冠心病心绞痛患者血尿酸与血脂相关研究

目的：探讨冠心病不稳定心绞痛患者血尿酸与血中甘油三酯（TG）、胆固醇（TC）、低密度脂蛋白（LDL）的关系。方法：检测120例冠心病不稳定心绞痛患者与140例正常健康人血尿酸、TG、TC、LDL水平，并进行相关的统计学分析。结果：与对照组进行比较，发现冠心病不稳定心绞痛病人组血尿酸水平明显高于对照组（P≤0．05），其TG与TC、LDL水平明显高于对照组。结论：血尿酸与血中TG、TC、LDL存在线性正相关。血尿酸是冠心病心绞痛发病的重要相关因素。     

心绞痛患者血尿酸血脂水平相关性的研究

目的 :探讨冠心病心绞痛患者血尿酸与血液中甘油三脂 (TG)、胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL)的关系。方法 :检验冠心病心绞痛患者 78例 (实验组 )与同龄段对照者 80例的血尿酸、TG、TC、LDL水平 ,并进行相关的统计学分析。结果 :实验组的血尿酸、TG、TC、LDL水平明显高于对照组 (P <0 0 5 )。结论 :血尿酸与血液中的胆固醇、TG、TC、LDL水平呈线性正相关。血尿酸是冠心病心绞痛发病的重要因素     

116例不稳定心绞痛患者脂质水平分析

目的　对不同病因的不稳定性心绞痛 (UA)患者脂质水平进行分析。方法　测定 116例UA患者入院 2 4h内的空腹血清总胆固醇 (TC)、甘油三酯 (TG)、高密度脂蛋白胆固醇 (HDL c)、低密度脂蛋白胆固醇 (LDL c)和脂蛋白a[LP(a) ] ,并以不同年龄、有无高血压、有无糖尿病作分组对比分析。结果　UA患者TG1.7～ 2 2mmol/L者占 2 3 .3 % ,TG≥ 6.2 4mmol/L者占 19.8% ,TC≥ 4.68mmol/L者 47例 (40 .5% ) ;糖尿病组和 <60岁年龄组TG、TC、LDL c分别高于非糖尿病组和≥ 60岁年龄组 (P <0 .0 5) ;高血压组仅TG高于非高血压组 (P <0 .0 5)。结论　UA患者脂质水平增高 ,且以合并糖尿病及低龄者更明显     

冠心病与血脂的关系

目的：探讨总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL－C）异常与冠心病的关系。方法：105例冠心病患者为一组,100例普通患者为对照组,全部患者血清样本于清晨空腹采集,每份样本均作TC,TG,HDL－C测定。结果：105例冠心病患者中TC升高仅占16例,TG升高占14例,与对照组无差异,HDL－C降低与对照组有显著差异（P＜0．01）。结论：血三脂中HDL与冠心病关系较大,另外可以通过计算动脉粥样硬化指数（AI）值评价冠心病发生的可能性。     

血脂与脑卒中相关性的探讨

比较分析295例脑卒中患者与对照组血脂检查结果，发现脑卒中（尤其是脑梗塞）与总胆固醇、甘油三酯、低密度脂蛋白胆固醇升高有密切关系。     

体检人群同型半胱氨酸与血脂水平相关性研究

目的探讨体检人群中血清同型半胱氨酸(Hcy)水平的分布及与四项血脂水平的相关性。方法分析2 112例体检人群Hcy水平分布特征,分别依性别分组及Hcy水平高低分组,并通过单因素及多因素回归模型分析探讨Hcy与血脂水平(包括TG、TC、LDL-C和HDL-C)的关系。结果男性组Hcy水平中位数为13.71μmol/L,女性组Hcy中位值为10.70μmol/L,男性组明显高于女性组(P0.05),低Hcy组TG水平明显低于高Hcy组(P0.05),而低Hcy组HDL-C水平明显高于高Hcy组(P0.05)。回归模型分析显示,lnHcy和ln LDL-C正相关(β=0.066,SE=0.021,P=0.002)而lnHcy和ln HDL-C负相关(β=-0.046,SE=0.019,P=0.013),高lnHcy是发生HDL-C异常降低的危险因素(OR=1.502,95%CI:1.021～2.209,P=0.039)。结论高Hcy独立相关于低HDL-C水平,且回归模型分析显示Hcy与TG及LDL-C水平也有一定的相关性。更大样本更详尽的临床数据分析有助于进一步揭示Hcy和血脂代谢的关系,从而为临床血脂代谢异常的治疗及预防提供依据。     

