Severe aortic regurgitation from systemic hypertension (without aortic dissection) requiring aortic valve replacement: Analysis of four patients

Clinical and morphologic observations are described in four patients who had severe aortic regurgitation from severe systemic hypertension un-associated with aortic dissection; each patient underwent aortic valve replacement. Although aortic regurgitation of minimal or mild degree is well recognized to occur in patients with systemic hypertension, severe degrees of aortic regurgitation are rare in such patients; aortic valve replacement in such patients has not previously been reported. Why these four patients had such severe aortic regurgitation was not determined. Although systemic hypertension is rarely a cause, it nevertheless must be added to the list of causes of severe pure aortic regurgitation.     

Assessment and management of aortic valve disease in patients with left ventricular dysfunction

The onset of symptoms or left ventricular systolic dysfunction heralds a poor prognosis for patients with either aortic stenosis or aortic regurgitation. Echocardiography is the primary imaging modality for assessment of aortic valvular lesions. Cardiac catheterization is indicated to determine the severity of the aortic valve lesion when there is a discrepancy between the clinical findings and the results of echocardiography in patients with either symptoms or left ventricular dysfunction. For patients with low-gradient, low-output aortic stenosis, dobutamine provocation should be used to differentiate truly severe aortic stenosis from patients with a primary cardiomyopathy and low aortic valve area due to low forward flow. Aortic valve surgery improves myocardial performance by relief of ventricular afterload in both patients with severe stenosis and those with severe regurgitation. Surgery should be pursued in both patients with severe aortic stenosis and those with severe regurgitation regardless of the degree of left ventricular dysfunction.     

First report of a simultaneous transcatheter mitral valve‐in‐valve and aortic valve replacement in a left ventricular assist device patient

Transcatheter aortic valve replacement is standard of care for patients with severe aortic stenosis at high risk for surgical aortic valve replacement. Although not intended for treatment of primary aortic insufficiency, several transcatheter aortic valve prostheses have been used to treat patients with severe aortic insufficiency (AI), including patients with left ventricular assist devices (LVAD), in whom significant AI is not uncommon. Similarly, transcatheter valve replacements have been used for valve‐in‐valve treatment, in the pulmonary, aortic, and mitral positions, either via a retrograde femoral approach or antegrade transseptal approach (mitral valve‐in‐valve). In this case report, we report an LVAD patient with severe aortic insufficiency and severe bioprosthetic mitral prosthetic stenosis, in whom we successfully performed transfemoral aortic valve replacement and transfemoral mitral valve‐in‐valve replacement via a transseptal approach. © 2017 Wiley Periodicals, Inc.     

Hemodynamic Evaluation of Suspected Severe Aortic Stenosis Leads to a Diagnosis of Renal Cell Carcinoma

The evaluation of aortic stenosis is not always straightforward. When symptoms of severe aortic stenosis are present with supporting Doppler echocardiographic or cardiac catheterization data, replacement of the aortic valve is recommended. Occasionally, Doppler- and catheter-derived data are discordant; appropriate treatment in such cases becomes less clear.We report a case in which a 66-year-old man''s symptoms and Doppler data suggested severe aortic stenosis. However, heart catheterization data suggested otherwise, and ultimately it led to the diagnosis of a highly vascular renal tumor. Shunting within the tumor resulted in high cardiac output, which, in combination with a small aortic root, masqueraded as severe aortic stenosis.     

Annulo-ectasing disease of the aorta: apropos of 10 cases

Ten patients were investigated and operated for severe aortic regurgitation due to dystrophic aortic dilatation. This is the third commonest cause of pure aortic regurgitation (18 p. 100) operated at Necker Hospital during the same period. This condition, comprising aneurysm of the ascending aorta, dilatation of the aortic ring and dystrophic aortic valves, is often responsible for severe aortic regurgitation and is noteworthy because of the associated risk of aortic dissection. Cardiovascular surgery is indicated and usually includes replacement of the ascending thoracic aorta with aortic valve replacement.     

