Weil截骨治疗(足母)外翻转移性跖痛

[目的]回顾分析Weil截骨治疗(踇)外翻转移性跖痛的疗效.[方法]自2004年至200:5年联合应用第1跖骨基截骨及Weil截骨治疗伴有外侧跖骨头转移性跖痛的中重度外翻17例25足.患足手术前后常规拍摄足正侧位片,测量足母外翻角(HVA),I-Il跖骨间角(IMA),使用美国足踝外科协会(踇)趾-跖趾-趾间关节评分系统(AOFAS)评分评估临床疗效.手术方法根据患者术前症状选择第1跖骨基底截骨联合外侧跖骨头Weil截骨.[结果]患者(踇)外翻角(HVA)术前为32°±5.7°,术后为12.8°±3.5°;Ⅰ-Ⅱ跖骨间角(IMA)术前为23.2°±3.7°,术后为10.5°±0.7°;AOFAS评分术前45.6±6.9分,术后86.9±4.6分;Weil截骨术后的跖骨短缩3-8 mm,平均4.5 mm;术后18足跖痛症状完全缓解,7例好转,所有患者日常生活正常,无需进一步治疗.[结论] (踇)母外翻术前应综合分析足部的生物力学变化,对伴有外侧转移性跖痛的严重(踇)外翻患者,联合使用第1跖骨基截骨和外侧跖骨头Weil截骨可获得良好疗效.     

微创截骨治疗小趾囊炎

[目的]回顾分析微创截骨治疗小趾囊炎方法及疗效。[方法]2002年7月～2007年8月采用微创截骨方法治疗小趾囊炎,其中37例69足资料完整并获得随访。患足均于手术前、后拍摄负重位正侧位X线片,并测量相关解剖角度。应用AOFAS趾-跖趾-趾间关节评分系统对治疗前后进行临床评估。[结果]第4、5跖骨间角术前为14.36°±7.32°,术后为9.36°±2.92°;小趾内翻角术前为20.44°±7.36°,术后为4.36°±1.35°;改良第4、5跖骨间角术前为10.36°±2.81°,术后为7.83°±2.37°;第5跖骨外翻角术前为5.46°±1.70°,术后为2.13°±0.38°。术前AOFAS评分为(45.7±5.6)分,术后为(85.3±5.1)分,两者相比,P<0.05,差异有统计学意义。[结论]微创截骨治疗小趾囊炎方法简单,疗效确切。     

联合趾截骨手术在外翻矫形中的价值

目的探讨趾截骨手术（Akin截骨术）在外翻畸形矫形中的价值。方法我院2010年5月至2011年4月联合使用Akin截骨术治疗外翻患者32例49足。在本组患者中,术前均拍摄患足负重正位X线片,测量外翻角、跖间角、远侧关节固定角,依据跖间角分别采用Chevron截骨术（Austin手术）,跖楔关节融合手术（Lapidus手术）或第一跖骨基底斜楔形截骨（Juvara手术）。术后及随访测量外翻角、跖间角、远侧关节固定角改变。采用AOFAS评分对患足进行功能评价。结果所有患者平均随访12个月。外翻角由术前（39.7±7.5）°纠正为（16.1±7.6）°,P〈0.05,平均纠正（25.9±9.5）°;跖间角由术前（15.4±3.9）°纠正为（7.6±2.5）°,P〈0.05,平均纠正（7.1±3.0）°;远侧关节固定角由术前（6.3±2.7）°纠正为（-5.3±4.0）°,P〈0.05,平均纠正（11.4±4.0）°;AOFAS得分由术前平均43.5分提高至85.6分,P〈0.05。结论 Akin截骨术是外翻矫形程序中的一种辅助手术,可以改善疗效、降低复发率且操作简便、安全。     

