脊髓损伤患者并发下肢深静脉血栓危险因素的回顾性研究

目的探讨脊髓损伤患者并发下肢深静脉血栓(DVT)的危险因素。方法回顾性分析2018年1月至2022年9月于空军军医大学第一附属医院康复医学科住院的276例脊髓损伤患者的临床资料, 按入院后是否合并下肢DVT, 将其分为DVT组(63例)和非DVT组(213例)。比较两组患者的性别、年龄、血型、吸烟史、手术史、入院距离脊髓损伤的时间、脊髓损伤原因、骨折情况、脊髓损伤节段、美国脊髓损伤协会(AISA)分级、合并症等相关指标, 采用二分类Logistics回归分析筛选脊髓损伤患者合并下肢DVT的危险因素。结果 276例脊髓损伤患者中, 有63例(22.83%)出现下肢DVT, 其中84.13%为小腿肌间静脉血栓(CMVT)。二分类Logistic回归分析结果显示, 脊髓损伤患者合并下肢DVT, 与贫血[OR=2.753, 95%CI(1.233, 6.146), P=0.013]、低钠血症[OR=5.349, 95%CI(1.970, 14.525), P=0.001]、入院距离脊髓损伤的时间[74～195 d, OR=0.231, 95%CI(0.084, 0.636), P=0.005;...     

脊髓损伤患者康复期皮肤损伤发生率及危险因素的回顾性研究

目的 分析康复医学科脊髓损伤患者住院期间皮肤损伤的发生率及相关危险因素。 方法 回顾性分析2021年1月至2023年6月由江苏省人民医院钟山康复分院收治的120例脊髓损伤患者的资料，收集患者住院期间皮肤损伤的发生情况、类型、部位及护理干预等信息，分析康复科脊髓损伤患者皮肤损伤的发生率及特点。按患者住院期间是否发生皮肤损伤，分为皮肤损伤组（33例）和对照组（87例）。统计两组患者入院时的一般情况、损伤和功能情况、合并症、康复和护理措施等资料，比较上述因素的组间差异，并应用多因素Logistic回归分析筛选出康复科脊髓损伤患者住院时发生皮肤损伤的危险因素。 结果 120例脊髓损伤患者中，有33例（27.5%）发生皮肤损伤，共发生46次皮肤损伤，其中擦伤发生27次（58.7%）、压力性损伤10次（21.7%）、撕裂伤5次（10.9%）、烫伤4次（8.7%）。皮肤损伤发生部位多集中在肢体（65.2%），其次是臀部和骶尾部（34.8%）。47.8%的皮肤损伤护理干预时间达到7 d以上。两组患者在住院时间、功能障碍、入院方式、压力性损伤风险、营养和辅助排尿方面比较，差异有统计学意义（P＜0.05）。组间比较未发现脊髓损伤节段和严重程度分级等因素存在显著差异（P>0.05）。多因素Logistic回归分析显示，康复科脊髓损伤患者发生皮肤损伤与住院时间［OR=1.015,95%CI(1.005,1.025),P=0.003］、压力性损伤发生风险［OR=15.129,95%CI(1.370,167.066),P=0.027］、营养水平［OR=6.181,95%CI(1.185,32.243),P=0.031］有关。 结论 康复科脊髓损伤患者住院期间皮肤损伤的发生率较高，住院时间长、有压力性损伤发生风险和营养水平差是患者发生皮肤损伤的独立危险因素。对于住院时间较长、入院评估有压力性损伤发生风险和营养差的患者，需要进一步加强皮肤管理的宣教，减少皮肤损伤对康复训练的影响。     

脊髓损伤患者入院合并泌尿系感染危险因素的回顾性研究

目的探讨脊髓损伤(SCI)患者入院合并泌尿系感染(UTI)的危险因素。方法回顾性分析空军军医大学第一附属医院康复医学科2017年8月至2022年6月收入院的403例SCI患者资料。按入院时是否合并UTI分为UTI组和非UTI组。分别比较两组患者的性别、年龄、损伤原因、损伤节段、肛门自主收缩情况、发病至入院时间、美国脊髓损伤协会(ASIA)分级、入院体温、合并症(糖尿病、高血压、骨盆骨折、压疮、贫血)、实验室检查结果(血白细胞、尿细菌定量)等相关指标。采用二元Logistic回归分析筛选SCI患者入院时合并UTI的危险因素。结果在最终纳入的354例患者中, 有62例患者(17.51%)入院时合并UTI。二元Logistic回归分析结果显示, SCI患者入院时合并UTI与肛门自主收缩消失[OR=3.305, 95%CI(1.472, 7.421),P=0.004]、发热[OR=5.027, 95%CI(1.606, 15.738), P=0.006]、贫血[OR=2.522, 95%CI(1.309, 4.856),P=0.006]、血白细胞升高[OR=3.367, 95%CI(1.641...     