Effect of catheter positioning on the variability of measured gradient in aortic stenosis

The purpose of this study was to quantify the variation in measured aortic valve gradient and calculated aortic valve area when different techniques of cardiac catheterization were utilized. Hemodynamic assessment of aortic stenosis severity requires an accurately determined pressure gradient. In aortic stenosis, the presence of intraventricular pressure gradients and downstream pressure recovery within the aorta means that a range of aortic valve gradients could be measured in a given patient depending upon catheter position and measurement technique. To quantify the degree of variation in measured gradient and calculated aortic valve area, we generated transvalvular gradients by nine different techniques in 15 patients (11 men, 4 women; 29-86 years old). Patients were divided into those with severe aortic stenosis (aortic valve area ≤ 0.6 cm², n = 6) and those with moderately severe aortic stenosis (aortic valve area 0.61-0.90 cm², n = 9). Considerable variation in measured gradient and calculated aortic valve area was observed. The maximum variation in gradient was similar in severe and moderately severe aortic stenosis groups (33 mm Hg. vs. 32 mm Hg., p = NS). However, the variation in gradient as a percent of maximum gradient was greater (P < 0.05) in the moderately severe aortic stenosis group. The maximum variation in calculated aortic valve area was 0.1 cm² in the severe group and 0.3 cm² in the moderately severe group (P < 0.01). An intraventricular gradient, present in 13 of 15 (87%) patients, was partially responsible for the variation in pressure gradient measurement and calculated aortic valve area. We conclude that in patients with valvular aortic stenosis, catheterization technique has an important impact on the hemodynamic assessment of aortic stenosis severity. This is particularly true in patients with moderately severe aortic stenosis where any variation tends to represent a larger percentage of the total gradient. © 1993 Wlley-Liss, Inc     

Severe aortic stenosis successfully treated with percutaneous aortic valve implantation]

Patients with severe calcific aortic stenosis are occasionally not amenable to surgery because of advanced age or severe co-morbidities. Percutaneous aortic valve dilation is used but has only limited time relief. While preclinical evidence on percutaneous aortic valve replacement seems promising, only very limited clinical data are available worldwide. We hereby present the first case of percutaneous aortic valve replacement successfully performed in Italy in a 74-year-old high-risk female. This case emphasizes the technical challenges inherent to this procedure and its promising role in selected very high-risk patients with severe aortic stenosis, notwithstanding the early and long-term risk of adverse events.     

Aortic arch plaque in stroke

Patients with severe aortic arch plaque are at high risk for stroke. This article addresses the complex nature of the association between aortic arch plaque and stroke. The aortic arch plaque poses a diagnostic and therapeutic challenge to the clinician. The different imaging modalities currently available for evaluating aortic plaque are discussed. Therapy to prevent emboli from aortic plaque is not yet established. Retrospective data in patients with severe aortic plaque support using oral anticoagulation and statins to prevent stroke. Iatrogenic embolization can occur as a result of aortic manipulation during invasive vascular procedures or cardiovascular surgery. The risks and benefits of these procedures must be carefully weighed, and alternate approaches should be considered for patients with severe aortic arch plaque. Assessing aortic arch plaque combined with a specific prevention strategy may reduce the risk of its feared complication, stroke.     

Revelation of quadricuspid aortic valve at aortography in elderly patient with severe aortic regurgitation

Aortic regurgitation is associated with numerous eponymous signs. It has been reported severe aortic regurgitation also due to a quadricuspid aortic valve, a rare congenital anomaly. We present a case of revelation of quadricuspid aortic valve at left ventriculography with aortography in a 71-year-old Italian woman with severe aortic regurgitation.     

