红细胞变形性与疾病关系研究的近况

红细胞在血液中作为氧的载体担负着对组织进行气体交换的任务。红细胞在血液流动时保持良好的变形能力对于维持血管中的正常流态，保证微循环正常灌注以及器官、组织氧和营养物质的供应是十分必要的，同时也有助于维持红细胞的正常寿命。1红细胞变形性的影响因素红细胞变形性（RCD）是指红细胞能通过比自身直径小的微血管的能力，它主要取决于3个因素：（1）红细胞内液的粘度；它主要受红细胞内平均血红蛋白浓度和血红蛋白物理化学性质的影响。当红细胞内粘度升高时，就使得红细胞膜坦克履带运动阻力增加，细胞适应流场的能力下降。因而变…     

~（60）Co－γ辐射对红细胞变形性的影响

红细胞的变形性是影响机体微循环的至关重要的因素。作者用激光衍射法测量了受６０Ｃｏ－γ射线照射小白鼠的红细胞的变形性，结果表明，受６０Ｃｏ－γ射线照射后，红细胞的变形性明显变差，且随着照射量的增加，红细胞的变形性受损更加严重。提出红细胞变形性的测量有可能成为放射病早期诊断的重要指标。     

^60Co—γ辐射对红细胞变形性的影响

红细胞的变形性是影响机体微循环的至关重要的因素。作者用激光衍射法测量了受＾６０Ｃｏ－γ射线照射小白鼠的红细胞的变形性，结果表明，受＾６０Ｃｏ－γ射线照射红细胞的变形性明显变差，且随着照射量的增加，红细胞的变形性受损更加严重，提出细胞变形性的测量有可能成为放射病早期诊断的重要指标。     

脑梗塞患者红细胞变形能力与膜磷脂组分的关系

为探讨脑梗塞患者红细胞膜磷脂各组分对红细胞变形能力的影响，采用高效液相色谱法对58例脑梗塞患者和26名健康人的红细胞膜磷脂各组分进行了测定，并同时检测了其红细胞胆固醇含量及红细胞变形能力。结果表明，脑梗塞患者红细胞膜磷脂酸胆碱（PC）、磷脂酸乙醇胺（PE）含量降低，胆固醇（CHO）含量升高，红细胞变形能力降低。直线相关分析，膜PC与红细胞滤过指数呈显著负相关。结论：脑梗塞患者红细胞膜你在以PE、PC变化为主的磷脂代谢紊乱，膜PC异常可能是影响红细胞变形能力的一个重要因素。     

红细胞变形性的影响因素

红细胞变形性的影响因素广州军区广州总医院（５１００１０）易仁亮，邹霞英红细胞在血液中作为氧的载体担负着对组织进行气体交换的任务，其直径约为８μｍ，但能通过直径为４μｍ的毛细血管腔，表明它具有良好的变形能力，红细胞变形是指它的高度柔顺性和对血流阻力的高...     

红细胞变形性对电阻法血细胞计数参数影响的探讨

近十几年来，利用电阻法血细胞自动计数仪已普及临床实验室，该仪器具有操作简单、快速、精度较好等优点，但在检测血细胞计数时，影响该仪器有关参数的因素较多，而红细胞变形性是其影响因素之一，作者探讨了红细胞变形性对电阻法测定红细胞压积与平均红细胞容积的影响，结果表明细胞变 形性不佳可导致这两项参数的结果偏高。     

红细胞的可变形性及其测量方法

红细胞的变形性是指红细胞在外力作用下采取新的形状的性能。红细胞的变形是一种重要的流变现象,也是影响血液流动性的重要因素之一。早在1675年 Leeuwenhoek 就报道过红细胞通过毛细血管时发生变形的现象。随后,大批学者做了很多试验,建立了许多测量方法,从而加深了对红细胞变形性在医学、生理学上重要性的认识。近年来,随着科学技术的发展和方法的改进,有关血液流变学和红细胞可变形性研究的论著不断增加。巳知红细胞     

