联合型瑞文测验辽宁城市和农村儿童智商常模的研制

目的：研制联合型瑞测验辽宁城市和农村儿童商常模（ＣＲＴ－ＬＮＣ、ＣＲＴ－ＬＮＲ）。方法用联合型瑞测验对城市、农村５－１４岁儿童取样。结果城市与农村儿童各年龄组原始得分差异显（ｔ＝２．８６－８．２４）,同年龄组的男、女儿童原得分均无显差异（城市ｔ＝０．０７－０．７７,农村ｔ＝０．０２－０．９１）;测题难度达到理想值（ＣＰ＝０．３－０．７,城市５６．８７％,农村６１．４３％）;区分度较好（ｒ〈     

联合型瑞文测验第2次修版在湖南的实证研究

目的 了解联合型瑞文测验第２次修订后的常模对评价湖南省儿童智商水平的适宜性。方法对１９９６年测试的１６６４名城乡在校学生的智商采用新常模进行了判定,并与原常模判定结果进行了比较。结果 第２次修订的常模判定城市、农村在校儿童的智商性别间无显著差异,智商接近于１００为均数的理论分布,在评价城市儿童智商时稍高,而第１次修订的常模判定的智商呈明显偏态分布,高智商比例明显增多。结论 对常模进行第２次修订是十     

联合型瑞文测验湖南城区和农村儿童常模的研制

目的　研制联合型瑞文测验湖南城区儿童常模（ Ｃ Ｒ Ｔ－ Ｈ Ｎ Ｃ）和农村儿童常模（ Ｃ Ｒ Ｔ－ Ｈ Ｎ Ｒ）。方法　运用联合型瑞文测验方法。结果　测题难度达理想值（ Ｃ Ｐ＝ ０．３～０．７）,区分度较好（ｒｐｂ＞ ０．１９５, Ｐ ＜ ０．０５）鉴别指数 Ｄ ＞ ０．２０ 者占 ８７７１％ 复测信度高（ｒ＝ ０．９１１３, Ｐ ＞ ０．０５）,同时效度理想（ｒ语＝ ０．４８, ｒ数＝ ０．４１, Ｐ ＜ ０．０１）。结论　此常模可作为我省卫生、教育等部门评价儿童智力状况的测量工具。     

湖南省城乡5—16岁儿童瑞文测验智力水平分析

用瑞文测验方法测定了湖南省碘缺乏病非病区或轻度缺碘地区城市和农村５～１６岁儿童智力水平。结果表明，城乡儿童智商发育基本正常，均值高于全国常模，呈轻度偏态分布。农村儿童的学龄前期、小学和中学的三个阶段智商呈上升趋势，认为这与社会刺激较少及升学率不高有关     

Breast feeding and maternal smoking as predictors of wheezing in children age 6 to 10 years

The possibility that controllable environmental factors such as passive smoking and non-breast feeding contribute substantially to wheezing has implications for prevention. Effects of passive smoking and non-breast feeding on wheezing in children aged 6 to 10 years were explored in a historical cohort study of 223 children. Family history of respiratory allergy or asthma, male sex, maternal smoking, and non-breast feeding were significantly associated (p less than 0.05) with wheezing in bivariate analysis. In multivariate loglinear analyses, predictors of wheezing included non-breast feeding (p = 0.05, odds ration = 2.1), male sex (p less than 0.03, odds ratio = 3.1), and family history of respiratory allergy (p less than 0.03, odds ratio = 2.6). In a second model, predictors included an interaction of maternal smoking and family history (p less than 0.005, odds ratio = 4.6) in addition to male sex and family history of respiratory allergy. In further exploration based on tabular analysis, maternal smoking appeared to increase wheezing among children in whom the family history of respiratory allergy was positive (p less than 0.001). Among children in whom the family history of respiratory allergy was negative, non-breast feeding appeared to increase wheezing (p = 0.01). Promotion of breast feeding and reduction of maternal smoking might reduce childhood wheezing.     

二十岁以下慢性HBV感染者HBVDNA与HBeAg的定量关系

目的:探讨20岁以下慢性乙型肝炎病毒(HBV)感染者血清中HBV DNA、乙型肝炎病毒e抗原(HBeAg)定量之间关系.方法:用实时荧光定量聚合酶链反应(FQ-PCR)及时间分辩荧光免疫分析(TRFIA)技术检测339例(1-20岁)慢性HBV感染者血清中HBVDNA、HBeAg含量,用速率法检测ALT水平.结果:HBeAg定量＞0.3 NCU/mL、HBV DNA定量＞105 copies/mL、而ALT水平正常者占总检测病例的92.3%;HBV DNA定量(对数值)与HBeAg定量之间存在正相关关系(r=0.769,P＜0.001)和线性回归关系(b=0.32,R2=0.59,P＜0.001).结论:20岁以下慢性HBV感染者血清中HBVDNA水平与HBeAg水平存在同时消长的关系,但是有极少患者例外.HBV DNA定量与HBeAg定量两种检测方法相结合应能够更客观地反映患者HBV感染状况,二者具有互补性.     

