Brain systems for visual perspective taking and action perception

Taking another person's viewpoint and making sense of their actions are key processes that guide social behavior. Previous neuroimaging investigations have largely studied these processes separately. The current study used functional magnetic resonance imaging to examine how the brain incorporates another person's viewpoint and actions into visual perspective judgments. Participants made a left–right judgment about the location of a target object from their own (egocentric) or an actor's visual perspective (altercentric). Actor location varied around a table and the actor was either reaching or not reaching for the target object. Analyses examined brain regions engaged in the egocentric and altercentric tasks, brain regions where response magnitude tracked the orientation of the actor in the scene and brain regions sensitive to the action performed by the actor. The blood oxygen level-dependent (BOLD) response in dorsomedial prefrontal cortex (dmPFC) was sensitive to actor orientation in the altercentric task, whereas the response in right inferior frontal gyrus (IFG) was sensitive to actor orientation in the egocentric task. Thus, dmPFC and right IFG may play distinct but complementary roles in visual perspective taking (VPT). Observation of a reaching actor compared to a non-reaching actor yielded activation in lateral occipitotemporal cortex, regardless of task, showing that these regions are sensitive to body posture independent of social context. By considering how an observed actor's location and action influence the neural bases of visual perspective judgments, the current study supports the view that multiple neurocognitive “routes” operate during VPT.     

Differential involvement of the posterior temporal cortex in mentalizing but not perspective taking

Understanding and predicting other people''s mental states and behavior are important prerequisites for social interactions. The capacity to attribute mental states such as desires, thoughts or intentions to oneself or others is referred to as mentalizing. The right posterior temporal cortex at the temporal–parietal junction has been associated with mentalizing but also with taking someone else''s spatial perspective onto the world—possibly an important prerequisite for mentalizing. Here, we directly compared the neural correlates of mentalizing and perspective taking using the same stimulus material. We found significantly increased neural activity in the right posterior segment of the superior temporal sulcus only during mentalizing but not perspective taking. Our data further clarify the role of the posterior temporal cortex in social cognition by showing that it is involved in processing information from socially salient visual cues in situations that require the inference about other people''s mental states.     

The role of the right temporo–parietal junction in social decision‐making

Identifying someone else's noncooperative intentions can prevent exploitation in social interactions. Hence, the inference of another person's mental state might be most pronounced in order to improve social decision‐making. Here, we tested the hypothesis that brain regions associated with Theory of Mind (ToM), particularly the right temporo–parietal junction (rTPJ), show higher neural responses when interacting with a selfish person and that the rTPJ‐activity as well as cooperative tendencies will change over time. We used functional magnetic resonance imaging (fMRI) and a modified prisoner's dilemma game in which 20 participants interacted with three fictive playing partners who behaved according to stable strategies either competitively, cooperatively or randomly during seven interaction blocks. The rTPJ and the posterior–medial prefrontal cortex showed higher activity during the interaction with a competitive compared with a cooperative playing partner. Only the rTPJ showed a high response during an early interaction phase, which preceded participants increase in defective decisions. Enhanced functional connectivity between the rTPJ and the left hippocampus suggests that social cognition and learning processes co‐occur when behavioral adaptation seems beneficial.     

Seeing your own or someone else's hand moving in accordance with your action: The neural interaction of agency and hand identity

Forward models can predict sensory consequences of self‐action, which is reflected by less neural processing for actively than passively generated sensory inputs (BOLD suppression effect). However, it remains open whether forward models take the identity of a moving body part into account when predicting the sensory consequences of an action. In the current study, fMRI was used to investigate the neural correlates of active and passive hand movements during which participants saw either an on‐line display of their own hand or someone else's hand moving in accordance with their movement. Participants had to detect delays (0–417 ms) between their movement and the displays. Analyses revealed reduced activation in sensory areas and higher delay detection thresholds for active versus passive movements. Furthermore, there was increased activation in the hippocampus, the amygdala, and the middle temporal gyrus when someone else's hand was seen. Most importantly, in posterior parietal (angular gyrus and precuneus), frontal (middle, superior, and medial frontal gyrus), and temporal (middle temporal gyrus) regions, suppression for actively versus passively generated feedback was stronger when participants were viewing their own compared to someone else's hand. Our results suggest that forward models can take hand identity into account when predicting sensory action consequences.     