Complications of aortic atherosclerosis: Atheroemboli and thromboemboli

Opinion statement Patients with severe aortic atherosclerosis are at high risk for stroke and other embolic complications. Therapy to prevent emboli from aortic plaque is not yet established. Therefore, patients with atherosclerosis or risk factors for embolic disease should be identified and treated aggressively. Aspirin, smoking cessation, and control of blood pressure and glucose are important. Retrospective data in patients with severe aortic plaque support the use of statins to prevent stroke. Iatrogenic embolization can occur as a result of aortic manipulation during invasive vascular procedures or cardiovascular surgery. The risks and benefits of these procedures must be carefully weighed, and alternate approaches should be considered for patients with severe aortic atherosclerosis. For those who require coronary artery bypass graft (CABG) surgery, off-pump CABG is an option. Prophylactic aortic arch atherectomy should not be routinely performed. Aortic filters or stenting have been introduced but have not yet been fully evaluated. For patients who require angiography and have severe descending aortic, aortic arch, or abdominal aortic plaque, it is possible that a brachial (rather than a femoral) approach may avoid embolic complications.     

Aortic abnormalities in Marfan's syndrome]

Three different forms of aortic lesions in Marfan's Syndrome are demonstrated: 1. moderately severe aortic valve insufficiency due to sinus of Valsalva aneurysm; 2. severe aortic valve insufficiency due to aneurysmal widening of the ascending aorta; 3. an unusually wide dissecting aneurysm extending from the aortic root to the aortic bifurcation. A review of the current literature of the changes in Marfan's Syndrome is given. It is obvious that early diagnosis of the cardiovascular changes is important for the patient's prognosis, allowing the optimal time for surgical intervention to be chosen.     

Echocardiographic and hemodynamic features of severe aortic regurgitation with diastolic opening of the aortic valve

Severe aortic regurgitation may be associated with premature aortic valve opening. Several possible etiologies for this diastolic opening have been suggested. We present a patient with hemodynamic data, M-mode and 2-D echocardiography in the setting of severe aortic regurgitation and diastolic aortic valve opening. Our data lead us to conclude that aortic valve opening in this situation is neither from passive flotation nor dependent on atrial systole. We believe that active ventricular recoil mechanisms can facilitate increases in diastolic ventricular pressure which then can transiently exceed aortic pressure in the setting of severe aortic regurgitation. This hemodynamic observation suggests that the valve opening is an active process.     

Severe aortic regurgitation complicating percutaneous aortic valve valvuloplasty

An 88-year-old patient undergoing percutaneous aortic balloon valvuloplasty of a tricuspid aortic valve is described. The patient had mild aortic regurgitation prior to the procedure but developed severe aortic regurgitation after balloon dilatation of the valve. At the time of surgery there was no anatomic disruption of the valve or supporting structures. Development of severe aortic incompetence following balloon valvuloplasty has not been previously reported.     

Congenitally bicuspid aortic valve causing severe,pure aortic regurgitation without superimposed infective endocarditis: Analysis of 13 patients requiring aortic valve replacement

Although stenosis and infective endocarditis are commonly appreciated complications of the congenitally bicuspid aortic valve, pure severe aortic regurgitation complicating this congenital malformation, unassociated with either stenosis or infection, is not well recognized. Among 189 patients who had aortic valve replacement at the National Heart, Lung, and Blood institute because of isolated pure aortic regurgitation, the congenitally bicuspid aortic valve, never the site of infective endocarditis, was responsible for the aortic regurgitation in 13 (7 percent). This report describes certain clinical and morphologic findings in 13 men, aged 26 to 65 years (mean 43), who required aortic valve replacement because of severe aortic regurgitation secondary to a noninfected, nonstenotic congenitally bicuspid aortic valve. Although not generally recognized, the noninfected congenitally bicuspid aortic valve is an important cause of pure aortic regurgitation severe enough to warrant aortic valve replacement.     

