CLINICAL OBSERVATION ON ACUPUNCTURE TREATMENT OF MILD TO MODERATE HYPERTENSION

Objective: To determine the effects of acupuncturing point Renying(ST9) at different frequencies on mild to moderate hypertension.Methods: From July 2012 to June 2013, the hypertension clinic at the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine completed treatment on 38 patients(20 cases in Renying high-frequency group(RHFG), and 18 cases in Renying low-frequency group(RLFG)), using 24-hour ambulatory blood pressure indicators to investigate the effects of different needle manipulations on blood pressure.Results: Compared with before treatment, nighttime blood pressure of the RHFG was significantly lower after 6 and 12 weeks of treatment(P0.05); da ytime and nighttime blood pressure of the RLTG was lower after 6 weeks of treatment, but tended to rebound after 12 weeks of treatment.Conclusion: Renying high-frequency acupuncture has a lasting effect in lowering nighttime blood pressure; whereas Renying low-frequency acupuncture tends to lower both daytime and nighttime blood pressure, but is prone to develop tolerance.     

EFFICACY OF ACUPUNCTURE FOR MOTION SICKNESS:A RANDOMIZED CONTROLLED CLINICAL TRIAL

Objective: In this randomized, controlled study, we observed the efficacy of acupuncture in motion sickness.Methods: We did a randomized and controlled trial of acupuncture in volunteers with motion sickness.A total of 60 patients were randomly assigned to acupuncture or standard care group.The acupuncture group received treatments on acupuncture points including GV20(Baihui), EX-HN1(Sishencong), bilateral PC6(Neiguan) and ST36(Zusanli), twice per week for 5 weeks.The control group received only usual care during the same period.The two experimental groups received tests with motion sickness device in the same environment.Graybiel score and the degrees of discomfort were used to evaluate the degree of motion sickness.Car trials were used for the evaluation of clinical efficacy.Analysis was performed on the last score except patients who were dropped out before completion.Results: The Graybiel scores were 10.12±3.37 and 9.95±2.60 in the acupuncture group and the control group respectively with no significant difference(P0.05) before treatment.The Graybiel scores were 0.92±0.40 and 9.86±2.53 in the acupuncture group and the control group respectively with significant differences(P0.05) after treatment.The motion sickness degree distribution in the acupuncture group was N, 0;I, 0; IIB, 0; IIA, 7; III, 16; and F, 2 before treatment; and N, 3; I, 22; IIB, 0; IIA, 0; III, 0; and F, 0 after treatment.The distribution of the control group was N, 0; I, 0; IIB, 0; IIA, 5; III, 16; and F, 1 before and after treatment.After the experiment, the degrees of discomfort in the acupuncture group significantly decreased(P0.01).Total effective rates of the acupuncture group and the control group were 96% and 0% respectively with significant differences(P0.05).No adverse effects of acupuncture were reported.Conclusion: These data suggest that acupuncture is an effective therapy for patients with motion sickness.The anti-motion sickness capabilities are improved and the sufferings of patients with motion sickness were alleviated after acupuncture treatment.     

INFLUENCE OF DIFFERENT ELECTROACUPUNCTURE TREATMENT ON THE EXPRESSION OF TRH IN HYPOTHALAMUS OF RATS WITH CHRONIC UNPREDICTABLE MILD STRESS-INDUCED DEPRESSION

Objective: To investigate the influence of different electroacupuncture(EA) treatment on the expression of thyrotropin-releasing hormone(TRH) in the hypothalamus of rats with chronic unpredictable mild stress, and to elucidate the possible role of TRH in the development of experimental depression and the effect of different EA for them.Methods: Adult male SD rats were randomly divided into normal control group(n=12), model group(n=12), pulsed EA group(n=12), music EA group(n=12) and fluoxetine group(n=12).Depression model was established by raising alone andchronic unpredictable mild stress for 21 d.Open-field test was performed to test the behavior of the rats.The expression of hypothalamic TRH was detected by using immunohistochemistry, enzyme-linked immunosorbent assay(ELISA) and real-time PCR techniques respectively.Results: The cross and rear scores of the model group were significantly lower than those of the normal control group, while pulsed EA, music EA and fluoxetine could reverse it.The expression of hypothalamic TRH in the model group decreased significantly, and the three kinds of treatment could improve these pathological changes, but the effect of fluoxetine was better than the other two EA treatments.In addition, there were no statistical differences between the effects of pulsed EA and music EA treatments.Conclusion: The level of TRH in hypothalamus of depression rats was lower than normal level.EA treatments may have antagonism against depression by increasing the level of TRH in hypothalamus, and there is no difference between the effects of pulsed EA treatment and music EA treatment for depression.     