40岁以下肺癌病人放疗与化疗疗效分析

目的探讨40岁以下失去手术机会的肺癌病人放疗与化疗的疗效及影响预后因素。方法103例40岁以下病人单纯化疗45例,化疗与放疗综合治疗54例,单纯放疗4例。结果103例中CR23．3％（24／103）,总有效率75．73％。1、2、5年生存率分别为52．37％、29．87％、7．8％,中位生存期15个月。结论放疗与化疗综合治疗疗效优于单一方法治疗;血清CEA、误诊及机体免疫功能为影响愈后的重要因素。     

CHADS2 and CHA2DS2-VASc scores as predictors of platelet reactivity in acute coronary syndrome

BackgroundPlatelet function testing (PFT) in patients treated with P2Y₁₂ inhibitors has been widely evaluated for the prediction of stent thrombosis, myocardial infarction, and bleeding events following percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS). Thus, PFT-guided treatment could positively affect patient outcomes. Data regarding clinical parameters for predicting platelet reactivity in ACS patients are limited. Therefore, our study aims to evaluate CHADS2 and CHA2DS2-VASc scores as predictors for platelet reactivity in ACS patients.MethodsTwo hundred and ninety-one consecutive patients who underwent PCI and were treated with aspirin and clopidogrel due to ACS were tested for their CHADS2, CHA2DS2-VASc scores and platelet reactivity using adenosine diphosphate (ADP)-induced aggregation (conventional aggregometry). Patients were classified into groups according to their CHADS2 and CHA2DS2-VASc scores. Low-risk group (0–1 score) for CHADS2 and CHA2DS2-VASc scores and high-risk group (2–6, 2–9) for CHADS2 and CHA2DS2-VASc scores, respectively. Furthermore, platelet reactivity in each group were compared (low CHADS2 group vs high CHADS2 group, and low CHA2DS2-VASc vs high CHA2DS2-VASc). Platelet reactivity was defined as low platelet reactivity (<19 U), optimal platelet reactivity [(OPR); 19–46 U], and high on-treatment platelet reactivity [(HPR); >46 U]. Thereafter receiver operating characteristic curve analysis was conducted to verify whether CHADS2 and CHA2DS2-VASc scores could predict platelet reactivity.ResultsLow CHADS2 and CHA2DS2-VASc scores were significantly correlated with lower mean platelet ADP-induced aggregation as compared with high CHADS2 and CHA2DS2-VASc scores [45.5 U (± 16) vs. 54.8 U (±15) and 44.2 U (±16) vs. 51.0 U (±17), respectively, p = 0.01 for both].ConclusionIn ACS patients treated with clopidogrel following PCI, high CHADS2 and CHA2DS2-VASc scores correlated with HPR and lower scores correlated with OPR. Further studies are needed to evaluate our findings’ clinical implications.     

Atrial fibrillation (AF) and co-morbidity in elderly. A population based survey of 85 years old subjects

The occurrence of AF increases sharply with age. The aim of this study was to explore and compare prevalent co-morbidity and self-estimated health-related quality of life (HRQoL) in subjects with AF versus subjects with sinus rhythm or pacemaker in 85 years old subjects. We analyzed data from a population of 336 eighty-five years old subjects participating in the Elderly in Linköping Screening Assessment (ELSA-85) study. Medical history was obtained from postal questionnaire, medical records and during medical examination that included a physical examination, cognitive tests, non-fasting venous blood samples and electrocardiographic (ECG) examination. 19% had an ECG showing AF. There were very few significant differences regarding medical history, self-estimated quality of life (QoL), laboratory- and examination findings and use of public health care between the AF group and the non-AF group. The study showed that the population of 85 years old subjects with AF was surprisingly healthy in terms of prevalent co-existing medical conditions, healthcare contacts and overall HRQoL. We conclude that elderly patients with AF do not in general have increased co-morbidity than subjects without AF.     

梅毒患者病程中IL-2、IL-10的检测

目的探讨梅毒螺旋体感染的不同病程与细胞因子水平的关系。方法采用ELISA法检测一期、二期、潜伏期梅毒组、血清固定组患者血清中细胞因子IL-2、IL-10的含量。结果一期梅毒组IL-2高于对照组（q=6.68,P〈0.01）;二期梅毒组IL-2低于一期组（q=5.38,P〈0.01）;二期梅毒组IL-10高于一期梅毒组和对照组（q=6.03,P〈0.01）;血清固定组IL-10高于对照组（q=6.60,P〈0.01）。结论IL-2在一期梅毒达高峰,之后随病程进展显著降低。IL-10于二期梅毒显著升高,之后随病程进展呈升高趋势。宿主感染梅毒螺旋体后,其细胞免疫功能受到明显抑制,且随病程进展,其抑制现象愈加显著。