The audience effect in adolescence depends on who's looking over your shoulder

Adolescents have been shown to be particularly sensitive to peer influence. However, the data supporting these findings have been mostly limited to the impact of peers on risk-taking behaviours. Here, we investigated the influence of peers on performance of a high-level cognitive task (relational reasoning) during adolescence. We further assessed whether this effect on performance was dependent on the identity of the audience, either a friend (peer) or the experimenter (non-peer). We tested 24 younger adolescent (10.6–14.2 years), 20 older adolescent (14.9–17.8 years) and 20 adult (21.8–34.9 years) female participants. The presence of an audience affected adolescent, but not adult, relational reasoning performance. This audience effect on adolescent performance was influenced by the participants' age, task difficulty and the identity of the audience. These findings may have implications for education, where adolescents often do classwork or homework in the presence of others.     

The quality of adolescents’ peer relationships modulates neural sensitivity to risk taking

Adolescents'' peer culture plays a key role in the development and maintenance of risk-taking behavior. Despite recent advances in developmental neuroscience suggesting that peers may increase neural sensitivity to rewards, we know relatively little about how the quality of peer relations impact adolescent risk taking. In the current 2-year three-wave longitudinal study, we examined how chronic levels of peer conflict relate to risk taking behaviorally and neurally, and whether this is modified by high-quality peer relationships. Forty-six adolescents completed daily diaries assessing peer conflict across 2 years as well as a measure of peer support. During a functional brain scan, adolescents completed a risk-taking task. Behaviorally, peer conflict was associated with greater risk-taking behavior, especially for adolescents reporting low peer support. High levels of peer support buffered this association. At the neural level, peer conflict was associated with greater activation in the striatum and insula, especially among adolescents reporting low peer support, whereas this association was buffered for adolescents reporting high peer support. Results are consistent with the stress-buffering model of social relationships and underscore the importance of the quality of adolescents’ peer relationships for their risk taking.     

Substance Abuse in an Adolescent Boy: Waking the Object

The analysis of an adolescent boy abusing alcohol, marijuana, and other drugs is used to discuss unconscious object relationships that can underlie substance dependence. Differentiating experimental from dangerous substance use is particularly challenging in the treatment of adolescents. The boy's escalating substance use is viewed both as an effort to numb himself and to “speak” through symptoms of problems he could not yet name. I utilize Rosenfeld's (1960/1966) view of the relationship of drug addiction to an identification with an ill or dead object to explicate the boy's psychodynamics. In this case, my patient was identified with both an ill mother and a neglectful father. Aspects of containment by the analyst that contribute in different ways to an adolescent's capacity to think about their self-destructiveness are discussed, along with the need for confrontation and the meaning of ancillary care when an adolescent's substance abuse become life threatening.     

In your place: neuropsychological evidence for altercentric remapping in embodied perspective taking

Humans are able to mentally adopt the spatial perspective of others and represent the visual world from their point of view. Here, we present neuropsychological evidence that information inaccessible from an egocentric perspective can be accessed from the perspective of another person. Patients affected by left neglect were asked to describe arrays of objects from their own egocentric perspective, from an opposite perspective (disembodied perspective taking), and from the point of view of another person actually seated in front of them (embodied perspective taking). Although disembodied perspective-taking ameliorated neglect severity, there was an even stronger positive effect of embodied perspective-taking: items presented on the left and neglected when reported from the egocentric perspective were instead recovered when patients assumed the perspective of the other. These findings suggest that perspective-taking entails an altercentric remapping of space, i.e. remapping of objects and locations coded with reference to the other person''s body.     

But do you think I’m cool?: Developmental differences in striatal recruitment during direct and reflected social self-evaluations

The current fMRI study investigates the neural foundations of evaluating oneself and others during early adolescence and young adulthood. Eighteen early adolescents (ages 11–14, M = 12.6) and 19 young adults (ages 22–31, M = 25.6) evaluated whether academic, physical, and social traits described themselves directly (direct self-evaluations), described their best friend directly (direct other-evaluations), described themselves from their best friend's perspective (reflected self-evaluations), or in general could change over time (control malleability-evaluations). Compared to control evaluations, both adolescents and adults recruited cortical midline structures during direct and reflected self-evaluations, as well as during direct other-evaluations, converging with previous research. However, unique to this study was a significant three-way interaction between age group, evaluative perspective, and domain within bilateral ventral striatum. Region of interest analyses demonstrated a significant evaluative perspective by domain interaction within the adolescent sample only. Adolescents recruited greatest bilateral ventral striatum during reflected social self-evaluations, which was positively correlated with age and pubertal development. These findings suggest that reflected social self-evaluations, made from the inferred perspective of a close peer, may be especially self-relevant, salient, or rewarding to adolescent self-processing – particularly during the progression through adolescence – and this feature persists into adulthood.     

