实验动物动脉粥样硬化模型的建立及评价

动脉粥样硬化（atherosclerosis,AS）是冠心病的基本病理基础,但AS的发病机制仍不明确,因此建立一种脂质代谢和斑块与人类相似的实验性AS整体动物模型是评价抗AS药物的关键。据报道不同种的动物主动脉胆固醇酯酶活性不同,本文就各种实验动物动脉粥样硬化模型建立的情况进行综述。     

运动对动脉粥样硬化的影响研究

动脉粥样硬化(AS)已成为危害人类健康的主要疾病,运动作为一种经济、安全、有效的防治手段,可以从改善血脂水平、提高机体抗氧化能力、维护内皮细胞完整、提高机体抗炎能力、以及降低血液粘度和血流阻力,防止血栓形成等方面起到抗AS的作用。     

高血压患者动脉粥样硬化相关因素分析

动脉粥样硬化(Atherosclerosis,AS)性疾病已成为人类的第一杀手.传统的AS疾病危险因素有高血压、糖尿病、高脂血症、吸烟等.而目前认为AS又是一种慢性炎症性、全身性自身免疫性疾病.炎症和免疫功能异常同样是其发病的重要因索[1].     

瘦素与动脉粥样硬化的相关性研究现状

瘦素是近年来研究较多的蛋白质激素,与多种影响动脉粥样硬化的因子有着密切的关系,瘦素可降低动脉保护因子载脂蛋白M和脂联素水平,也可以诱导或者加剧致动脉粥样硬化(Atherosclerosis,AS)因子的表达,且瘦素本身也有促AS的作用,在AS的发生发展中起着重要的作用。     

蛋白质组学在动脉粥样硬化研究中的进展

动脉粥样硬化(atherosclerosis,AS)是心血管系统中最常见的严重危害人类健康的一类疾病。该病主要侵犯大、中动脉,导致心、脑等重要器官的供血不足或中断而产生致命性创伤。利用蛋白质组学技术和方法研究AS的组织细胞蛋白质组与正常组织细胞蛋白质组的差异表达及药物预防与治疗     

动脉粥样硬化的发病机制

动脉粥样硬化(atherosclerosis,AS)是血管病中的常见疾病,其发病率和致死率较高,严重影响人类健康。动脉粥样硬化的发病机制临床上尚不明确,但多年来,各国病理学家纷纷提出发病机制的假说,本文对各假说进行了分析,以探讨AS的发病机制。     

兔动脉粥样硬化的动物模型研究

血脂代谢异常与动脉粥样硬化(AS)的发生和发展有密切的关系,同时动脉粥样硬化的发生和发展的各个方面亟待人类不断地研究与阐明。因此,提供大量易得廉价的动脉粥样硬化动物模型就显得特别重要,它为动脉粥样硬化的研究创造了一个良好的技术平台。     

通脉胶囊对动脉粥样硬化斑块稳定性影响的实验研究

目的:通过分析基质金属蛋白酶-2(MMP-2)及其组织抑制因子(TIMP-2)在动脉粥样硬化(AS)斑块组织中的表达,了解通脉胶囊(当归、川芎、丹参、黄芪、党参等)对动脉粥样硬化(AS)斑块稳定性的作用.方法:复制实验性家兔AS模型,实验结果后,取主动脉行组织形态学观察及斑块组织MMP-2、TIMP-2免疫组织化学分析.结果:模型对照组MMP-2、TIMP-2表达明显高于正常对照组,但通脉胶囊组与模型对照组无明显差异(P＞0.05),通脉胶囊对AS斑块稳定性的作用与MMP-2、TIMP-2无必然联系.     

三七、黄芪有效成分配伍基于NF-κB信号通路防治动脉粥样硬化的研究进展

心血管疾病是当今引起人类死亡的主要病因,动脉粥样硬化（atherosclerosis,AS）是导致疾病发生的病理基础。NF-κB作为炎症反应中重要的核转录因子,参与AS形成过程中的多个环节。近年来,中医药在AS的防治上取得了一定成效。本文主要就三七、黄芪有效成分及其配伍基于NF-κB通路抗AS的研究现状作一综述。     

自拟降脂汤治疗高脂血症51例临床研究

脂质过氧化损伤是致动脉粥样硬化（AS）的重要因素,抗氧化治疗能明显地抑制动脉粥样硬化的形成。现代医学在降脂及抗AS方面确有良药,但长期应用多有不良反应而且价格昂贵。为寻求具有良好降脂作用兼抗氧化作用的药物,我们自拟降脂汤对血脂、LPO的影响,报告如下：     