Diagnostik und Indikation zum Klappenersatz bei asymptomatischer und symptomatischer Aorteninsuffizienz

Chronic volume overload is associated with dilatation and eccentric hypertrophy of the left ventricle (=ventricular remodeling). With the dilatation of the left ventricle and the shift of the pressure-volume-relationship to the right, the filling pressures can be kept normal despite severe regurgitation. Therefore, the patient with aortic regurgitation can remain asymptomatic over many years. Thus, the indication for aortic valve replacement in patients with severe aortic regurgitation is sometimes difficult and may lead to problems to choose the optimal time point for operation. As a general rule, symptomatic patients with severe aortic regurgitation should be operated as soon as possible. In asymptomatic patients with significant dilatation of the left ventricle and reduction of systolic pump function the therapy of choice is aortic valve replacement. Asymptomatic patients with normal left ventricular function have usually a good prognosis with a yearly mortality rate of approximately 0.04%. However, in the presence of significant dilatation of the left ventricle, i. e. enddiastolic chamber diameter more than 70 mm respectively endsystolic diameter more than 50 mm, patients have to be checked on a regular basis, i. e. in yearly intervals to detect left ventricular dysfunction in due time. According to the literature, asymptomatic patients with severe aortic regurgitation develop left ventricular dysfunction in a yearly rate of 4%. However, approximately 50% of all patients are even after 10 years asymptomatic. The indication for aortic valve replacement is given when the patient shows a deterioration of left ventricular function or becomes symptomatic. Valve replacement is also indicated in patients with an ejection fraction below 50% and/or endsystolic chamber diameter of more than 55 mm. Therapy of choice in symptomatic patients with severe aortic regurgitation is aortic valve replacement. In asymptomatic patients, operation depends on the degree of chamber dilatation respectively the severity of left ventricular dysfunction. In patients with severe aortic regurgitation but without clinical symptoms and moderate enlargement of the left ventricle regular check-ups in yearly intervals are indicated. In the presence of severe left ventricular dilatation check-ups should be performed on a half-year basis to prevent irreversible damage to the heart muscle.     

Aortic valve resistance as an adjunct to the Gorlin formula in assessing the severity of aortic stenosis in symptomatic patients.

OBJECTIVES. This study was conducted to determine the utility of aortic valve resistance in assessing the severity of aortic stenosis. BACKGROUND. Assessment of the severity of aortic stenosis has traditionally employed hemodynamic data and the Gorlin formula to calculate the area of the aortic valve. Recently, flow dependence of the Gorlin formula has been identified and the accuracy of the formula challenged. Aortic valve resistance, the quotient of gradient and cardiac output, has been advanced as potentially useful in assessing the severity of valve stenosis. METHODS. We studied 48 symptomatic patients with an initial diagnosis of severe aortic stenosis based on a calculated aortic valve area of less than or equal to 0.8 cm2 by the Gorlin formula. Forty of these patients (Group I) were confirmed to have severe aortic stenosis, whereas 8 (Group II) were subsequently proved not to have severe aortic stenosis. The 18 patients in Group I with a valve area of 0.6 to 0.8 cm2 (Group IA) were directly compared with Group II patients who had a similar valve area. RESULTS. Aortic valve area was nearly identical in Group IA and Group II patients (0.69 +/- 0.05 and 0.71 +/- 0.06 cm2, respectively, p = NS). However, aortic valve resistance was much less in Group II patients (212 +/- 6 vs. 316 +/- 11 dynes.s.cm-5, p less than 0.0001). In this small cohort, aortic valve resistance achieved nearly complete separation of patients in Groups IA and II. CONCLUSIONS. In some patients with relatively mild aortic stenosis, the calculated valve area may indicate that the stenosis is severe. The use of aortic valve resistance in conjunction with the Gorlin formula helps separate patients with truly severe aortic stenosis from those with milder disease.     

