共查询到20条相似文献,搜索用时 968 毫秒
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Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat. 总被引:88,自引:16,他引:72 下载免费PDF全文
E J Duh W J Maury T M Folks A S Fauci A B Rabson 《Proceedings of the National Academy of Sciences of the United States of America》1989,86(15):5974-5978
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Stimulation of a human T-cell clone with anti-CD3 or tumor necrosis factor induces NF-kappa B translocation but not human immunodeficiency virus 1 enhancer-dependent transcription 总被引:17,自引:0,他引:17 下载免费PDF全文
U Hazan D Thomas J Alcami F Bachelerie N Israel H Yssel J L Virelizier F Arenzana-Seisdedos 《Proceedings of the National Academy of Sciences of the United States of America》1990,87(20):7861-7865
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Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat. 总被引:14,自引:4,他引:14 下载免费PDF全文
C Li C F Lai D S Sigman R B Gaynor 《Proceedings of the National Academy of Sciences of the United States of America》1991,88(17):7739-7743
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A role for transcription factor NF-kB in intestinal inflammation 总被引:7,自引:1,他引:7
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Asbestos induces nuclear factor kappa B (NF-kappa B) DNA-binding activity and NF-kappa B-dependent gene expression in tracheal epithelial cells. 总被引:7,自引:0,他引:7 下载免费PDF全文
Y M Janssen A Barchowsky M Treadwell K E Driscoll B T Mossman 《Proceedings of the National Academy of Sciences of the United States of America》1995,92(18):8458-8462
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Regulation of human retroviral latency by the NF-kappa B/I kappa B family: inhibition of human immunodeficiency virus replication by I kappa B through a Rev-dependent mechanism. 总被引:5,自引:0,他引:5 下载免费PDF全文
B Y Wu C Woffendin C S Duckett T Ohno G J Nabel 《Proceedings of the National Academy of Sciences of the United States of America》1995,92(5):1480-1484
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Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B. 总被引:18,自引:2,他引:18 下载免费PDF全文
Y C Lin K Brown U Siebenlist 《Proceedings of the National Academy of Sciences of the United States of America》1995,92(2):552-556
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Identification and purification of a human immunoglobulin-enhancer-binding protein (NF-kappa B) that activates transcription from a human immunodeficiency virus type 1 promoter in vitro 总被引:63,自引:12,他引:63 下载免费PDF全文
K Kawakami C Scheidereit R G Roeder 《Proceedings of the National Academy of Sciences of the United States of America》1988,85(13):4700-4704
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Iron is both essential and toxic for cells and impaired iron homeostasis has been shown to cause or potentiate various forms of liver injury. Research in our laboratory suggests that iron also plays a pivotal role in intracellular signaling for NF-kappa B activation in hepatic macrophages (HM). Our results showed: 1) HM from alcohol-fed rats had a increase in the nonheme iron content accompanied by NF-kappa B activation; 2) iron chelation normalized nonheme iron concentration and blocked enhanced NF-kappa B activation and TNF-alpha expression in these cells; 3) LPS-induced NF-kappa B activation was also blocked by iron chelator; 4) iron directly induced TNF-alpha expression via IKK and NF-kappa B activation in normal HM. We propose that iron acts as an independent proinflammatory molecule via induction of the intracellular signaling for NF-kappa B activation in HM and primes the liver for chronic inflammation and injury. 相似文献