狼疮性肾炎患者预后影响因素分析

目的探讨狼疮性肾炎(lupus nephritis,LN)患者肾损害程度及预后影响因素。方法 303例LN患者根据肾小球有效滤过率(estimated glomerular filtration rate,eGFR)水平分为3组,85例eGFR≤60mL/(min·1.73m2)患者为预后不良组,72例eGFR>60~<90mL/(min·1.73m2)患者为预后中等组,146例eGFR≥90mL/(min·1.73m2)患者为预后良好组;记录各组性别、年龄、24h尿蛋白定量、血红蛋白、血小板计数、抗核抗体ANA、抗ds-DNA抗体、补体C3、补体C4水平、平均动脉压、血钙、血磷、尿酸、SLEDAI评分等指标,采用单因素相关分析和多因素回归分析评估影响肾损害的危险因素。结果 3组年龄、平均动脉压、24h尿蛋白定量、血小板计数、血红蛋白、补体C3、血尿酸水平比较差异有统计学意义(P<0.05),单因素logistic回归分析结果显示年龄(OR=1.31,95%CI:0.010~0.043,P=0.002)、高血压病史(OR=3.31,95%CI:0.711~1.685,P=0.000)、血红蛋白降低(OR=0.98,95%CI:-0.032^-0.013,P=0.000)、低补体血症(OR=0.34,95%CI:-1.800^-0.338,P=0.004)、24h尿蛋白定量增加(OR=1.08,95%CI:0.140~1.720,P=0.012)、尿酸增高(OR=1.00,95%CI:0.004~0.008,P=0.000)、血小板降低(OR=0.97,95%CI:-0.050^-0.000,P=0.370)是肾损害的影响因素;logistic多因素回归分析显示,年龄大(OR=1.67,95%CI:0.024~0.078,P=0.000)、贫血(OR=0.85,95%CI:-0.029^-0.002,P=0.028)、24h尿蛋白定量增加(OR=4.60,95%CI:1.001~2.102,P=0.032)、尿酸水平增高(OR=1.00,95%CI:0.005~0.010,P=0.000)是预后不良的独立危险因素。结论年龄大、贫血、24h尿蛋白定量增高及血尿酸水平增高与LN患者肾功能进一步恶化有关,对预后判断有意义。     

创伤弧菌脓毒症患者的预后影响因素分析

目的:探讨创伤弧菌脓毒症患者的预后影响因素。方法:回顾性分析温州医科大学附属第一医院2008年1月至2019年12月67例创伤弧菌脓毒症患者的病例资料,采用单因素分析比较死亡组和治愈组在一般资料、临床表现、入院实验室指标、抗菌药物和外科手术的差异。然后将单因素分析差异有统计学意义的指标纳入多因素分析,最终得出影响患者预后的因素。结果:单因素分析显示死亡组和治愈组患者是否有肝病、入院休克、多处肢体损伤、入院白细胞、血小板、pH值、白蛋白、乳酸、谷草转氨酶、肌酐、降钙素原、肌酸激酶、活化部分凝血活酶时间、凝血酶原时间差异有统计学意义 ( P<0.05)。多因素分析表明患者入院乳酸（ OR=0.628,95% CI：0.461~0.855, P=0.003）、白蛋白（ OR=1.330,95% CI：1.062~1.667, P=0.013）、肌酸激酶（ OR=0.999,95% CI：0.998~1.000, P=0.016）、入院至行外科手术时间（ OR=0.118,95% CI：0.015~0.938, P=0.043）是影响患者预后的重要因素。患者入院乳酸和肌酸激酶水平高、白蛋白水平低提示患者预后较差;入院至行外科手术时间≤12 h的患者预后较好。 结论:对于创伤弧菌脓毒症患者的救治,医护人员需在早期动态评估这些预后因素,并早期采用外科手术治疗以改善患者的预后。     

