共查询到20条相似文献,搜索用时 109 毫秒
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Shanhui Zhang Fei Zhou Donghai Liang Hongying Lv Hongsheng Yu 《Oncology and Translational Medicine》2020,(2):72-80
Objective This study aimed to compare the effectiveness of adjuvant chemoradiotherapy(CRT)and adjuvant chemotherapy(ChT)for T3–4/N+gastric cancer(GC)following D2/R0 dissection,and identify the specific subgroups that could benefit from adjuvant CRT.Methods All eligible patients were divided into the CRT group and ChT group.We assessed the survival outcomes and patterns of recurrence for each group,and determined the prognostic factors for survival by performing Cox proportional risk regression analyses.Results A total of 192 gastric cancer patients were included in the study.The estimated 3-year and 5-year disease-free survival(DFS)probabilities in the CRT and ChT groups were 52.9%vs.36.7%(P=0.024)and 41.2%vs.31.1%(P=0.148),respectively,and the estimated 3-year and 5-year overall survival(OS)probabilities were 82.4%vs.70.0%(P=0.044)and 52.0%vs.35.6%(P=0.022).Patients in the CRT group had a lower risk of locoregional recurrence than those in the ChT group(20.6%vs.34.4%;P=0.031).The subset analyses revealed that patients with stage N1–2 disease were more likely to benefit from adjuvant CRT than from adjuvant ChT(DFS:53.1%vs.36.4%;P=0.039;OS:53.1%vs.38.6%;P=0.036).Conclusion For locally advanced gastric cancer patients with LN+,adjuvant CRT showed superior survival benefits compared with adjuvant ChT alone.Patients with N1–2 achieved better survival from adjuvant CRT. 相似文献
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Xiangdong Cheng Yian Du Ling Huang Zhiming Jing Zhiguo Zheng 《中德临床肿瘤学杂志》2008,7(4):213-216
Objective:To investigate the death mode of human hepatoma cells exposed to matrine and the role of glutathione (GSH) and cytochrome c.Methods:The MTT test and Cell Death Detection ELISA were used to identify cell death mode and viability of cells exposed to matrine.The volume of intracellular GSH was detected by GSH reductase.Finally Western blotting was chosen to analyze the expression of cytochrome c and Caspase-9 in HepG2 cells treated by matrine.Results:The apoptotic cell death induced by matrine in Hep G2 cells dramatically increased in the time-,dose-dependent manner.Matrine can exhaust intracellular GSH effectively to change the redox state in cells.Furthermore it affect the cytotoxicity of matrine.Results of Western blotting showed that matrine induced the release of cytochrome c from mitochondria to cytoplasm,and then stimulate the cleavage of Cespese-9 in a time-dependent manner.Conclusion:Matrine induced apoptosis in Hep G2 cells through the mitochondrial pathway,and oxidative stress via depletion of GSH is directly involved in the apoptotic process. 相似文献
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放射治疗的物理质量控制与质量保证 总被引:4,自引:1,他引:4
严格的质量保证(QA)与质量控制(QC)程序是放射治疗取得预期效果的必要条件。放射治疗物理技术的QA内容麻根据病人体位同定、模拟定位影像获取,靶区确定和器官勾画,计划设计与剂量计箅和治疗操作各过程的精度要求制定。而QC则需要对每一过程中所使用设备的稳定性,计划设计的小确定度大小,治疗实施阶段的操作重复性与稳定度等进行测量、校准和修正。文章分析了放射治疗QA/QC的历史发展及其现状.并对我国的QA/QC存在的问题与发展方向作了分析。 相似文献
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放射治疗的质量保证与质量控制 总被引:3,自引:0,他引:3
文章主要阐述了放射治疗的质量管理,包括质量保证(QA)、质量控制(QC)、治疗计划和质量改进四个方面.QA是经过周密计划而采取的一系列必要措施,保证放射治疗的整个过程按国际标准安全地执行.QC是采取必要的措施保证QA的执行,并不断修改并进而达到新的QA级水平. 相似文献
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引言目前,放射治疗仍是治疗恶性肿瘤的主要手段之一[1]。在放射治疗过程中,摆位是计划执行的一个重要环节。为了保证患者在定位、验证以及每次治疗时体位的一致性,需要用到体位固定装置[2,3]。立体定向体架是保证精确摆位、定位、治疗前验证等必不可缺的工具。体架的精确度直接影响治疗的效果,所以必须对体架进行定期的质量保证和质量控制检验。本文主要讨论ELEKTA体架的质量保证和质量控制的内容与方法。1材料与方法1.1一般材料ELEKTA SLi电子直线加速器、剂量仪(Famer2570/1B)、TOSHIBA模拟定位机、胶片、刻度尺、金属小球装置、ELEKTA体架。1.2定向坐标的校正将一个金属小球装置固定在预先设置的坐标上,见图1,拍验证片,以检查体架坐标系统(指示标尺与内置金属丝坐标系统)的一致性。(1)把带有定向坐标尺的体架放在治疗床上,用水平尺把体架调整水平。调整治疗床到一个适当的位置。(2)把金属小球装置放在定向标尺一个适当的坐标上,调整激光灯到同一个坐标。(3)调整机架角度为90°,用10cm×10cm射野进行曝光。摄影条件为:管电压40KV、管电流100mA、曝光时间0.1s。(4)冲洗胶片,计算体架内... 相似文献
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Quality of life 总被引:1,自引:0,他引:1
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Quality of life 总被引:1,自引:0,他引:1
Stephens R 《Hematology / Oncology Clinics of North America》2004,18(2):483-497
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《Journal of psychosocial oncology》2013,31(2-3):171-185
"Quality of life" has become a relatively precise, operationally defined, patient-outcome measure over the past 15 years. This article discusses the evolution of the concept and its potential application to the evaluation of outcome, both for individual patients and for clinical trials. The author examines these concepts and applications in four parts: conceptual foundations (components and operational characteristics), the design of measurement tools, the conduct of trials, and the interpretation of results. 相似文献