广东省梅县盲和低视力流行病学调查

目的 调查梅县盲及低视力的流行病学情况。方法 采用分层随机抽样原因,以世界卫生组织盲目分级为标准,对全县按2.01%抽样比例抽取11327例进行盲和低视力的流行病学调查。结果 双眼盲及低视力患病率分别为0.47%（男性0.30%,女性0.63%）和0.89%（男性0.66%,女性1.12%）;双眼盲率：县城0.29%、附城郊区0.34%、山区0.56%。单眼盲、双眼低视力和单眼低视力的患病率分别为0.72%、0.89%和0.59%。≥50岁盲及低视力患者的患病率明显增高。结论 致盲和致低视力的眼病均以白内障居首位,其次为青光眼、屈光不正、弱视及翼状胬肉等。     

南通市新城桥街道60岁及以上人群盲和低视力的现况调查

目的调查江苏省南通市城市人口中60岁及以上人群盲和低视力的患病率及其原因。方法采用随机整群抽样方法,抽取新城桥街道14个社区中的8个,并对所有60岁及以上人群进行检查。分别检查小孔视力和日常生活视力,应用裂隙灯显微镜和直接检眼镜等仪器检查受检者外眼、眼前节及眼底等情况。正式调查前先进行预试验。结果共检录3352人,受检人数为3040人,应答率90．69％。按小孔视力和世界卫生组织视力损伤标准,双眼盲和低视力患病率分别为1．35％和1．84％,其中女性分别为1．92％和2．33％,男性为0．66％和1．24％;盲和低视力患病率随着年龄的增长而增加;致盲和低视力的首要原因为白内障。按日常生活视力和视力损伤标准,双眼盲和视力损伤的患病率分别为1．58％和13．59％,其中女性分别为2．10％和15．98％,男性为0．95％和10．66％;盲和视力损伤的患病率亦随年龄的增长而增加;致双眼盲的首要原因亦为白内障。结论南通市60岁及以上城市人群盲的患病率低于华北、华南及西部地区。女性与文盲的盲和低视力患病率分别高于男性与非文盲。南通市城市人口中致盲的主要原因依次为白内障、眼底异常、屈光不正及角膜瘢痕或混浊等。     

青海省玛沁县40岁及以上世居藏民盲与低视力的患病率调查

目的调查青海省玛沁县40岁及以上世居藏族人群中盲与低视力的患病率及致病原因。方法2004年3～5月采用整群抽样方法，对玛沁县的世居藏族人群进行视力及眼病抽样调查，共抽取26个大队(村)的2760人，根据世界卫生组织视力损伤标准(标准A)及日常生活视力和视力损伤标准(标准B)计算盲与低视力的患病率。结果在应受检的2760人中，实际受检人数为2511人，受检率为90．98％．(1)以标准A计算，双眼盲的患病率为4．1％，双眼低视力的患病率为5．3％；(2)按标准B计算双眼盲的患病率为5．4％．结论玛沁县世居藏民盲的患病率明显高于内地，高于林周县的2．3％(标准A)和3．2％(标准B)。白内障是盲与低视力的最主要原因。     

西藏自治区墨脱县人群盲和低视力现况调查

目的探讨与了解西藏自治区墨脱县人群盲与低视力的流行病学变化情况。方法以村为基础,采用随机整群抽样原则,抽取6个行政村作为调查地点。采用世界卫生组织制定的盲与低视力标准,对全县按2．05％抽样比例抽取样本进行盲与低视力的流行病学调查。结果检录821人中,受检人数为735人,受检率为89．52％。双眼盲19人,盲率为2．59％（男性1．72％,女性3．40％）;双眼低视力32人,低视力患病率为4．35％（男性4．02％,女性4．67％）。≥40岁盲及低视力患者的患病率明显增高。致盲的眼病依次为白内障（42．11％）、角膜病（21．05％）及青光眼（15．79％）。结论西藏自治区墨脱县人群中盲和致低视力的眼病以白内障居首位,因此手术治疗白内障仍是今后防盲治盲工作的首要任务。     

我国白内障的流行病学调查资料分析

目的 探讨我国白内障的患病率与各地检查条件、诊断标准及地理环境的关系。方法 采用世界卫生组织盲与低视力标准,对全国抽样调查资料进行统计学分析。结果 双眼视力〈０．３的白内障患者约５００万人,患病率为０．４６％;盲与低视力的患病率分别为０．４３％和０．５８％。盲人中白内障致盲占４１．０６％;低视力患者中４９．３８％为白内障所致;白内障致老年盲（年龄≥６０岁）及低视力占７３．１３％。以晶体混及视力〈０     

