曲康唑具有抑制血管生成及肿瘤细胞生长的作用。现就伊曲康唑在国内外治疗皮肤肿瘤的研究进展作一综述。     

Dermatology in private practice in France in 2000

OBJECTIVES: Data regarding French dermatological practice are scarce. Our objective was to identify the skin disorders most commonly diagnosed by office-based dermatologists. We also documented the severity of these skin disorders, as reflected by the repercussions on patient's everyday life, and the way physicians managed patients. DESIGN: We carried out a one-day survey of visits to a randomly selected sample of 900 French office-based dermatologists. The randomization was stratified according to the five French different dialing area codes. RESULTS: Office-based dermatologists saw 6411 patients with 7839 skin disorders during the survey. The daily number of visits to French dermatologists was estimated at 47 000 and the annual number between 12 and 14 millions. Office-based dermatologists mostly managed warts, acne, nevus, dermatitis, malignancies and pre-malignancies, fungal infection and psoriasis. Repercussions on patients'everyday life were assessed by physicians as important or very important in 28 p. 100 of cases. Half of the patients received topical treatment, 20.5 p. 100 a systemic drug and 40 p. 100 a minor surgical procedure (including cryotherapy). CONCLUSION: Although dermatologists frequently see benign skin disorders such as warts or nevus, more severe diseases represent an important part of their activity.     

Decrease in neutrophils observed in vivo in psoriatics after PUVA therapy

Summary In 56 patients leucocyte and differential counts were done before and at weekly intervals during PUVA treatment of chronic recalcitrant psoriasis. A statistical significant (P<0.01) decrease in the percentage of neutrophils was observed during the first week of the PUVA therapy. This observation could be closely related to the clinical clearing of psoriasis (P=0.02).The effect of PUVA therapy in psoriasis may be due to a decrease in the number of immunocompetent neutrophils demonstrated in psoriatic lesions.     

37例麻风患者的家庭集聚性调查分析

目的:明确麻风家庭感染者的发病情况。方法:利用全国麻风病防治信息管理系统(LEPMIS)数据库,描述性分析麻风家庭感染者的发病情况。结果:符合条件的共17户家庭37例麻风患者,其中多菌型患者33例,少菌型4例;密切接触5年内发病4例(10.81%),5~10年发病者11例(29.73%),超过10年发病者13例(35.14%),不明时间者9例(24.32%);其中因父母子女关系感染17例(45.95%)、祖孙关系5例(13.51%)、兄弟关系2例(5.41%)。结论:多菌型麻风是家庭传染者的主要传染源。     

Progress in Malassezia Research in Korea

Yeasts of the genus Malassezia are part of the normal flora of human skin. However, they are also associated with various skin diseases. Since the introduction of Malassezia to the Korean Dermatologic Society two decades ago, remarkable progress has been made in our knowledge of this genus. In this paper, we review recent developments in Malassezia research, including taxonomy and methods for species identification, recent genome analyses, Malassezia species distribution in healthy conditions and in specific skin diseases, trials investigating the mechanisms underlying Malassezia-related diseases, as well as therapeutic options. This review will enhance our understanding of Malassezia yeasts and related skin diseases in Korea.     

Hard cornification in reptilian epidermis in comparison to cornification in mammalian epidermis

The structure of reptilian hard (beta)-keratins, their nucleotide and amino acid sequence, and the organization of their genes are presented. These 13-19 kDa proteins are basic, rich in glycine, proline and serine, and different from cytokeratins. Their mRNAs are expressed in beta-cells. The central part of beta-keratins (this region has been previously termed 'core-box' and is peculiar of all sauropsid proteins) is composed of two beta-folded regions and shows a high identity with avian beta-keratins. This central part present in all beta-keratins, including feather keratins, is the site of polymerization to build the framework of beta-keratin filaments. Beta-keratins appear cytokeratin-associated proteins. Their central region might have originated in an ancestral glycine-rich protein present in stem reptiles from which beta-keratins evolved and diversified into reptiles and birds. Stem reptiles of the Carboniferous period might have possessed glycine-rich proteins derived from exons/domains corresponding to the variable, glycine-rich region of cytokeratins. Beta-keratins might have derived from a gene coding for small glycine-rich keratin-associated proteins. The glycine-rich regions evolved differently in the lineage leading to modern reptiles and birds versus that leading to mammals. In the reptilian lineage some amino acid regions produced by point mutations and amino acid changes might have given rise to originate the central beta-pleated region. The latter allowed the formation of filamentous proteins (beta-keratins) associated with intermediate filament keratins and replaced them in beta-keratin cells. In the mammalian lineage no beta-pleated region was generated in their matrix proteins, the glycine-rich keratin-associated proteins. The latter evolved as glycine-tyrosine-rich, sulphur-rich, and ultra-sulphur-rich proteins that are used for building hairs, horns and nails.     

Experimental approaches to lymphocyte migration in dermatology in vitro and in vivo

Lymphocyte trafficking through the dermal compartment is part of the physiological surveillance process of the adaptive immune system. On the other hand, persistent or recurrent lymphocyte infiltrates are hallmarks of both types of chronic inflammatory skin diseases, Th1-type such as psoriasis or Th2/allergic-type like atopic dermatitis. A better understanding of the mechanisms underlying lymphocyte movements is one of the key prerequisites for developing more effective therapies. In this review, we introduce a range of simple-to-sophisticated experimental in vitro and in vivo approaches to analyze lymphocyte migration. These methods start from static in vitro adhesion and chemotaxis assays, include dynamic endothelial flow chamber, intravital dual photon, and transcutaneous live-video microscopy, and finally encompass specific genetically deficient or engineered animal models. Discussing pros and cons of these assay systems hopefully generates both state-of-the-art knowledge about the factors involved in most common chronic skin diseases as well as an improved understanding of the limitations and chances of new biologic pharmaceuticals that are currently introduced into clinical practice.     

Dermatoses in cement workers in southern Taiwan

Construction workers are known to have occupational dermatoses. The prevalence of such dermatoses was unknown in Taiwanese construction workers. The objective of this study was to determine the work exposure, prevalence of skin manifestations, and sensitivity to common contact allergens in cement workers of southern Taiwan. A total of 1147 current regular cement workers were telephone-interviewed about skin problems during the past 12 months, work exposure, and personal protection. Among those interviewed, 166 were examined and patch tested with common contact allergens. A high % of cement workers reported skin problems in the past 12 months. More men (13.9%) reported skin problems possibly related to work than women (5.4%). Prevalence was associated with lower use of gloves, duration of work as cement worker, and more time in jobs involving direct manual handling of cement, especially tiling. A high % of dermatitis was noted in the 166 workers examined, which correlated with reported skin problems. On patch testing, construction workers had a high frequency of sensitivity to chromate. Sensitivity to chromate or cobalt was associated with reported skin problems, or dorsal hand dermatitis on examination. These workers'dermatitis was under-diagnosed and inadequately managed. It is concluded that cement workers in southern Taiwan had a high prevalence of skin problems related to cement use. Protective measures, work practice, and physician education should be improved to prevent or manage such problems.