中风病人红细胞变形能力与血清SOD及MDA的关系

目前在流变学中,红细胞变形指数(简称DI)的检测越来越受到临床工作者的重视,红细胞变形性是指红细胞在流动中及在外力作用下改变形状的能力,是血液流变学中主要的指标之一。近年来的研究发现影响红细胞变形性的因素较多。本文就血清SOD活力及MDA含量对红细胞变形性的影响进行探讨。1　资料与方法1.1　研究对象对照组:健康志愿者30名,体检正常,无心、脑血管疾患,无高血压、肝病、糖尿病、高脂血症。年龄21～65岁,平均43岁。中风患者组(病人组):通过CT等手段诊断为中风的患者120例,年龄36～84岁,平均60岁。1.2　仪器和方法红细胞变形指数(…     

自发性高血压大鼠与正常血压大鼠红细胞可变形性的比较

本实验用激光衍射仪研究了自发性高血压大鼠（ＳＨＲ）与正常血压大鼠（ＷＫＹ）的红在切变流场中的变形能力，发现ＳＨＲ的红细胞具正常的变形性；并且与ＷＫＹ的相比ＳＨＲ的红细胞和其膜具有更变形能力。对于ＳＨＲ红细胞可变形性的研究也许会对红细胞可变形性的内在因素有一个新的认识。     

慢性间断减压缺氧过程中大鼠红细胞变形性的动态变化

红细胞变形性是体内调节血液粘度和微循环的重要因素之一。有关高原缺氧对红细胞变形性的影响报道不多,且结果不尽一致。为此我们用激光衍射法初步观察了间断减压缺氧过程中大鼠红细胞变形性的动态变化。Wistar大鼠70只,体重180～280克,随机分为平原对照组(C组)和减压1天、3天、7天、14天、21天和     

Effects of different levels of compression during sub-maximal and high-intensity exercise on erythrocyte deformability

The aim of the study was to test the hypothesis whether different levels of sock compression (0, 10, 20, and 40 mmHg) affect erythrocyte deformability and metabolic parameters during sub-maximal and maximal running. Nine well-trained, male endurance athletes (age 22.2 ± 1.3 years, peak oxygen uptake 57.7 ± 4.5 mL min(-1) kg(-1)) carried out four periods of sub-maximal running at 70% of peak oxygen uptake for 30 min followed by a ramp test until exhaustion with and without compression socks that applied different levels of pressure. Erythrocyte deformability, blood lactate, heart rate and arterial partial pressure of oxygen (pO(2)) were monitored before and during all of these tests. Erythrocyte deformability, heart rate, pO(2) and lactate concentration were unaffected by compression, whereas exercise itself significantly increased erythrocyte deformability. However, the increasing effects of exercise were attenuated when high compression was applied. This first evaluation of the potential effects of increasing levels of compression on erythrocyte deformability and metabolic parameters during (sub-) maximal exercise, revealed no effects whatsoever.     

Reduction of Erythrocyte Deformability in Rats with Cerebral Ischemia

Erythrocyte deformability was studied by laser interferometry in rats with cerebral ischemia. Ninety minutes after ligation of both common carotid arteries the erythrocyte deformability coefficient decreased by 11+/-2% in experimental group in comparison with the baseline level and by 12% in comparison with sham-operated animals and remained 16% decreased after 4 days.     

Effect of excess sodium bicarbonate on the blood volume and erythrocyte deformability of broiler chickens

Broiler chickens were treated with 7.5% of sodium bicarbonate in their drinking water from 7 to 29 days of age to test the hypothesis that excess dietary sodium bicarbonate increases blood volume and decreases erythrocyte deformability thus contributing to the development of pulmonary hypertension-induced right ventricular failure and ascites. Sodium bicarbonate treatment resulted in 16% mortality from ascites compared to 2% mortality from sudden death syndrome in control broilers. Blood volume was increased significantly at post-treatment days 1 (16%) and 3 (11%) and was higher in treated broilers for the remainder of the experiment. Erythrocyte deformability was significantly decreased at post-treatment days 2 (16%) and 4 (33%). Erythrocyte number, haemoglobin and haematocrit were lower at post-treatment days 1 and 2. After this time, these values were higher than in control broilers. Serum Na (+) concentration was significantly higher at post-treatment days 2 and 4. Right ventricle to total ventricular weight (an indication of pulmonary hypertension) was increased significantly at post-treatment days 1, 2, 21 and 22. These results indicate that reduction of erythrocyte deformability and increased blood volume may contribute to the development of pulmonary hypertension-induced right ventricular failure and ascites in sodium bicarbonate-treated birds.     

