冠心病患者介入治疗前后焦虑抑郁障碍的心理干预与评价

Objective To discuss the effect of psychological intervention of depression in coronary heart disease after percutaneous coronary intervention (PCI). Methods The depression of 105 cases of coronary heart disease after PCI treatment was investigated. One hundred and five patients were randomly divided into intervention group and control group. The patientsin intervention group were treated with psychological intervention before and after PCI. The patients in control group were treated with normal treatment. Results There was not significant difference of incidence of depression an self-rating depression scale score between two groups. The depression in intervention group was less severe than that in control group ( P ＜ 0.01 ). Multivariate analysis showed: education level, the recent negative life events, household income, length of stay and sequelae of catheter intervention had significantly correlated with depression in coronary heart disease. Conclusion Psychological intervention can reduce the ratio of depression in coronary heart disease after PCI.     

冠心病患者介入治疗前后焦虑抑郁障碍的心理干预与评价

Objective To discuss the effect of psychological intervention of depression in coronary heart disease after percutaneous coronary intervention (PCI). Methods The depression of 105 cases of coronary heart disease after PCI treatment was investigated. One hundred and five patients were randomly divided into intervention group and control group. The patientsin intervention group were treated with psychological intervention before and after PCI. The patients in control group were treated with normal treatment. Results There was not significant difference of incidence of depression an self-rating depression scale score between two groups. The depression in intervention group was less severe than that in control group ( P ＜ 0.01 ). Multivariate analysis showed: education level, the recent negative life events, household income, length of stay and sequelae of catheter intervention had significantly correlated with depression in coronary heart disease. Conclusion Psychological intervention can reduce the ratio of depression in coronary heart disease after PCI.     

免疫比浊法检测高脂血症患者血清Apo-E的临床意义

Objective To discuss the clinical significance of the detection of serum Apo-E level of patients with hyperlipidemia (HLP).Methods The serum Apo-E,TC,HDL-C,LDL-C,TG,Apo-Al and Apo-B in 120 patients with HLP and 130 health adults were detected by immunoturbidimetry.Results The serum Apo-E level in patients with HLP was significantly higher than that in normal group (55.2 ± 14.3mg/L,40.4 ± 12.5mg /L;P ＜0.01 ),and was significant positive correlated with the TG and Apo-B (r=0.538,0.432;P＜0.05).The Apo-E level was a risk factor of coronary heart disease and atherosclerosis.Conclusions The serum Apo-E levels in patients with HLP were significant increased.The detection of serum Apo-E level can be used as a diagnosis index of cardio-cerebral vascular disease.     

中青年男性冠心病患者PCI前后性生活质量的变化

Objective To investigate the effect of percutaneous coronary intervention (PCI) on the sexual quality of life among young and middle-aged male patients with coronary heart disease (CHD) by using Sexual Life Quality Questionnaire(SLQQ).Mothods 78 patients cured by PCI were kept in operation group and the drug therapy group contained 80 patients.The sexual quality of life one day before hospitalization and six months after discharge was surveyed with a retrospective questionnaire in both two groups.Results The sexual quality of life in 6 months after discharge in both groups was better than before hospitalization (P＜0.01);the operation group improved more obviously compared to the drug group (P＜0.01).Conclusions PCI can significantly improve the sexual quality of life among young and middle-aged male patients with CHD.     

急性冠状动脉综合征与高敏C反应蛋白相关性研究

Objective To investigate the relation among triglyce ride (TG), low density lipoprotein cholesterol(LD-C) and high sensitivity C reactive protein(hs-CRP) in acute coronary syndrome(ACS). Methods A total of 132 coronary heart disease patients which were divided as ACS and stable coronary heart dis-ease(SCHD)groups and 65 cases of the health physical exam inees were enrolled as the controls. The levels of hs-CRP, TG,HDL-C and LDL-C among the three groups were analyzed. Results The levels of hs-CRP of patients in ACS and SCHD groups were significantly higher than those in controls group(P ＜0.05). The level of hs-CRP in ACS group was obviously higher than that in SCHD group( P ＜0.01 ). There was a significant correlation between the concentration of hsCRP and TG( r = 0.62 ,P ＜ 0.01 ); there was a significant correlation between hs-CRPand LDL-C ( r =0.41, P ＜ 0.01 ); however there was a significantly negative correlation between hs-CRP and HDL-C ( r = -0.54, P ＜0.01 ). Conclusions The hs-CRP level in patients with acute coronary syndrome is obviously increased. hs-CRP is positively correlated with acute coronary syndrome, hs-CRP is the unstable sign of atheromatous plaque.     