成年脊髓损伤患者功能结局的预测模型研究

目的探索影响成年脊髓损伤患者功能结局的相关因素并构建预测模型。方法对2016年9月至2018年12月110例成年脊髓损伤截瘫住院患者的病历资料进行回顾性分析,系统收集可能影响功能预后的量化指标,包括年龄,住院天数,其他诊断数量,并发症数量,合并症数量,手术次数,发病到康复治疗介入的天数,出院和入院时的脊髓损伤神经学分类国际标准下肢运动总分(LEMS)、轻触觉(LT)总分、针刺觉(PP)总分以及改良Barthel指数(MBI),计算出入院MBI总分(MBI入院)的变化值及变换率,进行各变量间的单因素相关性分析,并对影响出院MBI总分(MBI出院)及出入院MBI总分变化值(MBI变化)的因素进行多元线性回归建模。结果 MBI出院与MBI入院、入院LEMS (LEMS入院)、入院PP总分、入院LT总分、发病到康复治疗介入的天数、手术次数和合并症数量共7个变量显著相关;最优回归方程:MBI出院=28.24+0.52×MBI入院+0.24×LEMS入院-1.23×合并症数量(R2=0.64, P 0.001)。MBI变化与MBI入院、发病到康复治疗介入的天数和住院天数3个变量显著相关;最优回归方程:MBI变化=18.44-0.29×MBI入院+0.06×住院天数(R2=0.29,P 0.001)。结论脊髓损伤患者入院时功能状态好,运动评分高,合并症少,住院时间长,则预期功能恢复良好。     

重症监护病房脓毒症患者危险因素的logistic回归分析

目的 探讨脓毒症患者入重症监护病房(ICU)时各项指标与预后的相关关系.方法 回顾性分析2004年1月-2008年12月450例脓毒症患者临床资料,选择24个可能对脓毒症预后产生影响的临床、化验及评分指标,通过非条件logistic回归模型进行单因素及多因素回归分析.结果 单因素回归分析显示:住院天数[优势比(OR)=0.951,P<0.001]、格拉斯哥昏迷评分(GCS,OR=0.858,P<0.001)、平均动脉压(MAP,OR=0.991,P=0.041)、血小板计数(PLT,OR=0.997,P<0.001)、总蛋白(TP,OR=0.975,P=0.003)、白蛋白(Alb,OR=0.955,P<0.001)、动脉血pH值(OR=0.077,P=0.001)、动脉血氧分压(PaO2,OR=0.996,P=0.014)为脓毒症预后的非危险因素,急性生理学与慢性健康状况评分系统Ⅰ(APACHE Ⅰ)评分(OR=1.115,P<0.001)、体温(OR=1.215,P=0.041)、凝血酶原时间(PT,OR=1.057,P=0.007)、天冬氨酸转氨酶(AST,OR=1.001,P=0.011)、血肌酐(SCr,OR=1.002,P=0.002)、血钾(OR=1.391,P=0.003)、血糖(OR=1.051,P=0.002)、C-反应蛋白(CRP,OR=1.245,P=0.001)为脓毒症预后的危险因素.多因素回归分析显示:APACHE Ⅰ评分(OR=1.094,P<0.001)、住院天数(OR=0.946,P<0.001)、PLT(OR=0.976,p=0.004)、Alb(OR=0.957,P=0.017)4个指标为脓毒症预后的独立危险因素.结论 APACHE Ⅰ评分、住院天数、PLT、Alb是临床上判断危重病患者预后的有效指标.     