The natural history of aortic regurgitation. A clinical and hemodynamic study

A combined prospective and retrospective analysis of clinical and hemodynamic data in 150 patients with aortic regurgitation was undertaken to review the natural history of this lesion. One hundred twenty-six patients were classified as having chronic aortic regurgitation and 24 as having acute aortic regurgitation. Serial hemodynamic studies were performed one to eight years apart in 24 patients with chronic aortic regurgitation.Clinical symptoms included dyspnea and fatigability as a consequence of reduced cardiac reserve, and chest pain and palpitations, symptoms not directly related to deteriorating cardiac function. As a rule, patients in younger age groups were free of symptoms; disability usually appeared in the fourth and fifth decades of life. Disability was poorly related to the degree of aortic regurgitation and extent of ventricular hypertrophy or cardiac enlargement. Hemodynamic abnormalities almost always preceded the development of clinical disability, but normal or near normal performance was usual in younger asymptomatic subjects despite severe degrees of aortic regurgitation and pronounced left ventricular hypertrophy.In patients with acute aortic regurgitation, findings ranged from near normal to severe cardiac decompensation requiring emergency surgical treatment.In our study (1) the protracted clinical course of chronic aortic regurgitation is confirmed: the asymptomatic state is present for decades in patients with severe aortic regurgitation even though serious hemodynamic deterioration can be documented; (2) the late appearance of clinical disability at a stage when irreversible myocardial damage may be present imposes, at present, an insoluble therapeutic dilemma with regard to the timing of surgical treatment; (3) except for the most severe, intolerable acute aortic regurgitation, there is considerable similarity between chronic and acute forms of aortic regurgitation; (4) ischemic cardiac pain is rare in aortic regurgitation, and syncope does not occur as part of this disease.     

Should asymptomatic aortic valve disease be treated surgically?]

The problems posed by asymptomatic aortic valve disease with regards to surgery differ according to whether the lesion is aortic stenosis or regurgitation. In stenotic lesions, even severe, the risk of spontaneous evolution is very small when the subject is totally asymptomatic. However, the quality of the results of surgery in asymptomatic or pauci-symptomatic patients and the increased difficulties in the very elderly are incentives not to differ surgery when the stenosis is severe, and especially when left ventricular function begins to degrade. In aortic regurgitation, the risk of progression is also low in asymptomatic patients but left ventricular dysfunction may develop before symptoms occur: this explains the necessity for regular clinical, echocardiographic and eventually radioisotopic examination of patients with severe aortic regurgitation. In dystrophic aortic regurgitation, an aneurysm of the sinuses of Valsalva and/or of the ascending aorta, or progressive fusiform dilatation of the ascending aorta are reasons for not postponing surgery for replacement of the aortic valve and the ascending aorta.     

Valve Replacement with a Sutureless Aortic Prosthesis in a Patient with Concomitant Mitral Valve Disease and Severe Aortic Root Calcification

Aortic valve replacement with concomitant mitral valve surgery in the presence of severe aortic root calcification is technically difficult, with long cardiopulmonary bypass and aortic cross-clamp times.We performed sutureless aortic valve replacement and mitral valve annuloplasty in a 68-year-old man who had severe aortic stenosis and moderate-to-severe mitral regurgitation. Intraoperatively, we found severe calcification of the aortic root. We approached the aortic valve through a transverse aortotomy, performed in a higher position than usual, and we replaced the valve with a Sorin Perceval S sutureless prosthesis. In addition, we performed mitral annuloplasty with use of an open rigid ring.The aortic cross-clamp time was 63 minutes, and the cardiopulmonary bypass time was 83 minutes. No paravalvular leakage of the aortic prosthesis was detected 30 days postoperatively.Our case shows that the Perceval S sutureless bioprosthesis can be safely implanted in patients with aortic root calcification, even when mitral valve disease needs surgical correction.     

Role of balloon dilatation of the aortic valve in pregnant patients with severe aortic stenosis.

The outcome of unrelieved severe symptomatic aortic stenosis in pregnancy is poor. Though the valve lesion can be corrected surgically before delivery at a low risk to the mother, cardiopulmonary bypass during pregnancy carries a high risk to the fetus. Two patients in the second trimester of pregnancy were successfully managed with balloon dilatation of the aortic valve. Both delivered healthy infants and were well a year later. Balloon dilatation of the aortic valve is a useful palliative procedure in the management of pregnant women with severe aortic stenosis.