USING ACUPUNCTURE TO RELIEVE PERIMENOPAUSAL SYNDROME:STUDY PROTOCOL OF A MULTICENTER RANDOMIZED CLINICAL TRIAL

Objective: In this article, we report the protocol of a randomized controlled trial of using acupuncture to treat perimenopausal syndrome, aiming to answer the question whether acupuncture is effective for relieving perimenopausal syndrome.Methods: A multicenter randomized controlled trial with two parallel arms is undergoing in China.Two hundred and six women with perimenopausal syndrome will be randomly assigned to a treatment group using acupuncture plus auricular acupressure(AA) and a control group using Climen? in a 1:1 ratio.Participants in the AA treatment group will receive acupuncture 3 times per week in the first 4 weeks and 2 times per week in the following 8 weeks, for a total 28 sessions over 12 weeks.Auricular points will be plastered by Semen Vaccariae 2 times per week for 12 weeks.The Climen? control group, a 28-day sequential hormone replacement therapy, is prescribing a tablet containing estradiol valerate(E2V) 2 mg per day for the first 11 d, and a tablet containing E2 V 2 mgplus cyproterone acetate(CPA) 1 mg per day for the following 10 d.The total treatment period of control group is three cycles.Post-treatment follow-up period will last 24 weeks.The primary outcome is Menopause Rating Scale(MRS) that assessed at baseline and 4, 8, 16, 24 and 36 weeks after randomization.The secondary outcomes are Menopause-Specific Quality of Life(MENQOL), average hot flash score during 24 h, and the serum estradiol(E2), follicle-stimulating hormone(FSH) and luteinizing hormone(LH) level.The first two secondary outcomes are measured at as the same point as MRS.And other second outcomes are measured at baseline and 12, and 24 weeks after randomization.Discussion: The result of this trial, which will be available in 2015, will clarify whether acupuncture is effective to relieve perimenopausal syndrome.     

A RANDOMIZED TRIAL OF ELECTROACUPUNCTURE FOR FATIGUE,SLEEP, AND PSYCHOLOGICAL DISTRESS IN BREAST CANCER PATIENTS WITH AROMATASE INHIBITOR-RELATED ARTHRALGIA

Background: While fatigue, sleep disturbance, depression and anxiety are associated with pain in breast cancer patients, it is unknown if acupuncture can decrease these co-morbid symptoms in cancer patients with pain.This study aimed at evaluating the effects of electroacupuncture(EA) on fatigue, sleep and psychological distress in breast cancer survivors who experience joint pain related to aromatase inhibitors(AIs).Methods: We performed a randomized controlled trial of an eight-week EA as compared to waitlist control(WLC) and sham acupuncture(SA) in postmenopausal women with breast cancer who self-reported joint pain attributable to AIs.Acupuncturists performed 10 EA/SA treatments over eight weeks using a manual protocol with 2 Hz electro-stimulation delivered by a TENS unit.Acupuncturists administered SA using Streitberger(nonpenetrating) needles at non-acupuncture points without electrostimulation.Fatigue, sleep disturbance, anxiety and depression were measured by the Brief Fatigue Inventory(BFI), Pittsburgh Sleep Quality Index(PSQI), and Hospital Anxiety and Depression Scale(HADS).The effects of EA and SA vs.WLC on these outcomes were evaluated using mixed-effects models.Results: Of the 67 randomly assigned patients, baseline paininterference was associated with fatigue(Pearson correlation coefficient r=0.75, P0.001), sleep(r=0.38, P=0.002 6), and depression(r=0.58, P0.001).Compared to the WLC, EA produced significant improvement in fatigue(P=0.009 5), anxiety(P=0.044), and depression(P=0.015) and marginal improvement in sleep(P=0.058) during the 12-week intervention and followup period.In contrast, SA only produced significant improvement in depression compared with WLC(P=0.008 8).Conclusion: Among women who experienced AI-related arthralgia, EA produced significant improvement in fatigue, anxiety and depression, while SA improved only depression.These findings provide initial evidence to suggest that EA may reduce pain-related symptom clusters in breast cancer survivors.     

