共查询到19条相似文献,搜索用时 156 毫秒
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目的 研究不同粘合剂对药用炭颗粒吸着力的影响。方法 以淀粉、糊精、明胶和羧甲基纤维素钠(CMC-Na)为粘合剂,制成药用炭颗粒,根据中国药典2000版所载方法测定其吸着力。结果 不同含量的淀粉、糊精、明胶均会降低药用炭颗粒的吸着力,而8%~10%CMC-Na能增强药用炭颗粒的吸着力。结论 粘合剂可显著影响药用炭颗粒的吸着力,其中以CMC-Na比较理想。 相似文献
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高速搅拌制粒工艺与片剂抗张强度的关系 总被引:10,自引:1,他引:9
考察了高速搅拌湿法制粒工艺中制粒及压片两步的处方、工艺因素与颗粒成片后片剂张强度的关系以及颗粒性质与片剂抗张强度的关系。结果表明,制粒一步中粘合剂用量及搅浆速度对抗张强度起正作用,原料粒度则起负作用,粘合剂加入速度对不同压力制的片剂抗张强度影响不同。而颗粒松密度及颗粒强度与片剂抗张强度亦有相关关系。压片时压片力及颗粒含水量对片剂的抗张强度起正 相似文献
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补肾健脑颗粒制备工艺研究 总被引:2,自引:0,他引:2
目的 确定补肾健脑颗粒的制备工艺。方法 以颗粒得率、吸湿百分率为指标筛选颗粒的辅料,并采用L^9(3^4)正交试验法,以颗粒得率、溶解率为考核指标进行综合评分,考察快速搅拌制粒工艺中的几个影响因素。结果 最佳制剂工艺是乳糖用量为0.2%,制粒机转速比为快/慢,制粒时间为210s。结论 试验结果可为补肾健脑颗粒制备工艺的确定提供依据。 相似文献
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目的建立测定药用炭片吸着力的分光光度法。方法利用药用炭对生物染色剂亚甲蓝的吸附特性,用分光光度法测定药用炭对亚甲蓝吸附的剩余量。结果亚甲蓝质量浓度与吸光度的线性范围为1.0~10.0μg/mL(r=0.99993,n=6),回收率为98.5%,RSD为0.97%。结论分光光度法测定结果准确,可用于测定药用炭片吸着力。 相似文献
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The effect of total solvent volume and the presence of dissolved material (other than binder) in the granulating solution, on the properties of granules prepared from lactose: boric acid mixtures has been studied. The total volume of binder solution available to powder mixtures during massing determines the ultimate average size of granules produced. Part-dissolution of powders being granulated contributes significantly to the average granule size by increasing the total solution volume and reducing the amount of powder to be wetted. Although the amount of PVP (binder) dissolved in the granulating solution contributed very little to granule size at the concentration examined, the combined effect of total volume of solution and amount of PVP present in the granulating solution determines granule strength and porosity. The effect of the initial particle size of lactose in a binary mixture with boric acid differs from its effect reported for single component systems. 相似文献
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目的采用流化床顶喷制粒技术优化和建立中药巴戟天寡糖颗粒一次成型的工艺路线和工艺参数。方法采用单因素考察法,设定流化床顶喷包衣锅的主要工艺参数范围,将巴戟天水提取物喷至一定量的微晶纤维素粉末上,制备巴戟天寡糖颗粒,并分别测定其休止角、抹角、松密度、轻敲密度、压缩度和均一度等,计算流动性指数和平均粒径。结果当进风温度设定为40~45℃;进风压力设定为0.35~0.45bar;雾化压力设定为1.5~2.0bar;喷液速率设定为15~25r·min^-1范围时,制备的巴戟天寡糖颗粒可顺利灌装装量均一的胶囊。结论该工艺使制剂一次成型,具有生产周期短、生产效率高、辅料用量小和产品成本低等优点,在中药制剂的成型工艺中值得推广应用。 相似文献
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目的:研究头孢呋辛酯片的干法制备工艺条件,确定制备方法。方法:以颗粒粒度、流动性及成品率为考察指标,筛选干法制粒的工艺条件,并进行质量考察和稳定性研究。结果:确定干法制粒三要素分别为液压压力2·5~3MPa、挤压速度15~20r·min-1、加料速度200~300g·min-1,控制压饼厚度1~2mm。循环干法制粒的合格颗粒(16~30目)可达90%以上,休止角约30°,流动顺畅,压片成品率约94%,经加速试验和长期稳定性试验考察,各项指标符合2005年版《中国药典》相关规定。结论:经筛选后的工艺参数及微调后的处方能适应干法制粒的要求,产品稳定性优于湿法样品,工艺重现性良好,生产周期缩短。 相似文献
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目的 以对乙酰氨基酚(扑热息痛)为模型药物制备新型口服速释剂型口腔崩解片。方法 以崩解时间为指标,采用正交试验筛选片剂的处方组成,并优化制备工艺。结果 以MCC/L-HPC 50:15作为崩解剂,部分制粒压片工艺制得的扑热息痛口腔崩解片,体外平均崩解时间为35s,置于口腔40s内可崩解,无砂砾感,片剂体外溶出度1min可达95%。结论 扑热息痛口腔崩解片于口腔内可迅速崩解,制备工艺简单可行,有效地改善了药物粉末的流动性,适宜于大生产。 相似文献
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Process optimization for the enhanced stability of diclofenac potassium granules and capsules 下载免费PDF全文
Jiangyan Liu Xiunan Li Xiaoxue Zhang Haoyan Huang Liqing Chen Jinghao Cui Qingri Cao 《中国药学》2018,27(2):82-91