北京市职业人群血脂现状及其变动趋势

目的 分析2001～2002年北京人群的血脂现状及血脂异常流行率，与1984～1986年类似的研究资料作对比。方法 以31068例政府机关、科教卫生人员为观察对象，男女比6：4。对受检作问卷调查、体检及查血。血脂指标包括总胆固醇(TC)、低密度与高密度脂蛋白胆固醇(LDL—C与HDL—C)及甘油三酯(TG)。结果 与80年代资料相比，TC、LDL—C与TG水平有明显上升，但血脂的性别差异与随龄变化规律不变、详细统计了血脂异常的年龄标化及不同性别与年龄组的流行率。与美国90年代的资料相比，TC低0．41(男)及0．47(女)mmol／L(男16、女18mg／d1)，LDL—C低0．52(男)及0．39(女)mmol／L(男20、女15mg／d1)，HDL—C显高于美国人。结论 北京人群血脂TC(LDL—C)上升主要在80年代后期，90年代稳定而略有下降。TG升高幅度较大，目前冠心病血脂危险水平仍明显低于美国人。     

西藏高原地区藏族人群血脂水平分析

目的 比较分析藏族和世居拉萨汉族健康人群血脂水平和血脂异常变化状况.方法 用全自动生化分析仪检测拉萨市13 037名成年健康体检人群(藏族8 163名,汉族4 874名)空腹血脂水平(TC、TG、HDL-C、LDL-C);比较分析藏族与世居拉萨汉族不同年龄组(藏族:＜25岁组298名、25岁～组1 136名、35岁～组2 039名、45岁～组2 119名、55岁～组1 580名、65岁～组905名、≥75岁组86名,汉族:＜25岁组307名、25岁～组1 254名、35岁～组1 874名、45岁～组1 022名、55岁～组272名、65岁～组129名、≥75岁组16名)、不同性别组(藏族:男4 505名、女3 658名,汉族:男2 976名、女1 898名)之间血脂水平差异.结果 藏族TC、HDL-C和LDL-C分别为(5.07±1. 10)、(1.54±0.49)和(3.33±1.31)mmol/L,世居拉萨汉族分别为(4.60±0.98)、(1.45±0.44)和(2.85±1.08)mmol/L,藏族各年龄组均高于世居拉萨汉族(t值分别为24.78、10,53和21.46,P均＜0.05);TG藏族为1.38(0.20～2.99)mmol/L,世居拉萨汉族为1.54(0.20～2.99)mmol/L,世居拉萨汉族各年龄组均高于世居拉萨藏族(F=224.88,P＜0.05).藏族总高血脂率为75.32%,世居拉萨汉族总高血脂率为69.02%;男性为78.56%,女性为65.42%.民族、性别间差异均有统计学意义(x2分别为9.678、44.138,P均＜0.05).结论 藏族人TC、LDL-C水平和高血脂率高于长期生活在拉萨地区的汉族人群.     

精神疾病合并糖尿病患者血脂检验结果分析

目的对精神疾病合并糖尿病患者血脂检验结果进行统计分析,为精神疾病合并糖尿病及其并发症的治疗提供依据。方法选择2011年1月至2012年12月在我院诊治的精神疾病合并糖尿病患者123例为研究组,同时随机选择106例健康体检者为对照组,取两组早晨空腹时血清,检测血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)含量、对数据进行统计比较分析。结果 123例精神疾病合并糖尿病患者血清中TG、HDL-C、LDL-C含量显著高于对照组,差异有统计学意义(P<0.01);TC含量差异无统计学意义(P>0.05)。结论精神疾病合并糖尿病患者易发生血脂异常,临床医师应对这类患者血脂进行定期检验,对及早治疗及其并发症的预防有重要意义。     

小而密低密度脂蛋白胆固醇与冠心病的相关性分析

目的 研究冠心病与小而密低密度脂蛋白胆固醇(sdLDL-L)的相关性.方法 选取常州市第七人民医院2016年12月至2019年12月收治的185例冠心病患者作为病例组,根据冠状动脉(简称冠脉)不同病变支数将其分为单支冠脉病变122例,双支冠脉病变36例,3支冠脉病变27例;根据冠脉不同狭窄程度将其分为狭窄<50％ 的9...     

