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1.
《Journal of orthopaedic research》2017,35(8):1625-1633
2.
We reviewed plain radiograms of anterior cruciate ligament injuries to determine the frequency of an abnormal lateral notch
found in the lateral femoral condyle, and we investigated a possible mechanism for its occurrence by determining the relationship
with associated injuries. We analyzed data for 216 patients who underwent ACL reconstruction between 1993 and 1996, whose
radiographic images of the contralateral knee were available. The numbers of male and female patients were 122 and 94, respectively,
and their ages ranged from 14 to 47 years (average, 25 years). The abnormal notch visualized by lateral radiograph was found
in 66 of 216 knees (30.6%) and was classified into three types. The type of abnormal notch seen most frequently (73%) was
located at the same site as the notch on the contralateral side, but appeared deeper than normal. Knees with abnormal notches
showed lateral meniscal injuries more frequently than those without such notches (P < 0.005). The abnormal notch was assumed to have formed at the time of injuries, after impingement of the lateral femoral
condyle on the lateral tibial condyle. Cartilage damage at the abnormal notch should be carefully observed in the future.
Received for publication on Aug. 14, 1998; accepted on Aug. 27, 1999 相似文献
3.
Dhavalakumar K Jain Rajkumar Amaravati Gaurav Sharma 《Indian Journal of Orthopaedics》2009,43(4):375-378
Background:
The diagnostic accuracy of anterior drawer (AD) sign, Lachman test and the pivot shift test for anterior cruciate ligament injury and McMurray test for medial and lateral meniscus is varied with sensitivity and specificity ranging from 2 to 100%. Generally, it is accepted that the pivot shift test is the most specific test to diagnose anterior cruciate ligament (ACL) tears and that the Lachman test is more sensitive than AD sign. This study was undertaken to calculate the sensitivity, specificity, positive predictive value, negative predictive value, and efficiency for the above-mentioned diagnostic tests.Materials and Methods:
Twenty-eight male patients with clinical ACL injury were examined in the outpatient department and under anaesthesia, the findings were compared with arthroscopy.Result:
The sensitivity and specificity for the Lachman test, AD sign and pivot shift test performed in the outpatient setting are 78.6 and 100%, 89.3 and 100%, and 75 and 100%, respectively. The sensitivity and specificity for the Lachman test, AD sign, and pivot shift test performed under anesthesia are 92.9 and 100%, 92.9 and 100%, and 100 and 100%, respectively. The sensitivity and specificity of the McMurray test for medial and lateral meniscus were 35.7 and 85.7% and 22.2 and 100%, respectively.Conclusion:
The Lachman test, AD sign and pivot shift test are highly specific tests to diagnose ACL laxity in a non-acute setting; pivot shift test under anesthesia is the most sensitive and specific test for diagnosing ACL laxity in a non-acute setting and the McMurray test is not a sensitive test to diagnose meniscal injury in the presence of ACL injury. 相似文献4.
Wei Jiang Shu-guang Gao Kang-hua Li Ling Luo Yu-sheng Li Wei Luo Guang-hua Lei 《Indian Journal of Orthopaedics》2012,46(5):514-519
Background:
The clinical relationship between medial meniscus tear and anterior cruciate ligament (ACL) rupture has been well documented. However, the mechanism of this clinical phenomenon is not exactly explained. Our aim is to investigate the biomechanical impact of partial and complete ACL rupture on different parts of medial meniscus.Materials and Methods:
Twelve fresh human cadaveric knee specimens were divided into four groups: ACL intact (ACL-I), anteromedial bundle transection (AMB-T), posterolateral bundle transection (PLB-T), and ACL complete transection (ACL-T) group. Strain on the anterior horn, body part, and posterior horn of medial meniscus were measured under 200 N axial compressive tibial load at 0°, 30°, 60°, and 90° of knee flexion, respectively.Results:
Compared with the control group (ACL-I), the ACL-T group had a higher strain on whole medial meniscus at 0°, 60°, and 90° of flexion. But at 30°, it had a higher strain on posterior horn of meniscus only. As to PLB-T group, strain on whole meniscus increased at full extension, while strain increased on posterior horn at 30° and on body of meniscus at 60°. However, AMB-T only brought about higher strain at 60° of flexion on body and posterior horn of meniscus.Conclusions:
Similar to complete rupture, partial rupture of ACL can also trigger strain concentration on medial meniscus, especially posterior horn, which may be a more critical reason for meniscus injury associated with chronic ACL deficiency. 相似文献5.