2009年上海市宝山区大场社区60岁及以上人群盲和低视力患病率调查

目的 探讨上海市宝山区大场社区60岁及以上人群的盲和低视力患病率、致盲原因及其相关因素。方法 横断面现况调查研究。由上海市眼病防治中心和上海市宝山区疾病预防控制中心于2009年10至12月期间对上海市宝山区大场社区60岁及以上并在当地居住10年以上的常住户籍人口进行随机整群抽样调查。对调查对象完成视力、眼压、验光、裂隙灯显微镜、免散瞳数字眼底照相等检查,采用世界卫生组织视力损伤标准和日常生活视力和视力损伤标准确立盲或低视力,并明确主要致盲原因。组间率的比较采用卡方检验。结果 实际受检4545人,受检率为87.42％。受检人群均为近10年内随着城市化进程从原农村人口转变而来的城市人口。按照世界卫生组织视力损伤标准：双眼盲30人,患病率0.67％;双眼低视力145人,患病率3.19％。白内障、黄斑变性、眼球萎缩或缺如、青光眼、糖尿病视网膜病变（或角膜病）是前5位致盲眼病。女性低视力患病率高于男性,差异有统计学意义(x2 =4.88,P＜0.05)。按照日常生活视力和视力损伤标准：双眼盲39人,患病率0.86％,双眼低视力401人,患病率8.82％;75岁后成为视力损害的高速发展期。白内障、未矫正的屈光不正、黄斑变性、眼球萎缩或缺如、青光眼是前5位致盲原因。女性低视力患病率高于男性,差异有统计学意义(x2=13.345,P＜0.01)。结论 在上海市城市化进程较快的老龄化社区中,白内障、未矫正的屈光不正、黄斑变性是引起日常生活视力盲的前3位原因,女性低视力患病率明显高于男性。对这类社区居民需要进行更多的有针对性眼的保健教育与服务工作。     

无锡市滨湖区50周岁及以上人群致盲和低视力因素调查

目的 调查无锡市滨湖区50周岁及以上人群致盲和低视力的原因.方法 采用分层整群随机抽样,在无锡市滨湖区抽取了28个调查点,对其中50周岁及以上人群中盲和低视力者的相关眼病进行分析.视力＜0.05者定义为盲,0.05～0.3者定义为低视力.使用SPSS 17.0统计软件进行分析处理.结果 最终受检6150人,检出单眼盲201例,双眼盲47例,单眼低视力214例,双眼低视力84例.201例单眼盲中,55例对侧眼为低视力.在盲的295只眼中,前三位致盲眼病分别为白内障、高度近视性黄斑变性、眼球缺失或萎缩,相关眼数分别为116、31、28只,占盲眼数的39.32％、10.51％、9.49％.在低视力的437只眼中,前三位眼病分别为白内障、高度近视性黄斑变性、老年性黄斑变性,相关眼数分别为223、41、41只,占盲眼数的51.03％、9.38％、9.38％.结论 致盲和低视力的主要原因均以白内障为首位,其次为高度近视性黄斑变性、老年性黄斑变性、眼球缺失或萎缩.     

上海浦东三林镇老年人盲和低视力流行病学调查

目的调查上海市浦东新区三林镇70岁及以上老年人盲和低视力的患病率及致病原因。方法以世界卫生组织制定的分级为标准,使用针孔镜矫正视力,统计其盲与低视力患病率,分析盲及低视力的主要病因。结果盲及低视力患病率分别为2.4%和8.8%,致盲和低视力的眼病均以白内障居首位,其次为老年性黄斑变性、角膜病和青光眼等。结论手术治疗白内障是降低盲与低视力患病率的主要措施,老年性黄斑变性等难治性眼病的防治亦应成为防盲治盲工作的重点。     

甘肃省平凉市崆峒区人群盲和低视力现况调查

目的:探讨与了解甘肃省平凉市崆峒区人群盲与低视力的患病率及致病原因。方法:应用横断面研究的流行病学调查方法,以村(社区)为基础,采用随机整群抽样原则抽取6个乡镇2个街道办事处作为调查地点。采用世界卫生组织制定的盲与低视力标准,对全区按0.719%抽样比例抽取样本进行盲与低视力的流行病学调查。结果:检录3235例中,受检人数为2801例,受检率为86.58%,双眼盲21例,盲率为0.75%(男0.59%,女0.91%);双眼低视力125例,低视力患病率为4.46%(男3.73%,女5.16%),≥60岁以上盲与低视力患者的患病率明显增高。致盲病因前三位的眼病依次为白内障(47.62%)、角膜病(14.29%)、青光眼(14.29%)。结论:崆峒区人群中盲和低视力的眼病以白内障居首位,因此手术治疗白内障仍是今后防盲治盲工作的首要任务。     