急性冠状动脉综合征与高敏C反应蛋白相关性研究

Objective To investigate the relation among triglyce ride (TG), low density lipoprotein cholesterol(LD-C) and high sensitivity C reactive protein(hs-CRP) in acute coronary syndrome(ACS). Methods A total of 132 coronary heart disease patients which were divided as ACS and stable coronary heart dis-ease(SCHD)groups and 65 cases of the health physical exam inees were enrolled as the controls. The levels of hs-CRP, TG,HDL-C and LDL-C among the three groups were analyzed. Results The levels of hs-CRP of patients in ACS and SCHD groups were significantly higher than those in controls group(P ＜0.05). The level of hs-CRP in ACS group was obviously higher than that in SCHD group( P ＜0.01 ). There was a significant correlation between the concentration of hsCRP and TG( r = 0.62 ,P ＜ 0.01 ); there was a significant correlation between hs-CRPand LDL-C ( r =0.41, P ＜ 0.01 ); however there was a significantly negative correlation between hs-CRP and HDL-C ( r = -0.54, P ＜0.01 ). Conclusions The hs-CRP level in patients with acute coronary syndrome is obviously increased. hs-CRP is positively correlated with acute coronary syndrome, hs-CRP is the unstable sign of atheromatous plaque.     

脑心通对急性冠脉综合征患者血脂及超敏C反应蛋白的影响

Objective To investigate the effects of atorvastatin combined with Naoxintong capsules on serum lipid level and hish sensitivity C-reactive protein(hs-CRP)in patients with acute coronary syndrome(ACS).Methods 82 ACS patients were randomly divided into observation group(10 mg/d of atorvastatin and 4 capsules 3 times of Naoxintong daily,n=41) and control group(20 mg/d of simvastatin daily,n=41).The levels of serum lipid and hs-CRP were detected before and after treatment.Results 8 weeks after treatment,the levels of serum hpid[TC (4.21±0.87)mmol/L,TG(1.99±0.48)mmol/L,LDL-C(2.71±0.83) mmol/L] and serum hs-CRP(5.63±1.38)mg/L in observation group were significantly lower than those in control group[TC(4.89±0.91)mmol/L,TG (2.58±0.52)mmol/L,LDL-C(3.28±0.89)mmol/L],and serum level HDL-C(1.89±0.47)mmol/L was higher than that in control group(1.63±0.45)mmol/L(t=2.55-4.36,P<0.01～0.05).Conclusion Adjuvant therapy of Naoxintong could promote the levels of serum lipid and hs-CRP in patients with ACS.and offer a better therapeutic effect in these patients.     

脑心通对急性冠脉综合征患者血脂及超敏C反应蛋白的影响

Objective To investigate the effects of atorvastatin combined with Naoxintong capsules on serum lipid level and hish sensitivity C-reactive protein(hs-CRP)in patients with acute coronary syndrome(ACS).Methods 82 ACS patients were randomly divided into observation group(10 mg/d of atorvastatin and 4 capsules 3 times of Naoxintong daily,n=41) and control group(20 mg/d of simvastatin daily,n=41).The levels of serum lipid and hs-CRP were detected before and after treatment.Results 8 weeks after treatment,the levels of serum hpid[TC (4.21±0.87)mmol/L,TG(1.99±0.48)mmol/L,LDL-C(2.71±0.83) mmol/L] and serum hs-CRP(5.63±1.38)mg/L in observation group were significantly lower than those in control group[TC(4.89±0.91)mmol/L,TG (2.58±0.52)mmol/L,LDL-C(3.28±0.89)mmol/L],and serum level HDL-C(1.89±0.47)mmol/L was higher than that in control group(1.63±0.45)mmol/L(t=2.55-4.36,P<0.01～0.05).Conclusion Adjuvant therapy of Naoxintong could promote the levels of serum lipid and hs-CRP in patients with ACS.and offer a better therapeutic effect in these patients.     