艾迪注射液联合MF/CF方案化疗晚期胃癌临床观察

目的：观察艾迪注射液联合MF/CF方案治疗晚期胃癌的疗效及其不良反应。方法：将晚期胃癌患者50例随机分成两组,治疗组25例,采用艾迪注射液联合MF/CF方案治疗,对照组25例,单用MF/CF方案化疗。四周为1个周期,2个周期后判定疗效,记录不良反应。结果：治疗组25例完全缓解（CR）3例,部分缓解（PR）14例,有效（CR＋PR）17例,总有效率68%。对照组25例CR2例（8%）,PR13例（52%）,有效15例（60%）。两组比较无显著统计学意义（P〉0.05）,不良反应治疗组恶心、呕吐、脱发、口腔溃疡、白细胞、血红蛋白及血小板减少较对照组明显减轻（P〈0.05）。结论：艾迪注射液联合MF/CF方案较单纯应用MF/CF方案治疗晚期胃癌疗效相当,但前者能降低化疗不良反应发生率,提高患者生活质量。     

CHARACTERISTICS OF RANDOMIZED CLINICAL TRIALS ON ACUPUNCTURE REGISTERED IN TRIAL REGISTRIES:A SYSTEMATIC ANALYSIS

Objective: To systematically analyze the characteristics of randomized clinical trials on acupuncture registered in major international trial registries and to evaluate trial methodological quality.Methods: Fifteen trial registries were searched to identify randomized clinical trials on acupuncture.Methodological quality of each registered trial was assessed using the Cochrane risk of bias tool including generation of allocation sequence, allocation concealment and blinding.Results: A total of 523 randomized trials were registered, of which 324 were registered after recruitment of the first participant.The number of registered acupuncture trials increased from 2 in 1999 to 83 in 2012.Majority of the trials were single-center(72.8%), parallel-group(76.7%), two-arms(67.7%), placebo/sham-controlled(52.0%), and funded by university, government or hospital(84.7%).The most frequent conditions were musculoskeletal(23.3%), nervous(12.1%), mental and behavioral disorders(10.5%), digestive(7.3%), and genitourinary(6.7%).The mostfrequently reported acupuncture components was treatment regimen(54.6%), followed by details of needling(45.7%), other interventions administered with acupuncture(23.3%), style of acupuncture(17.6%), and practitioner qualification(7.5%).Detailed information on randomization was obviously insufficient.For example, 85.5% lacked information on generation of allocation sequence, 93.1% did not provide details on allocation concealment.Of 339 trials using blinding, 23.5% applied blinding to participants, 4.6% applied blinding to both participants and personnel, and 5.4% reported blinding to participants, personnel and outcome assessors.More than two thirds of the trials reported primary and secondary outcomes, but only 14.7% and 2.3% reported safety outcome and health-economics outcome, respectively.Conclusion: Increasing number of clinical acupuncture studies have been registered in international trial registries.The study design of registered acupuncture trials has been improved in use of blinding.However, the methodological information in the registered acupuncture trials is insufficient, and the Standard Protocol Items for Randomized Trials should be followed.     

EVALUATION OF EFFICACY AND SAFETY PROFILE OF ELECTROACUPUNCTURE ASSESSED IN THE CHRONIC ATRIOVENTRICULAR BLOCK CANINE MODEL WITH SEVERE HYPERTENSION AND HEART FAILURE

Objective: Previous animal and clinical studies have shown that acupuncture is an effective alternative treatment in the management of stages I and II hypertension; however, information is still limited for stage III hypertension.In this study, we assessed the acute cardiohemodynamic and electrophysiological effects ofelectroacupuncture in the chronic atrioventricular block canine model with severe hypertension and heart failure(n=4).Methods: Seven sessions of electroacupuncture were performed for 2 weeks.In each session, needles were inserted at Renying(ST9) and Taichong(LR3), and then an electroacupuncture protocol consisting of 2 Hz frequency and 2 mA amplitude was carried out for 30 min with a Han's acupoint nerve stimulator.The animals were anesthetized with pentobarbital in the initial and last sessions to estimate the acute and chronic cardiohemodynamic and electrophysiological effects of electroacupuncture.Results: Ventricular rate decreased during continuous stimulation at the first and the seventh sessions(P0.05).Mean blood pressure increased and atrial rate decreased only during the first stimulation(P0.05).There was no significant change in the systolic blood pressure, diastolic blood pressure, cardiac output, total peripheral resistance, double product, and QRS width or QT interval during electrical stimulation in the first and the seventh sessions.There was no significant difference in any time-matched variable between those two sessions.Conclusion: These results suggest that electroacupuncture may rather expose a risk for hypertension crisis by a short application and that 7 sessions of treatment by electroacupuncture for 2 weeks might not be enough to lower the blood pressure in this special canine model.     