Kai Huang Hai-li Cai Peng-li Zhang Li-dong Wu 《Journal of orthopaedic research》2020,38(12):2721-2730
Animal osteoarthritis (OA) models have been developed to understand OA progression and evaluate new OA therapies. However, individual variations in joint lesions remain a critical problem in most current OA models. We established a novel rabbit model by creating a longitudinal tear in the medial meniscus body that was reproducible and similar to posttraumatic biomechanical disturbances in human OA. New Zealand rabbits underwent surgery and were assessed for 9 weeks. The rabbits were randomized into the sham control, medial meniscal tear (MMT), and anterior cruciate ligament transection (ACLT) groups. The animals were sacrificed at 4, 6, and 9 weeks posttreatment. The knee joints were harvested for histological and gene expression assessments. Both the MMT and ACLT procedures led to time-dependent degenerative changes in the femoral condyle cartilage. At each time point, the MMT group cartilage showed more severe degenerative changes than did the ACLT group cartilage. Consistently, inflammatory cytokine and catabolic gene expression were significantly higher, and anabolic gene expression was significantly lower in the MMT group than in the ACLT group. MMT treatment caused more severe structural damage to the cartilage and higher catabolic gene expression levels than the ACLT model at each time point. The MMT model may be highly beneficial in investigating posttraumatic OA (PTOA) development, especially PTOA from a meniscal injury. The MMT model replicated key features of human PTOA, including meniscal lesions, inflammatory responses, and the progression to osteoarthritic cartilage degeneration, thereby providing an exciting new avenue for translating promising treatments to clinical practice. 相似文献
6.
目的 探讨关节镜手术治疗前交叉韧带(ACL)合并半月板损伤的方法及疗效.方法 关节镜下对135例ACL合并半月板损伤患者行ACL重建,同时行半月板修复或半月板修整.结果 患者均获随访,时间3~12个月,术后未出现关节粘连、血管神经损伤等并发症,半月板修整患者均无交锁且回旋挤压试验阴性.半月板修复患者3个月时随访,回旋挤压试验阳性1例;12个月时随访,回旋挤压试验阳性3例,交锁1例,两者都有1例.Lysholm评分:手术前为(46.3±6.2)分,术后6个月为(73.4±7.6)分,术后12个月为(87.8±8.2)分,术前与术后比较差异有统计学意义(P<0.01).结论 ACL与半月板常同时损伤,手术前应作好ACL重建及半月板修复或修整准备,关节镜同期治疗ACL并半月板损伤可取得较好疗效. 相似文献
7.
Takayuki Furumatsu Shinichi Miyazawa Takaaki Tanaka Yukimasa Okada Masataka Fujii Toshifumi Ozaki 《International orthopaedics》2014,38(7):1393-1399
Purpose
Meniscus repair can restore meniscal function that transfers the axial compressive force to circumferential tensile strain. However, few reports have investigated the relationship between concurrent meniscus repair with acute anterior cruciate ligament (ACL) reconstruction and postoperative meniscal position. This study aimed to evaluate medial meniscal size and clinical results in patients who underwent ACL reconstruction and concomitant all-inside medial meniscus repair.Methods
Twenty patients underwent ACL reconstruction and concurrent medial meniscus repair of a peripheral longitudinal tear using the FasT-Fix meniscal repair device. Medial tibial plateau length (MTPL) and width (MTPW) were determined by radiographic images. We evaluated the Lysholm score, anteroposterior instability, meniscal healing and magnetic resonance imaging (MRI)-based medial meniscal length (MML) and width (MMW). Correlations between MRI-based meniscal size, radiographic measurement and height were investigated.Results
All patients showed complete healing of the repaired meniscus in arthroscopic evaluation. However, one patient needed a subsequent meniscus repair during the follow-up period. Lysholm score and anteroposterior instability improved significantly. A better correlation was observed between MMW and MTPW than between MML and MTPL. Concurrent all-inside medial meniscus repair with ACL reconstruction significantly increased MML percentage (%MML) (100 MML/MTPL) but did not affect MMW percentage (%MMW) (100 MMW/MTPW).Conclusions
Concurrent all-inside medial meniscus repair with ACL reconstruction had satisfactory clinical results. %MML was increased by concurrent medial meniscus repair without affecting %MMW. Our results suggest that medial meniscus repair associated with ACL reconstruction may restore meniscal function by adjusting the anteroposterior length of the torn medial meniscus. 相似文献8.