阿托伐他汀干预对急性冠状动脉综合征患者PCI术后粘附分子水平的影响

Objective To explore the impact of different dose atorvastatin on the adhesion molecules level in the acute coronary syndrome (ACS) patients who had received percutaneous coronary intervention (PCI). Methods Eighty-eight ACS patients were divided into three groups, group A (normal treatment group), group B (normal treatment plus atorvastatin 10mg per day) and group C (normal treatment plus atorvastatin 80mg per day). The patients in group B received atorvastatin 10 mg per day orally before PCI and after PCI subsequently, and the patients in group C received atorvastatin 80 mg per day orally before PCI and after PCI subsequently for three days, then the dose of atorvastatin was decrease to 10 mg per day. The concentrations of soluble intercellular adhesionmolecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were detected before PCI and at the 3rd, 7th 14th day after PCI. Results At the 7th day, the concentrations of sICAM-1 and sVCAM-1 in group C were significantly lower than those in group B, which showed sICAM-1 (68.35±23.80) μg/L vs (131.45±29.12) μg/L and sVCAM-1 (251. 65±36.61)μg/L vs (334.87±32.98) μg/L, respectively. Compared to group A, the adhesion molecule level in group B and group C were significantly decreased (P<0.05) and had no obviously affect on blood fat level. Conclusion The treatment of atorvastatin could significantly decrease the adhesion molecules' level after PCI, which may play an important role in lowing inflammation and coronary artery restenosis after PCI.     

阿托伐他汀干预对急性冠状动脉综合征患者PCI术后粘附分子水平的影响

Objective To explore the impact of different dose atorvastatin on the adhesion molecules level in the acute coronary syndrome (ACS) patients who had received percutaneous coronary intervention (PCI). Methods Eighty-eight ACS patients were divided into three groups, group A (normal treatment group), group B (normal treatment plus atorvastatin 10mg per day) and group C (normal treatment plus atorvastatin 80mg per day). The patients in group B received atorvastatin 10 mg per day orally before PCI and after PCI subsequently, and the patients in group C received atorvastatin 80 mg per day orally before PCI and after PCI subsequently for three days, then the dose of atorvastatin was decrease to 10 mg per day. The concentrations of soluble intercellular adhesionmolecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were detected before PCI and at the 3rd, 7th 14th day after PCI. Results At the 7th day, the concentrations of sICAM-1 and sVCAM-1 in group C were significantly lower than those in group B, which showed sICAM-1 (68.35±23.80) μg/L vs (131.45±29.12) μg/L and sVCAM-1 (251. 65±36.61)μg/L vs (334.87±32.98) μg/L, respectively. Compared to group A, the adhesion molecule level in group B and group C were significantly decreased (P<0.05) and had no obviously affect on blood fat level. Conclusion The treatment of atorvastatin could significantly decrease the adhesion molecules' level after PCI, which may play an important role in lowing inflammation and coronary artery restenosis after PCI.     

Degraded and undegraded carrageenans and experimental gastric and duodenal ulceration

The prevention of histamine-induced gastric and duodenal ulceration in the guinea-pig has been examined using a series of undegraded and degraded carrageenans. Undegraded carrageenans were active at lower doses than degraded carrageenans. The high viscosity of the undegraded carrageenans in solution prevented their use in larger doses. Degradation of carrageenan without serious loss of sulphate, gives a product which allows the dose to be increased to an extent that its effect more than offsets the slight loss in activity caused by the degradation. No single feature of carrageenan structure can be related to anti-ulcer activity although degradation, and hence reduction of molecular size, generally reduces activity. Sulphate contents over 30% have little apparent effect on activity; κ-carrageenans were not consistently different in anti-ulcer activity from Λ-carrageenans. This contrasts with the antipeptic activity of carrageenans where κ-carrageenans are less active than their Λ-counter-parts. As with antipeptic activity, the degree of anti-ulcer activity is probably determined by a combination of structural features which includes molecular size and polyanionic properties.     

Affective and Anxiety Disorders and Alcohol and Drug Dependence:

Depression and anxiety frequently coexist in patients with substance use disorders. This clinically-oriented article examiens the relationship between these conditions and emphasizes data showing that substances of abuse can cause signs and symptoms of both depression and anxiety. These substance-related syndromes appear to have a different course and prognosis than uncomplicated, independent anxiety and major depressive disorders, and clinicians should consider the role of alcohol and other drugs in all patients presenting with these complaints. The authors will also outline an approach for diagnosing and managing patients with the combination of a substance use and depressive or anxiety disorder.     

Alcohol and Substance Use and Abuse in Women and Children

No abstract available for this article.     

Synthesis and anti-nociceptive and anti-inflammatory effects of gaultherin and its analogs

The synthesis of gaultherin (1) and its analogs was carried out to provide 11 glycosides under phase-transfer catalytic conditions. The activities of all synthesized compounds were evaluated by nitric oxide production inhibitory assay in vitro. Methyl 2-O-(4-O-β-d-galactopyranosyl)-β-d-glucopyranosylbenzoate (5f) showed significantly anti-nociceptive and anti-inflammatory effects by the evaluation in vivo. Structure–activity relationships within these compounds were discussed.