EFFECTS OF ACUPUNCTURE ON ALLERGIC RHINITIS:A RANDOMIZED,CONTROLLED CLINICAL TRIAL

Objective: To assess the effects of acupuncture on allergic rhinitis in a randomized, controlled clinical trial.Methods: This study was a multicenter, randomized, parallelcontrolled study.Participants were randomized into active acupuncture, sham acupuncture, or waitlist groups.The active and sham acupuncture groups received acupuncture treatment three times per week for 4 weeks.In the sham group, minimal acupuncture at non-acupuncture points was used.The waitlist group did not receive any acupuncture treatment during the study.The clinical efficacy was assessed at every week after treatment.Results: Of the 98 participants, 40, 39, and 19 individuals were assigned to the active acupuncture, sham acupuncture, and waitlist groups, respectively.At baseline, the means of the total nasal symptom score(TNSS) were 6.76(SD: 3.31), 7.25(SD: 2.97), and 7.06(SD: 2.46), respectively.After 4 weeks of treatment, TNSS was significantly reduced in the active acupuncture and sham acupuncture groups compared to baseline.The changes of TNSS in the 2nd and 4th weeks from baseline in the active acupuncture group were significantly greater than the sham acupuncture and waitlist groups.In addition, the results showed that TNSS and the Rhinitis Quality of Life Questionnaire score had significant changes in the active acupuncture group compared with the sham acupuncture and the waitlist groups.Conclusion: Active acupuncture showed a significantly greater effect on symptoms of allergic rhinitis than sham acupuncture.Acupuncture is an effective and safe treatment for allergic rhinitis.     

绝经后妇女活性氧与破骨细胞活性的关系

为了探讨活性氧与破骨细胞活性的相关性 ,以进一步阐明活性氧与骨质疏松症的内在联系 ,选择符合纳入标准的绝经后妇女 ,测定其骨密度 (BMD) ,根据骨密度分为骨质疏松组、骨量减少组及正常组各 30例。检测各组研究对象的血清丙二醛(MDA)、超氧化物歧化酶 (SOD)及抗酒石酸盐酸性磷酸酶 (TRAP) ,比较各组之间的MDA、SOD及TRAP的不同并分析MDA、SOD与TRAP的相关性。结果显示MDA与TRAP呈正相关 (r=0 .6 13,P <0 .0 1) ,SOD与TRAP呈负相关 (r = 0 .733,P <0 .0 1) ;骨质疏松组、骨量减少组的血清MDA水平较正常组高而SOD含量降低 ,骨质疏松组的MDA和SOD亦较骨量减少组升高和降低 (P <0 .0 1)。这些结果说明活性氧能提高破骨细胞的活性 ,体内活性氧水平升高 ,进而使破骨细胞活性增强 ,可能是绝经后骨质疏松症发生的重要原因之一。     

ACUPUNCTURE FOR TREATMENT OF COOCCURRING PAIN AND STRESS AMONG WOMEN:A MIXED-METHOD CASE SERIES

Objective: Women are disproportionately affected by chronic pain and chronic stress, both of which represent significant public health problems.Chronic pain and stress often co-occur which can exacerbate the deleterious effects of each.Conventional treatment modalities(SSRIs, analgesics) have potentially serious side effects, especially when taken long term.The purpose of this study was to assess objective(including biomarkers) and subjective assessment of pain and stress improvement in women over an 8-week course of acupuncture treatment.Methods: Study design: case series of 3 women.Enrollment criteria: 3 women(ages 30-65) were recruited from large acupuncture practice.Must report:(1) consistent pain for 3+ months,(2) VAPS 6,(3) Cohen Perceived Stress Scale(PSS)21.Protocol: 3 women were assessed, treated, and prospectively followed weekly for 8 weeks.TCM principles and differential diagnoses were employed.Individualized treatments were used; needles were left in place for 30 min, with De-qi.At baseline, week 4, and week 8, diurnal cortisol(8 am and 4 pm) was assessed(buccal swab) and CBC(for ESR) and CRP were evaluated based on blood analysis.PCORI measures were evaluated weekly.Results: All women reported subjective improvements in pain and reduction of stress(self-report VAPS and PSS).Several PCORI measures trended in appropriate direction.Biomarker measures were more stable, although suggestive(reduction in inflammatory markers, and modified diurnal cortisol patterns).Conclusion: This small case-series pilot study demonstrated clinical and patient-centered improvements in pain and stress reduction and suggestive biomarker findings.Implications for clinical practice and future research designs will be discussed.     