When gaze turns into grasp

Previous research has provided evidence for a neural system underlying the observation of another person's hand actions. Is the neural system involved in this capacity also important in inferring another person's motor intentions toward an object from their eye gaze? In real-life situations, humans use eye movements to catch and direct the attention of others, often without any accompanying hand movements or speech. In an event-related functional magnetic resonance imaging study, subjects observed videos showing a human model either grasping a target object (grasping condition) or simply gazing (gaze condition) at the same object. These two conditions were contrasted with each other and against a control condition in which the human model was standing behind the object without performing any gazing or grasping action. The results revealed activations within the dorsal premotor cortex, the inferior frontal gyrus, the inferior parietal lobule, and the superior temporal sulcus in both "grasping" and "gaze" conditions. These findings suggest that signaling the presence of an object through gaze elicits in an observer a similar neural response to that elicited by the observation of a reach-to-grasp action performed on the same object.     

Identifying sensitive periods when changes in parenting and peer factors are associated with changes in adolescent alcohol and marijuana use

Purpose

There are well-established associations between parental/peer relationships and adolescent substance use, but few longitudinal studies have examined whether adolescents change their substance use in response to changes in their parents’ behavior or peer networks. We employ a within-person change approach to address two key questions: Are changes in parenting and peer factors associated with changes in adolescent marijuana and alcohol use? Are there sensitive periods when changes in parenting and peer factors are more strongly associated with changes in adolescent marijuana and alcohol use?

Methods

We analyzed longitudinal data collected annually on 503 boys, ages 13–19, recruited from Pittsburgh public schools. Questionnaires regarding parental supervision, negative parenting practices, parental stress, physical punishment, peer delinquency, and peer drug use were administered to adolescents and their caretakers. Alcohol and marijuana use were assessed by a substance use scale adapted from the National Youth Survey.

Results

Reductions in parental supervision and increases in peer drug use and peer delinquency were associated with increases in marijuana frequency, alcohol frequency, and alcohol quantity. Increases in parental stress were associated with increases in marijuana and alcohol frequency. The magnitudes of these relationships were strongest at ages 14–15 and systematically decreased across adolescence. These associations were not due to unmeasured stable confounders or measured time-varying confounders.

Conclusions

Reducing or mitigating changes in parenting and peer risk factors in early adolescence may be particularly important for preventing substance use problems as adolescents transition into young adulthood.

     

Development and implementation of a peer-based mental health support programme for adolescents orphaned by HIV/AIDS in South Africa

Aim: The article describes a framework and the process for the development of the peer-based mental health support programme and its implementation. The development of a peer-based mental health support programme is based on Erikson's theory on the adolescent phase of development, the psycho-educational processes; the peer approach and the orphaned adolescents lived experiences as conceptual framework.

Methods: A triangulation of five qualitative methods of photography, reflective diaries, focus groups, event history calendar and field notes were used to capture the lived experiences of adolescents orphaned to HIV and AIDS. Analysis of data followed Colaizzi's method of data analysis.

Results: The combination of psycho-education, Erikson's stages of development and peer support assisted the participants to gain knowledge and skills to overcome adversity and to assist them to become to more resilient.

Conclusion: The peer based mental health support programme if used would enhance the mental health of adolescent orphans.     