目的 对比前交叉韧带(ACL)撕裂与髌骨外侧脱位(LPD)患者之间,股骨滑车发育不良、髌骨高位、胫骨结节-股骨滑车沟(TT-TG)间距过宽检出率的差异。方法 回顾性分析79例ACL撕裂患者(ACL撕裂组)、46例LPD患者(LPD组)及100例膝关节未见明显异常者(对照组)的膝关节MRI,对比3组间股骨滑车发育不良、髌骨高位(Insall-Salvati指数>1.2)及TT-TG间距过宽(TT-TG间距>15mm为过宽)检出率的差异。结果 ACL撕裂组中,股骨滑车发育不良18例(18/79,22.78%),髌骨高位12例(12/79,15.19%),TT-TG间距过宽10例(10/79,12.66%);LPD组中,股骨滑车发育不良26例(26/46,56.52%),髌骨高位21例(21/46,45.65%),TT-TG间距过宽13例(13/46,28.26%);对照组股骨滑车发育不良9例(9/100,9.00%),髌骨高位6例(6/100,6.00%),TT-TG间距过宽5例(5/100,5.00%)。3组间股骨滑车发育不良、髌骨高位和TT-TG间距过宽检出率差异均有统计学... 相似文献
9.
Background:
The association of meniscal cartilage injury with anterior cruciate ligament (ACL) injury is well documented in literature. The aim of this study was to examine the relative risk factors for meniscal pathology at the time of arthroscopic ACL reconstruction.Materials and Methods:
A review of the case records including both in-patient and out-patient charts of all patients who underwent arthroscopic ACL reconstruction during the preceding 3 years was performed by either of the authors. The relative incidences of associated meniscal pathologies were analyzed in correlation with age, side of injury, time to surgery, mode of injury, and gender as the risk factors. Statistical analysis was performed to obtain individual data correlation.Results:
A total of 192 patients underwent ACL reconstruction during the 3-year time frame. Of these, complete data sets were available for 129 patients. Analysis revealed that the only factor that was statistically significant in raising the risk of meniscal pathology was the time to surgery (P = 0.001). There was a significant increase in medial, lateral, and both meniscal tears noted in cases operated beyond 24 weeks. Further, the incidence of medial meniscal tears as well as lateral meniscal tears increased with delay in presentation for surgery (P = 0.004). Mode of injury, age at presentation, sex, and side were not significantly associated with an increased incidence of meniscal pathology.Conclusion:
The single factor that significantly affects incidence of meniscal co-morbidity in ACL injury is the delay in presentation (i.e. the time to surgery). The incidence of lateral meniscal tears as well as medial meniscal tears increased with delay in surgery. This should guide us toward recommending all patients irrespective of age, gender, or mode of injury to undergo early reconstruction, thereby reducing the likelihood of developing meniscal pathology. 相似文献10.
MRI analysis of in vivo meniscal and tibiofemoral kinematics in ACL-deficient and normal knees. 总被引:2,自引:0,他引:2
Sandra J Shefelbine C Benjamin Ma Keh-Yang Lee Mark A Schrumpf Priyesh Patel Marc R Safran John P Slavinsky Sharmila Majumdar 《Journal of orthopaedic research》2006,24(6):1208-1217
The objectives of this study were to analyze simultaneously meniscal and tibiofemoral kinematics in healthy volunteers and anterior cruciate ligament (ACL)-deficient patients under axial load-bearing conditions using magnetic resonance imaging (MRI). Ten healthy volunteers and eight ACL-deficient patients were examined with a high-field, closed MRI system. For each group, both knees were imaged at full extension and partial flexion ( approximately 45 degrees ) with a 125N compressive load applied to the foot. Anteroposterior and medial/lateral femoral and meniscal translations were analyzed following three-dimensional, landmark-matching registration. Interobserver and intraobserver reproducibilities were less than 0.8 mm for femoral translation for image processing and data analysis. The position of the femur relative to the tibia in the ACL-deficient knee was 2.6 mm posterior to that of the contralateral, normal knee at extension. During flexion from 0 degrees to 45 degrees , the femur in ACL-deficient knees translated 4.3 mm anteriorly, whereas no significant translation occurred in uninjured knees. The contact area centroid on the tibia in ACL-deficient knees at extension was posterior to that of uninjured knees. Consequently, significantly less posterior translation of the contact centroid occurred in the medial tibial condyle in ACL-deficient knees during flexion. Meniscal translation, however, was nearly the same in both groups. Axial load-bearing MRI is a noninvasive and reproducible method for evaluating tibiofemoral and meniscal kinematics. The results demonstrated that ACL deficiency led to significant changes in bone kinematics, but negligible changes in the movement of the menisci. These results help explain the increased risk of meniscal tears and osteoarthritis in chronic ACL deficient knees. 相似文献
11.