脊髓损伤住院康复患者尿路感染相关危险因素回顾性分析

摘要 目的：了解脊髓损伤（spinal cord injury, SCI）住院康复患者尿路感染（urinary tract infection,UTI）相关危险因素,为SCI患者UTI管理提供参考。 方法：回顾性分析2017年1月—2021年12月中国科学技术大学附属第一医院（安徽省立医院）康复医学科576例SCI患者。收集入院时信息包括：自变量[性别、年龄、损伤原因、损伤部位、ASIA分级（美国脊髓损伤协会分级标准,American Spinal Cord Injury Association,ASIA分级）、是否手术、是否保留导尿、是否并发症（肺部感染及神经源性膀胱）、是否贫血（女：血红蛋白<110g/L,男：血红蛋白<120g/L）和血常规（血红蛋白水平、红细胞计数及血小板计数）],因变量（是否并发UTI）。根据是否并发UTI分为两组,比较基线资料情况并应用多元logistic回归分析自变量与因变量的关系。 结果：405（70.31%）例患者并发UTI。并发UTI者血红细胞计数（P<0.001）要低于无UTI者。并发UTI者手术治疗、保留导尿、神经源性膀胱及肺部感染比率高于无UTI者（P<0.001）。两组患者SCI损伤原因（P<0.001）、ASIA分级（P<0.001）、性别（P=0.008）构成比差异具有显著性意义,而损伤部位（P=0.080）、年龄（P=0.102）和是否贫血（P=0.648）构成比差异无显著性意义。保留导尿（OR=3.718）和神经源性膀胱（OR=4.559）是UTI的独立危险因素（OR>1,P<0.05）;增加血RBC计数（OR=0.675）、ASIA-D级（相对于ASIA-A级）（OR=0.515）以及损伤原因为非外伤（相对于外伤）（OR=0.587）是UTI保护因素（OR<1,P<0.05）。 结论：行康复治疗的SCI患者,住院期间发生UTI可能与保留导尿、神经源性膀胱、ASIA分级较高及损伤原因为外伤有关。拔除导尿管,治疗神经源性膀胱,以及促RBC生成治疗可能会有助于降低UTI发生率。     

早期脊髓损伤患者泌尿系感染的危险因素分析和对策

目的 分析早期脊髓损伤（SCI）患者住院期间发生泌尿系感染(UTI)的危险因素。 方法 回顾性分析2013年1月至2016年9月河南省人民医院康复医学科收治的病程在7～60 d SCI患者138例,根据是否发生UTI分为UTI组（58例）和无UTI组（80例）。记录２组患者的性别、年龄、病程、基础疾病、SCI程度、SCI分期、有无脊柱骨折、前期治疗、合并症、排尿方式、膀胱管理、康复治疗、健康教育等临床因素。先采用单因素logistic分析,再进行多因素logistic回归分析,筛选早期SCI患者发生UTI的危险因素。 结果 回归分析结果显示,患者年龄>50岁（OR=2.365,P=0.016）、留置导尿2～6周（OR=2.746,P=0.032）、SCI后UTI病史（OR=13.306,P=0.015）、大剂量激素应用（OR=3.767,P=0.026）、脊柱骨折（OR=5.872,P=0.037）、完全性SCI（OR=4.450,P=0.004）、脊髓休克期（OR=3.501,P=0.020）与早期SCI患者发生UTI有关。 结论 年龄>50岁、SCI后UTI病史、脊髓休克期、完全性SCI、脊柱骨折、大剂量激素治疗、留置导尿2~6周是早期SCI患者发生UTI的独立危险因素。     

脊髓损伤患者发生下肢血栓的影响因素病例对照研究

目的探讨脊髓损伤患者下肢血栓发生的影响因素,为临床更有效地防治血栓发生提供可行性依据。方法选择2015年9月-2016年8月我院脊髓损伤的住院患者422例。住院期间发生下肢血栓的脊髓损伤患者设为观察组;未发生下肢血栓的脊髓损伤患者作为对照组。采用对病例对照方法进行单因素和多因素Logistic回归分析。结果 422例脊髓损伤患者中共68例发生下肢血栓。多因素Logistic回归分析结果显示:患者的损伤程度(OR=2.105)、文化程度(OR=0.560)、低分子肝素的注射(OR=0.290)、血液循环泵的使用(OR=0.499)、下肢静脉血栓的认知水平(OR=0.911)是脊髓损伤患者下肢静脉血栓发生的影响因素(P0.05)。结论脊髓损伤患者发生下肢血栓存在多种影响因素,根据各因素识别高危患者,为临床有效的防治血栓发生提供依据。     

儿童低视力康复与助视器

目的：探讨助视器在儿童低视力门诊的应用效果。方法：143例6～14岁低视力患儿分别配戴远用和近用助视器。结果：低视力患儿配戴远用和近用助视器后，24．5％远视力≥0．5；54．5％的近视力≥0．5。结论：低视力患儿助视器的应用，不仅能提高视力，改善视功能，而且视觉康复推动了特教事业的发展。     

