Eosinophilia in newborn infants

To evaluate the clinical significance of eosinophilia in newborn infants, 261 admissions to the neonatal unit over a 12-month period were studied retrospectively; 33 babies with eosinophilia (<1.0 × 10⁹/1) were studied, Clinical and laboratory data for the first month of life were compared, where available, between gestational age-matched pairs with and without eosinophilia. Of the 33 babies with eosinophilia, 23 were < 26 weeks' gestation and all had age-matched controls; 10 were ≤26 weeks' gestation but had no appropriate gestational age-matched controls. Babies <26 weeks' gestation with eosinophilia had a significantly higher number of septic episodes than controls: 20 of 23 versus 4 of 23. All 10 babies ≤ 26 weeks' gestation with eosinophilia developed sepsis. Infections with gram-negative organisms and necrotizing enterocolitis occurred only in babies who developed eosinophilia. In 5 babies no cause for the eosinophilia was found. In conclusion, eosinophilia in the newborn is usually explainable and is most often associated with infection.     

新生儿嗜酸性粒细胞增多

目的　探讨新生儿嗜酸性粒细胞增多的原因 ,评价新生儿嗜酸性粒细胞增多的临床特征。方法　对 2 4例新生儿嗜酸性粒细胞增多患儿 ,监测血嗜酸性粒细胞计数 ,检测Ig系列 ,详细记录患儿入院后情况及患儿家属情况 ,并对所有患儿进行随访。结果　在同期住院的 10 5 2例新生儿中 ,2 4例 (2 .3% )患儿存在嗜酸性粒细胞增多。嗜酸性粒细胞轻度增高占 2 9.2 % ,中度增高 5 4 .2 % ,重度增高 16 .7%。嗜酸性粒细胞增多的时间为入院后 0～ 2 0d不等 ,其中 2 5 .0 %患儿入院当时即发现有嗜酸性粒细胞增多 ,2 9.2 %患儿为入院后 1d发现有嗜酸性粒细胞增多 ,2例化脓性脑膜炎患儿在恢复期出现嗜酸性粒细胞增多。在Ig系列中 ,IgA增高 6例 (2 5 .0 % ) ,IgE增高 2例 (8.3% )。嗜酸性粒细胞增多患儿的恢复时间为 2～ 2 1d。患儿出院后 ,对所有患儿进行随访 ,其中 3例(12 .5 % )患儿有湿疹存在。截止至随访日期 ,尚未发现有过敏及哮喘发作。结论　嗜酸性粒细胞增多在新生儿期并不少见 ,常见的原因与新生儿感染有关。     

Supraventricular tachycardia in newborn infants and infants

Four types of supraventricular tachycardia were identified in a retrospective study of 71 babies who presented under the age of 3 months. The arrhythmia originated in the atrium in the first two types (25% of cases, atrial tachycardia 10 cases, chaotic atrial tachycardia 7 cases). In the other types the arrhythmia originated at the atrioventricular node. Reciprocal rhythms were most common (62%) and those starting in the bundle of His the least common (5%). It is relatively easy to distinguish the different types which are important because treatment may vary. Overall 75% recover completely, 11% have sporadic recurrences and 10% have a chronic arrhythmia. The junctional varieties have the worst prognosis.     

Triploidy in newborn infants

Human triploidy, a common condition occurring in about 1 to 2% of all clinically recognizable pregnancies, is a rare finding in live-born children. Not more than 44 live-born triploid infants have been reported in the available literature. Triploid infants surviving for more than a few days have been suspected to be hidden mosaicisms and mostly have turned out to be diploid-triploid mosaics. We observed two live-born female infants with a complete triploidy and describe the typical clinical picture.