Shu-guang Gao Can Zhang Rui-bo Zhao Zhan Liao Yu-sheng Li Fang Yu Chao Zeng Wei Luo Kang-hua Li Guang-hua Lei 《Indian Journal of Orthopaedics》2013,47(5):493-499
Background:
The relationship between medial meniscus tear and posterior cruciate ligament (PCL) injury has not been exactly explained. We studied to investigate the biomechanical effect of partial and complete PCL transection on different parts of medial meniscus at different flexion angles under static loading conditions.Materials and Methods:
Twelve fresh human cadaveric knee specimens were divided into four groups: PCL intact (PCL-I), anterolateral bundle transection (ALB-T), posteromedial bundle transection (PMB-T) and PCL complete transection (PCL-T) group. Strain on the anterior horn, body part and posterior horn of medial meniscus were measured under different axial compressive tibial loads (200-800 N) at 0°, 30°, 60° and 90° knee flexion in each groups respectively.Results:
Compared with the PCL-I group, the PCL-T group had a higher strain on whole medial meniscus at 30°, 60° and 90° flexion in all loading conditions and at 0° flexion with 400, 600 and 800 N loads. In ALB-T group, strain on whole meniscus increased at 30°, 60° and 90° flexion under all loading conditions and at 0° flexion with 800 N only. PMB-T exihibited higher strain at 0° flexion with 400 N, 600 N and 800 N, while at 30° and 60° flexion with 800 N and at 90° flexion under all loading conditions.Conclusions:
Partial PCL transection triggers strain concentration on medial meniscus and the effect is more pronounced with higher loading conditions at higher flexion angles. 相似文献12.
Injury to the anterior cruciate ligament (ACL) not only causes mechanical instability but also leads to a functional deficit in the form of diminished proprioception of the knee joint. “Functional” recovery is often incomplete even after “anatomic” arthroscopic ACL reconstruction, as some patients with a clinically satisfactory repair and good ligament tension continue to complain of a feeling of instability and giving way, although the knee does not sublux on clinical testing. Factors that may play a role could be proprioceptive elements, as the intact ACL has been shown to have significant receptors. Significant data have come to light demonstrating proprioceptive differences between normal and injured knees, and often between injured and reconstructed knees. ACL remnants have been shown to have proprioceptive fibers that could enhance functional recovery if they adhere to or grow into the reconstructed ligament. Conventionally the torn remnants are shaved off from the knee before graft insertion; modern surgical techniques, with remnant sparing methods have shown better outcomes and functional recovery, and this could be an avenue for future research and development. This article analyzes and reviews our understanding of the sensory element of ACL deficiency, with specific reference to proprioception as an important component of functional knee stability. The types of mechanoreceptors, their distribution and presence in ACL remnants is reviewed, and suggestions are made to minimize soft tissue shaving during ACL reconstruction to ensure a better functional outcome in the reconstructed knee. 相似文献
13.
关节镜下膝关节前、后交叉韧带重建53例 总被引:3,自引:0,他引:3
目的总结关节镜下前、后交叉韧带(ACL、PCL)及膝内外侧复合体重建的经验。方法关节镜下移植中1/3骨-髌腱-骨组织、4股腘绳肌腱及LARS人工韧带重建膝关节ACL、PCL。合并膝内、外侧结构损伤患者在重建的同时进行膝关节侧副韧带和关节囊的修补。术后佩戴可调式膝关节固定带3个月行康复训练。结果53例随访2个月~5年4个月,Lysholm评分由术前平均(20±4.6)分提高到(85±7.3)分。所有患者术前抽屉试验及Lachman试验存在阳性体征,术后1例后抽屉试验阳性,4例Lachman试验弱阳性。所有患者关节功能明显改善。结论在关节镜直视下交叉韧带重建能准确定位ACL、PCL解剖止点,具有损伤小,关节粘连率低,恢复快的优点,能达到坚强固定,早期功能锻炼的目的。 相似文献
14.