第一跖骨基底部闭合楔形截骨结合锁定钢板治疗中重度外翻

[目的]探讨第一跖骨基底部开口向外闭合楔形截骨结合锁定钢板固定治疗中重度外翻的临床疗效。[方法]2008年3月~2014年4月共治疗32例(35足),男8例8足,女24例27足,年龄48~73岁,平均58岁,单侧29例,双侧3例,中度外翻19例(22足),重度外翻13例(13足)。采用第一跖骨基底部开口向外闭合楔形截骨,使用锁定钢板固定。术前、术后12周及末次随访时均拍摄足部负重正位X线片,测量外翻角(hallux valgus angle,HVA)、第1、2跖骨间角(inter metatarsal angle,IMA)、籽骨位置及美国足踝外科协会(AOFAS)评分。比较术前和术后随访时外翻相关的各X线片测量值以及AOFAS评分。[结果]本组病例均得到随访,随访时间13~42个月,平均26个月。术后12周时HVA由(39.83±4.58)°,改善至(11.67±1.22)°,IMA由(14.27±0.84)°改善至(7.85±0.83)°,籽骨位置由(8.35±1.82)mm改善至(3.26±0.84)mm,末次随访时HVA为(13.81±1.66)°,IMA为(9.27±0.62)°,籽骨位置为(4.14±0.57)mm,AOFAS评分由术前的(62.54±5.36)分改善至末次随访时的(92.35±6.73)分。[结论]采用第一跖骨基底部开口向外闭合楔形截骨结合锁定钢板固定治疗中重度外翻,术后临床疗效良好,外翻复发少。     

第1跖骨远端改良Chevron截骨治疗[足母]外翻

背景：[足母]外翻的手术治疗方式众多,传统Chevron有一定的手术操作局限性。目的：观察采用第1跖骨远端改良Chevron截骨治疗轻中度[足母]外翻的临床治疗效果。方法：2011年12月至2012年10月采用Chevron截骨对22例患者（28足）进行[足母]外翻矫正,记录患者术前、术后美国足踝外科医师协会评分（AOFAS）,术前、术后测量第1、2跖骨间角（IMA）和躅外翻角（HVA）变化以评估矫正程度,采用AOFAS前足评分和生活功能评分简表（SF．36）评估功能恢复情况。结果：22名患者术后平均随访时间13．36个月（8～18个月）,术前患者平均AOFAS评分（43．59±6．85）分,术后平均85．55±5．66分。术前患者平均SF．36量表评分（45．42±5．54）分,术后平均（83．23±8．81）分,两者术前、术后比较有显著统计学差异（P〈0．01）。IMA术前13．80°±1．67°,术后6．70°±1．51°（P〈0．01）;HVA术前平均29．30°±2．78°,术后7．47°±2．82。（P〈0．01）。结论：第1跖骨远端改良Chevron截骨治疗轻中度蹰外翻手术操作技术简便,临床效果满意。     

Scarf截骨联合远端软组织松解术治疗中重度外翻

目的评价分析Scarf截骨联合软组织松解术治疗中重度足外翻的手术技术与治疗效果。方法对46例(49足)中重度足外翻行第一跖骨Scarf截骨联合远端软组织松解(内收肌腱切断、籽骨悬韧带松解+内侧囊与骨赘切除)手术,本组46例(49足)获10~17个月随访,平均随访13个月。术后采用美国足踝AOFAS评分评价术前术后临床效果,记录患者术前、术后6周与末次随访时外翻角(hallux valgus angle,HVA)与第1、2跖骨间夹角(intermetatarsal angle,IMA)角度以及术前与末次随访时籽骨位置变化,结果应用SPSS 15.0统计软件进行数据比较分析。结果患者AOFAS评分由术前的平均50.03分提高到术后的87.18分,放射学检查:患者HVA由术前的平均29.43°减低到术后6周的12.79°,维持在末次随访的平均13.51°。第1、2跖骨间夹角由术前的平均15.29°减低到术后6周的5.74°,维持在末次随访的平均7.81°;籽骨位置与术前比较,显著改变(P0.05),具有明确统计学意义;术后末次随访与术后6周影像学比较,HVA角度未见统计学改变,IMA增大约2.07°,但是患者未见临床复发症状。结论采用Scarf截骨联合远端软组织松解术治疗中、重度足外翻可以获得良好的临床效果,短期随访结果满意。     

改良Mitchell手术治疗(足母)外翻

[目的]观察改良Mitchell手术治疗外翻的疗效.[方法]自2000年4月～2003年10月对18例28足(足母)外翻患者行改良Mitchell手术.术前摄负重X线片,测量(足母)外翻角(hallux valgus angle,HVA)平均为30.5°,第1、2跖骨间角(Intermetatarso-phalangeal angle,IMA)13.5°.本术式与传统Mitchell手术不同的是在第1跖骨远端只行一次横行截骨,不留外侧棘,根据IMA的大小决定截骨远端外移的多少,再向跖侧移位2～3 mm,用可吸收螺钉固定.[结果]随访28足,随访时间为10～32个月,优24足,良3足,差1足,优良率为92.9%.术后负重X线片测量HVA 15.5°,平均改善15°;IMA平均为8.5°,平均改善5°.[结论]改良Mitchell手术可矫正第1跖骨内翻,更重要的在于矫正畸形而不破坏(足母)趾的生物力学作用,第1跖骨头的跖侧移位,重建了足横弓,恢复了(足母)趾的负重功能.     