The organization of the posterior parietal cortex devoted to upper limb actions: An fMRI study

The present fMRI study examined whether upper‐limb action classes differing in their motor goal are encoded by different PPC sectors. Action observation was used as a proxy for action execution. Subjects viewed actors performing object‐related (e.g., grasping), skin‐displacing (e.g., rubbing the skin), and interpersonal upper limb actions (e.g., pushing someone). Observation of the three action classes activated a three‐level network including occipito‐temporal, parietal, and premotor cortex. The parietal region common to observing all three action classes was located dorsally to the left intraparietal sulcus (DIPSM/DIPSA border). Regions specific for observing an action class were obtained by combining the interaction between observing action classes and stimulus types with exclusive masking for observing the other classes, while for regions considered preferentially active for a class the interaction was exclusively masked with the regions common to all observed actions. Left putative human anterior intraparietal was specific for observing manipulative actions, and left parietal operculum including putative human SII region, specific for observing skin‐displacing actions. Control experiments demonstrated that this latter activation depended on seeing the skin being moved and not simply on seeing touch. Psychophysiological interactions showed that the two specific parietal regions had similar connectivities. Finally, observing interpersonal actions preferentially activated a dorsal sector of left DIPSA, possibly the homologue of ventral intraparietal coding the impingement of the target person's body into the peripersonal space of the actor. These results support the importance of segregation according to the action class as principle of posterior parietal cortex organization for action observation and by implication for action execution. Hum Brain Mapp 36:3845–3866, 2015. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.     

Brain responses reveal young infants’ sensitivity to when a social partner follows their gaze

Infants’ ability to follow another person's eye gaze has been studied extensively and is considered to be an important and early emerging social cognitive skill. However, it is not known whether young infants detect when a social partner follows their gaze to an object. This sensitivity might help infants in soliciting information from others and serve as an important basis for social learning. In this study, we used functional near-infrared spectroscopy (fNIRS) to measure 5-month-old infants’ frontal and temporal cortex responses during social interactions in which a social partner (virtual agent) either followed the infants’ gaze to an object (congruent condition) or looked to an object that the infant had not looked at before (incongruent condition). The fNIRS data revealed that a region in the left prefrontal cortex showed an increased response when compared to baseline during the congruent condition but not during the incongruent condition, suggesting that infants are sensitive to when someone follows their gaze. The findings and their implications for the development of early social cognition are discussed in relation to what is known about the brain processes engaged by adults during these kinds of social interactions.     

Sexual acting out as an abortive mourning process in female adolescent inpatients

The development of psychologically healthy means for coping with sexuality is particularly difficult for disturbed adolescents who need residential treatment. One of the clearly definable psychodynamic constellations that underlie sexual acting-out—an abortive mourning process in response to separations or losses suffered by female adolescent inpatients—is discussed. John Bowlby's theory of the mourning process is emphasized in understanding the immediate reaction to loss. Case material is presented in support of the hypothesis that with some disturbed female adolescents, heterosexual acting-out wards off a regressive wish, kindled by object loss, to reunite symbiotically with the preoedipal mother. Suggestions are given for milieu management and psychotherapy in such cases.     

Thinking about the past,present and future in adolescents growing up in Children's Homes

The present study tested the hypothesis that adolescents growing up in Children's Homes differ from adolescents growing up in a family environment in how they think about their past, present and future, in the way they make decisions about future events and rewards, and in their levels of empathy and perspective taking. The participants were 40 adolescents from Children's Homes in Budapest, Hungary, and 40 age- and gender-matched controls. Group differences were found in participants' past and present time perspectives, and girls from Children's Homes showed reduced consistency in their plans for the future. Additionally, gender differences emerged in empathy, perspective taking, and in participants' present and future time perspectives. We discuss the implications of our findings for interventions to improve the future prospects of adolescents in Children's Homes.     

Neurochemical effects of cocaine in adolescence compared to adulthood

Adolescence is a time of high risk behavior and increased exploration. This developmental period is marked by a greater probability to initiate drug use and is associated with an increased risk to develop addiction and adulthood dependency. Human adolescents are predisposed toward an increased likelihood of risk taking behaviors [M. Zuckerman, Sensation-seeking and the endogenous deficit theory of drug abuse. NIDA Res Monogr. 74 (1986) 59-70.], including drug use or initiation. In the present study, adolescent and adult animals were first tested on several behavioral measures (novel environment exploratory behavior, novel object preference, novelty-induced impulsivity and novelty-induced exploration) which were used to categorize them as high- (HR) or low-responders (LR). The purpose of the present study was to characterize the neurochemical responsivity of the nucleus accumbens septi (NAcc) in HR and LR adolescent and adult animals in response to a systemic challenge of cocaine. Regardless of age, animals that were more reactive when placed in a novel environment had greater cocaine-induced increases in dopamine (DA). Several important and complex neurochemical differences existed between adolescent and adult animals. Adolescent animals that rapidly approached the novel object (i.e., HR) were the only group to show greater cocaine-induced responsivity. However, adult animals that spent less time near the novel object (i.e., LR) were the only group to have greater cocaine-induced responsivity. Adolescent animals that approached a novel object faster (HR) showed an increased dopaminergic (DAergic) response to an acute cocaine challenge. In contrast, adolescent animals that spent less time with the novel object had an increased cocaine-induced DAergic response compared to HR adults. Adults that approached the object less had a greater cocaine-induced DA response relative to HR adults. Finally, cocaine yielded a greater DA response in adolescent animals that showed a high novelty-induced exploration and impulsivity response, whereas the opposite was true for adults. The differences in response to cocaine between ages and groups are likely due to ontogenetic differences in brain regions that are involved in reward and/or stress responsivity.     