脂血对PT、APTT、Fbg和TT结果测定的影响探讨

目的：探讨脂血对PT、APTT、Fbg和TT结果测定的影响。方法：收集住院患者标本100例,进行PT、APTT、TT和Fbg测定。结果：脂血组与脂血重抽复测组（非脂血组）PT、APTT、TT、Fbg测定结果的差异具有统计学意义（P〈0．05）。结论：临床检测中标本脂血对凝血结果的检测均有干扰,建议患者空腹12h后重抽复测。     

Effect of Spirulina maxima on postprandial lipemia in young runners: a preliminary report

Trained people exhibit low plasma concentrations of triacylglcyerols in both fasting and postprandial states. Exercise practice is commonly believed to improve postprandial lipemia. In addition, elevated postprandial lipemia is an indicator of poor lipid clearance, and it has been associated with atherosclerosis, insulin resistance, and obesity. Spirulina maxima is an edible microorganism with a high nutritional value. When it is consumed, beneficial properties to health have been demonstrated, such as hypolipemic and antihypertensive properties in human beings. This work evaluates the effects of orally administrated S. maxima on postprandial lipemia in a young Mexican sporting population after 15 days of consumption, as a possible alternative treatment to improve their lipid clearance. Forty-one runners (10-26 years old; 21 men and 20 women) volunteered to participate in the study. All of them were physically active for at least 1 year before the study and were not undergoing training during the study. The subjects consumed 5 g of Spirulina during 15 days. Before and after the treatment with Spirulina, they consumed (12 h fasting) a standardized meal with high fat content (53.2% total calories). Postprandial lipemia was measured at 1.5, 3, and 4.5 h after the fatty meal. Fasting plasma triacylglycerol (TAG) concentrations were lower after Spirulina treatment than before treatment. In addition, the postprandial area under the curve of TAG concentrations was lower after the treatment with Spirulina. Sixty-two percent of the youngest runners (10-16 years) studied exhibited the best response to the treatment. Orally administered S. maxima decreased postprandial lipemia in sporting teenagers. The youngest people were the most responsive to the beneficial effects of Spirulina on postprandial lipemia.     

绝经期女性激素水平与动脉粥样硬化的关系

目的 研究绝经期女性激素水平与动脉粥样硬化(AS)的关系.方法 纳入2018年1月-2019年4月于银川市中医医院心血管内科住院的接受冠脉造影的绝经女性142例为研究对象,均行性激素水平检测,包括雌二醇(E2)、睾酮(T)、促卵泡生成素(FSH)、促黄体生成素(LH)水平及E2/T值.所有患者均接受冠脉造影,根据冠脉造...     

Evaluation of immune responses elicited in mice against a recombinant malaria vaccine based on Plasmodium vivax Duffy binding protein

Plasmodium vivax Duffy binding protein (PvDBP) binds the Duffy blood group antigen as the obligate receptor for erythrocyte invasion. We have tested in mice the immunogenicity of recombinant P. vivax region II (PvRII), the receptor-binding domain of PvDBP, formulated with five adjuvants, namely, Montanide ISA720, AS02A, alum, QS21 and MF59. All the formulations elicited high titer antibodies, with Montanide ISA720 and AS02A yielding the highest titers followed by MF59, QS21 and alum. Sera raised against PvRII formulated with AS02A and Montanide ISA720 followed by alum were most effective at blocking PvRII binding to erythrocytes in a functional assay. Analysis of cellular immune responses indicated that all adjuvant groups induced significant interferon-gamma, with alum being the highest interferon-gamma inducer. These results suggest that recombinant PvRII formulated with human compatible adjuvants is immunogenic in small animal models and that Montanide ISA720, AS02A and alum perform better than MF59 and QS21 in terms of their ability to elicit high titer binding inhibitory antibodies.     