第1跖骨基底斜行闭合截骨治疗中重度外翻畸形

[目的]回顾性研究第1跖骨基底长斜行闭合截骨治疗外翻的临床效果。[方法]2007年2月～2008年11月间行第1`跖骨基底长斜形截骨结合远端软组织松解内侧关节囊重叠缝合治疗外翻共21例24足,均属中重度外翻,第1、2跖间角均大于15°,行第1跖骨基底斜行闭合截骨螺钉内固定术。[结果]平均随访7.6个月,术前平均HVA、IM1-2角分别为31.30°±6.68°和16.62°±2.65°,术后平均HVA、IM1-2角分别为12.96°±7.15°和9.80°±2.43°,平均矫正HAV角19.6°、IM角8.2°,术前、术后平均有明显统计学差异(P0.001),第1跖骨长度与第2跖骨长度比术前、术后分别为(89±6.7)%、(84±5.6)%,有明显统计学差异(P0.05)。[结论]第1跖骨基底长斜形闭合截骨手术方法治疗中重度外翻畸形可以取得比较好的矫正结果。     

跖骨远端Chevron截骨结合关节囊松解治疗轻、中度拇外翻

目的探讨跖骨远端Chevron截骨结合关节囊松解治疗轻、中度拇外翻的临床效果。方法对32例患者(48足)行Chevron截骨手术治疗,测量手术前后拇趾外翻角(HVA),第1、2跖骨间夹角(IMA)的变化,评估足部疼痛及关节活动恢复情况。结果 29例(44足)获得随访,时间12~16(14.5±4.1)个月;3例(4足)失访。患者对术后临床效果满意,截骨部位愈合时间为4~6周。术前HVA为30°±4.1°、IMA为14°±1.7°;术后3个月HVA为4°±4.2°、IMA为10°±2.4°,术后1年HVA为5°±4.5°、IMA为11°±3.3°,均较术前明显减小,差异有统计学意义(P0.05);术后1年与术后3个月的HVA、IMA比较差异无统计学意义(P0.05)。结论跖骨远端Chevron截骨结合关节囊松解治疗轻、中度拇外翻疗效满意。     

第1跖骨颈截骨应用“T型阶梯接骨板”内固定治疗外翻

[目的]探讨第1跖骨颈截骨应用T型阶梯接骨板内固定治疗足外翻的疗效。[方法]回顾性研究2013年1月~2014年1月采用T型阶梯接骨板治疗的50例足外翻畸形患者(88足);年龄26~65岁,平均43.6岁,比较术前和术后末次随访时外翻角(hallux valgus angle,HVA)和第1~2跖骨间角(intermetatarsal angle,IMA)。根据美国足踝外科协会(AOFAS)足趾、跖趾关节、趾间关节评分评估患者功能愈后。[结果]有45例(76足)患者获随访,其中男性5例(8足),女性40例(68足);平均随访时间21.3个月(15~27个月),HVA由术前平均(35.1±2.7)°减小至术后平均(17.7±2.0)°(P0.05);IMA由术前平均(13.5±2.5)°减小至术后平均(8.7±0.7)°(P0.05),AOFAS评分由术前平均(45.7±8.6)分提高至术后平均(91.2±4.3)分(P0.05);无感染、骨不愈合和转移性跖骨痛发生,有4例6足(7.9%)出现趾僵硬,2例3足(3.9%)出现足外翻复发。功能评级:优51足,良16足,差9足,优良率为88.2%。[结论]足外翻第1跖骨颈截骨应用T型阶梯接骨板内固定安全可靠,疗效显著。     

Vasopressor hormone response following mesenteric traction during major abdominal surgery