安徽省两地人群盲和低视力及眼病的流行病学抽样调查（一）

目的方法结果结论对安徽省两地人群盲和低视力及眼病的流行病学情况进行抽样调查。选择阜阳市颍州区和宣城市绩溪县,采用随机整体抽样方法,对所属居民进行眼部及其他情况的调查。两地的受检人数和受检率分别为3336人（91.40%）和3602人（92.10%）,达到抽样调查要求;两地双眼盲、单眼盲、双眼低视力和单眼低视力的患病率分别为1.05%和0.69%、1.71%和1.25%、1.02%和0.97%、0.87%和0.89%;两地盲和低视力的主要原因分别为：白内障、弱视、青光眼和白内障、眼球萎缩/缺如、青光眼;两地主要眼病都为：屈光不正、白内障、翼状胬肉和沙眼;两地的白内障手术率分别为600和278。据不完全资料估计我省盲和低视力的患病率远高于全国平均水平,盲和低视力的高发人群为50岁以上老年人,女性,孤寡,文盲,低收入者,白内障仍是最主要致盲原因,屈光不正/弱视已日益成为影响人民特别是青少年视力的最主要因素,广泛宣传正确用眼方式,推广青少年正确验光配镜方法,提高相关人员验光配镜水平对于有效降低弱视致残率至关重要。     

视网膜母细胞瘤治疗及研究进展

随着基础研究和临床实践的逐步深入,视网膜母细胞瘤（ RB）的治疗模式已发生改变。目前,RB的治疗方法包括局部治疗、化学治疗、放射治疗、手术治疗、基因治疗等,本文将就RB的治疗及研究进展进行综述。     

角膜和全眼高阶波前像差的特点及年龄相关性变化的研究

目的 研究人眼角膜和全眼单色高阶波前像差特点及年龄相关性变化.方法 使用Tracey-iTrace视觉功能分析仪测量113只正常国人眼计59人,年龄5～73岁,平均(33.81±20.50)岁,角膜和全眼的球差(Z40)、总高阶像差(HOAs)、总彗差(TC)、总球差(TS)、总三叶草像差(TT).并对角膜和全眼高阶波前像差进行年龄相关性分析.结果 角膜Z40的均方根系数值平均为(0.27±0.07)μm(0.130～0.451)μm,虽然角膜Z40随年龄略呈增加趋势,但无统计学意义(r=0.172,p=0.069).全眼的Z40随年龄增加而增加(r=0.545,p=0.000).角膜的HOAs(r=0.499,p=0.000)、TC(r=0.149,p=0.021)、TT(J=0.344,p=0.000)和全眼的HOAs(r=0.427,p=0.000)、TC(r=0.253,p=0.007)、TT(r=0.185,p=0.050)均随年龄的增加而增加.角膜HOAs、TC、,TT.与全眼相对应像差呈正相关(r=0.327,p=0.000;r=0.233,p=0.013;r=0.481,p=0.000).角膜TS不随年龄而变化(r=0.180,p=0.057),但全眼的TS随年龄的增加而增加(r=0.560,p=0.000).结论 国人角膜的HOAs、Tc、1Tr随年龄的增加而增加,并导致了全眼的上述波前像差随年龄的增加而增高.角膜的TS和Z40不随年龄发生明显变化,全眼的TS和Z40随年龄增加是由于晶状体总球差和球差随年龄增加的结果.国人角膜球差具有较大个体差异性,手术前角膜球差的测量是非球面IOL选择的必要步骤.     