目的探讨外侧半月板后根部(lateral meniscus posterior root,LMPR)修复联合前十字韧带(anterior cruciate ligament,ACL)重建术治疗合并LMPR慢性撕脱损伤的ACL撕裂的临床疗效。方法回顾性分析2015年7月至2017年6月LMPR慢性撕脱合并ACL撕裂患者33例,男30例,女3例;年龄(27.7±7.5)岁(范围17~45岁)。由同一术者施行胫骨隧道拉出式LMPR修复自体腘绳肌腱ACL解剖单束重建术,随访2年以上。根据二次关节镜下探查结果评估半月板愈合,根据Lysholm和Tegner评分评估膝关节主观功能,根据麻醉下KT-1000侧侧差值和轴移试验评估膝关节客观稳定性,根据矢状面MRI上胫骨前移距离评估股骨-胫骨静态位置关系。以术前胫骨前移距离进行分组,前移至少6 mm者(前移阳性组)18例,前移小于6 mm者(前移阴性组)15例,比较术前及术后2年两组患者胫骨前移距离及其降低程度的差异。结果所有患者随访(27.5±4.0)个月(范围24~39个月)。LMPR完全愈合23例(70%)、部分愈合9例(27%)、不愈合1例(3%)。Lysholm评分由(60.4±13.6)分提高至术后1年的(82.7±11.1)分、术后2年的(91.4±9.1)分(F=155.996,P<0.001);Tegner评分由3(2,5)分[M(P25,P75)]提高至术后1年的4(3,5)分、术后2年的6(4,6)分(χ^2=47.791,P<0.001)。KT-1000侧侧差值由(9.1±3.3)mm降低至(2.0±1.7)mm(t=11.197,P<0.001);轴移试验由Ⅰ度10例、Ⅱ度20例、Ⅲ度3例改善至正常30例、Ⅰ度3例(U=5.161,P<0.001)。胫骨前移距离由(5.7±3.9)mm减少至(3.5±3.2)mm(t=3.530,P=0.001)。术后2年,前移阳性组的胫骨前移由(8.7±1.8)mm下降至(5.0±3.3)mm(t=4.765,P<0.001),前移阴性组的胫骨前移与术前比较差异无统计学意义(t=0.400,P=0.695)。前移阳性组胫骨前移下降幅度为(3.7±3.3)mm,大于前移阴性组的(0.3±2.8)mm(t=3.115,P=0.004)。结论胫骨隧道拉出式LMPR修复联合ACL重建术治疗合并LMPR慢性撕脱损伤的ACL撕裂,术后2年半月板愈合率高;膝关节主观功能及客观稳定性提高,能够有效改善术前胫骨前移≥6 mm患者的股骨-胫骨静态位置关系。 相似文献
15.
目的探讨同种异体骨-腱-骨(B-PT-B)同时重建膝关节前交叉韧带(ACL)、后交叉韧带(PCL)急性损伤的临床疗效。方法在关节镜下早期使用同种异体B-PT-B重建ACL、PCL急性损伤患者22例。结果22例均获随访,时间1618个月。患者屈膝范围从术前7990(85.5±4.5)°提高到术后134140(138±1.5)°,Lysholm膝关节功能评分从术前023(8.6±3.0)分提高到术后8596(92.0±3.6)分(P〈0.01)。未发现感染、移植物断裂、排异反应等。结论早期关节镜下应用同种异体B-PT-B重建ACL、PCL急性损伤,具有手术操作简便、创伤小、免疫排斥反应小、术后并发症少的优点,能最大限度恢复患者膝关节的本体感觉功能及运动功能。 相似文献
16.
17.