Background : We investigated the vasopressor hormone response following mesenteric traction (MT) with hypotension due to prostacyclin (PGI₂) release in patients undergoing abdominal surgery with a combined general and epidural anesthesia. Methods : In a prospective, randomized, placebo-controlled study we administered 400 mg ibuprofen (i.v.) in 42 patients scheduled for abdominal surgery. General anesthesia was combined with epidural anesthesia (T4-L1). Before as well as 5, 15, 30, 45, and 90 min after MT we recorded plasma osmolality, hemodynamics and measured 6-keto-PGFlα (stabile metabolite of PGI₂), TXB₂ (stabile metabolite of thromboxane A₂) active renin, and arginine vasopressin (AVP) plasma concentrations by radioimmunoassay. Catecholamine levels were assessed by high-pressure liquid chromatography (HPLC) with electrochemical detection. Results : Following MT, arterial hypotension occurred along with a substantial PGI₂ release. This was completely abolished by ibuprofen administration. Although plasma levels of 6-keto-PGF_1α (1133 (708) vs. 60 (3) ng/L, median (median absolute deviation), P=0.0001, placebo vs. ibuprofen) remained significantly elevated, blood pressure was restored within 30 min after MT in the placebo group. At the same point in time plasma concentrations of TXB² (164 (87) vs. 58 (1) ng/L, P=0.0001), epinephrine (46 (33) vs. 14 (6) ng/L, P=0.001), AVP (41 ± (18) vs. 12 (7) ng/L, P=0.0004), and active renin (27 (12) vs. 12 (4) ng/L, P = 0.001) were significantly higher in placebo-treated patients. Conclusion : Under combined general and epidural anesthesia arterial hypotension following MT due to endogenous PGI₂ release is associated with enhanced release of AVP, active renin, epinephrine and thromboxane A₂, presumably contributing to hemodynamic stability within 30 min after MT.     

A Teaspoon Pump for Pumping Blood with High Hydraulic Efficiency and Low Hemolysis Potential

Abstract: Virtually all blood pumps contain some kind of rubbing, sliding, closely moving machinery surfaces that are exposed to the blood being pumped. These valves, internal bearings, magnetic bearing position sensors, and shaft seals cause most of the problems with blood pumps. The original teaspoon pump design prevented the rubbing, sliding machinery surfaces from contacting the blood. However, the hydraulic efficiency was low because the blood was able to "slip around" the rotating impeller so that the blood itself never rotated fast enough to develop adequate pressure. An improved teaspoon blood pump has been designed and tested and has shown acceptable hydraulic performance and low hemolysis potential. The new pump uses a nonrotating "swinging" hose as the pump impeller. The fluid enters the pump through the center of the swinging hose; therefore, there can be no fluid slip between the revolving blood and the revolving impeller. The new pump uses an impeller that is comparable to a flexible garden hose. If the free end of the hose were swung around in a circle like half of a jump rope, the fluid inside the hose would rotate and develop pressure even though the hose impeller itself did not "rotate"; therefore, no rotating shaft seal or internal bearings are required.     

A comparison of the inhibitory effects of four volatile anaesthetics on the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits

Background: Halothane inhibits in vitro and in vivo activity of cytochrome P-450 (CYP) 2E1. There are several fluorinated volatile anaesthetics besides halothane, and most of them are defluorinated by CYP2E1. It is unclear whether other fluorinated anaesthetics inhibit the in vivo activity of CYP2E1.
Methods: We compared the inhibitory effects of therapeutic concentrations of four inhalational anaesthetics, halothane, enflurane, isoflurane, and sevoflurane, on chlorzoxazone metabolism in rabbits receiving artificial ventilation.
Results: All four inhalational anaesthetics decreased arterial blood pressure and increased plasma chlorzoxazone concentration. However, no significant differences in the plasma chlorzoxazone concentration were found between the four anaesthetics. The estimated chlorzoxazone clearance increased after beginning inhalation with all four agents, but no significant difference in clearance was noted between agents.
Conclusions: At therapeutic concentrations, the in vivo inhibitory effect on chlorzoxazone metabolism was similar for all four inhalational anaesthetics examined, even though their chemical characteristics and extent of hepatic metabolism differ considerably.     