新风胶囊对活动期类风湿关节炎患者血小板参数的影响

目的：观察新风胶囊对活动期类风湿关节炎患者血小板参数的影响。方法：将54例RA患者随机分为两组，治疗组34例应用新风胶囊，对照组20例应用正清风痛宁缓释片，治疗1个疗程后，观察临床症状、体征、血小板计数（PLT）、血小板压积（PCT）、血小板平均体积（MPV）、血小板分布宽度（PDW）及其他实验室指标的变化。结果：活动期RA患者PLT、PCT、MPV均显著高于正常对照组，新风胶囊治疗组在改善症状体征、活动性指标等方面与对照组相似，但在改善脾虚湿盛血瘀症状、症状总积分、血小板参数（PLT、PCT）方面明显优于对照组（P〈0．05）。结论：新风胶囊可显著降低活动期RA患者PLT及PCT，且能有效改善RA的关节及全身病变，其作用机制可能与调节细胞因子网络平衡有关。     

尼龙搭扣小夹板的临床应用研究

为验证尼龙搭扣小夹板在治疗四肢闭合性骨折方面的优越性。从绑扎时间、运动试验和彩超血流动力学测试及临床应用等方面与传统夹板进行了对比。结果显示绑扎时间加快了１～８倍。运动试验表明较传统夹板牢靠。彩超测试表明,按传统绑扎,稍放松后,其血流明显增加,而搭扣式夹板仍非常牢固。经临床应用１０４７例,均未发现绑带、夹板和固定垫松脱、移动等现象。尼龙搭扣小夹板在使用时具有绑扎方便、快速实用,使用后固定牢靠,有利     

电针频率是决定家兔电针镇痛效果是否能被纳洛酮阻断的重要因素

<正> 人们在临床实践中体验到,在同一穴位上运用不同的针刺手法可产生不同的治疗效果。这一现象愈来愈引起针灸原理研究工作者的兴趣。近二十年来针刺镇痛原理的研究日益深入,业已证明,电针刺激可使中枢神经系统释放阿片肽产生镇痛作用。但阿片颉颃剂纳洛酮阻断大鼠电针镇痛的程度和所需的剂量与电针频率密切相     

电针治疗头痛的效果与红血球乙酰胆碱酯酶含量的关系

<正> 在以前的工作中,我们曾发现头痛患者在针刺或经络治疗后,血浆多巴胺-β-羟化酶(DβH)活性受到相对抑制者,其疗效好。由于DβH是去甲肾上腺素合成过程中的最后一个合成酶,当交感神经受到刺激后,它与去甲肾上腺素呈比例由交感神经末梢释出,因而提出针刺治疗头痛的疗效可能与交感神经系统的调整有关。而针刺释镇痛是否也有外周胆碱能神经介质参与,这方面的工作少,且结果不一。众所周知,乙酰胆碱(ACh)是在胆碱酯酶的作用下,水解成胆碱和乙酸而失活;因之,测定外周血中,尤其是红血球的乙酰胆碱酯酶(AChE,真性或特异性胆碱酯酶),在一定程度上可用以作为反映外周胆碱能神经介质活动的指标。而有关针刺治疗头痛,对红血球AChE     

ACUPUNCTURE CREDIBILITY SCALE SCORES ASSOCIATED WITH TCM ACUPUNCTURE VERSUS A SHAM ACUPUNCTURE PROCEDURE:IMPLICATION FOR CLINICAL TRIAL DESIGN

Objective: To compare self-reported perceptions of the credibility of traditional Chinese medicine(TCM) acupuncture and a shallowneedling sham procedure, and to explore whether study subjectscan distinguish between real acupuncture and sham acupuncture in controlled clinical trials for headache when they are exposed to both.Methods: Thirty-seven patients with frequent headaches and no prior experience with acupuncture received both a TCM acupuncture treatment and a sham acupuncture procedure in random order.Study participants were not informed that one of the treatments was intended to be a sham procedure.The main outcome measure was patient-perceived credibility of each procedure as assessed by the Acupuncture Credibility Scale.Results: The TCM acupuncture treatment was associated with mean credibility scale scores of 21.2(SD=4.0), whereas the sham acupuncture procedure was associated with a mean scale score of 19.6(SD=4.6).The difference in mean scores associated with the two protocols was 1.6(95% CI: 0.6-2.6; P=0.002).Mean credibility scale scores increased from the first to second treatment for TCM acupuncture, but decreased for the sham acupuncture procedure.Conclusion: The clinical significance of a 1.6-point difference on a 30-point scale is unclear, but the observation that study participants may be able to distinguish between TCM and sham acupuncture protocols after a single exposure to each provides support for the policy of excluding patients with prior experience with acupuncture from participation in clinical trials that involve a sham acupuncture control.     