不稳定型心绞痛患者血清尿酸水平的观察

目的通过测定不稳定型心绞痛（UAP）患者心绞痛入院时血清尿酸（UA）水平,并与稳定型心绞痛（SAP）患者及健康者比较,探讨尿酸与心绞痛发作之间的关系。方法测定219例于本院诊断为“不稳定型心绞痛”患者入院时的高敏C反应蛋白（hs—CRP）和UA水平。在门诊体检者中选取稳定型心绞痛（SAP）患者75例和健康对照组87例。结果各组间UA水平：UAP组（357±63）μmol／L,SAP组（259±42）μmol／L,健康对照组（207±35）μmol／L。UAP组与SAP组及健康对照组比较差异均有统计学意义（P均〈0．05）。结论血清尿酸与不稳定型心绞痛的发生有一定的关系,故检测不稳定型心绞痛患者的尿酸水平,有助于了解和评价病情,早期干预可能会减少心血管事件的发生。     

Effect of acetylsalicylic acid on uric acid metabolism in patients with rheumatism

Concentrations of uric acid (UA) in the blood, saliva, circadian urine and serum xanthinoxidase activity were studied in 150 rheumatic fever patients during acetylsalicylic acid (ASA) therapy. UA concentrations were also studied in the organs (myocardium, mitral cusp, liver and kidneys) of the dead. Low salicylemia in nonreactive rheumatic fever and therapeutic salicylemia in recurrent rheumatic carditis produced a normalizing effect on uric acid metabolism but in limited renal and salivary gland excretory capacity ASA therapy aggravated uric acid metabolic disorder.     

LDL and HDL subclass distribution in patients with end-stage renal diseases

OBJECTIVES: To examine the alterations in LDL and HDL subclass distribution in ESRD patients compared with a control group and to investigate the relationship of LDL particle size to the other plasma lipoproteins levels. DESIGN AND METHODS: Plasma lipids, LDL and HDL subclasses were determined in 63 hemodialysis patients (HD), 42 predialysis patients and 345 control subjects. Lipoprotein subclasses were separated by polyacrylamide 3 to 31% gradient gel electrophoresis. RESULTS: In predialysis group, 88% subjects had small LDL particles compared with 58.5% of hemodialysis patients and 16.5% of control subjects. Mean LDL size particle diameter was significantly smaller in HD and predialysis patients in comparison with controls (p < 0,0005, p < 0,0001; respectively). Significant inverse correlation between LDL particle size and triglyceride level was observed for both patient groups. Decreased levels of the largest HDL2b subclass was found in both predialysis (16.5%) and in HD patients (30%) as compared with controls (50%), and increased levels of the small HDL3a subclass was found only in predialysis group (21%) in comparison with controls (4.5%). CONCLUSIONS: Alterations in LDL and HDL subclass distribution toward smaller particles is the main lipid abnormality associated with atherogensis found in ESRD. ESRD is associated with reduced levels of HDL2b subclass and increased levels of HDL3c subclass, which occurs in coronary artery disease (CAD) as well.     

Serum total, HDL, LDL cholesterol, and triglyceride levels in patients with rheumatoid arthritis

Patients with rheumatoid arthritis are at risk of increased prevalence of coronary heart disease. In general, the plasma level of high density lipoprotein cholesterol (HDL) correlates with the risk of incidence of ischemic heart disease. The levels of total, HDL, low density (LDL) cholesterol, and triglycerides were measured in sera of patients with rheumatoid arthritis and in healthy controls. In patients with rheumatoid arthritis (26 men and 103 women), the serum total and LDL cholesterol were higher, whereas the HDL cholesterol and triglycerides were lower (p less than 0.001) compared to the values observed in controls (625 men and 749 women). Similar patterns were seen when results of age and sex matched controls were compared to the results of patients suffering from rheumatoid arthritis. The lipid parameters of patients with rheumatoid arthritis were not different when the patients were treated with steroidal or nonsteroidal anti-inflammatory drugs.     