Microspheres Based Detoxification System: A New Method in Convective Blood Purification

Abstract: A variety of protein-bound or hydrophobic substances, accumulating as a result of pathologic conditions such as exogenous or endogenous intoxications, are removed poorly by conventional detoxification methods because of low accessibility (hemodialysis), insufficient adsorption capabilities (hemosorption), low efficiency (peritoneal dialysis), or economic limitations (high-volume plasmapheresis). Combining advantages of existing methods with microspheric technology, a module-based system was designed. Major operating parameters of the latter can be modified to allow for adjustment to individual clinical situations. An extracorporeal blood circuit including a plasmafilter is combined with a secondary high-velocity plasma circuit driven by a centrifugal pump. Different microspheric adsorbers can be combined in one circuit or applied in sequence. Thus, a prolonged treatment can be tailored using specially designed selective adsorber materials. Comparing this system with existing methods (high-flux hemodialysis, molecular adsorbent recycling system), results from our in vitro studies and animal experiments demonstrate the superior efficiency of substance removal.     

Tissue perfusion in relation to cardiac output during continuous positive-pressure ventilation and administration of propranolol or verapamil

Background : Our objective was to determine whether administration of propranolol or verapamil modifies the hemodynamic adaptation to continuous positive-pressure ventilation (CPPV), in particular the regional distribution of cardiac output (CO).
Methods : General hemodynamics and regional blood flows assessed by microsphere technique (15 (μm) were recorded in 16 anesthetized pigs during spontaneous breathing (SB) and CPPV with 8 cm H₂O end-expiratory pressure (CPPV8) before and after intravenous administration of propranolol (0.3 mg · kg⁻¹ followed by 0.15 mg · kg⁻¹ · h⁻¹, n=8) or verapamil (0.1 mg · kg⁻¹ followed by 0.3 mg · kg⁻¹ · h⁻¹, n=8).
Results : CPPV8 depressed CO by 25% without shifts in its relative distribution with the exception of a noteworthy increase in adrenal perfusion. Propranolol increased arterial blood pressure, and due to a fall in heart rate, CO dropped by 25%. The kidneys and, to a lesser extent, the splanchic region and central nervous system received increased fractions of the remaining CO at the expense of skeletal muscle flow. Similar patterns were seen during SB and CPPV8 such that the combination of propranolol and CPPV8 depressed CO by 50%. The circulatory effects of verapamil were less evident but myocardial perfusion tended to increase.
Conclusions : The combination of propranolol or verapamil with CPPV does not result in any specific hemodynamic interaction in anesthetized pigs, except that the combined effect of propranolol and CPPV may severely reduce CO.     

Volatile anaesthetics reduce adhesion of blood platelets under low-flow conditions in the coronary system of isolated guinea pig hearts

Background : Inhibitory effects of volatile anaesthetics on platelet aggregation have been demonstrated in several studies. However, the influence of volatile anaesthetics on intracoronary platelet adhesion has not been elucidated so far.
Methods : Isolated hearts of guinea pigs were perfused with buffer in the absence or presence of volatile anaesthetics (0.5 and 1 MAC) at constant coronary flow rates of 5 ml/min for 25 min, then 1 ml/min for 30 min and again 5 ml/min for 10 min. Before, during and after low-flow perfusion, a bolus of human platelets was applied into the coronary system. To simulate thrombogenic conditions, 0.3 U/ml human thrombin was infused during low-flow perfusion and reperfusion. The number of platelets sequestered to the endothelium was calculated from the difference between coronary in- and output of platelets. The myocardial production of lactate and consumption of pyruvate and coronary perfusion pressure were also determined.
Results : At a flow rate of 5 ml/min only about 3% of the applied platelets did not emerge from the coronary system, in any group. In contrast, 13.1±1.2% (mean±SEM) of infused platelets became adherent in low-flow perfusion in the control group without anaesthetic. The adherence was reduced with each 1 MAC isoflurane (to 6.2±1.2%), sevoflurane (to 4.4±0.9%) or halothane (to 3.2±1.5%) (each P <0.05 vs. control). Volatile anaesthetic, 0.5 MAC, did not inhibit platelet adhesion to a statistically significant extent in any case. Perfusion pressure and metabolic parameters were not statistically different between the control and the hearts exposed to anaesthetics.
Conclusion : Volatile anaesthetics in a concentration of 1 MAC can reduce the adhesion of platelets in the coronary system under reduced flow conditions. This action does not arise from vasodilation or inhibition of ischaemic stress.     