This study aimed to investigate the effects of different process parameters on the physical properties, in vitro dissolution rate, and short and long-term stability of diclofenac potassium (DFP) granules and capsules. DFP granules exhibited low total amounts of impurities when prepared through the wet granulation method using a granulating solvent with a low water/ethanol ratio. The impurities of the wet DFP mass dried at 70 °C were higher than those dried at 50 °C or 60 °C. DFP granules were stable under strong light exposure during preparation. DFP granules prepared using a granulating solvent with a 1:4 water/ethanol ratio had a relatively smaller particle size and higher angle of repose than those prepared using granulating solvents with other water/ethanol ratios. The dissolution rate of DFP capsules prepared using four different water/ethanol ratios was less than 2% after 10 min of dissolution and increased to 95% within 30 min of dissolution. The total amount of drug impurities of DFP capsules prepared using a granulating solvent with 1:4 water/ethanol ratio was considerably lower than those of DFP capsules prepared using a granulating solvent with a 1:0 water/ethanol solvent ratio. Regardless of the water/ethanol ratio, the capsules showed poor stability when exposed to high temperature (60 °C) and strong light (4500±500 Lux) for 10 days, but were relatively stable at high humidity (92.5% RH). The results of the long-term stability (25±2 °C and 60%±10% relative humidity) study showed that DFP granules were more stable than DFP capsules, and were stable for 12 months. The type of encapsulating material did not affect the 2-month stability of DFP. DFP granules are sensitive to granulating solvent and drying temperature and DFP capsules should be stored away from high temperature and strong light. 相似文献
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Van Nijlen T Brennan K Van den Mooter G Blaton N Kinget R Augustijns P 《International journal of pharmaceutics》2003,254(2):173-181
The purpose of this study was to enhance the dissolution rate of artemisinin in order to improve the intestinal absorption characteristics. The effect of: (1) micronisation and (2) formation of solid dispersions with PVPK25 was assessed in an in vitro dissolution system [dissolution medium: water (90%), ethanol (10%) and sodium lauryl sulphate (0.1%)]. Coulter counter analysis was used to measure particle size. X-ray diffraction and DSC were used to analyse the physical state of the powders. Micronisation by means of a jet mill and supercritical fluid technology resulted in a significant decrease in particle size as compared to untreated artemisinin. All powders appeared to be crystalline. The dissolution rate of the micronised forms improved in comparison to the untreated form, but showed no difference in comparison to mechanically ground artemisinin. Solid dispersions of artemisinin with PVPK25 as a carrier were prepared by the solvent method. Both X-ray diffraction and DSC showed that the amorphous state was reached when the amount of PVPK25 was increased to 67%. The dissolution rate of solid dispersions with at least 67% of PVPK25 was significantly improved in comparison to untreated and mechanically ground artemisinin. Modulation of the dissolution rate of artemisinin was obtained by both particle size reduction and formation of solid dispersions. The effect of particle size reduction on the dissolution rate was limited. Solid dispersions could be prepared by using a relatively small amount of PVPK25. The formation of solid dispersions with PVPK25 as a carrier appears to be a promising method to improve the intestinal absorption characteristics of artemisinin. 相似文献
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