Disruption and reacquisition of binocular vision in childhood and in adulthood

PURPOSE OF REVIEW: This article reviews the most recent studies that address the loss of and restoration of binocular vision in childhood and adulthood and summarizes recent changes in treatment approaches. RECENT FINDINGS: Studies during the last two years support the idea of continued plasticity of the binocular visual system throughout life. Children and adults with strabismus onset following binocular vision maturation are susceptibility to a permanent disruption of stereopsis and sensory fusion. Plasticity of the binocular visual system, however, also means continued restorability of function. Despite a rather short critical time interval for restoration of normal function (three months in children and 12 months in adults), peripheral or extramacular binocular visual function can be restored in most patients whose onset of disruption follows binocular maturation. SUMMARY: Stereoacuity loss can occur in the visually mature patient who develops strabismus later in life and delay of treatment can be deleterious to the restoration of normal macular binocular vision. However, despite any delay of treatment, most patients with strabismus acquired following binocular vision maturation will manifest some stereoacuity or sensory fusion following eye realignment. These findings suggest all patients with strabismus need to have their eyes aligned, either surgically or optically, to maximize their binocular vision outcome.     

Expression and characterization of SPARC in human lens and in the aqueous and vitreous humors

SPARC (secreted protein, acidic and rich in cysteine) is a matricellular glycoprotein that regulates morphogenesis, cellular proliferation, and differentiation. SPARC is a critical factor in the development and maintenance of lens transparency in mice. SPARC-null mice develop lenticular opacity at an early age that progresses gradually to mature cataract. Despite the high level of homology between the mouse and human genes, little is known about SPARC in the human lens. We have studied the expression of SPARC protein in human lens and surrounding ocular tissues from normal human donors (60-70 years old). Immunohistochemical and immunoblot analyses were conducted on lens, aqueous humor, vitreous, ciliary epithelium, pigment epithelium, cornea and retina. The epithelia and capsule of the lens contained SPARC, whereas the cortical and nuclear fibers did not. In contrast, the aqueous humor and vitreous, which provide nutrients to the lens and regulate its development and function, contained significant amounts of SPARC. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of extracts of various ocular tissues revealed bands of 43 and 29 kD after disulfide bond reduction that were reactive with anti-SPARC IgG. Despite the presence of protease inhibitors during sample preparation, we observed cleavage of intact SPARC to a 29 kD fragment, a peptide reported in other tissues and attributed to endogenous proteolysis. In addition, bands of molecular mass 150 and 200 kD were present that appeared to be disulfide-bonded complexes of SPARC monomers. Human cornea, ciliary epithelium, pigment epithelium and retina also contained SPARC. The presence of SPARC in the aqueous humor and vitreous, as well as in the lens, indicates a functional importance of SPARC in adult human eye as well as in lens development.     

Efficacy and safety of bimatoprost in glaucoma and ocular hypertension in non-responder patients

AIM: To establish the efficacy and safety of bimatoprost 0.03% monotherapy in glaucoma and ocular hypertension (OHT) patients with inadequate intraocular pressure (IOP)on current therapy. METHODS: Pre- and post-switch IOPs were analyzed for 59 consecutive patients who were switched from current therapy to bimatoprost monotherapy between 2011-2015. Demographic information, diagnosis, and any adverse events were recorded. Change in IOP post-pre switch was analyzed using a 2-sided Student''s paired t-test at the 5% significance level. RESULTS: There was a statistically significant mean reduction in IOP at the first follow up visit, which was maintained at subsequent follow up visits for patients regardless of diagnosis, or pre-switch treatment (P<0.001). Subgroup analysis also demonstrated a statistically significant mean reduction in IOP when looking at OHT patients only, as well as patients with any diagnosis switched from latanoprost monotherapy to bimatoprost monotherapy (P<0.001). CONCLUSION: This is the largest independent data set which supports switching glaucoma patients with poor response to current treatment onto bimatoprost monotherapy before considering other adjuvant medical or more invasive therapy.     

Changes in visual function and optical and tear film quality in computer users

Purpose

To assess changes in visual function and optical and tear film quality in computer users.

Methods

Forty computer workers and 40 controls were evaluated at the beginning and end of a working day. Symptoms were assessed using the Quality of Vision questionnaire (QoV), 5-item Dry Eye Questionnaire (DEQ-5) and Symptom Assessment in Dry Eye version II (SANDE II). Tear film quality was evaluated using the Medmont E300 dynamic corneal topography tool to measure the tear film surface quality (TFSQ), TFSQ area and auto tear break-up time (TBUT). Optical quality was assessed by measuring high, low and total ocular aberrations with a Hartmann–Shack wavefront sensor. Visual performance was assessed by measuring photopic and mesopic visual acuity, photopic and mesopic contrast sensitivity and light disturbance.