M.D. Masayuki Hamada M.D. Konsei Shino M.D. Kiyoshi Kawano M.D. Yutaka Araki M.D. Yoshito Matsui M.D. Teruo Doi 《Arthroscopy》1994,10(6)
In order to determine the usefulness of magnetic resonance imaging (MRI) for detection of intrasubstance tears or degeneration of the lateral discoid meniscus, we compared findings obtained with MRI with those of histological examination. Sixty-four symptomatic lateral discoid menisci were studied using MRI before surgical treatment. Of these, 18 (28%) met the criteria that MRI signals did not extend to the surface and that no visible tears were observable at arthroscopy. Findings of intrameniscal regions of high signal intensity and flattening in shape on MR images were found to represent intrasubstance tears or degeneration not detected at arthroscopy. Our findings thus demonstrate that MRI is more sensitive than arthroscopy in the detection of intrasubstance pathologies of the lateral discoid menisci. 相似文献
18.
Torbj rn Strand Lars B. Engesaeter Anders O. M lster Tor S. Raugstad L. Stangeland O. Stray Antti Alho 《Acta orthopaedica》1984,55(2):181-184
A retrospective consecutive series of 60 patients treated with primary suture of knee ligament injuries is presented. All patients had an anterior ligament (ACL) tear. In 54 patients this injury was combined with a medial compartment tear. Four patients had isolated tears of the ACL. At follow-up after 4 years, 11 patients complained of instability, and in eight of these an anterolateral rotatory instability was demonstrated by the Slocum test. In contrast, only five of 49 patients with subjectively stable knees had positive Slocum tests. Thirty of 47 patients with negative Slocum tests had excellent function, compared with four of 13 patients with positive tests. 相似文献
19.
Hyung Suk Choi 《Indian Journal of Orthopaedics》2015,49(2):251-254
Discoid shapes of lateral menisci are relatively common finding, whereas discoid medial menisci are less common. Discoid medial meniscus with associated anomalous variants has been reported. However, symptomatic complex tear of complete type discoid medial meniscus with anomalous blending with anterior cruciate ligament is an extremely rare pathology. A 35-year-old male was admitted to our hospital with left knee pain and loss of terminal extension for 2 years. On physical examination, the patient presented with clicking and restriction during the extension motion of the knee joint. Magnetic resonance imaging and arthroscopy indicated complex tear of complete discoid medial meniscus in association with anomalous connection between entire apical portion of discoid medial meniscus and tibial insertion portion of the anterior cruciate ligament. We obtained a successful outcome with arthroscopic resection and shaping in one-piece method using no. 11 scalpel blade. 相似文献
20.
Sean W. Flannery Ata M. Kiapour David J. Edgar Martha M. Murray Jillian E. Beveridge Braden C. Fleming 《Journal of orthopaedic research》2022,40(1):277-284
Quantitative magnetic resonance imaging enables quantitative assessment of the healing anterior cruciate ligament or graft post-surgery, but its use is constrained by the need for time consuming manual image segmentation. The goal of this study was to validate a deep learning model for automatic segmentation of repaired and reconstructed anterior cruciate ligaments. We hypothesized that (1) a deep learning model would segment repaired ligaments and grafts with comparable anatomical similarity to intact ligaments, and (2) automatically derived quantitative features (i.e., signal intensity and volume) would not be significantly different from those obtained by manual segmentation. Constructive Interference in Steady State sequences were acquired of ACL repairs (n = 238) and grafts (n = 120). A previously validated model for intact ACLs was retrained on both surgical groups using transfer learning. Anatomical performance was measured with Dice coefficient, sensitivity, and precision. Quantitative features were compared to ground truth manual segmentation. Automatic segmentation of both surgical groups resulted in decreased anatomical performance compared to intact ACL automatic segmentation (repairs/grafts: Dice coefficient = .80/.78, precision = .79/.78, sensitivity = .82/.80), but neither decrease was statistically significant (Kruskal-Wallis: Dice coefficient p = .02, precision p = .09, sensitivity p = .17; Dunn post-hoc test for Dice coefficient: repairs/grafts p = .054/.051). There were no significant differences in quantitative features between the ground truth and automatic segmentation of repairs/grafts (0.82/2.7% signal intensity difference, p = .57/.26; 1.7/2.7% volume difference, p = .68/.72). The anatomical similarity performance and statistical similarities of quantitative features supports the use of this automated segmentation model in quantitative magnetic resonance imaging pipelines, which will accelerate research and provide a step towards clinical applicability. 相似文献