The role of intergenerational similarity and parenting in adolescent self-criticism: An actor–partner interdependence model

Research investigating the development of adolescent self-criticism has typically focused on the role of either parental self-criticism or parenting. This study used an actor–partner interdependence model to examine an integrated theoretical model in which achievement-oriented psychological control has an intervening role in the relation between parental and adolescent self-criticism. Additionally, the relative contribution of both parents and the moderating role of adolescent gender were examined. Participants were 284 adolescents (M = 14 years, range = 12–16 years) and their parents (M = 46 years, range = 32–63 years). Results showed that only maternal self-criticism was directly related to adolescent self-criticism. However, both parents' achievement-oriented psychological control had an intervening role in the relation between parent and adolescent self-criticism in both boys and girls. Moreover, one parent's achievement-oriented psychological control was not predicted by the self-criticism of the other parent.     

Sensitivity of alpha and beta oscillations to sensorimotor characteristics of action: An EEG study of action production and gesture observation

The sensorimotor experiences we gain when performing an action have been found to influence how our own motor systems are activated when we observe others performing that same action. Here we asked whether this phenomenon applies to the observation of gesture. Would the sensorimotor experiences we gain when performing an action on an object influence activation in our own motor systems when we observe others performing a gesture for that object? Participants were given sensorimotor experience with objects that varied in weight, and then observed video clips of an actor producing gestures for those objects. Electroencephalography (EEG) was recorded while participants first observed either an iconic gesture (pantomiming lifting an object) or a deictic gesture (pointing to an object) for an object, and then grasped and lifted the object indicated by the gesture. We analyzed EEG during gesture observation to determine whether oscillatory activity was affected by the observer's sensorimotor experiences with the object represented in the gesture. Seeing a gesture for an object previously experienced as light was associated with a suppression of power in alpha and beta frequency bands, particularly at posterior electrodes. A similar pattern was found when participants lifted the light object, but over more diffuse electrodes. Moreover, alpha and beta bands at right parieto-occipital electrodes were sensitive to the type of gesture observed (iconic vs. deictic). These results demonstrate that sensorimotor experience with an object affects how a gesture for that object is processed, as measured by the gesture-observer's EEG, and suggest that different types of gestures recruit the observer's own motor system in different ways.     

Validity of the Brief Dyadic Scale of Expressed Emotion in Adolescents

PurposePerceived expressed emotion is a valuable predictor of clinical outcome in psychiatric and community samples, but its assessment is limited to few instruments. A recent development to briefly assess expressed emotion from the patient's perspective is the 14-item Brief Dyadic Scale of Expressed Emotion (BDSEE). Although psychometric properties of the BDSEE have been provided for adult eating disorders, validity for adolescents is still lacking. In this study, BDSEE's factorial, convergent, and divergent validity was tested in an adolescent sample with binge-eating disorder and a matched community sample.MethodsFor validation, well-established self- and mother-report questionnaires and adolescent's Five Minute Speech Sample were used.ResultsConfirmatory factor analysis on the German BDSEE replicated the proposed three-factor structure in adolescents. BDSEE's convergent validity with the Five Minute Speech Sample and construct-related questionnaires was shown. Divergent validity was documented with BDSEE subscales being unrelated to socio-demographic and clinical characteristics. Further, BDSEE subscales were unrelated to measures of maternal distress.ConclusionsWhile the results underline that the BDSEE is a valid self-report measure for assessing perceived expressed emotion in adolescents with and without binge-eating disorder, the evaluation of its predictive validity is still in need.