Results

Poorer DEQ-5, QoV and SANDE II scores were obtained in computer workers at the end of the working day compared with controls (p ≤ 0.02). Computer workers exhibited a higher (worse) TFSQ and TFSQ area at visit 2 compared with visit 1 (p ≤ 0.04), while no significant differences in TBUT (p = 0.19) or ocular aberrations were observed (p ≥ 0.09). Additionally, both light disturbance (p ≤ 0.04) and mesopic and photopic contrast sensitivity worsened at several spatial frequencies (p ≤ 0.04) throughout the working day in computer workers, while visual acuity remained unchanged (p ≥ 0.07). In contrast, control subjects exhibited no decrease in any variable during the day.

Conclusions

While visual acuity remained unchanged, several aspects of visual function and quality of vision decreased over a day of computer use. These changes were accompanied by greater dry eye symptoms and tear film changes, which are likely to have played a fundamental role. The present study provides insight into new metrics to assess digital eye strain.     

厦门地区城市与农村儿童近距离用眼与近视的关系

目的 :调查中国厦门城市与农村 8～ 9岁儿童近视的患病情况 ,并以此评估环境因素对近视患病率的影响。方法 :对中国厦门城市 (n =119)和农村 (n =91)的小学二年级学生进行散瞳电脑验光和眼生物参数测量 ,并采用同一标准的调查表进行面对面地问卷调查 ,内容包括社会经济地位、近距离用眼活动情况、读写习惯、近视眼家族史等。结果 :近视的发病率在城市为 19.3% [95 %可信区间confidenceinterval(CI) :12 .3,2 9],在农村是 6 .6 % (95 %CI:2 .4 ,14 .3)。城市在校学生每天课外读写平均时间是 2 .2h ,农村学生的收稿日期 :2 0 0 2 -0 3 -14 ;修回日期 :2 0 0 2 -0 5 -0 8基金项目 :新加坡政府及厦门开元区科委资助项目。作者简介 :张铭志 (195 7-) ,女 ,山东费县人 ,医学硕士 ,副主任医师。研究方向 :白内障、青光眼、近视。通信作者 :张铭志 (E -mail:fu- zhifu @hotmail.com)。时间是 1.6h(P <0 .0 0 1) ,所得结果经近视眼家族史因素校正后 ,总体读写时间比值比为 2 .2 (95 %CL :1.1,4 )。结论 :近视眼发病率 ,城市高于农村。城市儿童的课外读书时间比农村儿童长 ,城市和农村的近视儿童在读书上花费的时间明显高于非近视儿童。近距离用眼的增多可能导致了近视眼的发生 ,这为近距离用眼学说提供了更多依据     

Active and passive rubidium influx in normal human lenses and in senile cataracts

The aim of this study was to investigate the mechanisms responsible for the osmotic imbalance which occurs in a majority of human senile cataracts. Active and passive influx of rubidium has been determined in vitro in human lenses both normal and cataractous. It is concluded that the active transport of cations is on the average normal in senile cataractous lenses. It is possible that the activity of the cation pump is defective in a few cataractous lenses but no direct direct evidence of this can be given. The results indicate that cryo-extracted lenses may be utilized in this type of study provided that cryo-treatment during surgery is kept at the lowest possible level.     

Survivin and p53 expression in primary and recurrent pterygium in Chinese patients

AIM: To assess the expression of anti-apoptotic protein survivin and tumor suppressor p53 protein in primary and recurrent pterygium and to investigate the relationship between them. METHODS: Survivin was assessed immunohistochemically using rabbit polyclonal antibody and p53 using mouse monoclonal antibody in a study sample of 20 cases of primary pterygium, 10 cases of recurrent pterygium and 10 cases of normal conjunctiva. RESLULTS: In our study, 35% of primary (7 of 20) and 40% of recurrent (4 of 10) pterygium specimens were positive for survivin staining; 45% of primary (9 of 20) and 50% of recurrent (5 of 10) pterygium specimens were positive for p53 expression; and all normal conjunctiva showed no staining of either survivin or p53. The p53 and survivin immunoreactivity in primary and recurrent pterygium groups was greater than those in normal conjunctiva group (P<0.05). There were no differences in p53 and survivin immunoreactivity between groups of primary and recurrent pterygium (P>0.05). The expression of survivin clearly segregated with p53-positive pterygium as compared with p53-negative cases [8 of 14 cases (57.1%) vs 3 of 16 cases (15.2%)]. The Fisher's exact test analysis confirmed a highly statistically significant correlation between survivin and p53 expression (P<0.05). CONCLUSION: The survivin and p53 are overexpressed with correlation between them in primary and recurrent pterygium.