Differences in Comorbidities on Low Back Pain and Low Back Related Leg Pain

Objective: Investigate the influence of external factors such as depression and BMI among subjects with primary severe low back pain (LBP) and low back related leg pain (LBLP). Background: The report of disability in patients with LBP may be significantly influenced by confounding and moderating variables. No similar studies have examined the influence of these factors on LBLP. Methods: This study included 1,448 consecutive subjects referred to a tertiary spine clinic. Unconditional binary logistic regression was used to determine the influence of comorbidities on the relationship between self‐reported back and leg pain. A change in estimate formula was used to quantify this relationship. Results: Among those subjects with primary LBP the unadjusted odds ratio was 8.58 (95% CI 4.87, 15.10) and when adjusting for BMI, depression and smoking was 5.94 (95% CI 3.04, 11.60) resulting in a 36.7% change due to confounding by these comorbidities. Among those with primary LBLP, the unadjusted odds ratio was 4.49 (95% CI 2.78, 7.27) and when adjusting for BMI and depression was 4.60 (95% CI 2.58, 8.19) resulting in a 1.7% change due to confounding by these comorbidities. Conclusion: The disability statuses of the patients with primary LBP in this study were more significantly affected by comorbidities of BMI, depression and smoking than patients with report of LBLP. However, these comorbidities contribute little to the relationship of primary low back related leg pain and Oswestry scores ≥ 40.     

81例儿童低视力的病因及视觉康复

目的：分析儿童低视力的病因及配用助视器后视功能康复情况。方法：对3—14岁的低视力儿童83例（166眼）进行病因分析及验配助视器,并了解他们视觉康复情况。结果：儿童低视力病因以先天及遗传眼病为主,早产儿视网膜病变也是低视力的原因。83例中25例（30.1%）经常规屈光矫正后视力有改善;裸眼使用助视器脱残率低于戴镜后用助视器的脱残率（62.8%、89.2%,P〈0.01）。83例中有23例选用近用助视器,其中73.9%近视力≥0.5。结论：重视防止低视力发生;低视力儿童应常规进行屈光检查,配戴眼镜并配合使用助视器则效果更佳。     

敦煌艾灸疗法结合腰背肌功能锻炼治疗慢性腰腿痛的效果观察

目的 探讨敦煌艾灸疗法结合腰背肌功能锻炼治疗慢性腰腿痛的临床效果.方法 选择2018年3月-2020年3月我院收治的慢性腰腿痛患者110例,按随机数字表法分为对照组和观察组,各55例.对照组实施腰背肌功能锻炼,观察组在对照组的基础上结合敦煌艾灸疗法.比较两组临床疗效、干预前后疼痛程度(VAS)、腰椎功能障碍程度(ODI...     

低密度、氧化低密度脂蛋白对内皮细胞分泌内皮素的影响

目的 观察低密度脂蛋白（LDL）、氧化低密度脂蛋白（ox-LDL）对内皮细胞分泌内皮素（ET）的影响，以及后者在体外是否对前者具有氧化修饰作用.方法 采用不同浓度的LDL、ox-LDL及LDL＋ox-LDL与脐静脉内皮细胞株ECV-304进行孵育，24 h后分别收集细胞和上清液，采用放免分析法测定ET含量.结果 LDL、ox-LDL均能促进内皮细胞合成、分泌ET，但ox-LDL的作用更显著，而LDL＋ox-LDL组上清ET浓度大于两者单独作用之和.结论 LDL、ox-LDL均能促进内皮细胞合成、分泌ET，但后者的作用更为明显，且在体外对LDL具有氧化修饰作用。     

A 3-year analysis of plateletpheresis donor deferral pattern in a tertiary health care institute: assessing the current donor selection criteria in Indian scenario

Introduction: This study reports the frequency and nature of plateletpheresis deferrals and evaluates donors with low platelet count and hemoglobin levels so as to assess the possibility of reentry without hampering donor safety. Materials and methods: Three‐year retrospective data of plateletpheresis deferral was collected. Data from actual procedures was also reviewed to analyze the safety of performing plateletpheresis in donors with low hemoglobin and platelet values. Results: Four hundred sixteen donors were deferred for various reasons among 1,515 screened (27.5%), of which 69.7% deferrals were because of low platelet count (55.8%) and less hemoglobin levels. Among the low platelet count donor group, 20.3% had a count between 141 and 149 × 10⁹/L and 41.8% below 120 × 10⁹/L. Of the 14% donors deferred for low hemoglobin, 62.1% had values in the range of 11.5–12.4 g/dL with normal mean corpuscular volume and red cell distribution width in most (86.2%) of them. Expected blood loss in each procedure varied between 20 and 30 mL, whereas RBC contamination in the product varied from 0 to 1.6 mL in 538 procedures. There were 176 donations with predonation platelet count <180 × 10⁹/L (32.7%). None of the 14 procedures performed on donors with platelet count of 150 × 10⁹/L showed evidence of thrombocytopenia or donor reaction. Conclusion: Lowering the cut‐off value for plateletpheresis from 12.5 g/dL to 11.5 g/dL has no deleterious effect on donor safety as the blood loss is minimal. One‐fifth deferrals can be reconsidered if the criteria of plateletpheresis donor selection are relaxed for hemoglobin and platelet count. J. Clin. Apheresis, 2008. © 2008 Wiley‐Liss, Inc.     

