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1.
In 190 1,Taylorreportedthefirstcaseofaspinalcordtumorassociatedwithpapilloedema ThetumorwasattheC3level ArseniandMaretsisreviewed 2 89casesofspinalcordtumor (1935- 196 5) ,andfoundonly 3casesassociatedwithpapilloedema 1 Matzkin 1992reviewed 53casesofspinaltumorassociated…  相似文献   

2.
Endothelin (ET)wasoriginallyidentifiedin 1988asavasoconstrictorcompoundintheculturesupernatantofporcineaorticendothelialcells 1 ETs (ET 1,ET 2andET 3)are 2 1aminoacidpeptides 2  NumerouscellssynthesizeandreleaseETs ,includingmainlyETcells ,butalsohumanisolatedbronc…  相似文献   

3.
Molecular cloning, sequencing and expression of obese gene in the Chinese   总被引:1,自引:0,他引:1  
Theobese(ob)gene,whichcausesseverehereditaryobesityandnoninsulindependentdiabetesmellitus(NIDDM)inmice,hasbeenclonedrecently1 Inmice,mutationsorabnormalexpressionofthisgenecauseprofoundobesity1 Theadministrationofrecombinantobprotein(leptin)cancorrecttheo…  相似文献   

4.
Etimicinsulfate (Antibiotic 89 0 7)isacategoryⅠdrugdevelopedbytheInstituteofMicrobiologyofJiangsuProvince ,China ItisanacetylderivativeofgentamicinC1a ThechemicalstructureisshowninFig 1Theresultsfromaninvitroantibacterialactivitystudyon 110 6strainsofclinicalpa…  相似文献   

5.
Neutrophilsplayanimportantrolehostdefensesystemagainstinfection Theneutrophilsgranulesfallintoperoxidase positivegranulesdefinedbytheircontentsofmyeloperoxidase (MPO)andperoxidase positivegranuleswhichmaybefurthersubdividedintospecificgranulesandgelatin…  相似文献   

6.
Mostofgynecologicmalignancesaresensitivetochemotherapy Bonemarrowsuppressionisthemaindose relatedtoxicityofmanychemotherapeuticdrugs Standardtreatmentforthiscomplicationinvolvestheuseoftransfusionalsupport,hematopoieticcytokines ,pharmacologicalrescue ,a…  相似文献   

7.
Management of cerebral ischemia due to Takayasu''''s arteritis   总被引:2,自引:0,他引:2  
Aortoarteritis ,alsocalledTakayasu’sarteritis ,isachronicidiopathicinflammatorydiseasethataffectslargeandmediumsizearteries Clinicalfeaturesreflectlimbororganischemiaresultingfromstenosistoobliterationofinvolvedarteries Thisdisease ,describedbyTakayasuin…  相似文献   

8.
Inhalationofirritantgasesisaneasyandreliablewaytoproduceananimalmodelofchronicbronchitis 1 ThefirstsuchmodelwasestabishedbyReid2  in 196 3andhasbeenwidelyusedsincethattime 3 Chronicobstructivepulmonarydiseaseisdefinedasaconditioninwhichthereispermanentairf…  相似文献   

9.
Withinthepasttenyears,therehasbeenincreasinginterestinthedetectionofspecificDNAsequencesusingmethodswhichdonotrequiretheuseofradioisotopes ,enzymesorfluorophores Biosensorsystemsbasedonnucleicacidnotonlyeliminatetheneedforsuchlabelsbutalsoofferthepoten…  相似文献   

10.
Intercellularadhesionmolecule 1(ICAM 1) ,asingle chain 76 - 110kDaglycoprotein ,isamemberoftheimmunoglobulinsupergenefamily ICAM 1hasbeenidentifiedasaligandforleukocyteadhesionmoleculedesignatedasalymphocytefunction associatedantigen(LFA 1) TheinteractionofICAM 1wi…  相似文献   

11.
Vasoactive effects of adrenotensin and its interactions with adrenomedullin   总被引:4,自引:0,他引:4  
Proadrenomedullin (Pro ADM)isaprecursorencodedbytheadrenomedullingene Therearetypicallythreepairedbasicaminoacids ,whichrepresentsitesforproteolyticprocessingsignalinPro ADM ProteolyticcleavagesofPro ADMatthreesitesreleasefourpeptides :Pro ADM2 2 4 1(prodepino…  相似文献   

12.
Lineargrowthisasensitiveindicatorofthegeneralhealthofchildrenandheightmeasurementisthereforeoneofthemostimportantclinicalfindinginpaediatrichealthsurveillance Infact,shortstature (SS)isacommonproblemforchildrenandadolescentsworldwideandisfrequentlyapre…  相似文献   

13.
BrainMRIhasbroughtonrevolutionarychangesinthemanagementofpatientswithepilepsy AlargenumberofpatientswhowerepreviouslydiagnosedtohavecryptogenicepilepsyarenowreclassifiedassymptomaticepilepsysincecausescanbeidentifiedafterbrainMRI Thisnotonlyimprovesth…  相似文献   

14.
Nitricoxide (NO)asanubiquitousmoleculeplaysanimportantroleintheneuraldevelopmentandintheprocessofapoptosis 1 Recentreportsindicatedthatheatshockproteins (hsps)couldfacilitatedifferentiationinthemalignanttumorcells2  andthattheneuronspecificenolase(NSE)coul…  相似文献   

15.
Deep cerebral venous thrombosis in adults   总被引:23,自引:0,他引:23  
Deepcerebralvenousthrombosis (DCVT)isarareformofcerebralvasculardisease Itmostoftenoccursinchildrenandinfants DCVTdiagnosisandprognosismayoftenbedifficult OurrecentexperiencehasledustorecognizethatDCVTpresentswithanatypicalsyndromeandtimecourse ,characte…  相似文献   

16.
Thrombin ,aserineprotease ,mediatescoagulation ,andstimulatescellproliferation ,adhesion ,migration ,andangiogenesis Italsoinducestheexpressionofcertaincytokinesandgrowthfactors 1,2  Plasminogenactivatorinhibitor 1(PAI 1)isrecognizedasthemajorinhibitoroftheplasm…  相似文献   

17.
EndotoxicshockisasystemicdisordercharacterizedbyexcessiveactivationofvariousorgansLungisknowntobeaprimetargetorganofendotoxinlipopolysaccharide(LPS)1Recently,nitricoxide(NO)wasfoundtobeinvolvedinexperimentalendotoxemia,2 andhasbeenregardedasthemajorfacto…  相似文献   

18.
ethods p53mutationswerescannedin 50gliomaswithvariousmalignantgradesusingthepolymerasechainreactionsinglestrandconformationpolymorphism(PCR SSCP)assay ,andwereconfirmedbydirectsequencing LOHforchromosome 10 ,17pandamplificationoftheEGFRgenewerealsoassessedusi…  相似文献   

19.
About 10 % - 15%ofcoupleswillexperienceinfertilityatsometimeduringreproductiveyearsandmalefactorsmaybeinvolvedin 30 % - 50 %ofthesecases 1,2  Azoospermiacausedbyprimarytesticularfailure ,i e non obstructiveazoospermia (NOA ) ,isusuallyirreversibleanditwaspreviouslynotp…  相似文献   

20.
BoththeUSCentersforDiseaseControl (CDC) 1 andtheWorldHealthOrganization (WHO )recommendthatisoniazidpreventivetherapy (IPT)againsttuberculosis (TB)beroutinelygiventohumanimmunodeficiencyvirus (HIV)infectedpersonswithpositiveskinteststothepurifiedproteinderiva…  相似文献   

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