Age-dependent differences in cation-osmotic haemolysis in rats

Erythrocyte microrheology changes were measured by cation-osmotic hemolysis (COH) in rats of different age groups (3, 12 and 24 months). COH in 12-month-old rats was significantly lower in low ionic strength media (spectrin skeleton) in comparison with 3-month-old rats. This decrease was much more pronounced in 24-month-old animals, in which a significant decrease in COH in incubating media with higher ionic strength was also observed. The relationship between COH and eryhtrocyte deformability is also discussed. We suggest that changes in biophysical state of spectrin skeleton are followed by changes in lipid bilayer properties.     

轻度烧伤后红细胞流变学特性的变化

我们用轻度烧伤动物模型研究了烧伤后红细胞（RBC）变形性及渗透脆性的变化。结果发现,轻度烧伤后红细胞变形性随时间有一先抑后扬的变化趋势。烧伤后立即取血（0h）所测结果与烧伤前比较,RBC最大变形指数(DI)max、积分变形指数IDI及红细胞渗透脆性都未见显著性差异;烧伤后1、2h时(DI)max、IDI显著降低（P<0.01或P<0.05）;4、7h时(DI)max、IDI虽略低于烧伤前水平,但未见显著性差异（P>0.05）。烧伤后不同时间点（0、1、2、4、7h）所取血样的RBC渗透脆性与烧伤前比较,除在烧伤后4h时显著增加外,在其余各时间点均未见显著变化。说明在用该动物模型所得结果中,(DI)max、IDI的受损及RBC渗透脆性的增加,可能都只与体液因素的作用有关。但RBC变形性的受损与其渗透脆性的变化不是同步的,说明可能存在着不同的损伤机制。     

Cation-osmotic haemolysis in stroke patients

Erythrocyte microrheology changes were measured by cation-osmotic haemolysis (COH) in healthy donors, patients with ischameic stroke, and patients who died within four days after a stroke. COH in patients with stroke was significantly decreased in comparison with that from healthy donors. In patients who died, COH was significantly decreased compared to patients who survived. The relationship between cationosmotic haemolysis and erythrocyte deformability is discussed.     

Cation-osmotic haemolysis in stroke patients

Erythrocyte microrheology changes were measured by cation-osmotic haemolysis (COH) in healthy donors, patients with ischameic stroke, and patients who died within four days after a stroke. COH in patients with stroke was significantly decreased in comparison with that from healthy donors. In patients who died, COH was significantly decreased compared to patients who survived. The relationship between cationosmotic haemolysis and erythrocyte deformability is discussed.     

Évaluation de la déformabilité érythrocytaire des sujets porteurs de trait drépanocytaire au cours d’un match de football : effet de l’hydratation ad libitum

This study compared erythrocyte changes between a group of subjects with sickle cell trait (SCT) and controls (subjects without hemoglobinopathy) during a soccer game in two conditions: with and without hydration. Erythrocyte deformability of subjects was assessed by the coefficient of erythrocyte rigidity (Tk) which was calculated before and after football match. Our results showed a significant increase in erythrocyte rigidity (Tk) in SCT at the end of physical activities without hydration; however when water was provided ad libitum their Tk decreased significantly, reaching values of controls. And adequate hydration is recommended in subjects with sickle cell trait during and after exercise.     

用电阻抗法研究红细胞的松弛过程

提出用“红细胞流变特性测定义”测量红细胞在中粘悬浮介质中的松弛过程。并从Ｆｒｉｃｋｅ－Ｖｅｌｉｃｋ悬浮液电导理论出发，对该方法测量结果进行了理论探讨，证明所测得的ΔＲ／Ｒ０－ｔ曲线确能间接反映红细胞群体的变形性及变形后的粘弹性。