USE ACUPUNCTURE TO TREAT FUNCTIONAL DYSPEPSIA:STUDY PROTOCOL OF A RANDOMIZED CONTROLLED TRIAL

Objective: The problem of whether acupuncture is efficacious for patients with functional dys pepsia is still controversial, so we designed a randomized controlled trial to settle the problem.Design: We designed a multicenter, two-arm, sham-controlled clinical trial.Two hundred participants with functional dyspepsia will be randomly assigned to true acupuncture(TA) group and sham acupuncture(SA) group in a 1:1 ratio.Participants in the TA group will receive acupuncture at points selected according to syndrome differentiation.Participants in the SA group will receive penetrations at sham points.Participants in both groups will receive 20 sessions of electroacupuncture for 4 weeks, 5 times continuously with a 2-day rest in a week.The primary outcome is the proportion of patients reporting absence of dyspeptic symptoms at 16 weeks after inclusion.The secondary outcomes include Short-Form Leeds Dyspepsia Questionnaire(SF-LDQ), Chinese version of 36-Item Short Form Survey(SF-36), Chinese version of Nepean dyspepsia index(NDI), etc.Discussion: The result of this trial is hopefully to be gained on August, 2014, which would possibly answer the question of whether acupuncture is efficacious for patients with functional dyspepsia.     

EVALUATION OF DIFFERENT MOXIBUSTION DOSES FOR LUMBAR DISC HERNIATION:A RANDOMISED CONTROLLED CLINICAL TRIAL OF MOXIBUSTION THERAPY ON CV4

Objective: Whether moxibustion therapy is effective for patients with lumbar disc herniation(LDH) is still unclear, but previous studies neglected the dose of moxibustion and usually adopted standardized 15-minute dose in the treatment of LDH.Dose of moxibustion plays an important role in obtaining good effects.Therefore, we report the protocol of a randomized controlled trial to confirm the efficacy of moxibustion for LDH and to clarify the relationship between the dose and efficacy of moxibustion for LDH.Methods: Forty participants with LDH were randomized into four groups.The small moxibustion dose group(SM), moderate moxibustion dose group(MM) and large moxibustion dose group(LM) respectively received 15-minute, 30-minute, and 60-minute treatment of suspended moxibustion on Guanyuan(CV4).The acupuncture group(AC) received acupuncture treatment as the control group.Moxibustion and acupuncture were performed a total of five times(once per week), a total of 10 treatments in a 2-week treatment period.Outcome was evaluated by VAS pain intensity and Roland Morris Questionnaire(RMQ).Results: VAS and RMQ scores were improved in the four groups during the treatment.Significant reduction in pain intensity(P0.01) and RMQ(P0.01) was shown in the LM group.After treatment, the group that received large moxibustion dosereported less pain intensity compared to the acupuncture group or the groups that received 15-minute and 30-minute treatments of moxibustion, and the differences were statistically significant(P0.05).Conclusion: The large moxibustion dose treatment may be more effective in the treatment of LDH.The time of treatment was between 15 and 60 min, and efficacy of moxibustion on CV4 gradually improved with increasing of treatment time.     

驳骨灵口服液对绝经后骨质疏松症患者血清瘦素、一氧化氮及白介素-6的影响

目的：探讨驳骨灵口服液治疗绝经后骨质疏松症的作用杌理。方法：选择绝经后骨质疏松症患者30例，观察测定其治疗前及治疗6个月后血清中瘦素（Leptin）、一氧化氮（NO）、白介素-6（IL-6）、骨钙素（BGP）、雌二醇（E）含量以及L2-4椎体正位骨密度（BMD）。结果：患者经驳骨灵口服液治疗6个月后，血清中NO、E2、Leptin水平均明显上升（P〈0．01），IL-6、BGP水平均明显下降（P〈0．01）。骨密度（BMD）治疗前后比较，差异无统计学意义（P〉0．05）。结论：驳骨灵口服液为治疗绝经后骨质疏松症的一个有临床应用价值和开发价值的药物。