某高校13年来高血压、高脂血症与糖尿病的流行趋势及其相关性调查

目的了解高校高血压的人群患病率、高血压脂代谢异常与发生糖尿病的关系。方法通过回顾性调查自1989年以来记录的高血压、糖尿病防治情况及历年全院健康体检记录的血脂检查情况进行统计分析。结果我院高血压的患病率由1991年的10·74%升至2003年的14·68%(P<0·05);≥60岁人群的患病率由1991年的28·58%升至2003年的40·14%(P<0·05),且各年份≥60岁人群的患病率均明显高于全院教职工总的患病率(P<0·01),≥60岁的高血压患者占病人总数的比例由1991年的57·58%升至2003年的73·50%(P<0·05);糖尿病患者51·36%同时有高血压;高血压伴血脂异常和糖尿病者为18·56%。结论高校教职工特别是≥60岁人群高血压患病率有逐年增高的趋势,高血压并血脂异常及糖尿病的可能原因为胰岛素抵抗及高胰岛素血症。在降压治疗的同时应注意调脂治疗并预防高血压并发糖尿病的发生。     

Growth of bacteria in blood: Use of cation exchange resins for enhancing or suppressing growth*

It has been demonstrated experimentally that small numbers of a variety of different bacteria fail to survive or multiply in normal cow or human blood or in a mixture of blood and a suitable culture medium, owing to the binding of the magnesium ion and a protein component of the antimicrobial system. However, a satisfactory and simple method has now been evolved for the rapid multiplication of Gram-negative and Gram-positive bacteria in blood without the addition of a liquid culture medium. This method involves the addition to blood of optimum amounts of hydrogen and magnesium ion exchange resins and sodium citrate.     

具有红外线热扫描功能的人体表层血管显示仪的研制

目的:研制一种具有红外线热扫描功能的人体表层血管显示仪。方法:仪器设计有红外线热扫描功能的检测探头,探头对准人体表层皮肤后,其感光元件能感应人体表层皮肤和表层皮肤下的血管所辐射的红外线,进而将被测患者血管的静态分布图显示出来。结果:医生根据显示的血管分布图,可以快速地判定患者血管状况,实时准确地进行插管输液等必要的处理,该仪器是一种便携式诊疗工具。结论:该设备能便携、快速和准确地显示人体表层血管静态分布图,能帮助医护人员进行抢救、插管输液等医疗操作,安全、快捷、简单,值得推广应用。     

大豆纤维对实验性高脂大鼠动脉粥样硬化的预防作用和抗氧化效果

研究大豆纤维（ＳＦ）对实验性高脂大鼠的血液和肝组织脂质过氧化物（ＬＰＯ）水平、谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性和血脂指标的影响。结果表明，大豆纤维膳能明显降低血清总胆固醇（ＴＣ）、低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）和致动脉粥样硬化指数（ＡＩ）（Ｐ＜０．０５）。血清和肝组织ＬＰＯ水平明显下降，ＧＳＨ－Ｐｘ活力显著提高（Ｐ＜０．０５）．ＳＦ对血脂降低和对氧化低密度脂蛋白（Ｏｘ－ＬＤＬ）的阻断作用可能对防止动脉粥样硬化（ＡＳ）的形成起主要作用。     

肥胖症患者血脂和微量元素水平及其临床意义

我们抽样检测了我国肥胖病患者血脂、微量元素及血压。结果发现肥胖症患者血压、血糖、低密度脂蛋白、极低密度脂蛋白、载脂蛋白Ｂ，血清锌、铁、钠、钙、镁及锌／铜、钠／钾比值明显高于正常组，而高密度脂蛋白及钙／镁比值明显低于正常组。结合本研究的结果，我们对血脂和血压与微量元素的关系进行了分析。     

Magnesium in hypertension, cardiovascular disease, metabolic syndrome, and other conditions: a review.

Magnesium plays a role in a number of chronic, disease-related conditions. This article reviews current pertinent literature on magnesium, focusing on hypertension and cardiovascular diseases and implications for relationships with diabetes and metabolic syndrome. A major role for magnesium is in the regulation of blood pressure. While data are not entirely consistent, it does appear that an inverse relationship between magnesium intake and blood pressure is strongest for magnesium obtained from food rather than that obtained via supplements. Hypertension associated with preeclampsia appears to be alleviated when magnesium is administered; in addition, women with adequate intakes of magnesium are less likely to be affected by preeclampsia than those with an inadequate intake. A role for magnesium in other cardiovascular diseases has been noted in that increased magnesium intake may improve serum lipid profiles. Dietary magnesium is also recommended to aid in the prevention of stroke and is important for skeletal growth and development. Magnesium may also play a role in the development of diabetes mellitus, obesity, and metabolic syndrome. There are data from some studies, such as the DASH and PREMIER studies, that suggest that lifestyle changes (including adequate magnesium intake) can benefit blood pressure control, promote weight loss, and improve chronic disease risk.