低强度超声联合氢醌药膏对SD大鼠黄褐斑模型的疗效观察

目 的 探讨低频低强度超声联合氢醌药膏对SD大鼠黄褐斑病灶治疗的作用,有望为临床治疗黄褐斑提供新的思路。方 法 将建模成功的18只SD大鼠黄褐斑模型随机分对照组、低强度超声联合氢醌组、氢醌组,每组6只。联合组用声强0.32W/cm₂、频率为42KHz的超声辐照12min；氢醌组脱毛后均匀涂上氢醌轻揉至大概吸收；对照组则保持皮肤暴露,不做任何处理。1.实验过程中观察SD大鼠生理指标变化。2.采集斑块图片并观察变化趋势。3.采取血清、肝脏、皮肤,测其SOD活力和MDA含量。4.将皮肤制作病理切片,光镜下观察黑素颗粒的变化。 结 果 1.各组SD大鼠治疗前后各项生理指标无明显变化。2.超声联合氢醌组的斑块面积减少,颜色变浅；氢醌组变化略小。3.治疗后SOD活力均有上升,MDA含量均有下降,但是超声联合氢醌组更为明显,超声联合氢醌组有显著差异(P＜0.05)。4.病理可见治疗组黑色颗粒减少,超声联合氢醌组黑色素颗粒散在分布,氢醌组黑色素颗粒线性分布。     

Effects of Qigong practice in office workers with chronic non-specific low back pain: A randomized control trial

ObjectiveTo investigate the effects of Qigong practice, Guan Yin Zi Zai Gong level 1, compared with a waiting list control group among office workers with chronic nonspecific low back pain (CNLBP).MethodsA randomized controlled trial was conducted at offices in the Bangkok Metropolitan Region. Seventy-two office workers with CNLBP were screened for inclusion/exclusion criteria (age 20–40 years; sitting period more than 4 h per day) and were allocated randomly into two groups: the Qigong and waiting list groups (n = 36 each). The participants in the Qigong group took a Qigong practice class (Guan Yin Zi Zai Gong level 1) for one hour per week for six weeks at their workstation. The participants were encouraged to conduct the Qigong exercise at home every day. The waiting list group received general advice regarding low back pain management. The primary outcomes were pain intensity, measured by the visual analog scale, and back functional disability, measured by the Roland and Morris Disability Questionnaire. The secondary outcomes were back range of motion, core stability performance index, heart rate, respiratory rate, the Srithanya Stress Scale (ST-5), and the global perceived effect (GPE) questionnaire.ResultsCompared to the baseline, participants in the Qigong group experienced significantly decreased pain intensity and back functional disability. No statistically significant difference in these parameters was found in the waiting list group. Comparing the two groups, Qigong exercise significantly improved pain intensity, back functional impairment, range of motion, core muscle strength, heart rate, respiratory rate, and mental status. The Qigong group also had a significantly higher global outcome satisfaction than the waiting list group.ConclusionQigong practice is an option for treatment of CNLBP in office workers.     

Fell's 'Keeping us on track: a national program to reduce impaired driving in the United States'

This report uses data from an evaluation of low‐threshold methadone treatment in a natural setting. The data are routinely collected, and the process is designed to help management of individuals on the programme and to evaluate and explore the benefits of this approach, in particular its impact on injecting behaviour. The data presented are from two clinical databases: the first records data on drug management throughout the programme; and the second is based on routine data collected using the Maudesley Addiction Profile, modified for clinical use. One hundred and one people were recruited into the programme at its inception and 69 were still in 8‐week follow‐up, when the data were analysed. Analyses of the data provided evidence of reduced injecting activity. There was also a positive impact on physical and psychological health as well as a reduction in illegal activity. Although these outcome data focus on a limited time period, further interviews are conducted after 16 weeks. Only limited information is available at this point in the 8‐week follow‐up. Although some successful outcomes have been achieved in the short term, further evaluation is required in a bid to explore longer‐term maintenance of behaviour change.