Symptoms of unstable angina in patients with and without diabetes

Patients with diabetes experience cardiac autonomic neuropathy that may affect the way they perceive the symptoms of unstable angina (UA). The purpose of this study was to examine symptom differences in patients with and without diabetes during an episode of UA. A convenience sample of 50 women and 50 men were recruited. Patients with diabetes were more likely to have a history of hypercholesterolemia (83% vs. 60%), prior history of heart disease (85% vs. 65%), and prior angiogram (85% vs. 67%). Patients with diabetes reported having less nausea (20% vs. 40%), less squeezing (25% vs. 48%) and less aching (25% vs. 45%) type pain, and more hyperventilation (27.5% vs. 11.7%). Other cardiac symptoms were similar between the groups. Further study of symptom presentation in patients with diabetes is warranted given their high levels of morbidity and mortality from cardiac disease.     

Pharmacokinetics of diltiazem in patients with unstable angina pectoris

The pharmacokinetics of diltiazem and its major metabolites, deacetyldiltiazem and N-monodemethyl-diltiazem, were studied after single and chronic oral administration in eight patients aged 45 to 69 years with unstable angina pectoris, treated by diltiazem, 120 mg t.i.d. After a single oral dose the time to peak plasma diltiazem concentration was 3.4 (2.1 to 5.0) hours and the elimination half-life was 6.6 hours (4.4 to 10.8 hours). These were unchanged after repeated oral administration (16 to 19 doses). The mean trough (8 hours after administration) plasma diltiazem level after six consecutive doses was 167 micrograms/L (63 to 286 micrograms/L) and was thereafter stable. With chronic administration the AUC increased by a factor of 2.24 +/- 0.31 (SEM; P less than 0.01). Plasma protein binding of diltiazem in these patients ranged from 83% to 93% whereas deacetyldiltiazem binding ranged from 58% to 75%. Plasma protein binding was independent of drug concentration and duration of treatment. Thus an average dose of 120 mg diltiazem given every 8 hours would appear to be a suitable regimen of treatment in most patients with angina pectoris, although users should be aware that there is a significant interpatient variability in steady-state diltiazem concentrations and that a significant accumulation of diltiazem occurs with chronic therapy.     

曲美他嗪治疗不稳定型心绞痛的疗效观察

目的　观察在常规治疗基础上加用曲美他嗪治疗不稳定型心绞痛的疗效。方法　 10 3例确诊为不稳定型心绞痛的患者被随机分为两组 ,常规治疗组 5 1例 ,接受硝酸酯类、钙离子阻滞剂、血管紧张素转换酶抑制剂、β受体阻滞剂和抗血小板药物治疗。曲美他嗪组 5 2例 ,在常规治疗基础上加用曲美他嗪。两组治疗时间均为 (2 8± 2 )天。观察两组症状、心率、血压、动态心电图的变化及副作用。结果　与常规治疗组比较 ,曲美他嗪组的疗效更好 ,差异有统计学意义 (P <0 .0 1) ;曲美他嗪对心率、血压和率压乘积无影响 ;曲美他嗪组缺血发作次数、ST段最大下降幅度、总缺血时间的减少更为明显 ,差异均有统计学意义 (均P <0 .0 1)。结论　在常规治疗基础上加用曲美他嗪能更有效地改善不稳定型心绞痛症状 ,明显减少缺血发作次数、ST段最大下降幅度和总缺血时间。对血流动力学无影响。不良反应轻。是安全、有效、更完善的治疗方案     

LDL susceptibility to oxidation and HDL antioxidant capacity in patients with renal failure

Objectives

This study examines the susceptibility to oxidation and the ability to stimulate reactive oxygen species of LDL from hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients. It was also designed to evaluate the antioxidant activity of HDL from uremic patients.

Design and methods

Lipoprotein properties were determined in 28 HD patients, 30 CAPD patients and 30 control subjects by spectrophotometric, chemiluminescence and electrophoresis methods.

Results

CAPD LDL were more resistant to oxidation than control LDL. HD and control LDL, in contrast to CAPD LDL, stimulated reactive oxygen species generation in granulocytes. The HDL ability to protect LDL against oxidation was impaired in renal patients.

Conclusions

The risk of atherosclerosis development in patients with renal failure does not appear to be related to less resistance of LDL to oxidation, but rather to the decreased HDL antioxidant capacity.