Bariatric Surgery in Some "Central and East-European (former Eastern bloc)"Countries - Current Status and Prediction for the Next Millennium

Background: Obesity is increasing globallly, including in the formerly "Eastern Bloc" countries. Methods: A survey was made of obesity and bariatric surgery. Results: In the 8 East and Central European countries studied, with total population 300 million, roughly 43% of the population was overweight (BMI 25-30), 23% obese (BMI > 30), with about 15 million people morbidly obese (BMI > 40). From 0-10 morbidly obese individuals/100,000/year undergo bariatric surgery. Conclusion: Most countries were found to provide inadequate treatment for obesity.The majority of the morbidly obese are not treated effectively. However, health-care awareness of obesity and bariatric surgeons are slowly increasing.     

Synergistic interaction between the effects of propofol and midazolam with fentanyl on phrenic nerve activity in rabbits

Background: It has been shown that the depressive effects of both propofol and midazolam on consciousness are synergistic with opioids, but the nature of their interactions on other physiological systems, e. g. respiration, has not been fully investigated. The present study examined the effect of propofol and midazolam alone and in combination with fentanyl on phrenic nerve activity (PNA) and whether such interactions are additive or synergistic. Methods: PNA was recorded in 27 anaesthetised and artificially ventilated rabbits. In three groups, propofol, fentanyl and midazolam were administered intravenously in incremental doses to construct dose-response curves for the depressant effects of each one on PNA. In another two groups, the effect of pretreatment with either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. on the effects of propofol and fentanyl respectively on PNA were studied. Results: Propofol and fentanyl caused a dose-dependent depression of PNA with complete abolition at the highest total doses of 16 mg · kg^?1 i. v. and 32 μg · kg^?1 i. v., respectively. In contrast, midazolam in incremental doses to a total of 0.8 mg · kg^?1 reduced mean PNA by 63%, but approximately 12% of PNA remained at a total dose as high as 6.4 mg · kg^?1. The mean ED₅₀s, calculated from dose-response curves, were 5.4 mg · kg^?1, 3.9 μg · kg^?1 and 0.4 mg · kg^?1 for propofol, fentanyl and midazolam, respectively. Initial doses of either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. acted synergistically with subsequent doses of either propofol or fentanyl to abolish PNA at total doses of 8 mg · kg^?1 and 8 μg · kg^?1, respectively. Conclusion: Fentanyl has a synergistic interaction with both propofol and midazolam on PNA and hence potentially on respiration.     

Influence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery

Background: Catecholaminergic support is often used to improve haemodynamics in patients undergoing major abdominal surgery. Dopexamine is a synthetic vasoactive catecholamine with beneficial microcirculatory properties. Methods: The influence of perioperative administration of dopexamine on cardiorespiratory data and important regulators of macro- and microcirculation were studied in 30 patients undergoing Whipple pancreaticduodenectomy. The patients received randomized and blinded either 2 μg · kg^?1 · min^?1 of dopexamine (n=15) or placebo (n=15, control group). The infusion was started after induction of anaesthesia and continued until the morning of the first postoperative day. Endothelin-1 (ET-1), vasopressin, atrial natriuretic peptide (ANP), and catecholamine plasma levels were measured from arterial blood samples. Measurements were carried out after induction of anaesthesia, 2 h after onset of surgery, at the end of surgery, 2 h after surgery, and on the morning of the first postoperative day. Results: Cardiac index (CI) increased significantly in the dopexamine group (from 2.61±0.41 to 4.57±0.78 1 · min^?1 · m^?2) and remained elevated until the morning of the first postoperative day. Oxygen delivery index (DO₂I) and oxygen consumption index (VO₂I) were also significantly increased in the dopexamine group (DO₂I: from 416±91 to 717±110 ml/m² · m²; VO₂I: from 98±25 to 157±22 ml/m² · m²), being significantly higher than in the control group. pHi remained stable only in the dopexamine patients, indicating adequate splanchnic perfusion. Vasopressive regulators of circulation increased significantly only in the untreated control patients (vasopressin: from 4.37±1.1 to 35.9±12.1 pg/ml; ET-1: from 2.88±0.91 to 6.91±1.20 pg/ml). Conclusion: Patients undergoing major abdominal surgery may profit from prophylactic perioperative administration of dopexamine hydrochloride in the form of improved haemodynamics and oxygenation as well as beneficial influence on important regulators of organ blood flow.